Search Results - (Author, Cooperation:C. E. King)
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1Latest Papers from Table of Contents or Articles in PressV. M. D'Costa ; C. E. King ; L. Kalan ; M. Morar ; W. W. Sung ; C. Schwarz ; D. Froese ; G. Zazula ; F. Calmels ; R. Debruyne ; G. B. Golding ; H. N. Poinar ; G. D. Wright
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-09-02Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Anti-Bacterial Agents/pharmacology ; Bacteria/classification/enzymology/genetics ; Bayes Theorem ; Crystallography, X-Ray ; DNA, Chloroplast/genetics ; Freezing ; Genes, Bacterial/*genetics ; Genes, Mitochondrial/genetics ; Genes, Plant/genetics ; Geologic Sediments/microbiology ; History, Ancient ; Hydrogen Bonding ; *Metagenomics ; Models, Molecular ; Molecular Sequence Data ; Phylogeny ; Protein Conformation ; RNA, Ribosomal/genetics ; RNA, Ribosomal, 16S/genetics ; Siberia ; Vancomycin Resistance/drug effects/*genetics ; Vertebrates/genetics ; beta-Lactamases/geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressR. G. Bingham ; F. Ferraccioli ; E. C. King ; R. D. Larter ; H. D. Pritchard ; A. M. Smith ; D. G. Vaughan
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-28Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
3Articles: DFG German National LicensesRodger, J. ; Lindsey, K. A. ; Leaver, S. G. ; King, C. E. ; Dunlop, S. A. ; Beazley, L. D.
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The vertebrate retina projects topographically to visual brain centres. In the developing visual system, gradients of ephrins and Eph receptors play a role in defining topography. At maturity, ephrins but not Ephs are downregulated. Here we show that optic nerve section in adult rat differentially regulates the expression of ephrin-A2 in the superior colliculus (SC) and of EphA5 in the retina. Expression was quantified immunohistochemically; ephrin-A2 levels were also estimated by semiquantitative reverse transcriptase polymerase chain reaction. In the normal SC, ephrin-A2 was expressed at low levels. At 1 month, levels of protein and of mRNA were upregulated across the contralateral SC giving rise to an increasing rostro-caudal gradient. At 6 months, levels had fallen but a gradient remained. In the retina of normal animals, EphA5 was expressed as an increasing naso-temporal gradient. By 1 month, expression was decreased in far temporal retina, resulting in a uniform expression across the naso-temporal axis. We suggest that denervation-induced plastic changes within the SC modify expression of these molecules.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0266-3554Topics: HistoryNotes: BOOK REVIEWSURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0266-3554Topics: HistoryNotes: Book ReviewsURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0266-3554Topics: HistoryNotes: Book ReviewsURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1432-0533Keywords: Key words Taxol ; Neurofilaments ; Microtubules ; Alzheimer’s diseaseSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Cytoskeletal disruption is a key pathological change in numerous human neurodegenerative diseases. We have, therefore, examined the effect of taxol, a microtubule-stabilising agent, on the neuronal response to localised trauma in the central nervous system utilising a rodent experimental model that replicates cytoskeletal alterations which occur in conditions such as Alzheimer’s disease and head injury. At 1 day post-injury, 1 mM taxol administration to the damaged neocortex resulted in a statistically significant reduction in the density of abnormal neurites labelled with antibodies to neurofilaments. In addition, there was a relative preservation of MAP2 labelling of dendrites surrounding the injury site in taxol-treated, as compared to vehicle-treated, animals at 1 day post-injury. At 4 days post-injury, however, there was a statistically significant increase in the density of abnormal neurites surrounding the injury site in taxol-treated rats as compared to vehicle-treated animals. The degree of MAP2 labelling was also equally decreased in both vehicle- and taxol-treated animals as compared to normal cortex at this time point. Our data suggest that, in the short term, taxol may be stabilising neuronal microtubules and reducing reactive alterations in axons. After longer periods, however, our data indicate that the stereotypical neuronal reaction to trauma may be abnormally prolonged due to taxol administration, consistent with both in vivo work on taxol intoxication in the injured peripheral nervous system and in vitro culture studies.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1573-4803Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract The compounds Sm2Co17 and Pr2Co17 have been charged with hydrogen and the hydrogen compositions determined between pressures of approximately 2.5×10−2 and 13 atm at temperatures of 150 and 200° C. Very low rates of hydrogen absorption were observed below 150° C so that solubility measurements have not been obtained below this temperature. The X-ray diffraction studies show that the structure of the metal lattice is unchanged by the hydrogenation process, i.e. the rhombohedral, Th2Zn17 structure type with space groupR¯3m is maintained. As a result of the expansion the alloys become cracked and friable on hydrogenation.Type of Medium: Electronic ResourceURL: