Search Results - (Author, Cooperation:B. Solomon)
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1J. George ; J. S. Lim ; S. J. Jang ; Y. Cun ; L. Ozretic ; G. Kong ; F. Leenders ; X. Lu ; L. Fernandez-Cuesta ; G. Bosco ; C. Muller ; I. Dahmen ; N. S. Jahchan ; K. S. Park ; D. Yang ; A. N. Karnezis ; D. Vaka ; A. Torres ; M. S. Wang ; J. O. Korbel ; R. Menon ; S. M. Chun ; D. Kim ; M. Wilkerson ; N. Hayes ; D. Engelmann ; B. Putzer ; M. Bos ; S. Michels ; I. Vlasic ; D. Seidel ; B. Pinther ; P. Schaub ; C. Becker ; J. Altmuller ; J. Yokota ; T. Kohno ; R. Iwakawa ; K. Tsuta ; M. Noguchi ; T. Muley ; H. Hoffmann ; P. A. Schnabel ; I. Petersen ; Y. Chen ; A. Soltermann ; V. Tischler ; C. M. Choi ; Y. H. Kim ; P. P. Massion ; Y. Zou ; D. Jovanovic ; M. Kontic ; G. M. Wright ; P. A. Russell ; B. Solomon ; I. Koch ; M. Lindner ; L. A. Muscarella ; A. la Torre ; J. K. Field ; M. Jakopovic ; J. Knezevic ; E. Castanos-Velez ; L. Roz ; U. Pastorino ; O. T. Brustugun ; M. Lund-Iversen ; E. Thunnissen ; J. Kohler ; M. Schuler ; J. Botling ; M. Sandelin ; M. Sanchez-Cespedes ; H. B. Salvesen ; V. Achter ; U. Lang ; M. Bogus ; P. M. Schneider ; T. Zander ; S. Ansen ; M. Hallek ; J. Wolf ; M. Vingron ; Y. Yatabe ; W. D. Travis ; P. Nurnberg ; C. Reinhardt ; S. Perner ; L. Heukamp ; R. Buttner ; S. A. Haas ; E. Brambilla ; M. Peifer ; J. Sage ; R. K. Thomas
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-07-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Arumugam, Thiruma V ; Shiels, Ian A ; Margolin, Solomon B ; Taylor, Stephen M ; Brown, Lindsay
Oxford, UK : Blackwell Science Pty
Published 2002Staff ViewISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. Pirfenidone, an antifibrotic compound with anti-inflammatory effects, has been investigated in a rat model of acute experimental ischaemia–reperfusion injury of the small intestine.2. Occlusion of the superior mesenteric artery in young adult female rats for 30 min followed by reperfusion for 120 min induced significant local and systemic effects, including tissue haemorrhage with oedema, elevated serum concentrations of tumour necrosis factor (TNF)-α, neutropenia, hypotension and bradycardia.3. Administration of pirfenidone (200 mg/kg, p.o., i.v. or i.p.) 30 min before occlusion completely inhibited the increase in serum TNF-α concentrations. Pirfenidone inhibited, but did not completely prevent, tissue damage in the small intestine, as well as hypotension and oedema, but neutropenia and bradycardia were not significantly changed by treatment.4. Thus, pirfenidone effectively moderates both local and some systemic effects of ischaemia–reperfusion injury in the rat small intestine model.Type of Medium: Electronic ResourceURL: -
3SHIMIZU, Fujio ; FUKAGAWA, Masafumi ; YAMAUCHI, Shitotomo ; TANIYAMA, Masayoshi ; KOMEMUSHI, Sadao ; MARGOLIN, Solomon B ; KUROKAWA, Kiyoshi
Oxford, UK : Blackwell Publishing Ltd
Published 1997Staff ViewISSN: 1440-1797Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary: Pirfenidone (PFD) is a new drug which has been shown to prevent or even reverse the extracellular matrix accumulation in several organs. to examine the effect of PFD on the progressive glomerulosclerosis, we treated model rats with irreversible chronic renal disease per orally with 500 mg/kg bodyweight of PFD per day. the model rats were made by intravenous injection of anti-Thy-1 monoclonal antibody 1-22-3 at 1 h following unilateral nephrectomy, which results in chronic progressive glomerulosclerosis. Twenty-four hours later, 32 female Wistar rats were divided into two groups and were fed standard chow with (PFD group: P) or without PFD (control group: C). All rats were sacrificed on day 42. No significant difference in the bodyweight or the amount of chow intake was observed between the two groups. the remnant kidney was significantly (P〈0.05) heavier in C (2.11 ± 0.15 g) than in P (1.70 ± 0.13 g). This finding, together with light microscopic findings, showed that PFD administration resulted in the prevention of renal hypertrophy. On day 42, proteinuria in P (124.3 ± 31.9 mg/day) was significantly lower than in C (214.6 ± 8.1 mg/day), and P maintained significantly better renal function than C as judged by serum urea nitrogen and creatinine levels. Mean matrix score was less in P (178 ± 17) than in C (225 ± 22). Crescent formation was observed in 17% of glomeruli in P and in 35% in C. Tubulointerstitial lesions were also less severe in P. Furthermore, inflammation and sclerosis indices detected by immunohistochemistry (e.g. ED-1, OX8, TGF-beta α-smooth muscle actin, collagen type I, were less in P). These data suggest that PFD may be a promising agent for the prevention of progressive and irreversible glomerulosclerosis.Type of Medium: Electronic ResourceURL: -
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ISSN: 0030-851XTopics: Political ScienceSociologyEconomicsNotes: BOOKS REVIEWED IN THIS ISSUEURL: -
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ISSN: 0030-851XTopics: Political ScienceSociologyEconomicsURL: -
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ISSN: 0030-851XTopics: Political ScienceSociologyEconomicsNotes: BOOK REVIEWSURL: -
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ISSN: 0030-851XTopics: Political ScienceSociologyEconomicsNotes: BOOK REVIEWSURL: -
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ISSN: 0005-2736Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0005-2736Keywords: Glucose transport ; Insulin receptor ; Phospholipid vesicleSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0011-3530Topics: HistoryNotes: JAPAN TODAYURL: -
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ISSN: 0011-3530Topics: HistoryNotes: JAPAN, 1971URL: -
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ISSN: 0011-3530Topics: HistoryNotes: JAPAN IN THE SEVENTIESURL: -
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ISSN: 0013-0079Topics: GeographyEconomicsNotes: "Reviews"URL: -
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ISSN: 0013-0079Topics: GeographyEconomicsNotes: "Reviews"URL: -
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ISSN: 0013-0079Topics: GeographyEconomicsNotes: "REVIEWS"URL: -
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ISSN: 0013-0079Topics: GeographyEconomicsNotes: "Reviews"URL: -
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ISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
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ISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
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ISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: