Search Results - (Author, Cooperation:C. Abraham)

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  1. 1
    Staff View
    Publication Date:
    2018-03-07
    Publisher:
    National Academy of Sciences
    Print ISSN:
    0027-8424
    Electronic ISSN:
    1091-6490
    Topics:
    Biology
    Medicine
    Natural Sciences in General
    Published by:
    http://www.nasonline.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-05-09
    Publisher:
    American Physical Society (APS)
    Electronic ISSN:
    1098-4402
    Topics:
    Physics
    Keywords:
    Synchrotron Radiation and Free-Electron Lasers
    Published by:
    http://www.aps.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    E. S. Blum ; M. C. Abraham ; S. Yoshimura ; Y. Lu ; S. Shaham
    American Association for the Advancement of Science (AAAS)
    Published 2012
    Staff View
    Publication Date:
    2012-03-01
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Caenorhabditis elegans/*cytology/genetics/growth & development/*metabolism ; Caenorhabditis elegans Proteins/chemistry/*genetics/*metabolism ; *Cell Death ; Cell Nucleus/ultrastructure ; Cell Survival ; DNA-Binding Proteins/genetics/metabolism ; Gene Expression Regulation ; Genes, Helminth ; Genome, Helminth ; MAP Kinase Kinase 4/genetics/metabolism ; Male ; Molecular Sequence Data ; Mutant Proteins/chemistry/metabolism ; Peptides/chemistry ; Protein Structure, Tertiary ; RNA Interference ; Sequence Deletion ; Transcription Factors/genetics/metabolism ; Transgenes
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2012-10-19
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; *Cell Transformation, Neoplastic ; Colitis/complications/metabolism/pathology ; Colon/metabolism/pathology ; Colonic Neoplasms/complications/metabolism/pathology ; Disease Models, Animal ; Down-Regulation ; Epithelial Cells/metabolism/pathology ; Genes, APC ; Inflammasomes/*metabolism ; Interleukin-18/metabolism ; Interleukins/deficiency/genetics/metabolism ; Intestines/*metabolism/*pathology ; Mice ; Mice, Knockout ; Receptors, Interleukin/deficiency/genetics/*metabolism ; Time Factors ; Weight Loss
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    L. Jostins ; S. Ripke ; R. K. Weersma ; R. H. Duerr ; D. P. McGovern ; K. Y. Hui ; J. C. Lee ; L. P. Schumm ; Y. Sharma ; C. A. Anderson ; J. Essers ; M. Mitrovic ; K. Ning ; I. Cleynen ; E. Theatre ; S. L. Spain ; S. Raychaudhuri ; P. Goyette ; Z. Wei ; C. Abraham ; J. P. Achkar ; T. Ahmad ; L. Amininejad ; A. N. Ananthakrishnan ; V. Andersen ; J. M. Andrews ; L. Baidoo ; T. Balschun ; P. A. Bampton ; A. Bitton ; G. Boucher ; S. Brand ; C. Buning ; A. Cohain ; S. Cichon ; M. D'Amato ; D. De Jong ; K. L. Devaney ; M. Dubinsky ; C. Edwards ; D. Ellinghaus ; L. R. Ferguson ; D. Franchimont ; K. Fransen ; R. Gearry ; M. Georges ; C. Gieger ; J. Glas ; T. Haritunians ; A. Hart ; C. Hawkey ; M. Hedl ; X. Hu ; T. H. Karlsen ; L. Kupcinskas ; S. Kugathasan ; A. Latiano ; D. Laukens ; I. C. Lawrance ; C. W. Lees ; E. Louis ; G. Mahy ; J. Mansfield ; A. R. Morgan ; C. Mowat ; W. Newman ; O. Palmieri ; C. Y. Ponsioen ; U. Potocnik ; N. J. Prescott ; M. Regueiro ; J. I. Rotter ; R. K. Russell ; J. D. Sanderson ; M. Sans ; J. Satsangi ; S. Schreiber ; L. A. Simms ; J. Sventoraityte ; S. R. Targan ; K. D. Taylor ; M. Tremelling ; H. W. Verspaget ; M. De Vos ; C. Wijmenga ; D. C. Wilson ; J. Winkelmann ; R. J. Xavier ; S. Zeissig ; B. Zhang ; C. K. Zhang ; H. Zhao ; M. S. Silverberg ; V. Annese ; H. Hakonarson ; S. R. Brant ; G. Radford-Smith ; C. G. Mathew ; J. D. Rioux ; E. E. Schadt ; M. J. Daly ; A. Franke ; M. Parkes ; S. Vermeire ; J. C. Barrett ; J. H. Cho
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-11-07
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Colitis, Ulcerative/genetics/immunology/microbiology/physiopathology ; Crohn Disease/genetics/immunology/microbiology/physiopathology ; Genetic Predisposition to Disease/*genetics ; Genome, Human/genetics ; *Genome-Wide Association Study ; Haplotypes/genetics ; *Host-Pathogen Interactions/genetics/immunology ; Humans ; Inflammatory Bowel Diseases/*genetics/immunology/*microbiology/physiopathology ; Mycobacterium/*immunology/pathogenicity ; Mycobacterium Infections/genetics/microbiology ; Mycobacterium tuberculosis/immunology/pathogenicity ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Reproducibility of Results
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Fenster, C. Abraham ; Goldstein, Alan M.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1971
    Staff View
    ISSN:
    1460-2466
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Media Resources and Communication Sciences, Journalism
    Notes:
    and adult listeners to label vocal communications as reflecting an excess of either positive or negative emotion was investigated by using tapes of child and adult speakers. Adult and child subjects were asked to identify which of six emotions each of the speakers was attempting to communicate. It was found that: (a) listeners do not tend to label vocal communications with an excess of either positive or negative emotion; (b) no differences were found between child and adult listeners with regard to the number of positive and negative labels given to vocal communications; and, (c) child and adult speakers do not tend to elicit an excess of positive or negative emotional labels from either child or adult speakers. The significance of this research is discussed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1460-2466.1971.tb02934.x

    Articles: DFG German National Licenses
  7. 7
    Fenster, C. Abraham ; Goldstein, Alan M.

    Philadelphia, etc. : Periodicals Archive Online (PAO)
    Published 1971
    Staff View
    ISSN:
    0021-9916
    Topics:
    Media Resources and Communication Sciences, Journalism
    URL:
    http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5419-1971-021-04-000005

    Articles: DFG German National Licenses
  8. 8
    Goldstein, Jacob ; Fenster, C. Abraham

    Minneapolis, Minn. : Periodicals Archive Online (PAO)
    Published 1994
    Staff View
    ISSN:
    0363-1990
    Topics:
    History
    Sociology
    URL:
    http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:h179-1994-019-01-000002

    Articles: DFG German National Licenses
  9. 9
    Staff View
    Type of Medium:
    article
    Publication Date:
    2024
    Keywords:
    Lehre ; Staat ; Studium ; Hochschule ; Student ; Ausland ; Niederlande
    In:
    Higher education quarterly, Bd. 78 (2024) H. 1, S. 254-267, 0263-9769
    0951-5224
    1468-2273
    Language:
    English

    FIS Bildung Literaturdatenbank
  10. 10
    Staff View
    Publication Date:
    2018-04-10
    Publisher:
    BMJ Publishing
    Electronic ISSN:
    2044-6055
    Topics:
    Medicine
    Keywords:
    Open access, Cardiovascular medicine
    Published by:
    http://group.bmj.com/

    Latest Papers from Table of Contents or Articles in Press
  11. 11
    Staff View
    ISSN:
    1365-2826
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Adrenomedullin is a peptide hormone with multifunctional biological properties. Its most characteristic effects are the regulation of circulation and the control of fluid and electrolyte homeostasis through peripheral and central nervous system actions. Although adrenomedullin is a vasodilator of cerebral vasculature, and it may be implicated in the pathomechanism of cerebrovascular diseases, the source of adrenomedullin in the cerebral circulation has not been investigated thus far. We measured the secretion of adrenomedullin by radioimmunoassay and detected adrenomedullin mRNA expression by Northern blot analysis in primary cultures of rat cerebral endothelial cells (RCECs), pericytes and astrocytes. We also investigated the expression of specific adrenomedullin receptor components by reverse transcriptase-polymerase chain reaction and intracellular cAMP concentrations in RCECs and pericytes. RCECs had approximately one magnitude higher adrenomedullin production (135 ± 13 fmol/105 cells per 12 h; mean ± SD, n = 10) compared to that previously reported for other cell types. RCECs secreted adrenomedullin mostly at their luminal cell membrane. Adrenomedullin production was not increased by thrombin, lipopolysaccharide or cytokines, which are known inducers of adrenomedullin release in peripheral endothelial cells, although it was stimulated by astrocyte-derived factors. Pericytes had moderate, while astrocytes had very low basal adrenomedullin secretion. In vivo experiments showed that adrenomedullin plasma concentration in the jugular vein of rats was approximately 50% higher than that in the carotid artery or in the vena cava. Both RCECs and pericytes, which are potential targets of adrenomedullin in cerebral microcirculation, expressed adrenomedullin receptor components, and exhibited a dose-dependent increase in intracellular cAMP concentrations after exogenous adrenomedullin administration. Antisense oligonucleotide treatment significantly reduced adrenomedullin production by RCECs and tended to decrease intraendothelial cAMP concentrations. These findings may suggest an important autocrine and paracrine role for adrenomedullin in the regulation of cerebral circulation and blood–brain barrier functions. Cerebral endothelial cells are a potential source of adrenomedullin in the central nervous system, where adrenomedullin can also be involved in the regulation of neuroendocrine functions.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2826.2002.00778.x

    Articles: DFG German National Licenses
  12. 12
    Sloane, J. A. ; Hinman, J. D. ; Lubonia, M. ; Hollander, W. ; Abraham, C. R.

    Oxford, UK : Blackwell Science Ltd
    Published 2003
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Myelin provides important insulating properties to axons allowing for propagation of action potentials over large distances at high velocity. Disruption of the myelin sheath could therefore contribute to cognitive impairment, such as that observed during the normal aging process. In the present study, age-related changes in myelin, myelin proteins and oligodendrocyte proteins were assessed in relationship to calpain-1 expression and cognition in the rhesus monkey. Isolation of myelin fractions from brain white matter revealed that as the content of the intact myelin fraction decreased with age, there was a corresponding increase in the floating or degraded myelin fraction, suggesting an increased breakdown of intact myelin with age. Of the myelin proteins examined, only the myelin-associated glycoprotein decreased with age. Levels of the oligodendrocyte-specific proteins 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) and myelin/oligodendrocyte-specific protein (MOSP) increased dramatically in white matter homogenates and myelin with age. Age-related increases in degraded CNPase also were demonstrable in white matter in association with increases in activated calpain-1. Degraded CNPase was also detectable in myelin fractions, with only the floating fraction containing activated calpain-1. The increases in the activated enzyme in white matter were much greater than those found in myelin fractions suggesting a source other than the myelin membrane for the marked overexpression of activated calpain-1 with age. In addition, CNPase was demonstrated to be a substrate for calpain in vitro. In summary, changes in myelin and oligodendrocyte proteins occur with age, and they appear to have a significant relationship to cognitive impairment. The overexpression of CNPase and MOSP suggests new formation of myelin by oligodendrocytes, which may occur in response to myelin degradation and injury caused by proteolytic enzymes such as calpain.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1471-4159.2003.01541.x

    Articles: DFG German National Licenses
  13. 13
    SELKOE, D. J. ; ABRAHAM, C. ; RASOOL, C. G. ; McCLUSKEY, A. ; KOSIK, K. S. ; DUFFY, L. K.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1985
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1985.tb50438.x

    Articles: DFG German National Licenses
  14. 14
    KULANGARA, ABRAHAM C. ; MENON, M. K. KRISHNA ; WILLMOTT, MARY

    [s.l.] : Nature Publishing Group
    Published 1965
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Bovine serum albumin (BSA) (Fraction V of Armour Laboratories, Chicago) was dissolved in saline and sterilized by Seitz filtration. The protein content, estimated by the biuret reaction, was 85 mg/ml. This solution was used for raising antisera in monkeys and for skin tests on, and injection of, ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/2061259a0

    Articles: DFG German National Licenses
  15. 15
    MUCKE, L. ; ABRAHAM, C. R. ; MASLIAH, E.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1996
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Notes:
    To better understand the role the human amyloid precursor protein (hAPP) plays in Alzheimer's disease (AD), it is essential to define its primary function(s). Here we expressed different hAPPs in neurons of transgenic (tg) mice to characterize their effects on the intact central nervous system (CNS). Immunolabeled brain sections of tg and non-tg mice were compared quantitatively by microdensitometry and computer-aided analysis of laser scanning confocal digitized images. Compared with non-tg mice, tg mice overexpressing hAPPs showed an increase in the number of synaptophysin immunoreactive presynaptic terminals as well as in the expression of the growth-associated marker GAP-43. While non-tg controls and tg mice expressing hAPP751 at moderate levels displayed a normal pattern of reinnervation of the dentate gyrus following perforant pathway transection, tg mice expressing hAPP695 at severalfold higher levels showed an accentuation of the synaptic loss and no sprouting reaction. In addition, expression of hAPP751 at moderate levels effectively protected neurons against excitotoxic injury induced either acutely by systemic injection of kainic acid or chronically by transgene-driven glial production of the soluble HIV-1 protein gp120. Neuronal expression of hAPP695 at higher levels provided less excitoprotection. Our findings are consistent with the postulate that APP plays a role in the formation/maintenance of synapses and that processes which affect this function could contribute to the synaptic pathology seen in AD. Our study also revealed that hAPPs can exert important excitoprotective functions in vivo and that the efficiency of this protection may depend on the hAPP isoform expressed as well as on the level of neuronal hAPP expression. Neuronal overexpression of hAPP beyond a certain level may have detrimental effects on the CNS, particularly in the context of secondary neural injuries.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1996.tb34405.x

    Articles: DFG German National Licenses
  16. 16
    SELKOE, D. J. ; ABRAHAM, C. ; RASOOL, C. G. ; McCLUSKEY, A. ; DUFFY, L. K.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1985
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1985.tb50472.x

    Articles: DFG German National Licenses
  17. 17
    Staff View
    ISSN:
    1572-946X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00645108

    Articles: DFG German National Licenses
  18. 18
    Gershon, H. ; Merhav, S. ; Abraham, C.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0047-6374
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0047-6374(79)90118-0

    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1573-093X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Physics
    Notes:
    Abstract It is shown that narrow-band radio bursts of right- and left-hand circular polarizations from the Sun and flare stars can be produced via nonlinear conversion of Langmuir waves into high-frequency electromagnetic electron cyclotron waves near the plasma frequency by coupling to low-frequency electromagnetic cyclotron waves such as Alfvén-ion cyclotron or magnetosonic-whistler waves.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1023/A:1004939919783

    Articles: DFG German National Licenses
  20. 20
    KELLER, ABRAHAM C.

    New York : Periodicals Archive Online (PAO)
    Published 1959
    Staff View
    ISSN:
    0035-8118
    Topics:
    Romance Studies
    URL:
    http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:1196-1959-050-02-000003

    Articles: DFG German National Licenses