Search Results - (Author, Cooperation:C. Dean)

2018-06-22

Nature Publishing Group (NPG)

2041-1723

Biology

Chemistry and Pharmacology

Natural Sciences in General

Physics

Karnopp, Dean C.; Margolis, Donald L.; Rosenberg, Ronald C.

Unknown

514 S.

second edition

0-471-62171-4

a unified approach

2014-09-16

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Amino Acid Sequence ; Arabidopsis/enzymology/*genetics ; Arabidopsis Proteins/*genetics/metabolism ; Cellular Reprogramming/genetics ; Chromosome Mapping ; DNA Methylation ; *Epigenesis, Genetic ; *Gene Expression Regulation, Plant ; Gene Silencing ; MADS Domain Proteins/*genetics ; Molecular Sequence Data ; Mutation ; Sequence Alignment ; Transcription Factors/genetics/metabolism

2015-03-06

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; *Biodiversity ; *Fossils ; Hominidae/*anatomy & histology/*classification ; Humans ; Imaging, Three-Dimensional ; Mandible/anatomy & histology ; *Phylogeny ; Skull/anatomy & histology

2018-05-04

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Geosciences

Computer Science

Medicine

Natural Sciences in General

Physics

Ecology, Science and Policy

2013-05-04

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Amino Acid Sequence ; Arabidopsis/*genetics/metabolism ; Arabidopsis Proteins/chemistry/*genetics/*metabolism ; Chromatin/metabolism ; DNA, Plant/chemistry/metabolism ; DNA, Single-Stranded/chemistry/metabolism ; Gene Expression Regulation, Plant ; Homeodomain Proteins/chemistry/*metabolism ; MADS Domain Proteins/*genetics/metabolism ; Molecular Sequence Data ; Nucleic Acid Conformation ; Promoter Regions, Genetic ; Protein Binding ; RNA, Antisense/chemistry/*genetics/metabolism ; RNA, Long Noncoding/chemistry/*genetics/metabolism ; RNA, Plant/chemistry/*genetics/metabolism ; Transcription Termination, Genetic ; *Transcription, Genetic

2012-07-17

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Arabidopsis/*genetics/growth & development ; Arabidopsis Proteins/*genetics/*metabolism ; Chromatin/genetics/metabolism ; Chromatin Immunoprecipitation ; *Cold Temperature ; DNA-Binding Proteins/genetics/metabolism ; Enhancer Elements, Genetic ; Flowers/*genetics/growth & development ; *Gene Expression Regulation, Plant ; *Gene Silencing ; Histones/genetics/metabolism ; Lysine/genetics/metabolism ; MADS Domain Proteins/*genetics ; Methylation ; Polycomb-Group Proteins ; Polymorphism, Genetic ; Repressor Proteins/genetics/*metabolism ; Seasons

2012-03-31

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Arabidopsis/*genetics/metabolism ; Arabidopsis Proteins/*genetics/metabolism ; Base Sequence ; Chromatin/genetics/metabolism ; Chromatin Immunoprecipitation ; *Gene Expression Regulation, Plant ; MADS Domain Proteins/genetics/metabolism ; Molecular Sequence Data ; Mutation ; Polyadenylation ; Protein Structure, Tertiary ; RNA Interference ; RNA, Messenger/genetics/metabolism ; RNA, Plant/*genetics/metabolism ; RNA-Binding Proteins/*genetics/metabolism ; Ribonuclease III/chemistry/genetics/*metabolism ; *Transcription, Genetic ; Transgenes

2012-08-10

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Biological Evolution ; Classification ; Face/anatomy & histology ; *Fossils ; Hominidae/*anatomy & histology/*classification ; Humans ; Kenya ; Mandible/anatomy & histology ; Palate/anatomy & histology ; Skull/anatomy & histology ; Tooth/anatomy & histology

2011-07-26

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Arabidopsis/*genetics/physiology ; Arabidopsis Proteins/genetics ; Chromatin Immunoprecipitation ; *Epigenesis, Genetic ; *Gene Expression Regulation, Plant ; Gene Silencing ; Histones/metabolism ; MADS Domain Proteins/genetics ; Methylation ; Models, Genetic ; Plant Roots/metabolism ; Polycomb-Group Proteins ; Repressor Proteins/*metabolism ; Reproducibility of Results ; Seasons ; Temperature

2018-06-15

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Geosciences

Computer Science

Medicine

Natural Sciences in General

Physics

1524-4741

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

▪ Abstract: The purpose of this study was to determine outcomes for patients with operable noninflammatory stage IIIA/B locally advanced breast cancer (LABC) with positive axillary lymph nodes receiving high-dose chemotherapy (HDC) with peripheral blood stem cell (PBSC) support. One hundred fifteen patients with LABC who were no evidence of disease (NED) after initial surgery received standard dose induction chemotherapy, chemotherapy for mobilization of PBSC, and high-dose cyclophosphamide, thiotepa, and carboplatin with PBSC support for adjuvant therapy. Following hematopoietic recovery, all patients were scheduled to receive radiation therapy and tamoxifen was administered if the primary tumor was estrogen receptor/progesterone receptor (ER/PR) positive. Eighty-eight percent of patients were admitted to the hospital following HDC for a median of 11 days (range 3–26) and 12% were treated entirely as outpatients. There was one treatment-related death (0.9%) from infection occurring on day 8 after HDC. Forty-four (38%) have relapsed at a median of 20 months (range 10–55) from diagnosis, 11 (10%) with local-regional and 33 (28%) with metastatic disease. The probabilities of overall (OS) and event-free survival (EFS) for all 115 patients at 3 years were 0.73 and 0.61, respectively, with a median follow-up of 42 months (range 10–89) from diagnosis. In univariate and multivariate analyses, no factors could be identified that were statistically predictive for OS or EFS. However, there were trends for patients with ER/PR-negative primary tumors to have worse OS (p = 0.16) and EFS (p = 0.10) than patients with ER/PR-positive tumors. This adjuvant combined modality strategy incorporating HDC is safe and compares favorably to historical studies of neoadjuvant or adjuvant treatment for LABC. Further attempts to improve outcomes of patients with LABC receiving HDC are warranted. ▪

Electronic Resource

1460-9592

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

0022-0973

Education

1932-7064

History

1932-7064

History

1573-2614

Brain: blood volume ; Measurement techniques: spectroscopy ; Monitoring: oxygen ; Brain: oxygen consumption

Springer Online Journal Archives 1860-2000

Computer Science

Medicine

Abstract Near-infrared spectroscopy is a noninvasive bedside technique for monitoring hemoglobin saturation (HbO2%) in brain vasculature. The method linearly relates the optical signal detected from the surface of the head to HbO2%. To do so, the method relies on constant transcranial optical pathlength and light scattering as well as minimal interference by tissues overlying the brain. This study examined these premises. Optical signals from a dual-wavelength, near-infrared spectrometer were correlated with sagittal sinus HbO2% in 7 anesthetized piglets subjected to 7 different physiological conditions: normoxia, moderate and severe hypoxia, hyperoxia, hypocapnia, hypercapnic hyperoxia, and hypotension. These conditions were induced by varying the inspired O2 concentration (7–100%),k ventilatory rate (5–35 breaths/min), and blood pressure (phlebotomy 20 ml/kg) to force HbO2% over a wide range (5–93%). To evaluate interference by tissues overlying the brain, correlations were repeated after the scalp and skull were rendered ischemic. Transcranial optical pathlength was measured by phase-modulated spectroscopy. Linear relationships between optical signals and sagittal sinus HbO2% were found with correlation coefficients ranging from −0.89 to −0.99 (p〈0.05) among animals; however, slope and intercept had coefficients of variability of approximately 15 and 333%, respectively. Almost identical linear expressions were observed whether scalp and skull were ischemic or perfused. Transcranial optical pathlength was constant in each animal, but ranged from 10 to 18 cm among animals. The data indicate that the assumptions underlying near infrared spectroscopy are reasonably accurate in a given animal, but that the constants for transcranial optical pathlength and light scattering are not the same in all animals. Since this variability may give rise to errors in quantifying HbO2% in the clinical setting, further study is recommended before the method can be used to manage patients.

Electronic Resource

1573-2614

Oximetry ; near-infrared ; spectroscopy ; infant ; pediatric ; optical path length

Springer Online Journal Archives 1860-2000

Computer Science

Medicine

Abstract Background. Near-infrared spectroscopy (NIRS) is an emerging technique for noninvasive, bedside monitoring of cerebral oxygenation and blood flow. Traditionally, it has relied on the Beer's Law relationship in which the concentration of light-absorbing oxygen-carrying pigments is proportional to their light absorbance, and inversely proportional to an optical path length (a measure of the distance traveled by photons passing through the tissue). In practice, NIRS has been based upon assumptions that mean transcranial optical path length, the average optical path length for a given patient, is constant among patients and independent of the wavelength of light used.Objective. The objective of our study was to measure mean optical transcranial path length in infants as a step in allowing quantitation of cerebral oxygenation.Methods. We measured mean transcranial optical path length in 34 infants, aged 1 day to 3 years, using amplitude-modulated phase-shift spectroscopy at 754 nm and 816 nm. Optical transcranial path lengths (mean±SEM) were 8.6±0.9 cm, 11.1±0.9 cm, and 11.3±0.9 cm at 754 nm, and 8.8±0.9 cm, 11.2±0.8 cm, and 11.1±0.9 cm at 816 nm, using emitter-detector separations of 1.8, 2.5, and 3.0 cm, respectively. Optical path length increased as emitter-detector separation, head circumference, or age increased. Variance in the ratio of mean optical path lengths at the two different wavelengths exceeded that accounted for by variation in repeated measures alone (p〈0.001), suggesting that optical path length is also not independent of wavelength.Conclusions. NIRS instrument emitter-detector geometry, subject age, head size, and wavelength used each influence optical path length. Quantitative NIRS measurements in clinical use may require concurrent measurement of both absorbance and optical path length at each wavelength, or use of newer measures that are not based upon Beer's Law assumptions.

Electronic Resource

1435-8107

Springer Online Journal Archives 1860-2000

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Abstract The effect of chlorflurenol (methyl 2-chloro-9-hydroxyfluorene-9-carboxylate) (CF) on chlorophyll (chl) content was studied in intact plants and floating leaf disks. For intact soybean (Glycine max (L.) Merrill) plants grown in the growth chamber, 2.5 μg/ml CF applied 10 to 20 d after planting retarded chl decline in senescing tissues such as cotyledons and unifoliate leaves and increased chl content in recently expanded tissues such as trifoliate leaves. CF did not retard chl decline in the dark unless regulator application was followed by a period of 24 h in the light prior to darkness. In floating leaf disk tests, CF retarded chl decline in dock (Rumex obtusifolius L.) and radish (Raphanus sativus L.) at concentrations of 10−4 M, but was ineffective at lower concentrations. Chl decline was significantly hastened by CF in tobacco (Nicotiana tabacum L.) and soybean, but was unchanged in barley (Hordeum vulgare L.). CF treatment increased tissue weight (g fresh wt/cotyledon; g dry wt/ cm2 for unifoliate and trifoliate leaves), decreased moisture content, and increased leaf thickness, palisade layer thickness, and palisade and spongy mesophyll cell counts. We conclude that plants treated with morphactins show greater green coloration predominantly because of growth effects, and only in small part because of prevention of chl decline in senescing tissues.

Electronic Resource

book

1982

Lehrerausbildung ; Aufsatzsammlung

English