Search Results - (Author, Cooperation:C. A. Purdie)

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  1. 1
    S. Nik-Zainal ; H. Davies ; J. Staaf ; M. Ramakrishna ; D. Glodzik ; X. Zou ; I. Martincorena ; L. B. Alexandrov ; S. Martin ; D. C. Wedge ; P. Van Loo ; Y. S. Ju ; M. Smid ; A. B. Brinkman ; S. Morganella ; M. R. Aure ; O. C. Lingjaerde ; A. Langerod ; M. Ringner ; S. M. Ahn ; S. Boyault ; J. E. Brock ; A. Broeks ; A. Butler ; C. Desmedt ; L. Dirix ; S. Dronov ; A. Fatima ; J. A. Foekens ; M. Gerstung ; G. K. Hooijer ; S. J. Jang ; D. R. Jones ; H. Y. Kim ; T. A. King ; S. Krishnamurthy ; H. J. Lee ; J. Y. Lee ; Y. Li ; S. McLaren ; A. Menzies ; V. Mustonen ; S. O'Meara ; I. Pauporte ; X. Pivot ; C. A. Purdie ; K. Raine ; K. Ramakrishnan ; F. G. Rodriguez-Gonzalez ; G. Romieu ; A. M. Sieuwerts ; P. T. Simpson ; R. Shepherd ; L. Stebbings ; O. A. Stefansson ; J. Teague ; S. Tommasi ; I. Treilleux ; G. G. Van den Eynden ; P. Vermeulen ; A. Vincent-Salomon ; L. Yates ; C. Caldas ; L. V. Veer ; A. Tutt ; S. Knappskog ; B. K. Tan ; J. Jonkers ; A. Borg ; N. T. Ueno ; C. Sotiriou ; A. Viari ; P. A. Futreal ; P. J. Campbell ; P. N. Span ; S. Van Laere ; S. R. Lakhani ; J. E. Eyfjord ; A. M. Thompson ; E. Birney ; H. G. Stunnenberg ; M. J. van de Vijver ; J. W. Martens ; A. L. Borresen-Dale ; A. L. Richardson ; G. Kong ; G. Thomas ; M. R. Stratton
    Nature Publishing Group (NPG)
    Published 2016
    Staff View
    Publication Date:
    2016-05-03
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Purdie, C A ; Piris, J

    Oxford, UK : Blackwell Science Ltd
    Published 2000
    Staff View
    ISSN:
    1365-2559
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2559.2000.09734.x

    Articles: DFG German National Licenses
  3. 3
    Purdie, C A ; Piris, J

    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Published 2000
    Staff View
    ISSN:
    1365-2559
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    We investigated parameters which might help identify poor prognosis colorectal cancers and, in particular, we stratified Dukes' stage B carcinomas in order to identify those patients who would benefit from adjuvant therapy.〈section xml:id="abs1-2"〉〈title type="main"〉Methods and resultsHistopathological parameters and DNA ploidy were analysed in a consecutive series of 256 resected colorectal cancers and their relationship with patient survival were investigated. By univariate analysis, Dukes' stage, degree of differentiation, nature of the invasive margin and DNA ploidy all correlated with prognosis. However, degree of differentiation assessed by the worst pattern seen anywhere in the tumour correlated more significantly with clinical outcome than did the predominant pattern. This was confirmed by multivariate analysis which showed only Dukes' stage and worst pattern differentiation as independent prognostic variables. Mucinous carcinomas showed no significant difference in outcome when compared to adenocarcinomas. DNA ploidy correlated with prognosis but only at a low level (P = 0.035) but this was maintained for Dukes' B carcinomas.〈section xml:id="abs1-3"〉〈title type="main"〉ConclusionsDukes' stage and degree of differentiation provide independent prognostic information in colorectal cancer. However, differentiation should be assessed by the worst pattern and not by the predominant pattern as is currently recommended by the UKCCCR. DNA ploidy provides some prognostic information and does stratify Dukes' B cancers and thus might provide useful information on which to base decisions concerning adjuvant therapies in this difficult group. Mucinous differentiation has no prognostic significance.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2559.2000.00826.x

    Articles: DFG German National Licenses
  4. 4
    Clarke, A. R. ; Purdie, C. A. ; Harrison, D. J. ; Morris, R. G. ; Bird, C. C. ; Hooper, M. L. ; Wyllie, A. H.

    [s.l.] : Nature Publishing Group
    Published 1993
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] We compared normal thymocytes with those from mice in which, as a result of gene targeting, a deletion was introduced to disable the p53 gene. E14 embryonic stem (ES) cells, derived from strain 129/Ola (ref. 9), and cultured in leukaemia inhibiting factor (LIF)-supplemented medium, were used ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/362849a0

    Articles: DFG German National Licenses