Search Results - (Author, Cooperation:B. Ryffel)

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  1. 1
    L. E. Sander ; M. J. Davis ; M. V. Boekschoten ; D. Amsen ; C. C. Dascher ; B. Ryffel ; J. A. Swanson ; M. Muller ; J. M. Blander
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-05-24
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adaptor Proteins, Vesicular Transport/deficiency/immunology ; Animals ; Antibodies, Bacterial/immunology ; Bacteria/genetics/immunology/pathogenicity ; Bacterial Vaccines/genetics/immunology ; Carrier Proteins/metabolism ; Cells, Cultured ; Dendritic Cells/cytology/immunology/microbiology ; Immunity, Innate/*immunology ; Inflammasomes/immunology/metabolism ; Interferon-beta/genetics/immunology ; Macrophages/cytology/immunology/microbiology ; Mice ; Mice, Inbred C57BL ; Microbial Viability/*genetics/*immunology ; Phagocytosis ; Phagosomes/immunology/microbiology ; RNA, Bacterial/genetics/*immunology ; RNA, Messenger/genetics/*immunology ; Vaccines, Attenuated/genetics/immunology ; Vaccines, Inactivated/immunology ; Virulence Factors
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2013-11-23
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adoptive Transfer ; Animals ; Anti-Bacterial Agents/administration & dosage ; Antineoplastic Agents/*therapeutic use ; Bacterial Translocation/*drug effects ; Cyclophosphamide/*therapeutic use ; Germ-Free Life ; Gram-Positive Bacteria/drug effects/physiology ; Immunologic Memory ; Immunosuppressive Agents/*therapeutic use ; Intestine, Small/*microbiology ; Lymphoid Tissue/immunology/microbiology ; Mice ; Microbiota/drug effects/*physiology ; Neoplasms/*drug therapy/*immunology ; Th17 Cells/immunology/transplantation
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2018-01-05
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Geosciences
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Immunology, Medicine, Diseases
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    MIHATSCH, M.J. ; THIEL, G. ; RYFFEL, B.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1990
    Staff View
    ISSN:
    1365-2133
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    At therapeutic drug levels, the functional changes which occur are a reduction of glomerular filtration rate and renal plasma flow. At higher doses, morphological changes develop which may result, particularly in severe cases, in acute or chronic renal failure. The threshold for the development of irreversible vascular-interstitial lesions mainly depends on the increment of serum creatinine, age and drug dosage or drug blood level. Based on the experience with cyclosporin A (CyA), the following recommendations have been made for its clinical use, especially in patients with autoimmune diseases. The initial dose should not exceed 5 mg/kg body weight and the dose should be reduced if blood CyA levels are over 250 ng/ml; in addition, a dose reduction is recommended if serum creatinine values exceed 30% of pre-treatment values or if other signs of CyA toxicity, such as hepatotoxicity or hypertension, are found. Strict adherence to these suggestions should allow treatment of patients for prolonged periods without irreversible morphological lesions.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2133.1990.tb02888.x

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    0005-2736
    Keywords:
    (Human blood) ; Affinity binding ; Ciclosporin ; Cyclophilin ; Drug-membrane interaction
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0005-2736(88)90142-3

    Articles: DFG German National Licenses
  6. 6
    Ryffel, B. ; Woerly, G. ; Murray, M. ; Eugster, H.P. ; Car, B.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/bbrc.1993.1931

    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    0925-4439
    Keywords:
    Cyclosporin A ; Cyclosporin binding protein ; Fibroblast ; Lymphocyte ; Photolabel
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0925-4439(92)90050-W

    Articles: DFG German National Licenses
  8. 8
    Besemer, J. ; Schnitzel, W. ; Monschein, U. ; Ryffel, B.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    1043-4666
    Keywords:
    IL-8 ; NAP-2 dimers ; chemokines ; receptors
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/1043-4666(93)90043-5

    Articles: DFG German National Licenses
  9. 9
    Ryffel, B. ; Deyssenroth, H. ; Borel, J. F.
    Springer
    Published 1981
    Staff View
    ISSN:
    1420-908X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Cyclosporin A (CY-A), an immunosuppressive cyclic endecapeptide, causes thymus weight reduction in mice 4 days after single oral administration. This effect was compared with that of hydrocortisone acetate (HCA), or of azathioprine (AZ). The latter had no effect on thymus weight, whereas HCA induced a marked reduction 2 days after administration. A possible mediation by the pituitary adrenal gland system (PAG) of the CY-A induced effect was suggested by the observation of an elevated corticosterone plasma level after CY-A administration and by the prevention of the thymocytolytic effect by adrenalectomy. However, the immunosuppressive activity of CY-A in humoral immunity and cell mediated immunity tests was not affected by adrenalectomy. It must therefore be concluded that the immunosuppression produced by CY-A in vivo is not mediated by stimulation of the PAG system, contrary to its effect on the mouse thymus, which is a glucocorticosteroid effect.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01982473

    Articles: DFG German National Licenses
  10. 10
    Ryffel, B.
    Springer
    Published 1989
    Staff View
    ISSN:
    1434-0879
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00261044

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1432-0738
    Keywords:
    Cyclosporin A ; Animal toxicity ; Carcinogenicity ; Teratogenicity ; Mutagenicity ; Immunosuppression
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Toxicological studies in a variety of different animal species have shown that cyclosporin A (CS-A) is a unique immunosuppressant, since it does not cause myelotoxic, teratogenic, mutagenic, or carcinogenic effects. This is undoubtedly due to the fact that CS-A produces its immunosuppressive effects by a specific action on T lymphocytes rather than by a cytotoxic mechanism. The incidence of acute inflammatory lesions was also not significantly higher in treated animals than in controls. Clear-cut organ toxicity only occurred in rats and cynomolgus monkeys, where at high doses nephro- and hepatotoxicity were observed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00302721

    Articles: DFG German National Licenses