Search Results - (Author, Cooperation:B. Sutter)

Showing 1 - 20 results of 25, query time: 0.29s Refine Results
  1. 1
    Staff View
    Publication Date:
    2013-09-28
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    D. W. Ming ; P. D. Archer, Jr. ; D. P. Glavin ; J. L. Eigenbrode ; H. B. Franz ; B. Sutter ; A. E. Brunner ; J. C. Stern ; C. Freissinet ; A. C. McAdam ; P. R. Mahaffy ; M. Cabane ; P. Coll ; J. L. Campbell ; S. K. Atreya ; P. B. Niles ; J. F. Bell, 3rd ; D. L. Bish ; W. B. Brinckerhoff ; A. Buch ; P. G. Conrad ; D. J. Des Marais ; B. L. Ehlmann ; A. G. Fairen ; K. Farley ; G. J. Flesch ; P. Francois ; R. Gellert ; J. A. Grant ; J. P. Grotzinger ; S. Gupta ; K. E. Herkenhoff ; J. A. Hurowitz ; L. A. Leshin ; K. W. Lewis ; S. M. McLennan ; K. E. Miller ; J. Moersch ; R. V. Morris ; R. Navarro-Gonzalez ; A. A. Pavlov ; G. M. Perrett ; I. Pradler ; S. W. Squyres ; R. E. Summons ; A. Steele ; E. M. Stolper ; D. Y. Sumner ; C. Szopa ; S. Teinturier ; M. G. Trainer ; A. H. Treiman ; D. T. Vaniman ; A. R. Vasavada ; C. R. Webster ; J. J. Wray ; R. A. Yingst
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-12-11
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Bays ; Carbon Dioxide/analysis/chemistry ; *Exobiology ; Extraterrestrial Environment/*chemistry ; Geologic Sediments/analysis/chemistry ; Hydrocarbons, Chlorinated/*analysis ; *Mars ; Oxygen/analysis/chemistry ; Sulfides/analysis/chemistry ; Volatile Organic Compounds/*analysis ; Water/analysis/chemistry
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2014-12-18
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    C. R. Webster ; P. R. Mahaffy ; G. J. Flesch ; P. B. Niles ; J. H. Jones ; L. A. Leshin ; S. K. Atreya ; J. C. Stern ; L. E. Christensen ; T. Owen ; H. Franz ; R. O. Pepin ; A. Steele ; C. Achilles ; C. Agard ; J. A. Alves Verdasca ; R. Anderson ; D. Archer ; C. Armiens-Aparicio ; R. Arvidson ; E. Atlaskin ; A. Aubrey ; B. Baker ; M. Baker ; T. Balic-Zunic ; D. Baratoux ; J. Baroukh ; B. Barraclough ; K. Bean ; L. Beegle ; A. Behar ; J. Bell ; S. Bender ; M. Benna ; J. Bentz ; G. Berger ; J. Berger ; D. Berman ; D. Bish ; D. F. Blake ; J. J. Blanco Avalos ; D. Blaney ; J. Blank ; H. Blau ; L. Bleacher ; E. Boehm ; O. Botta ; S. Bottcher ; T. Boucher ; H. Bower ; N. Boyd ; B. Boynton ; E. Breves ; J. Bridges ; N. Bridges ; W. Brinckerhoff ; D. Brinza ; T. Bristow ; C. Brunet ; A. Brunner ; W. Brunner ; A. Buch ; M. Bullock ; S. Burmeister ; M. Cabane ; F. Calef ; J. Cameron ; J. Campbell ; B. Cantor ; M. Caplinger ; J. Caride Rodriguez ; M. Carmosino ; I. Carrasco Blazquez ; A. Charpentier ; S. Chipera ; D. Choi ; B. Clark ; S. Clegg ; T. Cleghorn ; E. Cloutis ; G. Cody ; P. Coll ; P. Conrad ; D. Coscia ; A. Cousin ; D. Cremers ; J. Crisp ; A. Cros ; F. Cucinotta ; C. d'Uston ; S. Davis ; M. Day ; M. de la Torre Juarez ; L. DeFlores ; D. DeLapp ; J. DeMarines ; D. DesMarais ; W. Dietrich ; R. Dingler ; C. Donny ; B. Downs ; D. Drake ; G. Dromart ; A. Dupont ; B. Duston ; J. Dworkin ; M. D. Dyar ; L. Edgar ; K. Edgett ; C. Edwards ; L. Edwards ; B. Ehlmann ; B. Ehresmann ; J. Eigenbrode ; B. Elliott ; H. Elliott ; R. Ewing ; C. Fabre ; A. Fairen ; K. Farley ; J. Farmer ; C. Fassett ; L. Favot ; D. Fay ; F. Fedosov ; J. Feldman ; S. Feldman ; M. Fisk ; M. Fitzgibbon ; M. Floyd ; L. Fluckiger ; O. Forni ; A. Fraeman ; R. Francis ; P. Francois ; C. Freissinet ; K. L. French ; J. Frydenvang ; A. Gaboriaud ; M. Gailhanou ; J. Garvin ; O. Gasnault ; C. Geffroy ; R. Gellert ; M. Genzer ; D. Glavin ; A. Godber ; F. Goesmann ; W. Goetz ; D. Golovin ; F. Gomez Gomez ; J. Gomez-Elvira ; B. Gondet ; S. Gordon ; S. Gorevan ; J. Grant ; J. Griffes ; D. Grinspoon ; J. Grotzinger ; P. Guillemot ; J. Guo ; S. Gupta ; S. Guzewich ; R. Haberle ; D. Halleaux ; B. Hallet ; V. Hamilton ; C. Hardgrove ; D. Harker ; D. Harpold ; A. M. Harri ; K. Harshman ; D. Hassler ; H. Haukka ; A. Hayes ; K. Herkenhoff ; P. Herrera ; S. Hettrich ; E. Heydari ; V. Hipkin ; T. Hoehler ; J. Hollingsworth ; J. Hudgins ; W. Huntress ; J. Hurowitz ; S. Hviid ; K. Iagnemma ; S. Indyk ; G. Israel ; R. Jackson ; S. Jacob ; B. Jakosky ; E. Jensen ; J. K. Jensen ; J. Johnson ; M. Johnson ; S. Johnstone ; A. Jones ; J. Joseph ; I. Jun ; L. Kah ; H. Kahanpaa ; M. Kahre ; N. Karpushkina ; W. Kasprzak ; J. Kauhanen ; L. Keely ; O. Kemppinen ; D. Keymeulen ; M. H. Kim ; K. Kinch ; P. King ; L. Kirkland ; G. Kocurek ; A. Koefoed ; J. Kohler ; O. Kortmann ; A. Kozyrev ; J. Krezoski ; D. Krysak ; R. Kuzmin ; J. L. Lacour ; V. Lafaille ; Y. Langevin ; N. Lanza ; J. Lasue ; S. Le Mouelic ; E. M. Lee ; Q. M. Lee ; D. Lees ; M. Lefavor ; M. Lemmon ; A. Lepinette Malvitte ; R. Leveille ; E. Lewin-Carpintier ; K. Lewis ; S. Li ; L. Lipkaman ; C. Little ; M. Litvak ; E. Lorigny ; G. Lugmair ; A. Lundberg ; E. Lyness ; M. Madsen ; J. Maki ; A. Malakhov ; C. Malespin ; M. Malin ; N. Mangold ; G. Manhes ; H. Manning ; G. Marchand ; M. Marin Jimenez ; C. Martin Garcia ; D. Martin ; M. Martin ; J. Martinez-Frias ; J. Martin-Soler ; F. J. Martin-Torres ; P. Mauchien ; S. Maurice ; A. McAdam ; E. McCartney ; T. McConnochie ; E. McCullough ; I. McEwan ; C. McKay ; S. McLennan ; S. McNair ; N. Melikechi ; P. Y. Meslin ; M. Meyer ; A. Mezzacappa ; H. Miller ; K. Miller ; R. Milliken ; D. Ming ; M. Minitti ; M. Mischna ; I. Mitrofanov ; J. Moersch ; M. Mokrousov ; A. Molina Jurado ; J. Moores ; L. Mora-Sotomayor ; J. M. Morookian ; R. Morris ; S. Morrison ; R. Mueller-Mellin ; J. P. Muller ; G. Munoz Caro ; M. Nachon ; S. Navarro Lopez ; R. Navarro-Gonzalez ; K. Nealson ; A. Nefian ; T. Nelson ; M. Newcombe ; C. Newman ; H. Newsom ; S. Nikiforov ; B. Nixon ; E. Noe Dobrea ; T. Nolan ; D. Oehler ; A. Ollila ; T. Olson ; M. A. de Pablo Hernandez ; A. Paillet ; E. Pallier ; M. Palucis ; T. Parker ; Y. Parot ; K. Patel ; M. Paton ; G. Paulsen ; A. Pavlov ; B. Pavri ; V. Peinado-Gonzalez ; L. Peret ; R. Perez ; G. Perrett ; J. Peterson ; C. Pilorget ; P. Pinet ; J. Pla-Garcia ; I. Plante ; F. Poitrasson ; J. Polkko ; R. Popa ; L. Posiolova ; A. Posner ; I. Pradler ; B. Prats ; V. Prokhorov ; S. W. Purdy ; E. Raaen ; L. Radziemski ; S. Rafkin ; M. Ramos ; E. Rampe ; F. Raulin ; M. Ravine ; G. Reitz ; N. Renno ; M. Rice ; M. Richardson ; F. Robert ; K. Robertson ; J. A. Rodriguez Manfredi ; J. J. Romeral-Planello ; S. Rowland ; D. Rubin ; M. Saccoccio ; A. Salamon ; J. Sandoval ; A. Sanin ; S. A. Sans Fuentes ; L. Saper ; P. Sarrazin ; V. Sautter ; H. Savijarvi ; J. Schieber ; M. Schmidt ; W. Schmidt ; D. Scholes ; M. Schoppers ; S. Schroder ; S. Schwenzer ; E. Sebastian Martinez ; A. Sengstacken ; R. Shterts ; K. Siebach ; T. Siili ; J. Simmonds ; J. B. Sirven ; S. Slavney ; R. Sletten ; M. Smith ; P. Sobron Sanchez ; N. Spanovich ; J. Spray ; S. Squyres ; K. Stack ; F. Stalport ; T. Stein ; N. Stewart ; S. L. Stipp ; K. Stoiber ; E. Stolper ; B. Sucharski ; R. Sullivan ; R. Summons ; D. Sumner ; V. Sun ; K. Supulver ; B. Sutter ; C. Szopa ; F. Tan ; C. Tate ; S. Teinturier ; I. ten Kate ; P. Thomas ; L. Thompson ; R. Tokar ; M. Toplis ; J. Torres Redondo ; M. Trainer ; A. Treiman ; V. Tretyakov ; R. Urqui-O'Callaghan ; J. Van Beek ; T. Van Beek ; S. VanBommel ; D. Vaniman ; A. Varenikov ; A. Vasavada ; P. Vasconcelos ; E. Vicenzi ; A. Vostrukhin ; M. Voytek ; M. Wadhwa ; J. Ward ; E. Weigle ; D. Wellington ; F. Westall ; R. C. Wiens ; M. B. Wilhelm ; A. Williams ; J. Williams ; R. Williams ; R. B. Williams ; M. Wilson ; R. Wimmer-Schweingruber ; M. Wolff ; M. Wong ; J. Wray ; M. Wu ; C. Yana ; A. Yen ; A. Yingst ; C. Zeitlin ; R. Zimdar ; M. P. Zorzano Mier
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-07-23
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2018-06-08
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Geosciences
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Geochemistry, Geophysics, Planetary Science
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    Publication Date:
    2018-06-08
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Geosciences
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Geochemistry, Geophysics, Planetary Science
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  7. 7
    Hoo-Paris, R. ; Moreau, C. ; Castex, C. ; Sutter, B.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0011-2240
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0011-2240(87)90128-3

    Articles: DFG German National Licenses
  8. 8
    Hoo-Paris, R. ; Aina, E. ; Castex, C. ; Sutter, B.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0300-9629
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0300-9629(84)90596-6

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    0300-9629
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0300-9629(85)90135-5

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1434-601X
    Keywords:
    23.20.Ck ; 2320.Lv ; 27.60.+j
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Physics
    Notes:
    Abstract The β− decay of101Zr has been investigated at the fission-product separators JOSEF and LOHENGRIN. The half-life of101Zr has been determined to 2.5(1) s and a level scheme for101Nb has been established fromγ ray singles as well as X/3-γ and γ—γ coincidence measurements. Conversion coefficients for transitions in101Nb and level half-lives between 10 ps and 2 ns have been determined. Three rotational bands are identified among the low-lying levels with band heads at 0 keV, 206 keV and 208 keV. The bands are probably based on the Nilsson configurations [422 5/2+], [301 3/2−] and [303 5/2−], respectively. The deformation has been determined to βq=0.40(4) and 0.41(8) for the ground state band and the band based on the 206 keV level from the half-lives of the first and second excited members of these bands. This shows that the rapid onset of deformation at N=60 which is typical for the A=100 region of neutron-rich nuclei, takes also place in the Nb isotopes. Nilsson model calculations describe the experimental data well, especially the several determined transition probabilities including those for E1 transitions from the 206 and 208 keV band heads to the ground state.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01284474

    Articles: DFG German National Licenses
  11. 11
    Sutter, B.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0083-6656
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0083-6656(75)90085-9

    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1433-2965
    Keywords:
    Key words:Bone mineral density – Dual-energy X-ray absorptiometry – Genetics – Heredity – Osteoporosis
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract: The relative influence of genetic and environmental determinants on bone mass is still unclear. Using an original multicentric mode of recruitment, based on absorptiometry current practice, the hypothesis of a familial predisposition to low bone mineral content was assessed. The study was based on dual-energy X-ray absorptiometry (DXA) measurements of lumbar and femoral neck bone mineral density (BMD), using daughters of women with a low BMD (case mothers). These BMD values were compared with those of control daughters of women with a normal BMD. Case mothers (n= 72) aged 54.3 ± 4.8 years were recruited on the basis of a questionnaire and a vertebral Z-score 〈 – 2 SD. Their healthy daughters of more than 20 years (n= 77) aged 28.2 ± 4.9 years had their vertebral and femoral BMD Z-score determined. The control groups were composed of mothers aged 54.1 ± 4.7 years, paired by age ± 2 years to the case mothers, and of their daughters of more than 20 years old, aged 27.7 ± 5.8 years. For daughters, a significant difference was found between the mean vertebral Z-scores (–0.82 ± 1.08 for cases and 0.01 ± 1.14 for controls, p 〈 0.0001). The difference was in the same direction but was not statistically significant for mean femoral Z-scores (–0.58 ± 1.15 for cases and –0.22 ± 1.33 for controls, p 〈0.073). These findings confirm the hypothesis of a familial predisposition to low BMD.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001980050078

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1433-2965
    Keywords:
    Bone histomorphometry ; Corticosteroid ; Dual-photon absorptiometry ; Mechanical testing ; Osteoporosis ; Rabbit
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The effects of corticosteroid on bone were examined in female growing rabbits treated with 0.7 mg/kg per day prednisolone for 5 months. The evolution of whole-body total bone mineral measured by dual-photon absorptiometry showed a significant difference between the prednisolone-treated group and the control group from the first to the fifth month. The histomorphometric profile of corticosteroid-induced osteoporosis was observed, in particular the lower bone volume and thinner and fewer trabecular plates. Mechanical tests are possible on rabbit vertebrae and showed a very significant difference in bone strength between the prednisolone-treated and control groups, and a good correlation between mechanical tests and histomorphometric or densitometric results. This bone corticosteroid model shows that vertebral compression tests are possible on rabbit lumbar vertebrae. It may contribute to a better evaluation of corticosteroid treatments.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01623240

    Articles: DFG German National Licenses
  14. 14
    Faure, A. ; Billaudel, B. ; Sutter, B. Ch. J.
    Springer
    Published 1984
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Rat ; islets of Langerhans ; oestradiol treatment ; adrenal glands ; corticosterone treatment ; insulin
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Ovarian-adrenal interactions on insulin secretion during oestradiol treatment were studied in sham-operated, ovariectomized and adrenalectomized-ovariectomized female rats, the latter thus treated to suppress interference from endogenous hormones. Islets of Langerhans isolated from oestradiol or oestradiol + corticosterone treated and control rats were incubated with various glucose concentrations. Oestradiol treatment enhanced basal and glucose stimulated insulin secretion from sham-operated (+12%) or ovariectomized rats (+24%). This effect disappeared in adrenalectomized-ovariectomized rats but reappeared when adrenalectomized-ovariectomized rats were treated with oestradiol + corticosterone (+37%). A 14-day oestradiol treatment had a trophic effect on total protein content independent of adrenal presence (+14%; +15%; +31%; +23% versus respective control groups). Our data demonstrate that corticosterone is necessary for the stimulating effect of oestradiol on insulin secretion.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00252268

    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Adrenal medulla ; adrenaline ; serum insulin
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Résumé L'insuline «totale», l'insuline «non supprimable» et l'insuline «supprimable», dosées par la méthode du diaphragme de Rat, ainsi que l'insuline immunoréactive, ont été mesurées dans le sérum de rats normaux, de rats surrénalectomisés traités par des hormones corticosurrénaliennes et de rats à surrénale énucléée. — Les différentes formes d'activité insulinique sont plus élevées chez le Rat médulloprive que chez le Rat normal. L'insuline immunoreactive est, par contre, identique dans les deux groupes d'animaux. Ceci s'explique par le fait déjà démontré que l'adrénaline est un inhibiteur (et non un antagoniste) de l'effet de l'insuline sur le muscle et le tissu adipeux. — L'influence du niveau glycémique sur la sécrétion pancréatique se traduit, chez le Rat normal, par une relation linéaire entre la glycémie et linsulinémie. En l'absence de la médullosurrénale, les pentes des droites correspondant aux trois formes d'insuline mesurées par la méthode du diaphragme sont augmentées. Il ne s'agit cependant pas d'un effet de l'adrénaline sur la sécrétion insulinique mais de l'absence de l'effet inhibiteur de l'adrénaline dans le sérum des rats médulloprives, comme l'ont montré des expériences«in vitro». — Les réponses pancréatiques à des surcharges en glucose et la sécrétion d'insuline «invitro» dans du tampon ou du sérum de rats surrénalectomisés glucoses à 1 mg ou 7.5 mg/ml, n'ont pas permis de mettre en évidence une influence de l'adrénaline endogène sur la sécrétion d'insuline par le pancréas.
    Abstract:
    Zusammenfassung Die “totale“, die “nicht hemmbare“ und die „hemmbare“ Insulinaktivität wurde im Rattenserum, mit der Zwerchfellmethode gemessen, ferner das immunoreaktive Insulin (IRI). Die Bestimmungen wurden bei normalen Ratten, bei nebennierenlosen Tieren, mit oder ohne Nebennierenrmdenhormonenbehandlung und bei Ratten ohne Nebennierenmark vorgenommen. —Nach Nebennierenmarkexstirpation ist die Insulinaktivität des Serums größer als zuvor, doch das IRI bleibt unverändert. Diese Differenz ist dem Adrenalin, das ein Inhibitor des Insulins ist und dessen Effekt auf die Glucoseaufnahme des Zwerchfells und des Fettgewebes verringert, zuzuschreiben. — Bei den normalen Tieren besteht eine lineare Beziehung zwischen der Glykämie und dem Insulingehalt des Serums. Wenn kein Nebennierenmark mehr vorhanden ist, ist die Neigung der Geraden stärker, gleich um welche der Insulinaktivitäten es sich auch handelt. Dies ist nicht einer Wirkung des Adrenalins auf die Insulinsekretion, vielmehr der Abwesenheit des inhibitorischen Effektes dieses Hormons bei den nebennierenmarklosen Ratten, wie es die„in vitro“ Experimente zeigen, zuzuschreiben. — Ein Einfluß des endogenen Adrenalins auf die Insulinsekretion bei Tieren, die keinem Stress unterworfen waren, konnte nicht bewiesen werden, obwohl das Verhalten unter Glucosebelastung und die„in vitro“ Insulinsekretion überprüft wurden.
    Notes:
    Summary “Total”, “non-suppressible” and “suppressible” serum insulin-like activities in normal rats, in adrenalectomized rats treated with corticosteroids and in rats with demedullated adrenals were measured using the rat diaphragm “in vitro” and the immunoreactive insulin determined by a radio-immunological procedure. — The three forms of insulin-like activities were higher in the demedullated than in the normal rat. In contrast, the levels of immunoreactive insulin were identical in the two groups of animals. These results can be explained by the fact that epinephrine is an inhibitor (and not an antagonist) of insulin action on muscle and adipose tissue. —The influence of the basal serum glucose level on insulin secretion was seen in the normal rat, by a linear relationship between the serum glucose levels and the serum insulin concentrations. In the absence of the adrenal medulla, the slopes corresponding to the three forms of insulin-like activities measured by the rat diaphragm were increased. However, this phenomenon was not related to an influence of epinephrine on insulin secretion: “in vitro” experiments showed that the inhibitory effect of physiological doses of epinephrine was greater when the concentration of insulin in the medium was elevated, which explains the observations made“in vivo”. — The serum response “in vivo” to glucose loads, and the insulin secretion “in vitro” into a medium or into sera taken from adrenalectomized rats and brought to a glucose concentration of 1 or 7.5 mg/ml, have not led to the demonstration of an influence of basal concentrations of endogenous epinephrine on the pancreatic secretion of insulin.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01309903

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Adrenal cortex ; corticosteroids ; serum insulin ; permissive action
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Résumé La surrénalectomie diminue l'insuline «supprimable» et l'insuline «non supprimable» mises en évidence par la méthode du diaphragme ainsi que celle que mesure la technique immunologique. — Nous n'avons pas pu mettre en évidence d'interaction périphérique entre hormones corticosurrénaliennes et insuline. Par contre, nous avons précisé l'influence de la corticosurrénale sur la sécrétion insulinique de trois façons. — La relation glycémieinsulinémie, qui n'existe pas chez le Rat surrénalectomisé, est rétablie après un traitement par la corticosterone ou l'hydrocortisone. On l'observe chez le Rat à surrénale énucléée si son sérum contient de la corticostérone. —Lors d'une surcharge en glucose le pancréas du Rat surrénalectomisé répond mal à l'augmentation de la glycémie, alors que le Rat à surrénale énucléée répond aussi bien que le Rat normal. — Enfin, les expériences de sécrétion pancréatique «in vitro» dans un milieu tampon ou dans du sérum ont montré que les fragments de pancréas prélevés sur des rats surrénalectomisés sécrètent moins d'insuline que ceux de rats normaux ou de rats à surrénale énucléée, si la concentration en glucose est dans des limites physiologiques. Pour des concentrations en glucose élevées (7.5 mg/ml) la sécrétion d'insuline du pancréas de rats surrénalectomisés s'accroît, mais n'atteint pas les valeurs observées dans les deux autres groupes de rats. — Par conséquent, la présence d'hormones corticosurrénaliennes dans le sérum est nécessaire pour que la sécrétion insulinique réponde normalement aux variations du glucose sanguin.
    Abstract:
    Zusammenfassung Die hemmbare und die nicht hemmbare Insulinaktivität (Zwerchfellmethode) und das immunologisch meßbare Insulin wird bei der Ratte durch Nebennierenexstirpation verringert. — Eine gegenseitige Beeinflussung der Nebennierenrinden-Hormone und des Insulins in der Peripherie konnte nicht nachgewiesen werden, dagegen wurde der Einfluß der Nebennierenrinde auf die Insulin-Sekretion bestätigt. — Die lineare Funktion, die zwischen Blutzucker- und Insulinspiegeln bei normalen Tieren besteht, existiert nach der Adrenalektomie nicht mehr, wird aber durch Behandlung der operierten Ratten mit Nebennierenrinden-Hormonen wieder hervorgerufen. — Während einer Glucosebelastung antwortet das Pankreas der adrenalektomierten Ratte nur geringfügig auf die Blutzuckererhöhung, dagegen reagierten Tiere, denen das Nebennierenmark entfernt worden war, mit normaler Insulinausschüttung. — Bei Inkubation von Pankreasstückchen in Pufferlösung oder Serum zeigte sich, daß innerhalb physiologischer Glucosekonzentrationen die Pankreasteilchen von adrenalektomierten Ratten auchin vitro weniger Insulin ausschütten als die von Normaltieren oder Tieren nach Entfernung des Nebennierenmarkes. Bei hohen Glucosekonzentrationen steigt die Insulinsekretion der Pankreasstückchen von nebennierenlosen Tieren geringer als die der Gewebsteilchen der beiden anderen Gruppen an. — Zusammenfassend läßt sich sagen, daß Nebennierenrinden-Hormone im Serum vorhanden sein müssen, um eine normale Anpassung der Insulin-ausschüttung an Änderungen des Blutzuckerspiegels zu ermöglichen.
    Notes:
    Summary Adrenalectomy decreased “suppressible” and “nonsuppressible” serum insulin-like activities, which were shown by the rat diaphragm method, and insulin which was measured by an immunological procedure. —We were not able to find any peripheral correlation between eorticosteroid hormones and insulin. On the other hand, we have shown the influence of the adrenal cortex on insuline by 3 means. — The relation between serum glucose and serum insulin concentration, which was not present in the adrenalectomized rat, was reestablished after corticosterone or hydrocortisone treatment. It was also seen in the demedullated rat when corticosterone was present in the serum. — During a glucose tolerance test, the pancreatic insulin response was poor in the adrenalectomized rat, but was as good in the demedullated as in the normal rat. — Finally, “in vitro” experiments demonstrated that pancreas fragments obtained from adrenalectomized rats secreted less insulin than pancreas fragments obtained from demedullated or normal animals, when the incubation was carried out in buffer or serum, at physiological glucose levels. When the buffer or serum glucose concentration was raised to 7.5 mg/ml, the amount of insulin secreted by the pancreas obtained from adrenalec tomized rats was increased, but it still remained less than the amount of insulin secreted in the other groups. — Therefore, the presence in the serum of corticosteroid hormones was necessary to permit a normal pancreatic insulin secretion in response to changes in blood glucose concentration.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01309904

    Articles: DFG German National Licenses
  17. 17
    Faure, A. ; Sutter-Dub, M. -T. ; Sutter, B. C. J. ; Assan, R.
    Springer
    Published 1983
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Oestradiol treatment ; rat ; ovariectomy ; adrenalectomy ; plasma glucose ; plasma insulin ; plasma glucagon
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The interference of adrenal hormones with the oestradiol-induced modifications of endocrine pancreatic function remains controversial. For this reason, we compared sham-operated, ovariectomized and adrenalectomized-ovariectomized female rats. In each group, control and 17-β-oestradiol-treated rats (0.1 mg/day for 14 days) were studied, the latter group being compared with similar rats treated with corticosterone (0.4 mg/day). Oestradiol treatment induced hypoglycaemia and hyperinsulinism in basal and glucose-stimulated states, and hypoglucagonaemia. The presence of adrenal glands was necessary for the full expression of oestradiol effects on pancreatic islet B cells: in adrenalectomized-ovariectomized rats, oestradiol treatment induced an unexpected decrease in insulin response to intravenous glucose, and in pancreatic insulin content. Corticosterone treatment partly restored the oestradiol-induced rise of plasma insulin, and restored the B cell response to intravenous glucose. A permissive action of glucocorticoids may be a prerequisite for the effect of oestrogens on B cells. Since oestrogens by themselves augment the plasma corticosterone level, the insulinotropic effect of oestrogens may be partly mediated by the increase in endogenous corticosteroids. In contrast, oestradiol seems to suppress islet A cell function.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00297394

    Articles: DFG German National Licenses
  18. 18
    Castex, Ch. ; Sutter, B. Ch. J.
    Springer
    Published 1981
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Edible dormouse (Glis glis) ; hibernating mammal ; dynamics of insulin release ; insulin secretion ; glucose-stimulated insulin secretion ; perfused pancreas ; B cell ; seasonal variations
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary In order to characterize seasonal variations of beta cell function in the edible dormouse (Glis glis), the dynamics of insulin release were examined during perfusion of the isolated pancreas. The B cells exhibited biphasic insulin secretion; however, the dynamic response differed from that of the rat in that there was a steady-state second release phase. Glucose-induced insulin release changed according to the seasons. With 16.8 mmol/l glucose, the average insulin release of the late phase was 30.8 ±12.6 ng/min in winter, 7.4±3.2 ng/min in spring, 13.1±3 ng/min in summer and 23.3±4.4 ng/min in autumn. The glucose-induced insulin release, expressed as percent of the insulin content of the pancreas, varied according to the season: it represented 2.23±0.31% in winter, 1.28±0.10% in spring, 1.56±0.15 in summer and 2.6±0.11 in autumn. It is suggested that in spring and summer, the edible dormouse B cell secretion mechanism is less sensitive to glucose than in the other seasons.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00253413

    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1432-0428
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Résumé L'≪insulinémie apparente≫ a été estimée dans des serums de rats ou des mélanges d'insuline et d'adrénaline par les méthodes du diaphragme et du tissu adipeux de rat. Chez le rat, l'autogreffe ou l'énucléation de la surrénale augmentent l'≪insulinémie apparente≫, alors que l'adjonction d'adrénaline à un sérum normal la diminue. L'adrénaline, à concentrations physiologiques, n'agit pas en antagoniste, mais en inhibiteur de l'insuline. Enfin, l'augmentation de l'≪insulinémie apparente≫ consécutive à la dilution du sérum semble être due, à la fois, à la dilution des substances antagonistes et inhibitrices, en particulier de l'adrénaline, et à la libération d'une fraction insulinique normalement masquée dans le sérum entier.
    Abstract:
    Zusammenfassung Die insulinähnliche Aktivität von Rattenserum und Insulin-Adrenalin-Mischungen wurde mit der Zwerchfell- sowie mit der Fettgewebs-Methode gemessen und in μE/ml ausgedrückt. Demedullation oder Transplantation der Nebenniere bei der Ratte steigert die insulinähnliche Aktivität, die Zugabe von Adrenalin zum Normalserum dagegen vermindert sie. In physiologischen Konzentrationen wirkt Adrenalin nicht als Antagonist, sondern als Inhibitor des Insulins, da Adrenalin in Abwesenheit des Insulins ohne Effekt auf das Zwerchfell und auf das Fettgewebe ist. Die durch Verdünnen des Serums auftretende Steigerung der insulinähnlichen Aktivität scheint zwei Ursachen zu haben: Die Verdännung der hemmenden Substanzen (Adrenalin) und die Freisetzung einer im unverdünnten Serum unwirksamen Insulinfraktion.
    Notes:
    Summary The insulin-like activity (ILA) of rat serum and of insulin-adrenaline mixtures was estimated by both rat diaphragm and rat adipose tissue methods and expressed in μ units/ml. The ILA of the rat serum strikingly increases after demedullation or transplantation of the adrenal gland; the addition of adrenaline to normal rat serum decreases its ILA. In “in vitro” experiments, it was found that adrenaline exhibits an inhibitory but not antagonistic effect upon insulin activity, i.e. that adrenaline has no action upon muscle or adipose tissue in the absence of insulin. Finally the rise of the ILA provoked by dilution of rat serum seems to be due to the dilution of inhibitory substances (such as adrenaline) and to the liberation of an insulin fraction which is masked in the whole serum.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01338717

    Articles: DFG German National Licenses
  20. 20
    Sutter, B. ; Friehs, G. ; Pendl, G. ; Tölly, E.
    Springer
    Published 1995
    Staff View
    ISSN:
    0942-0940
    Keywords:
    Bovine dowel ; cervical discectomy ; interbody fusion
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Anterior cervical discectomy and vertebral interbody fusion is a widely used technique in the treatment of radicular or cord compression. Instead of using autologous bone removed from the iliac crest, a heterologous bovine dowel was used for fusion. Sixty-six patients presenting with radicular pain or myelopathy were entered into the study retrospectively. Medial herniated, soft or calcified disc, osteophytes with and without herniated disc material, and bony stenosis at one or two levels were shown by CT or MRI studies. Postoperatively, 88% of the patients noted relief of pain and motor improvement. Most of the patients' sensory deficits and myelopathy improved within 6–12 months. No complications occurred and only one re-operation had to be performed at the same level. In the follow-up period between 1–4 years, no cases of instability after surgery were reported. Operating time and postoperative pain were reduced because bone harvest from the iliac crest was not necessary. In postoperatively performed CT and MRI, the bovine dowel was surrounded by a “halo”-like structure and the specific structure of the bovine implant was still present. No real bony fusion occurred, but clinical stability was equivalent to autologous bone fusion reported in the literature. However, there was no MRI evidence of “living bone tissue” within the bovine dowel. This finding is in contrast to the current belief that the bovine implant is replaced or infiltrated by bony growth.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02187193

    Articles: DFG German National Licenses