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1J. B. Brown ; N. Boley ; R. Eisman ; G. E. May ; M. H. Stoiber ; M. O. Duff ; B. W. Booth ; J. Wen ; S. Park ; A. M. Suzuki ; K. H. Wan ; C. Yu ; D. Zhang ; J. W. Carlson ; L. Cherbas ; B. D. Eads ; D. Miller ; K. Mockaitis ; J. Roberts ; C. A. Davis ; E. Frise ; A. S. Hammonds ; S. Olson ; S. Shenker ; D. Sturgill ; A. A. Samsonova ; R. Weiszmann ; G. Robinson ; J. Hernandez ; J. Andrews ; P. J. Bickel ; P. Carninci ; P. Cherbas ; T. R. Gingeras ; R. A. Hoskins ; T. C. Kaufman ; E. C. Lai ; B. Oliver ; N. Perrimon ; B. R. Graveley ; S. E. Celniker
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-03-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alternative Splicing/genetics ; Animals ; Drosophila melanogaster/anatomy & histology/cytology/*genetics ; Female ; *Gene Expression Profiling ; Male ; Molecular Sequence Annotation ; Nerve Tissue/metabolism ; Organ Specificity ; Poly A/genetics ; Polyadenylation ; Promoter Regions, Genetic/genetics ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics/metabolism ; Sex Characteristics ; Stress, Physiological/genetics ; Transcriptome/*geneticsPublished by: -
2M. B. Gerstein ; J. Rozowsky ; K. K. Yan ; D. Wang ; C. Cheng ; J. B. Brown ; C. A. Davis ; L. Hillier ; C. Sisu ; J. J. Li ; B. Pei ; A. O. Harmanci ; M. O. Duff ; S. Djebali ; R. P. Alexander ; B. H. Alver ; R. Auerbach ; K. Bell ; P. J. Bickel ; M. E. Boeck ; N. P. Boley ; B. W. Booth ; L. Cherbas ; P. Cherbas ; C. Di ; A. Dobin ; J. Drenkow ; B. Ewing ; G. Fang ; M. Fastuca ; E. A. Feingold ; A. Frankish ; G. Gao ; P. J. Good ; R. Guigo ; A. Hammonds ; J. Harrow ; R. A. Hoskins ; C. Howald ; L. Hu ; H. Huang ; T. J. Hubbard ; C. Huynh ; S. Jha ; D. Kasper ; M. Kato ; T. C. Kaufman ; R. R. Kitchen ; E. Ladewig ; J. Lagarde ; E. Lai ; J. Leng ; Z. Lu ; M. MacCoss ; G. May ; R. McWhirter ; G. Merrihew ; D. M. Miller ; A. Mortazavi ; R. Murad ; B. Oliver ; S. Olson ; P. J. Park ; M. J. Pazin ; N. Perrimon ; D. Pervouchine ; V. Reinke ; A. Reymond ; G. Robinson ; A. Samsonova ; G. I. Saunders ; F. Schlesinger ; A. Sethi ; F. J. Slack ; W. C. Spencer ; M. H. Stoiber ; P. Strasbourger ; A. Tanzer ; O. A. Thompson ; K. H. Wan ; G. Wang ; H. Wang ; K. L. Watkins ; J. Wen ; K. Wen ; C. Xue ; L. Yang ; K. Yip ; C. Zaleski ; Y. Zhang ; H. Zheng ; S. E. Brenner ; B. R. Graveley ; S. E. Celniker ; T. R. Gingeras ; R. Waterston
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-08-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Caenorhabditis elegans/embryology/*genetics/growth & development ; Chromatin/genetics ; Cluster Analysis ; Drosophila melanogaster/*genetics/growth & development ; *Gene Expression Profiling ; Gene Expression Regulation, Developmental/genetics ; Histones/metabolism ; Humans ; Larva/genetics/growth & development ; Models, Genetic ; Molecular Sequence Annotation ; Promoter Regions, Genetic/genetics ; Pupa/genetics/growth & development ; RNA, Untranslated/genetics ; Sequence Analysis, RNA ; Transcriptome/*geneticsPublished by: -
3M. O. Duff ; S. Olson ; X. Wei ; S. C. Garrett ; A. Osman ; M. Bolisetty ; A. Plocik ; S. E. Celniker ; B. R. Graveley
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-05-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Base Sequence ; Cells, Cultured ; Drosophila melanogaster/*genetics ; Exons/genetics ; Female ; Genes, Insect/genetics ; Genome, Insect/*genetics ; Humans ; Introns/genetics ; Male ; Nuclear Proteins/deficiency/genetics/metabolism ; Nucleotides/*genetics ; RNA Splice Sites/genetics ; RNA Splicing/*genetics ; Reproducibility of Results ; Ribonucleoproteins/deficiency/genetics/metabolismPublished by: -
4B. R. Graveley ; A. N. Brooks ; J. W. Carlson ; M. O. Duff ; J. M. Landolin ; L. Yang ; C. G. Artieri ; M. J. van Baren ; N. Boley ; B. W. Booth ; J. B. Brown ; L. Cherbas ; C. A. Davis ; A. Dobin ; R. Li ; W. Lin ; J. H. Malone ; N. R. Mattiuzzo ; D. Miller ; D. Sturgill ; B. B. Tuch ; C. Zaleski ; D. Zhang ; M. Blanchette ; S. Dudoit ; B. Eads ; R. E. Green ; A. Hammonds ; L. Jiang ; P. Kapranov ; L. Langton ; N. Perrimon ; J. E. Sandler ; K. H. Wan ; A. Willingham ; Y. Zhang ; Y. Zou ; J. Andrews ; P. J. Bickel ; S. E. Brenner ; M. R. Brent ; P. Cherbas ; T. R. Gingeras ; R. A. Hoskins ; T. C. Kaufman ; B. Oliver ; S. E. Celniker
Nature Publishing Group (NPG)
Published 2010Staff ViewPublication Date: 2010-12-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alternative Splicing/genetics ; Animals ; Base Sequence ; Drosophila Proteins/genetics ; Drosophila melanogaster/embryology/*genetics/*growth & development ; Exons/genetics ; Female ; *Gene Expression Profiling ; Gene Expression Regulation, Developmental/*genetics ; Genes, Insect/genetics ; Genome, Insect/genetics ; Male ; MicroRNAs/genetics ; Oligonucleotide Array Sequence Analysis ; Protein Isoforms/genetics ; RNA Editing/genetics ; RNA, Messenger/analysis/genetics ; RNA, Small Untranslated/analysis/genetics ; Sequence Analysis ; Sex Characteristics ; Transcription, Genetic/*geneticsPublished by: -
5Staff View
ISSN: 1617-4623Keywords: Transcription ; RNA polymerase I ; Elongation ; TFIISSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract Efficient transcription elongation by RNA polymerase I (Pol I) requires a specific Pol I-associated factor, termed TIF-IC. Here we show that TFIIS, a factor that has previously been shown to promote read-through past many types of blocks to elongation by RNA polymerase II, also enhances Pol I- directed transcription elongation. In a reconstituted transcription system containing purified proteins, TFIIS stimulates Pol I transcription by increasing the overall rate of RNA chain elongation. As with Pol II, ternary Pol I complexes cleave the 3′ end of the nascent transcripts in response to TFIIS. The truncated RNAs remain bound to the template, are subject to pyrophosphorolysis, and can be chased into longer transcripts. Moreover, we show by immunoprecipitation and specific affinity chromatography that TFIIS physically interacts with Pol I. The results suggest that nascent transcript cleavage by TFIIS or a TFIIS-related factor may be a general mechanism by which both Pol I and Pol II can bypass transcriptional impediments.Type of Medium: Electronic ResourceURL: