Search Results - (Author, Cooperation:C. Berne)

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  1. 1
    D. Shungin ; T. W. Winkler ; D. C. Croteau-Chonka ; T. Ferreira ; A. E. Locke ; R. Magi ; R. J. Strawbridge ; T. H. Pers ; K. Fischer ; A. E. Justice ; T. Workalemahu ; J. M. Wu ; M. L. Buchkovich ; N. L. Heard-Costa ; T. S. Roman ; A. W. Drong ; C. Song ; S. Gustafsson ; F. R. Day ; T. Esko ; T. Fall ; Z. Kutalik ; J. Luan ; J. C. Randall ; A. Scherag ; S. Vedantam ; A. R. Wood ; J. Chen ; R. Fehrmann ; J. Karjalainen ; B. Kahali ; C. T. Liu ; E. M. Schmidt ; D. Absher ; N. Amin ; D. Anderson ; M. Beekman ; J. L. Bragg-Gresham ; S. Buyske ; A. Demirkan ; G. B. Ehret ; M. F. Feitosa ; A. Goel ; A. U. Jackson ; T. Johnson ; M. E. Kleber ; K. Kristiansson ; M. Mangino ; I. Mateo Leach ; C. Medina-Gomez ; C. D. Palmer ; D. Pasko ; S. Pechlivanis ; M. J. Peters ; I. Prokopenko ; A. Stancakova ; Y. Ju Sung ; T. Tanaka ; A. Teumer ; J. V. Van Vliet-Ostaptchouk ; L. Yengo ; W. Zhang ; E. Albrecht ; J. Arnlov ; G. M. Arscott ; S. Bandinelli ; A. Barrett ; C. Bellis ; A. J. Bennett ; C. Berne ; M. Bluher ; S. Bohringer ; F. Bonnet ; Y. Bottcher ; M. Bruinenberg ; D. B. Carba ; I. H. Caspersen ; R. Clarke ; E. W. Daw ; J. Deelen ; E. Deelman ; G. Delgado ; A. S. Doney ; N. Eklund ; M. R. Erdos ; K. Estrada ; E. Eury ; N. Friedrich ; M. E. Garcia ; V. Giedraitis ; B. Gigante ; A. S. Go ; A. Golay ; H. Grallert ; T. B. Grammer ; J. Grassler ; J. Grewal ; C. J. Groves ; T. Haller ; G. Hallmans ; C. A. Hartman ; M. Hassinen ; C. Hayward ; K. Heikkila ; K. H. Herzig ; Q. Helmer ; H. L. Hillege ; O. Holmen ; S. C. Hunt ; A. Isaacs ; T. Ittermann ; A. L. James ; I. Johansson ; T. Juliusdottir ; I. P. Kalafati ; L. Kinnunen ; W. Koenig ; I. K. Kooner ; W. Kratzer ; C. Lamina ; K. Leander ; N. R. Lee ; P. Lichtner ; L. Lind ; J. Lindstrom ; S. Lobbens ; M. Lorentzon ; F. Mach ; P. K. Magnusson ; A. Mahajan ; W. L. McArdle ; C. Menni ; S. Merger ; E. Mihailov ; L. Milani ; R. Mills ; A. Moayyeri ; K. L. Monda ; S. P. Mooijaart ; T. W. Muhleisen ; A. Mulas ; G. Muller ; M. Muller-Nurasyid ; R. Nagaraja ; M. A. Nalls ; N. Narisu ; N. Glorioso ; I. M. Nolte ; M. Olden ; N. W. Rayner ; F. Renstrom ; J. S. Ried ; N. R. Robertson ; L. M. Rose ; S. Sanna ; H. Scharnagl ; S. Scholtens ; B. Sennblad ; T. Seufferlein ; C. M. Sitlani ; A. Vernon Smith ; K. Stirrups ; H. M. Stringham ; J. Sundstrom ; M. A. Swertz ; A. J. Swift ; A. C. Syvanen ; B. O. Tayo ; B. Thorand ; G. Thorleifsson ; A. Tomaschitz ; C. Troffa ; F. V. van Oort ; N. Verweij ; J. M. Vonk ; L. L. Waite ; R. Wennauer ; T. Wilsgaard ; M. K. Wojczynski ; A. Wong ; Q. Zhang ; J. Hua Zhao ; E. P. Brennan ; M. Choi ; P. Eriksson ; L. Folkersen ; A. Franco-Cereceda ; A. G. Gharavi ; A. K. Hedman ; M. F. Hivert ; J. Huang ; S. Kanoni ; F. Karpe ; S. Keildson ; K. Kiryluk ; L. Liang ; R. P. Lifton ; B. Ma ; A. J. McKnight ; R. McPherson ; A. Metspalu ; J. L. Min ; M. F. Moffatt ; G. W. Montgomery ; J. M. Murabito ; G. Nicholson ; D. R. Nyholt ; C. Olsson ; J. R. Perry ; E. Reinmaa ; R. M. Salem ; N. Sandholm ; E. E. Schadt ; R. A. Scott ; L. Stolk ; E. E. Vallejo ; H. J. Westra ; K. T. Zondervan ; P. Amouyel ; D. Arveiler ; S. J. Bakker ; J. Beilby ; R. N. Bergman ; J. Blangero ; M. J. Brown ; M. Burnier ; H. Campbell ; A. Chakravarti ; P. S. Chines ; S. Claudi-Boehm ; F. S. Collins ; D. C. Crawford ; J. Danesh ; U. de Faire ; E. J. de Geus ; M. Dorr ; R. Erbel ; J. G. Eriksson ; M. Farrall ; E. Ferrannini ; J. Ferrieres ; N. G. Forouhi ; T. Forrester ; O. H. Franco ; R. T. Gansevoort ; C. Gieger ; V. Gudnason ; C. A. Haiman ; T. B. Harris ; A. T. Hattersley ; M. Heliovaara ; A. A. Hicks ; A. D. Hingorani ; W. Hoffmann ; A. Hofman ; G. Homuth ; S. E. Humphries ; E. Hypponen ; T. Illig ; M. R. Jarvelin ; B. Johansen ; P. Jousilahti ; A. M. Jula ; J. Kaprio ; F. Kee ; S. M. Keinanen-Kiukaanniemi ; J. S. Kooner ; C. Kooperberg ; P. Kovacs ; A. T. Kraja ; M. Kumari ; K. Kuulasmaa ; J. Kuusisto ; T. A. Lakka ; C. Langenberg ; L. Le Marchand ; T. Lehtimaki ; V. Lyssenko ; S. Mannisto ; A. Marette ; T. C. Matise ; C. A. McKenzie ; B. McKnight ; A. W. Musk ; S. Mohlenkamp ; A. D. Morris ; M. Nelis ; C. Ohlsson ; A. J. Oldehinkel ; K. K. Ong ; L. J. Palmer ; B. W. Penninx ; A. Peters ; P. P. Pramstaller ; O. T. Raitakari ; T. Rankinen ; D. C. Rao ; T. K. Rice ; P. M. Ridker ; M. D. Ritchie ; I. Rudan ; V. Salomaa ; N. J. Samani ; J. Saramies ; M. A. Sarzynski ; P. E. Schwarz ; A. R. Shuldiner ; J. A. Staessen ; V. Steinthorsdottir ; R. P. Stolk ; K. Strauch ; A. Tonjes ; A. Tremblay ; E. Tremoli ; M. C. Vohl ; U. Volker ; P. Vollenweider ; J. F. Wilson ; J. C. Witteman ; L. S. Adair ; M. Bochud ; B. O. Boehm ; S. R. Bornstein ; C. Bouchard ; S. Cauchi ; M. J. Caulfield ; J. C. Chambers ; D. I. Chasman ; R. S. Cooper ; G. Dedoussis ; L. Ferrucci ; P. Froguel ; H. J. Grabe ; A. Hamsten ; J. Hui ; K. Hveem ; K. H. Jockel ; M. Kivimaki ; D. Kuh ; M. Laakso ; Y. Liu ; W. Marz ; P. B. Munroe ; I. Njolstad ; B. A. Oostra ; C. N. Palmer ; N. L. Pedersen ; M. Perola ; L. Perusse ; U. Peters ; C. Power ; T. Quertermous ; R. Rauramaa ; F. Rivadeneira ; T. E. Saaristo ; D. Saleheen ; J. Sinisalo ; P. E. Slagboom ; H. Snieder ; T. D. Spector ; U. Thorsteinsdottir ; M. Stumvoll ; J. Tuomilehto ; A. G. Uitterlinden ; M. Uusitupa ; P. van der Harst ; G. Veronesi ; M. Walker ; N. J. Wareham ; H. Watkins ; H. E. Wichmann ; G. R. Abecasis ; T. L. Assimes ; S. I. Berndt ; M. Boehnke ; I. B. Borecki ; P. Deloukas ; L. Franke ; T. M. Frayling ; L. C. Groop ; D. J. Hunter ; R. C. Kaplan ; J. R. O'Connell ; L. Qi ; D. Schlessinger ; D. P. Strachan ; K. Stefansson ; C. M. van Duijn ; C. J. Willer ; P. M. Visscher ; J. Yang ; J. N. Hirschhorn ; M. C. Zillikens ; M. I. McCarthy ; E. K. Speliotes ; K. E. North ; C. S. Fox ; I. Barroso ; P. W. Franks ; E. Ingelsson ; I. M. Heid ; R. J. Loos ; L. A. Cupples ; A. P. Morris ; C. M. Lindgren ; K. L. Mohlke
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-02-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adipocytes/metabolism ; Adipogenesis/genetics ; Adipose Tissue/*metabolism ; Age Factors ; *Body Fat Distribution ; Body Mass Index ; Continental Population Groups/genetics ; Epigenesis, Genetic ; Europe/ethnology ; Female ; Genome, Human/genetics ; *Genome-Wide Association Study ; Humans ; Insulin/*metabolism ; Insulin Resistance/genetics ; Male ; Models, Biological ; Neovascularization, Physiologic/genetics ; Obesity/genetics ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/*genetics ; Sex Characteristics ; Transcription, Genetic/genetics ; Waist-Hip Ratio
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    A. E. Locke ; B. Kahali ; S. I. Berndt ; A. E. Justice ; T. H. Pers ; F. R. Day ; C. Powell ; S. Vedantam ; M. L. Buchkovich ; J. Yang ; D. C. Croteau-Chonka ; T. Esko ; T. Fall ; T. Ferreira ; S. Gustafsson ; Z. Kutalik ; J. Luan ; R. Magi ; J. C. Randall ; T. W. Winkler ; A. R. Wood ; T. Workalemahu ; J. D. Faul ; J. A. Smith ; J. Hua Zhao ; W. Zhao ; J. Chen ; R. Fehrmann ; A. K. Hedman ; J. Karjalainen ; E. M. Schmidt ; D. Absher ; N. Amin ; D. Anderson ; M. Beekman ; J. L. Bolton ; J. L. Bragg-Gresham ; S. Buyske ; A. Demirkan ; G. Deng ; G. B. Ehret ; B. Feenstra ; M. F. Feitosa ; K. Fischer ; A. Goel ; J. Gong ; A. U. Jackson ; S. Kanoni ; M. E. Kleber ; K. Kristiansson ; U. Lim ; V. Lotay ; M. Mangino ; I. Mateo Leach ; C. Medina-Gomez ; S. E. Medland ; M. A. Nalls ; C. D. Palmer ; D. Pasko ; S. Pechlivanis ; M. J. Peters ; I. Prokopenko ; D. Shungin ; A. Stancakova ; R. J. Strawbridge ; Y. Ju Sung ; T. Tanaka ; A. Teumer ; S. Trompet ; S. W. van der Laan ; J. van Setten ; J. V. Van Vliet-Ostaptchouk ; Z. Wang ; L. Yengo ; W. Zhang ; A. Isaacs ; E. Albrecht ; J. Arnlov ; G. M. Arscott ; A. P. Attwood ; S. Bandinelli ; A. Barrett ; I. N. Bas ; C. Bellis ; A. J. Bennett ; C. Berne ; R. Blagieva ; M. Bluher ; S. Bohringer ; L. L. Bonnycastle ; Y. Bottcher ; H. A. Boyd ; M. Bruinenberg ; I. H. Caspersen ; Y. D. Ida Chen ; R. Clarke ; E. W. Daw ; A. J. de Craen ; G. Delgado ; M. Dimitriou ; A. S. Doney ; N. Eklund ; K. Estrada ; E. Eury ; L. Folkersen ; R. M. Fraser ; M. E. Garcia ; F. Geller ; V. Giedraitis ; B. Gigante ; A. S. Go ; A. Golay ; A. H. Goodall ; S. D. Gordon ; M. Gorski ; H. J. Grabe ; H. Grallert ; T. B. Grammer ; J. Grassler ; H. Gronberg ; C. J. Groves ; G. Gusto ; J. Haessler ; P. Hall ; T. Haller ; G. Hallmans ; C. A. Hartman ; M. Hassinen ; C. Hayward ; N. L. Heard-Costa ; Q. Helmer ; C. Hengstenberg ; O. Holmen ; J. J. Hottenga ; A. L. James ; J. M. Jeff ; A. Johansson ; J. Jolley ; T. Juliusdottir ; L. Kinnunen ; W. Koenig ; M. Koskenvuo ; W. Kratzer ; J. Laitinen ; C. Lamina ; K. Leander ; N. R. Lee ; P. Lichtner ; L. Lind ; J. Lindstrom ; K. Sin Lo ; S. Lobbens ; R. Lorbeer ; Y. Lu ; F. Mach ; P. K. Magnusson ; A. Mahajan ; W. L. McArdle ; S. McLachlan ; C. Menni ; S. Merger ; E. Mihailov ; L. Milani ; A. Moayyeri ; K. L. Monda ; M. A. Morken ; A. Mulas ; G. Muller ; M. Muller-Nurasyid ; A. W. Musk ; R. Nagaraja ; M. M. Nothen ; I. M. Nolte ; S. Pilz ; N. W. Rayner ; F. Renstrom ; R. Rettig ; J. S. Ried ; S. Ripke ; N. R. Robertson ; L. M. Rose ; S. Sanna ; H. Scharnagl ; S. Scholtens ; F. R. Schumacher ; W. R. Scott ; T. Seufferlein ; J. Shi ; A. Vernon Smith ; J. Smolonska ; A. V. Stanton ; V. Steinthorsdottir ; K. Stirrups ; H. M. Stringham ; J. Sundstrom ; M. A. Swertz ; A. J. Swift ; A. C. Syvanen ; S. T. Tan ; B. O. Tayo ; B. Thorand ; G. Thorleifsson ; J. P. Tyrer ; H. W. Uh ; L. Vandenput ; F. C. Verhulst ; S. H. Vermeulen ; N. Verweij ; J. M. Vonk ; L. L. Waite ; H. R. Warren ; D. Waterworth ; M. N. Weedon ; L. R. Wilkens ; C. Willenborg ; T. Wilsgaard ; M. K. Wojczynski ; A. Wong ; A. F. Wright ; Q. Zhang ; E. P. Brennan ; M. Choi ; Z. Dastani ; A. W. Drong ; P. Eriksson ; A. Franco-Cereceda ; J. R. Gadin ; A. G. Gharavi ; M. E. Goddard ; R. E. Handsaker ; J. Huang ; F. Karpe ; S. Kathiresan ; S. Keildson ; K. Kiryluk ; M. Kubo ; J. Y. Lee ; L. Liang ; R. P. Lifton ; B. Ma ; S. A. McCarroll ; A. J. McKnight ; J. L. Min ; M. F. Moffatt ; G. W. Montgomery ; J. M. Murabito ; G. Nicholson ; D. R. Nyholt ; Y. Okada ; J. R. Perry ; R. Dorajoo ; E. Reinmaa ; R. M. Salem ; N. Sandholm ; R. A. Scott ; L. Stolk ; A. Takahashi ; F. M. Van't Hooft ; A. A. Vinkhuyzen ; H. J. Westra ; W. Zheng ; K. T. Zondervan ; A. C. Heath ; D. Arveiler ; S. J. Bakker ; J. Beilby ; R. N. Bergman ; J. Blangero ; P. Bovet ; H. Campbell ; M. J. Caulfield ; G. Cesana ; A. Chakravarti ; D. I. Chasman ; P. S. Chines ; F. S. Collins ; D. C. Crawford ; L. A. Cupples ; D. Cusi ; J. Danesh ; U. de Faire ; H. M. den Ruijter ; A. F. Dominiczak ; R. Erbel ; J. Erdmann ; J. G. Eriksson ; M. Farrall ; S. B. Felix ; E. Ferrannini ; J. Ferrieres ; I. Ford ; N. G. Forouhi ; T. Forrester ; O. H. Franco ; R. T. Gansevoort ; P. V. Gejman ; C. Gieger ; O. Gottesman ; V. Gudnason ; U. Gyllensten ; A. S. Hall ; T. B. Harris ; A. T. Hattersley ; A. A. Hicks ; L. A. Hindorff ; A. D. Hingorani ; A. Hofman ; G. Homuth ; G. K. Hovingh ; S. E. Humphries ; S. C. Hunt ; E. Hypponen ; T. Illig ; K. B. Jacobs ; M. R. Jarvelin ; K. H. Jockel ; B. Johansen ; P. Jousilahti ; J. W. Jukema ; A. M. Jula ; J. Kaprio ; J. J. Kastelein ; S. M. Keinanen-Kiukaanniemi ; L. A. Kiemeney ; P. Knekt ; J. S. Kooner ; C. Kooperberg ; P. Kovacs ; A. T. Kraja ; M. Kumari ; J. Kuusisto ; T. A. Lakka ; C. Langenberg ; L. Le Marchand ; T. Lehtimaki ; V. Lyssenko ; S. Mannisto ; A. Marette ; T. C. Matise ; C. A. McKenzie ; B. McKnight ; F. L. Moll ; A. D. Morris ; A. P. Morris ; J. C. Murray ; M. Nelis ; C. Ohlsson ; A. J. Oldehinkel ; K. K. Ong ; P. A. Madden ; G. Pasterkamp ; J. F. Peden ; A. Peters ; D. S. Postma ; P. P. Pramstaller ; J. F. Price ; L. Qi ; O. T. Raitakari ; T. Rankinen ; D. C. Rao ; T. K. Rice ; P. M. Ridker ; J. D. Rioux ; M. D. Ritchie ; I. Rudan ; V. Salomaa ; N. J. Samani ; J. Saramies ; M. A. Sarzynski ; H. Schunkert ; P. E. Schwarz ; P. Sever ; A. R. Shuldiner ; J. Sinisalo ; R. P. Stolk ; K. Strauch ; A. Tonjes ; D. A. Tregouet ; A. Tremblay ; E. Tremoli ; J. Virtamo ; M. C. Vohl ; U. Volker ; G. Waeber ; G. Willemsen ; J. C. Witteman ; M. C. Zillikens ; L. S. Adair ; P. Amouyel ; F. W. Asselbergs ; T. L. Assimes ; M. Bochud ; B. O. Boehm ; E. Boerwinkle ; S. R. Bornstein ; E. P. Bottinger ; C. Bouchard ; S. Cauchi ; J. C. Chambers ; S. J. Chanock ; R. S. Cooper ; P. I. de Bakker ; G. Dedoussis ; L. Ferrucci ; P. W. Franks ; P. Froguel ; L. C. Groop ; C. A. Haiman ; A. Hamsten ; J. Hui ; D. J. Hunter ; K. Hveem ; R. C. Kaplan ; M. Kivimaki ; D. Kuh ; M. Laakso ; Y. Liu ; N. G. Martin ; W. Marz ; M. Melbye ; A. Metspalu ; S. Moebus ; P. B. Munroe ; I. Njolstad ; B. A. Oostra ; C. N. Palmer ; N. L. Pedersen ; M. Perola ; L. Perusse ; U. Peters ; C. Power ; T. Quertermous ; R. Rauramaa ; F. Rivadeneira ; T. E. Saaristo ; D. Saleheen ; N. Sattar ; E. E. Schadt ; D. Schlessinger ; P. E. Slagboom ; H. Snieder ; T. D. Spector ; U. Thorsteinsdottir ; M. Stumvoll ; J. Tuomilehto ; A. G. Uitterlinden ; M. Uusitupa ; P. van der Harst ; M. Walker ; H. Wallaschofski ; N. J. Wareham ; H. Watkins ; D. R. Weir ; H. E. Wichmann ; J. F. Wilson ; P. Zanen ; I. B. Borecki ; P. Deloukas ; C. S. Fox ; I. M. Heid ; J. R. O'Connell ; D. P. Strachan ; K. Stefansson ; C. M. van Duijn ; G. R. Abecasis ; L. Franke ; T. M. Frayling ; M. I. McCarthy ; P. M. Visscher ; A. Scherag ; C. J. Willer ; M. Boehnke ; K. L. Mohlke ; C. M. Lindgren ; J. S. Beckmann ; I. Barroso ; K. E. North ; E. Ingelsson ; J. N. Hirschhorn ; R. J. Loos ; E. K. Speliotes
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-02-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adipogenesis/genetics ; Adiposity/genetics ; Age Factors ; *Body Mass Index ; Continental Population Groups/genetics ; Energy Metabolism/genetics ; Europe/ethnology ; Female ; Genetic Predisposition to Disease/genetics ; *Genome-Wide Association Study ; Glutamic Acid/metabolism ; Humans ; Insulin/metabolism/secretion ; Male ; Obesity/*genetics/*metabolism ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics ; Synapses/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Brolin, S.E. ; Berne, C. ; Isacsson, U.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0003-2697
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0003-2697(72)90484-8

    Articles: DFG German National Licenses
  4. 4
    Agren, A. ; Berne, C. ; Brolin, S.E.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0003-2697
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0003-2697(77)90027-6

    Articles: DFG German National Licenses
  5. 5
    Berne, C. ; Fagius, J.
    Springer
    Published 1986
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Hypoglycaemia ; sympathetic nervous system ; skin nerve sympathetic activity ; microelectrode recording ; thermoregulation
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Microclectrode recordings of skin nerve sympathetic activity, consisting of sudomotor and vasoconstrictor signals, were performed in the peroneal nerve in seven healthy subjects during insulin-induced hypoglycaemia. The nerve activity was recorded at rest and for 90 min after intravenous injection of 0.15 IIJ insulin/kg body weight. The net outflow of skin nerve sympathetic activity was increased during hypoglycaemia, with the exception of one subject who exhibited a high initial level of activity. In all subjects a change of the temporal pattern of the outflow was found, suggesting a shift from mixed (sudomotor and vasoconstrictor) to pure sudomotor activity. This change coincided with a sensation of warmth, sweating and varying degrees of cutaneous vasodilatation, and was followed by a fall in body temperature. It is concluded that hypoglycaemia has a differential effect on sympathetic activity in skin nerves, with a strong increase of sudomotor impulses and simultaneous inhibition of vasoconstrictor signals. Thus, neurally mediated thermoregulatory adjustment contributes to heat loss during hypoglycaemia.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00870140

    Articles: DFG German National Licenses
  6. 6
    Pollare, T. ; Lithell, H. ; Selinus, I. ; Berne, C.
    Springer
    Published 1988
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Glucose tolerance ; hypertension ; insulin sensitivity ; lipids ; prazosin
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The aim of this study was to determine whether insulin sensitivity measured by the euglycaemic insulin clamp technique is lower in patients with primary hypertension than in matched healthy control subjects, and whether this sensitivity was affected after 12 weeks of antihypertensive treatment with the alpha 1-adrenoceptor blocking drug prazosin. Twelve moderately obese normoglycaemic patients (four men), with hypertension not previously treated with pharmacological agents and diastolic blood pressure above 100 mm Hg, and 12 healthy matched control subjects participated. Supine blood pressure decreased 12/5 mmHg (p〈0.01) and standing blood pressure 14/9 mmHg (p=0.001) during prazosin treatment (mean dosage 5.3±1.6 mg/day (SD)). During euglycaemic insulin clamp studies the control subjects showed a higher mean glucose uptake than the untreated hypertensive patients (7.5±1.0 and 5.8±1.9 mg·kg b.w.−1·min−1, respectively, p〈0.01). During prazosin treatment there was no significant difference between the hypertensive patients and the control subjects in this respect (6.6±2.8 and 7.5±1.0, respectively, p=0.21). During prazosin treatment, however, the disappearance rate of glucose decreased during the intravenous glucose tolerance test (from 1.7±0.9 to 1.3±0.6, p〈0.02) and the area under the glucose concentration-time curve decreased by 38% (from 473±119 to 294±99, p〈0.001). The peak insulin concentration decreased from 55±35 to 46±32 mU/l (p〈0.006) and the area under the insulin concentration-time curve was suppressed by 38% (from 2368±1597 to 1479±940, p〈0.01). This study shows that treatment of moderately obese hypertensive patients with prazosin is associated with an increase of the insulin-mediated glucose disposal and a decrease of the insulin response to an intravenous glucose load.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00271585

    Articles: DFG German National Licenses
  7. 7
    Stridsberg, M. ; Berne, C. ; Sandler, S. ; Wilander, E. ; Öberg, K.
    Springer
    Published 1993
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Amylin ; endocrine pancreatic tumour ; glucose tolerance ; insulin resistance ; islet amyloid polypeptide ; pancreatic islets
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Islet amyloid polypeptide or amylin is a polypeptide secreted mainly from the pancreatic beta cells together with insulin upon stimulation. High levels of islet amyloid polypeptide have also been shown to increase the peripheral insulin resistance and consequently a role for islet amyloid polypeptide in the glucose homeostasis has been suggested. We have studied the glucose homeostasis in a patient with a malignant endocrine pancreatic tumour producing large amounts of an islet amyloid polypeptide-like molecule (about 400 times the upper reference level for islet amyloid polypeptide). This patient developed insulin-requiring diabetes mellitus shortly after the tumour diagnosis. Both intravenous and oral glucose tolerance tests revealed inhibited early responses in insulin and C-peptide release, but the insulin and C-peptide response to glucagon stimulation was less affected. Aneuglycaemic insulin clamp showed normal insulin-mediated glucose disposal. In vitro experiments, where isolated rat pancreatic islets were cultured with serum from the patient, showed a moderately decreased islet glucose oxidation rate and glucose-stimulated insulin release compared to islets cultured with serum from healthy subjects. However, culture of rat islets with normal human serum supplemented with synthetic rat islet amyloid polypeptide did not affect the glucose-stimulated insulin release. In conclusion, the observed effects show that the diabetic state in this patient was associated with an impaired glucose-stimulated insulin release but not with an increased peripheral insulin resistance. Thus, the results suggest that if islet amyloid polypeptide has diabetogenic effects they are more likely to be exerted at the level of insulin secretion than at the level of peripheral insulin sensitivity.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00400360

    Articles: DFG German National Licenses
  8. 8
    Carlsson, P.-O. ; Berne, C. ; Jansson, L.
    Springer
    Published 1998
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Keywords Renin-angiotensin system ; ACE inhibitor ; angiotensin II ; pancreatic islets ; insulin release ; islet microcirculation
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary An intrinsic angiotensin system has been described in the pancreas, with angiotensin II specific receptors being present on both exocrine, endocrine and vascular cells. The aim of the present study was to evaluate the effects of angiotensin II on insulin secretion and blood flow regulation in the pancreas. Blood flows were determined with a microsphere technique. Infusion of angiotensin II induced a dose-dependent reduction in both whole pancreatic and islet blood flow, which was most pronounced in the former. Administration of enalaprilate, an inhibitor of angiotensin-converting enzyme, and saralasin, a non-selective angiotensin II receptor antagonist, preferentially increased islet blood flow. The effects of angiotensin II on insulin release were examined by measuring insulin concentrations in the effluents from isolated perfused pancreata. In these preparations, enalaprilate affected neither basal nor glucose-stimulated insulin release, whereas angiotensin II delayed the first phase of insulin release in response to glucose. The effect of angiotensin II was probably due to initial marked vasoconstriction. The retardation of insulin release could be avoided by adding angiotensin II to the perfusion medium 20 min before glucose administration, i. e. so that the vasoconstriction had disappeared when glucose-stimulation began. The present study suggests that the angiotensin-system is important in regulation of islet blood flow and points to a pivotal role of islet blood perfusion for an adequate insulin release. [Diabetologia (1998) 41: 127–133]
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001250050880

    Articles: DFG German National Licenses
  9. 9
    Eriksson, U. J. ; Tydén, O. ; Berne, C.
    Springer
    Published 1983
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Phosphatidyl glycerol ; diabetic pregnancy ; fetal lung ; rat
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The lungs of fetuses of streptozotocin-diabetic rats were examined for their ability to incorporate U-14C-glucose into phosphatidyl choline, phosphatidyl glycerol, phosphatidyl inositol and lysophosphatidyl choline. In the lungs of control rats an increased biosynthesis of phosphatidyl glycerol in late pregnancy suggested a close association between the production of this phospholipid and the terminal maturation of the fetal lung. In the offspring of diabetic rats the incorporation of 14C-glucose into phosphatidyl choline, lysophosphatidyl choline and phosphatidyl glycerol was markedly decreased compared with the control rats on gestational day 20, whereas no difference was seen at day 22. Insulin treatment of the pregnant rats restored the biosynthesis of phosphatidyl choline and lysophosphatidyl choline towards normal on gestational day 20, while the ratio of phosphatidyl glycerol to phosphatidyl inositol incorporation of 14C-glucose was decreased, suggesting that the biosynthesis of phosphatidyl glycerol is more sensitive than that of phosphatidyl choline and lysophosphatidyl choline to the metabolic disturbances inherent in maternal diabetes. The delayed fetal pulmonary maturation occurred without fetal hyperinsulinism which suggests that this latter feature may not be of crucial significance in the aetiology of the respiratory distress syndrome.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00250162

    Articles: DFG German National Licenses
  10. 10
    Berne, C. ; Fagius, J. ; Pollare, T. ; Hjemdahl, P.
    Springer
    Published 1992
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Sympathetic nervous system ; catecholamines ; insulin ; blood pressure ; glucose metabolism ; hypertension ; insulin resistance
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Sympathetic nervous system activation by insulin has been suggested as a mechanism explaining the association between insulin resistance and hypertension. We further examined the effect of insulin by direct microneurographic muscle and skin nerve sympathetic activity recordings during euglycaemic insulin clamps in healthy subjects. The mean plasma insulin level was elevated from 5.3±0.7 to 92.2±2.2 mU/l in seven subjects during a 90-min one-step clamp. In six other subjects plasma insulin was further raised from 85.7±4.0 mU/l to 747±53 mU/l between 45–90 min (two-step clamp). Four of the latter subjects received a sham clamp with NaCl infusions only on a second recording session. At the low dose of insulin muscle nerve sympathetic activity increased from a resting level of 22.7±5.0 bursts per min to 27.7±5.0 bursts per min at 15 min (p〈0.05). The increases in muscle nerve sympathetic activity were significant (p〈0.001; ANOVA) throughout insulin infusion, with a slight further increase (from 29.2±1.6 to 32.3±1.9 bursts per min) at the supraphysiological insulin concentration. During sham clamps muscle nerve sympathetic activity did not increase. Both insulin clamps induced minor, but significant, increases in forearm venous plasma noradrenaline concentrations. Skin nerve sympathetic activity (n=3) did not change during insulin infusions. Heart rate increased slightly but significantly (p〈0.005), during the insulin clamps. Blood pressure was not notably affected. In conclusion, hyperinsulinaemia was associated with increased vasoconstrictor nerve activity to skeletal muscle and with no change of sympathetic outflow to skin.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00399935

    Articles: DFG German National Licenses
  11. 11
    Lind, L. ; Berne, C. ; Andrén, B. ; Lithell, H.
    Springer
    Published 1996
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Keywords Non-insulin diabetes mellitus ; hypertension ; M-mode echocardiography ; heart function.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The existence of a distinct diabetic cardiomyopathy, characterized by a raised left ventricular mass, has previously been suggested. However, as diabetes mellitus is associated with both left ventricular hypertrophy and hypertension a confounding effect of raised blood pressure in diabetic patients has to be considered. In the present cross-sectional study an echocardiographical examination was performed as part of a health screening survey in 582 males, aged 70 years. After the exclusion of subjects with coronary heart disease or those on regular antihypertensive treatment, 30 normotensive subjects with diabetes were compared with 10 subjects with non-insulin-dependent diabetes (NIDDM) and a diastolic blood pressure 90 mm Hg or more and 203 normotensive control subjects with normal glucose tolerance. Both groups with NIDDM showed a significantly increased left atrial diameter (4.4 ± 0.7 vs 4.0 ± 0.5 cm, p 〈 0.05) and an increased atrial component in diastole (A-wave, p 〈 0.01) compared to the control subjects. Left ventricular mass was, however, only marginally and not significantly elevated in the diabetic subjects when compared to the healthy control subjects (133 ± 19 and 133 ± 28 vs 128 ± 25 g/m2). Only in the subjects with concomitant diabetes and a raised blood pressure was the intraventricular septum significantly enlarged (p 〈 0.05). Thus, in the present sample no distinct diabetic cardiomyopathy with an increased left ventricular mass, independent of the influence of hypertension could be detected. The myocardial alterations in these diabetic males were restricted to an increased left atrial size and an impaired diastolic function. [Diabetologia (1996) 39: 1603–1606]
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001250050621

    Articles: DFG German National Licenses
  12. 12
    Hammar, H. ; Berne, C.
    Springer
    Published 1970
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Hyperglycaemic syndrome of mice (NZO, obob) ; β-oxidation of fatty acids ; β-hydroxyacyl-CoA dehydrogenase ; islets of Langerhans ; liver, heart and skeletal muscle
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Résumé L'activité de laβ-hydroxyacyl-CoA déshydrogénase (EC 1.1.1.35.) a été mesurée, selon les principes de microtechniques de Lowry, dans les îlots et les acini pancréatiques, le foie, le muscle cardiaque et le muscle du squelette chez des souris de la souche obése de NouvelleZélande (NZO) et de la souche obése hyperglycémique (obob). L'enzyme dosé montrait la même dépendance du pH dans les îlots, le foie et le muscle cardiaque. L'activité enzymatique la plus élevée a été trouvée dans les îlots pancréatiques et le muscle cardiaque, et représentait 2 à 5 fois l'activité obtenue dans les acini pancréatiques, le foie et le muscle du squelette. Les résultats montrent qu'une condition nécessaire pour uneβ-oxydation rapide des acides gras existe dans les îlots de Langerhans.
    Abstract:
    Zusammenfassung Die Aktivität derβ-Hydroxyacyl-CoA Dehydrogenase (EC 1.1.1.35.) wurde nach den Prinzipien der Lowry-Mikrotechniken in den Pankreasinseln und -Acini, der Leber, dem Herzen und dem Skeletmuskel von Mäusen des fettsüchtigen New Zealand-Stammes (NZO) und in dem fettsüchtig-hyperglykämischen Stamm (obob) gemessen. Das untersuchte Enzym zeigte die gleiche pH-Abhängigkeit in Material aus den Inseln der Leber und dem Herzmuskel. Die höchste Enzymaktivität fand sich in Pankreasinseln und Herzmuskel; sie war zwei bis fünfmal höher als in den Pankreas-Azini, der Leber und der Skeletmuskulatur. Die Ergebnisse zeigen, daß eine Voraussetzung für eine schnelleβ-Oxydation von Fettsäuren in den Langerhans'schen Inseln erfüllt ist.
    Notes:
    Summary The activity ofβ-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35.) was measured according to the principles of the Lowry microtechniques in pancreatic islets and acini, liver, heart and skeletal muscle in mice of the New Zealand obese strain (NZO) and the obese hyperglycaemic strain (obob). The assayed enzyme showed the same pH dependence in material from islets, liver and heart muscle. The highest enzymatic activity was found in pancreatic islets and heart muscle, and this was 2 to 5 times the activity obtained in pancreatic acini, liver and skeletal muscle. The results show that one prerequisite for a fastβ-oxidation of fatty acids exists in the islets of Langerhans.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01211896

    Articles: DFG German National Licenses
  13. 13
    Fagius, J. ; Brattberg, A. ; Jameson, S. ; Berne, C.
    Springer
    Published 1985
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Diabetes mellitus ; polyneuropathy ; sorbitol accumulation ; aldose reductase inhibitor ; clinical trial
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The effects of the aldose reductase inhibitor, sorbinil, on symptomatic symmetrical diabetic polyneuropathy were studied during a 6-month period in a double-blind parallel group placebo-controlled trial. Twenty-seven patients received sorbinil and 28 placebo. The patients were assessed by clinical examination, neurophysiological measurements, sensory threshold determinations and tests of autonomic nerve function. No major clinical benefit was seen in the sorbiniltreated patients and no differences in sensory thresholds were observed. In three out of nine neurophysiological tests (motor nerve conduction velocity of the posterior tibial nerve, F-wave latency and sensory distal latency of the ulnar nerve) and one out of five tests of autonomic nerve function (heart rate variation during deep breathing) significant differences between the patient groups evolved in favour of sorbinil treatment. An overall evaluation of the temporal development of these and remaining neurophysiological and autonomic variables suggested a small but significant benefit from sorbinil treatment. There was no evidence of continuing improvement throughout the treatment period and beneficial effects observed were no greater than those seen in previous trials of considerably shorter treatment periods. It is concluded that sorbinil treatment results in some improvement in peripheral nerve function in symptomatic diabetic polyneuropathy, but that the long-term effect may be of limited value.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00283137

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    0992-7689
    Keywords:
    Hydrology (evapotranspiration; soil moisture; water-energy interactions)
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Geosciences
    Physics
    Notes:
    Abstract The MUREX (monitoring the usable soil reservoir experimentally) experiment was designed to provide continuous time series of field data over a long period, in order to improve and validate the Soil-vegetation-Atmosphere Transfer (SVAT) parameterisations employed in meteorological models. Intensive measurements were performed for more than three years over fallow farmland in southwestern France. To capture the main processes controlling land-atmosphere exchanges, the local climate was fully characterised, and surface water and energy fluxes, vegetation biomass, soil moisture profiles, surface soil moisture and surface and soil temperature were monitored. Additional physiological measurements were carried out during selected periods to describe the biological control of the fluxes. The MUREX data of 1995, 1996, and 1997 are presented. Four SVAT models are applied to the annual cycle of 1995. In general, they succeed in simulating the main features of the fallow functioning, although some shortcomings are revealed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s00585-999-0838-2

    Articles: DFG German National Licenses
  15. 15
    Schvarcz, E. ; Palmér, M. ; Åman, J. ; Berne, C.
    Springer
    Published 1997
    Staff View
    ISSN:
    1432-5233
    Keywords:
    Key words Hypoglycaemia ; Gastric emptying ; Atropine ; Motilin
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract This study examined whether or not changes in plasma concentrations of motilin and other gastrointestinal hormones known to affect gastric motility are associated with the accelerated gastric emptying seen during hypoglyc-aemia. While studying gastric emptying by scintigraphy in eight healthy subjects, the plasma concentrations of glucagon, adrenaline, motilin, gastrin, neuropeptide Y and somatostatin were measured during normoglycaemia and hypoglycaemia with simultaneous infusion of either atropine or saline. Blood glucose concentrations were checked by an insulin-glucose clamp. The plasma levels of glucagon and adrenaline increased markedly during both hypoglycaemic examinations compared with normoglycaemia. Neither motilin nor any of the other hormones displayed considerable changes during hypoglycaemia with and without atropine compared with normoglycaemia. No further information about the mechanisms behind the accelerated gastric emptying rate during hypoglycaemia was obtained by analysing motilin and the other gastrointestinal hormones.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s005920050073

    Articles: DFG German National Licenses
  16. 16
    Åman, J. ; Berne, C. ; Ewald, U. ; Tuvemo, T.
    Springer
    Published 1992
    Staff View
    ISSN:
    1432-5233
    Keywords:
    Insulin-dependent diabetes mellitus ; Hypoglycaemia ; Skin blood flow ; Reactive hyperaemia
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The aim of the present study was to compare the cutaneous postischaemic hyperaemic response in young insulin-dependent diabetic patients and healthy subjects during normoglycaemia, acute insulin-induced hypoglycaemia and in the posthypoglycaemic state. After a night of normoglycaemia the cutaneous postischaemic hyperaemic response in the forearm skin, measured by the transcutaneousPO 2 method, was the same in both groups. A reduction of the maximal postischaemic vasodilatory response was observed in diabetic patients from 2.4±0.3 to 2.0±0.2 kPa (P〈0.05) and in control subjects from 2.7±0.3 to 1.8±0.2 kPa (P〈0.02) during insulin-induced hypoglycaemia (plasma glucose〈2 mmol/l). Complete recovery of the vasodilatory response occurred in subjects in the posthypoglycaemic state. We conclude that hypoglycaemia induced a transient reduction of the vasodilatory response, which was rapidly reversed after glucose counter-regulation, in both diabetic patients and healthy controls. Thus, the prevailing blood glucose concentration must be taken into account when the postischaemic vasodilatory response is investigated in diabetic patients.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00572825

    Articles: DFG German National Licenses
  17. 17
    Staff View
    ISSN:
    1432-5233
    Keywords:
    Key words Glucose ; Insulin ; Hyperinsulinaemia ; Blood flow
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Insulin-mediated stimulation of blood flow to skeletal muscle has been proposed to be of major importance for insulin-mediated glucose uptake. The aim of this study was to investigate the relative importance of blood flow and glucose extraction as determinants of insulin-mediated glucose uptake in the human forearm. Forearm blood flow (FBF), glucose extraction and oxygen consumption were evaluated for 100 min during the euglycaemic hyperinsulinaemic clamp (92 mU/l) in nine healthy subjects. FBF was measured by venous occlusion plethysmography. Forearm glucose uptake increased sevenfold during the hyperinsulinaemia (P〈0.001). Forearm glucose extraction showed a minor increase during the first 10 min of hyperinsulinaemia, but the most marked increase took place between 10 and 20 min (+170%). Thereafter, only a minor further increase was seen. During the first 10 min of hyperinsulinaemia FBF was unchanged. Thereafter, FBF increased steadily to a plateau reached after 60 min (+50%, P〈0.001). A close relationship between whole body glucose uptake and FBF was seen at the end of the clamp (r = 0.75, P〈0.02), but at this time the relationship between whole body glucose uptake and forearm glucose extraction was not significant. The modest increase in O2 consumption seen at the beginning of the clamp (+19%) was not related to FBF during the early phase of the clamp. In conclusion, the early course of insulin-mediated glucose uptake in the human forearm was mainly due to an increase in glucose extraction. However, with time the insulin-mediated increase in blood flow increased in importance and after 100 min of hyperinsulinaemia FBF was the major determinant of glucose uptake.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s005920050132

    Articles: DFG German National Licenses
  18. 18
    Borg, L. A. H. ; Andersson, A. ; Berne, C. ; Westman, J.
    Springer
    Published 1975
    Staff View
    ISSN:
    1432-0878
    Keywords:
    Islands of Langerhans ; Mitochondria ; Enzymes ; Tissue Culture ; Electron Microscopy
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary Isolated islets of Langerhans from mice were maintained in tissue culture for one week at either a high (28 mM) or a low (3.3 mM) extracellular glucose concentration. Electron microscopic morphometry by means of stereological methods revealed a much greater volume of mitochondria in islet cells cultured at low glucose than in those cultured at high glucose. The former islets also showed a higher activity of the mitochondrial marker enzyme, L-3-hydroxyacyl-CoA-dehydrogenase (E.C.1.1.1.35). These results indicate a true mitochondrial hypertrophy at the low glucose concentration. Although it is known from previous studies that the islet cell metabolism is diminished after low-glucose culture, the present observations of an increased mitochondrial volume probably do not reflect a degenerative process, but rather adaptive changes towards oxidation of energy yielding substrates other than glucose.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00220177

    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1573-2649
    Keywords:
    Diabetes mellitus ; outcomes ; quality of life ; reliabllity ; sex factors ; validity
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract In order to implement the St Vincent Declaration programme, instruments for quality assurance of medical outcomes as well as measures of psychological outcomes of diabetes care had to be developed. This paper presents baseline values for three questionnaires measuring psychological Wellbeing, Treatment Statisfaction and General Health among a representative sample of adult people with diabetes in Sweden consisting of 423 individuals of which 153 were insulin treated and 270 were diet/tablet-treated. Cronbach's α indicated that each of the Well-being and Treatment Satisfaction subscales was internally reliable, alphas ranging from 0.66–0.88. Factor analysis resulted in identification of five subscales (depression, anxiety, positive well-being, treatment satisfaction and metabolic control). There was no relation between any of the quality of life subscales with HbA1c, BMI, duration of diabetes, frequency of blood glucose tests per day, insulin regimens or diabetic complications. Females reported a more negative impact of diabetes on daily life compared with males (p〈0.001). In conclusion, the Well-being and Treatment Satisfaction scales are reliable for quality assurance purposes in diabetes while the briefer general health instrument provides a useful assessment of the global impact of a chronic disease.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00634746

    Articles: DFG German National Licenses