Search Results - (Author, Cooperation:C. Czerkinsky)

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  1. 1
    Staff View
    Publication Date:
    2011-08-26
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Cholera/*epidemiology/microbiology/*transmission ; Genome, Bacterial/genetics ; Haiti/epidemiology ; Humans ; Likelihood Functions ; Molecular Epidemiology ; Pandemics/*statistics & numerical data ; Phylogeny ; Polymorphism, Single Nucleotide/genetics ; Vibrio cholerae/classification/*genetics/*isolation & purification ; Zimbabwe/epidemiology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    AHLFORS, E. ; CZERKINSKY, C.

    Oxford, UK : Blackwell Science Ltd
    Published 1997
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    The effect of intragastric administration of antigen on the development of a mucosal cell-mediated immune response has been examined in a mouse model. Feeding mice with picryl sulfonic acid (PSA) abrogated development of buccal delayed-type contact hypersensitivity (CS) responses upon buccal challenge with picryl chloride (PCl) in animals that had previously been sensitized in the oral mucosa. In contrast, such feeding had no effect on buccal CS reactivity in animals similarly challenged but sensitized at skin sites. Conversely, gastric administration of PSA suppressed PCl-induced skin CS reactivity in skin-sensitized animals but had no effect on skin CS reactivity in buccally sensitized mice. Enterically induced suppression of buccal mucosa CS reactivity was associated with marked reductions in the numbers of infiltrating CD11b+ macrophages and CD4+ cells, and a virtual disappearence of CD8+ cells in buccal tissue specimens examined 24 h after local challenge. Thus, depending on the initial site of immune sensitization, oral antigens may also suppress mucosal T cell reactivity.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  3. 3
    Sun, J.-B. ; Stadecker, M. J. ; Mielcarek, N. ; Lakew, M. ; Li, B.-L. ; Hernandez, H. J. ; Czerkinsky, C. ; Holmgren, J.

    Oxford, UK : Blackwell Science Ltd
    Published 2001
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Granulomatous inflammation in schistosomiasis is a delayed-type hypersensitivity reaction mediated by CD4+ T cells specific for parasite egg antigens (Ags). In an attempt to control T-cell responses leading to excessive harmful inflammation and granuloma formation, especially in the liver, BALB/c mice were intranasally (i.n.) treated with soluble Schistosoma mansoni egg Ags (SEA) conjugated to cholera toxin B subunit (CTB), a mucosa-binding protein with demonstrated capacity to suppress inflammatory T-cell functions after mucosal administration. Treatment with CTB–SEA significantly conjugate a reduced liver granuloma formation in infected mice associated with decreased SEA specific Th1- and Th2-type immune responses by liver leukocytes. Importantly, treatment with CTB–SEA conjugate also significantly reduced the mortality in chronically infected mice. In S. mansoni-infected large-granuloma forming CBA mice, i.n. treatment with purified Sm-p40, the major egg antigen, conjugated to CTB likewise significantly inhibited hepatic egg granuloma formation. A reduction of SEA-driven lymphoproliferation and of interferon (IFN)-γ, interleukin (IL)-4 and IL-5 production, together with an increase in transforming growth factor (TGF)-β1 production, were observed in splenic cells from CTB-Sm-p40-treated SEA-sensitized mice, as well as in liver leukocytes from CTB-Sm-p40-treated schistosome-infected mice. These results indicate that mucosal administration of SEA or purified Sm-p40 antigen in conjunction with CTB is highly effective in curtailing immunopathologic manifestations of schistosomiasis in vivo in infected hosts.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  4. 4
    Hanson, L. Å. ; Telemo, E. ; Wiedermann, U. ; Dahlman, A. ; Saalman, R. ; Ahlstedt, S. ; Friman, V. ; Holmgren, J. ; Czerkinsky, C. ; Dahlgren, U.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1993
    Staff View
    ISSN:
    1399-3038
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  5. 5
    CZERKINSKY, C. ; NILSSON, L.-Å. ; OUCHTERLONY, Ö. ; TARKOWSKI, A. ; GRETZER, C.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1984
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Culture and assay procedures are described for the generation and the subsequent detection of single antigen-specific antibody-secreting cells after in vitro stimulation of human peripheral blood lymphocytes with tetanus toxoid. Simple, specific and sensitive, this new assay-culture system is well suited for the analysis of specific antibody production in man.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses