Search Results - (Author, Cooperation:B. Rode)
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1J. Li ; B. Hou ; S. Tumova ; K. Muraki ; A. Bruns ; M. J. Ludlow ; A. Sedo ; A. J. Hyman ; L. McKeown ; R. S. Young ; N. Y. Yuldasheva ; Y. Majeed ; L. A. Wilson ; B. Rode ; M. A. Bailey ; H. R. Kim ; Z. Fu ; D. A. Carter ; J. Bilton ; H. Imrie ; P. Ajuh ; T. N. Dear ; R. M. Cubbon ; M. T. Kearney ; K. R. Prasad ; P. C. Evans ; J. F. Ainscough ; D. J. Beech
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-08-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Embryo, Mammalian/blood supply/metabolism ; Endothelial Cells/*cytology/*physiology ; Female ; *Friction ; Hemorheology ; Ion Channels/*metabolism ; Male ; Mice ; *Stress, MechanicalPublished by: -
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ISSN: 0020-1693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
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ISSN: 0020-1693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
4Rode, B. ; Bavdek, S. V. ; Lacković, G. ; Fazarinc, G. ; Bidovec, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1998Staff ViewISSN: 1439-0264Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The immunohistochemical study of chamois (Rupicapra rupicapra L.) skin showed that a limited number of available monoclonal and polyclonal antibodies expressed reactivity with skin cell components. These included cytokeratins, vimentin, desmin, neuron-specific enolase and S-100 protein with almost the same distribution pattern as already described in the skin of humans and animals. Antibodies used for labelling skin-associated lymphoid tissues and other cells with the immuno-logic function in human skin failed to demonstrate these cells in the chamois skin with the exception of LCA and OKT6 antibodies. Epidermal Langerhans cells were reliably demonstrated only by the enzyme histochemical method for adenosine triphosphatase, while the majority of mononuclear cells in dermal infiltrates showed a strong immunoreaction with OKT6 antibody. The histologic and histochemical analysis showed that the dermal infiltrations in infested skin consisted of macro-phages, lymphocytes, granulocytes, mastocytes and fibroblasts. The chamois skin affected with sarcoptes mange showed a significant loss of cytokeratins in the epidermis and its derivatives. Particular keratinocytes showing nonspecific staining with several antibodies were also described and discussed in this paper.Type of Medium: Electronic ResourceURL: -
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ISSN: 0304-8853Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0020-1693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
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ISSN: 0009-2614Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0378-4363Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0304-8853Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0304-8853Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0304-8853Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0304-8853Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0304-8853Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 1434-4475Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyDescription / Table of Contents: Zusammenfassung Mit Hilfe eines Nährungsverfahrens konnten die Säurestärken von HJ, FSO3H und CF3SO3H in Eisessig aus Leitfähigkeitsmessungen bestimmt werden. Die Dissoziationskonstanten berechnen sich zu $$K_{Diss.}^{HJ} = 10^{ - 5,8_, } K_{Diss.}^{FSO_3 H} = 10^{ - 6,1} bzw. K_{Diss.}^{CF_3 SO_3 H} = 10^{ - 4,7} $$ Damit erweist sich CF3SO3H als stärkste bekannte Säure in Eisessig, HJ ist etwas schwächer dissoziiert als HBr und FSO3H nimmt eine Mittelstellung zwischen HJ und H2SO4 ein.Notes: Abstract Using an approximation method, the dissociation constants of HJ, FSO3H and CF3SO3H in glacial acetic acid could be derived from conductivity measurements: $$K_{diss}^{HJ} = 10^{ - 5,8_, } K_{diss}^{FSO_3 H} = 10^{ - 6,1} and K_{diss}^{CF_3 SO_3 H} = 10^{ - 4,7} $$ These values show CF3SO3H to be the strongest known acid in glacial acetic acid, HJ to be slightly weaker than HBr and FSO3H intermediate between HJ and H2SO4.Type of Medium: Electronic ResourceURL: -
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ISSN: 1434-4475Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyNotes: Abstract CNDO/2-MO-SCF calculations have been performed for the system ClO4 −−HCOOH, which indicated small solvation energy and very small changes in molecular geometries as a result of solvation, but higher solvation numbers for ClO4 −, compared to monoatomic anions. These results have been examined by means of1H-NMR investigations of solutions of NaCl, NaClO4, NaBr and Na2SO4 in HCOOH. The experimental data agree with the conclusions drawn from quantum chemical results. The semiempirical SCF calculations proved as valuable stimulation and supplement for the experimental working.Type of Medium: Electronic ResourceURL: -
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ISSN: 1434-4475Keywords: Prebiotic peptide formation ; Evolution ; Clay catalysisSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyDescription / Table of Contents: Zusammenfassung Die Fähigkeit von Tonmineralien der Montmorillonitklasse zur Katalyse von Peptidbildungsreaktionen aus Aminosäuren in wäßriger Lösung wurde am Beispiel von Glyzin und Kupfer sowie Kalzium und Morillonit untersucht. Experimente mit Verdampfungszyklen haben gezeigt, daß kleinere Mengen von Di- und Tripeptiden aus der Aminosäure gebildet werden. Die weitere Polymerisation von Dipeptiden hingegen scheint wesentlich leichter in diesem Reaktionssystem zu verlaufen als der Anfangsschritt der Bildung des Dipeptides. Eine mögliche Rolle von Tonmineralien in der präbiotischen Peptidevolution kann daher in der Verlängerung von Peptidketten gesehen werden. Kupferionen in der Tonmatrix zeigen keinerlei Vorteile gegenüber den üblichen Kalziumionen, die in natürlichem Montmorillonit vorkommen.Notes: Summary The ability of montmorillonite clay minerals for catalyzing peptide formation from amino acids in aqueous solution has been investigated using glycine and Cu2+ and Ca2+ containing montmorillonites as reaction systems. Evaporation cycle experiments showed that minor amounts of di- and tripeptide are formed from the amino acid. Further polymerization of dipeptide, however, seems to be more favoured by this reaction system than the initial step of dipeptide formation, and a possible role of clays in prebiotic peptide evolution could be seen therefore in the prolongation of peptide chains. Cu2+ ions in the clay matrix did not show any advantage over the usual Ca2+ ions embedded in natural montmorillonite.Type of Medium: Electronic ResourceURL: -
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ISSN: 1434-4475Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyNotes: Abstract The applicability of theCNDO/2 method for compounds containing boron, phosphorus and hydrogen is tested, comparing the results with ab initio calculations. Good agreement is found for most data; for P−H bonds, however, some methodical artefacts are found, leading to erroneous results, especially in regard to charge densities. An imperfect parametrization of phosphorus is supposed to be responsible for these artefacts. Calculations were performed for a recently prepared compound, γ-phosphinodiborane, and one possible isomer, in their respectiveCNDO minimum geometries. The energies obtained lead to the same predictions about their relative stability as is found experimentally. Bonding is discussed by means of localized molecular orbitals, and the hybridization model, frequently used for such species, is tested critically.Type of Medium: Electronic ResourceURL: -
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ISSN: 1434-4475Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyDescription / Table of Contents: Zusammenfassung Am Beispiel der dimeren Ameisensäure wird untersucht, inwieweit semiempirischeMO-SCF-Methoden (CNDO/2) ein Bild des Autoprotolysevorganges von Carbonsäuren wiedergeben können. Die aus den Berechnungen abzuleitende Reaktionsenthalpie liegt beträchtlich über den mit Hilfe elektrostatischer Modelle berechneten Werten. Für nicht zu große Abstände liefert die verwendete Methode plausible Ergebnisse für die Beschreibung des beginnenden Dissoziationsschrittes. An Hand der Ladungsverteilung zeigt sich, daß innerhalb dieses Teilbereiches bereits gewisse Erkenntnisse über den Reaktionsablauf der Autoprotolyse gewonnen werden können.Notes: Abstract The applicability of semiempiricalMO-SCF-methods (CNDO/2) to describe autoprotolysis reactions of carboxylic acids is investigated by calculations on dimeric formic acid. The calculated energy values are compared with those obtained by simple electrostatic model calculations, proving such a model to be unsatisfactory. The method used here leads to reasonable results and enables a discussion of the phenomena accompanying dissociation within not too big distances. The calculated charge distributions give some informations about the mechanism of autoprotolysis within this range.Type of Medium: Electronic ResourceURL: -
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ISSN: 1434-4475Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyDescription / Table of Contents: Zusammenfassung Durch Vergleiche experimenteller Daten und quantenchemisch berechenbarer Größen (Protonenaffinitäten und H-Ladungsdichten) wird die Möglichkeit diskutiert, aus der chemischen Konstitution von Protonensäuren direkte Beziehungen zu ihrem aciden Verhalten in verschiedenen Medien abzuleiten. Die für Wasser und Eisessig als Solventien dabei erhaltenen linearen Korrelationen zwischen pK-Werten und berechneten Protonenaffinitäten erweisen sich als sinnvolle Ergänzung bisher bekannter Untersuchungen von Protolysereaktionen. Sie ermöglichen außerdem, Hinweise auf ungewöhnliches chemisches Verhalten von Säuren in diesen Lösungsmitteln zu erhalten. Die berechneten Ladungsdichten erweisen sich als nur bedingt brauchbare Größe für derartige Untersuchungen.Notes: Abstract Comparing experimental results with data calculated by means of quantum chemical treatment (proton affinities and H-charge-densities) the possibility is discussed, to obtain informations about the acidic properties of proton acids from their chemical constitution. The linear correlations of calculated proton affinities and pK-values, as found for water and acetic acid as solvents, lead to some general considerations about protolysis reactions. They also allow to obtain indications to exceptional chemical behaviour of an acid in these solutions. Hydrogen charge densitites are found to be less useful for investigations of this kind.Type of Medium: Electronic ResourceURL: -
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ISSN: 1434-4475Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyNotes: Abstract CNDO/2 calculations have been performed for the compounds CF3NCO, H3SiNCO, and F2PNCO. The calculated minimum geometries are found to be in agreement with spectroscopic results. The NCO group, however, turns out to be nonlinear in CF3NCO and H3SiNCO, as in other compounds of this series. Only F2PNCO seems to have a NCO angle of 180 degrees. Charge density distribution and the character of the bonds are discussed for the molecules under investigation.Type of Medium: Electronic ResourceURL: