Search Results - (Author, Cooperation:B. Turner)

2018-06-26

BMJ Publishing Group

0022-2593

1468-6244

Medicine

Open access

2018-11-21

American Chemical Society (ACS)

1520-5207

Chemistry and Pharmacology

Physics

2018-07-10

The American Association of Immunologists (AAI)

0022-1767

1550-6606

Medicine

2013-04-13

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

DNA Mutational Analysis ; Genetic Loci ; *Haploinsufficiency ; Heterotaxy Syndrome/*genetics ; Humans ; Mutation ; Pedigree ; Penetrance ; Receptors, Laminin/*genetics ; Ribosomal Proteins/*genetics ; Spleen/*abnormalities/growth & development

0021-9673

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource

2018-08-04

The American Society for Biochemistry and Molecular Biology (ASBMB)

0021-9258

1083-351X

Biology

Chemistry and Pharmacology

2018-05-25

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Geosciences

Computer Science

Medicine

Natural Sciences in General

Physics

Ecology

2018-05-25

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Geosciences

Computer Science

Medicine

Natural Sciences in General

Physics

Ecology

1089-7550

AIP Digital Archive

Physics

The process of excimer laser ablation has been studied while varying the laser fluence from 0.237 to 19.1 J/cm2. Ion time-of-flight, total charge, target etch depth per pulse, and etch volume per pulse have been measured. Results indicate a maximum ablation volume and minimum ionization fraction occur near 5 J/cm2. Several of the parameters measured vary rapidly in the 1–5 J/cm2 range. Variation in these parameters strongly influences the properties of films grown by this technique.

Electronic Resource

1089-7690

AIP Digital Archive

Physics

Chemistry and Pharmacology

The competition between photoionization and spontaneous dissociation involving the 3Π states of CO has been investigated both experimentally and theoretically. In this study we analyzed the mass and kinetic energy spectra of the photofragments generated after irradiating CO with a line narrowed (≈0.75 cm−1) tunable ArF* laser (λ≈193 nm) and calculated the cross section (3.2 Mb) for photoionizing the c 3Π Rydberg state of CO at the excitation energy. The basic conclusions of this study are that the interaction between the 3Π Rydberg states and the 3Π valence states near 12.8 eV causes rapid (picosecond time scale or faster) dissociation of CO which impedes photoionization and that multiphoton dissociation completely dominates multiphoton ionization at laser power densities up to at least 30 GW/cm2.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

An excimer laser-based photofragmentation instrument capable of quantitatively probing ionization and dissociation dynamics in small molecular systems is described. This instrument combines single and multiphoton excitation techniques, with fluorescence and time-of-flight ion detection techniques to excite specific excited states of parent molecules and to determine the partitioning of energy among neutral and ionic photofragments. The results of a series of prototype photofragmentation experiments on CO will be used to demonstrate how the experimenter obtains a clearer picture of the fragmentation mechanism when both the ionic and neutral photofragments are interrogated quantitatively rather than when only one type of fragment is studied. Specifically, the authors address the discrepancy in the interpretations of previous fluorescence work on the CO system. It will be shown further that the spectra of the photofragments generated after decomposition of CO by 193-nm radiation can be used to calibrate the laser bandwidth (0.75 cm−1) and the absolute frequency (to within 2 cm−1) when an ArF* excimer laser is employed.

Electronic Resource

1467-9493

Blackwell Publishing Journal Backfiles 1879-2005

Geography

Electronic Resource

1365-3040

Blackwell Publishing Journal Backfiles 1879-2005

Biology

Phosphatase activities and environmental features were characterized for 12 terrestrial and aquatic mosses in upland northern England, along with four species sampled from subarctic Sweden. Phosphomonoesterase (PMEase) and phosphodiesterase (PDEase) activities of shoot tips were measured using para-nitrophenyl phosphate (p-NPP) and bis-pNPP. All species showed PMEase activity, but not all showed PDEase activity. The mean pH optimum was 5·0 for PMEase and 5·7 for PDEase. The kinetic parameters Km and Vmax were calculated from three linear transformations of the Michaelis–Menten equation. The mean Km values of the mosses ranged between 77 and 468 µm for PMEase and 26 and 414 µm for PDEase. The corresponding Vmax values were 0·6–205 µmol pNP g−1 DW h−1 for PMEase and 1·4–110 µmol pNP g−1 DW h−1 for PDEase. Mosses from Sweden displayed greater Km and smaller Vmax values than those from England. The aquatics Fontinalis antipyretica and Rhynchostegium riparioides displayed two-phase kinetics for PMEase and PDEase, with Km and Vmax being dependent on substrate concentration. Staining suggested that PMEase activity was located in the cell wall of most mosses. Phosphatase assays provide a rapid method for screening environmental nutrient status and a standard procedure is recommended.

Electronic Resource

1360-0443

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Psychology

Aims. Researchers must develop effective strategies for disseminating research-based treatments. This study evaluates the application of a dissemination model based on principles of social marketing and diffusion theory. Design. A case study describes how the model was implemented. A qualitative design was employed to examine rates of adoption and adaptation of an early intervention program by a targeted system of addictions agencies. Setting. The interventions were developed at the Addiction Research Foundation in Toronto and disseminated to Assessment and Referral (A/R) Centres in Ontario, Canada. Participants. Study participants included the managers and a designated therapist for 33 participating A/R centres. Measurements. Managers were asked mainly open-ended questions concerning whether their agency had made a formal decision to adopt the intervention and whether therapists in their agency were using the early intervention program. "Adoption" was operationalized as offering the complete four-session intervention to at least one client. Findings. At 12 months after the completion of training workshops, 68% of 34 agencies in the target system had adopted the program while 85% of the agencies were using some components of the intervention with clients. Conclusions. The dissemination model appeared to be effective although its application proved to be time-consuming and labour-intensive. The "market analysis", systems focus and field-test components of the model appeared to contribute to its success.

Electronic Resource

1750-3841

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Process Engineering, Biotechnology, Nutrition Technology

A laboratory thermal processing unit and reactor cell were adapted to aseptically process browned and unbrowned cubes from Choice an Utility Grade beef. Processing parameters of heating medium flow rate, time and temperature were established. Processed product was analyzed for changes in flavor and texture on day 0 and after 30 days refrigerated storage. Because sterility of each sample was not verified, sensory evaluation was only performed at day 0. Pre-browning improved flavor quality and did not reduce tenderness or yield. Low quality beef could be effectively utilized with proper processing parameters. Lipid oxidation and loss of sulfur compounds during storage were limiting factors in aseptically processing beef particulates.

Electronic Resource

1750-3841

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Process Engineering, Biotechnology, Nutrition Technology

Neutral lipid (NL) and phospholipid (PL) fractions and their corresponding fatty acid (FA) profiles from the L. dorsi of Angus-Hereford heifers (n=27) were compared as a function of forage grazing (FG) and time in the feedlot after grazing (DIF) on pasture. There were no differences in total PL content or FA composition of the individual PL as influenced by initial FG. As DIF increased, there was an increase in PL concentration and significant changes in the FA composition of the total PL and several of the individual PL fractions, separated by high performance liquid chromatography. Total PL content and FA content of the individual PL were significantly correlated with differences in the flavor characteristics of ground beef which were determined by a descriptive panel.

Electronic Resource

1095-8649

Blackwell Publishing Journal Backfiles 1879-2005

Biology

The killifish Rivulus marmoratus is the only known selfing hermaphroditic vertebrate, and males of the species are usually exceedingly rare or non-existent in nature. Collections on several Belize cays in 1988 and 1989 yielded 13.5–24% males. Factors responsible for this unusually high proportion of males are currently not understood. Likewise, the biological significance of males in populations which otherwise consist of selfing hermaphrodites (with internal fertilization) is problematic and awaits further study.

Electronic Resource

1095-8649

Blackwell Publishing Journal Backfiles 1879-2005

Biology

Repetitive sequences are predominant components of eukaryotic genomes, including those of fishes, but they represent largely unchartered territory for the student of fish evolution and population differentiation. Three examples of the use of repetitive sequences are presented. In one, a Hind 111 monomeric unit of an adjacent repeat (satellite) sequence was characterized, by cloning and sequencing, from the genome of the sheepshead minnow, Cyprinodon variegates, a species which ranges from Cape Cod to Mexico. The characteristic monomeric sequence of each population sample (termed the ‘canonical sequence’) is divergent. The data demonstrate that molecular drive, usually invoked only for interspecific divergence, can apparently produce characteristic suites of repetitive sequences in conspecific local populations. The two other examples deal with dispersed simple-sequences and minisatellites which provide individual-specific DNA fingerprint phenotypes. In both cases, previous allozyme studies failed to resolve potentially important variation. In Rivulus marmoratus, a selling hermaphroditic species with homozygous, clonal population structure, fingerprinting demonstrates unprecedented levels of intrapopulation genetic heterogeneity, and strongly suggests that there are significant mutational distances between even sympatric clones. The data warrant serious re-evaluation of the genetic variation of this species, its adaptive significance and its origins. In the striped bass, Morone saxatilis, a species of enormous economic and recreational importance, fingerprinting demonstrates that even hatchery stocks have very high levels of genetic variation. Though the species essentially lacks allozyme variation, it is apparently not approaching genome-wide homozygosity. Taken together, the data argue that the analyses of various kinds of repetitive sequences will play an increasingly greater role in future attempts to understand the structure and differentiation offish populations.

Electronic Resource

1095-8649

Blackwell Publishing Journal Backfiles 1879-2005

Biology

The systematic relationships of the freshwater teleost family Goodeidae inferred from a distance Wagner analysis of allozyme data are mainly consistent with previous systematic hypotheses, including some of those based on karyology. However, a recently proposed hypothesis based on bony anatomy of the mouth is not supported. Branching patterns of species within genera were 100% supported based on a jack knife consensus test except for Xenotoca, which is apparently a polyphyletic lineage. A fossil goodeid of Miocene age was used to calibrate the molecular clock for goodeids at Nei D= 1.0 = 11.3 million years.

Electronic Resource

1750-3841

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Process Engineering, Biotechnology, Nutrition Technology

Neutral lipid (NL) and phospholipid (PL) fractions and their corresponding fatty acid profiles from the L. dorsi of Bison, Hereford, and Brahman steers of similar age finished on identical diets were determined. Compositional differences were related to sensory characteristics of the samples. Phosphatidylcholine + lysophosphatidylethanolamine (PC + LPE) existed in the highest concentration in all samples evaluated followed by lysophosphatidylcholine (LPC), phosphatidylethanolamine (PE), sphingomyelin (SPH), fraction one and phosphatidylserine (PS). Bison contained more total PL, particularly PC + LPE and LPC, than the other two bovine species. Polyunsaturated fatty acid (PUFA) composition of these PL was greater for Bison. Off-flavor and aftertaste increased with increasing levels of PC + LPE and LPC due to their greater composition of PUFA.

Electronic Resource