Search Results - (Author, Cooperation:B. Polic)

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  1. 1
    J. Strid ; O. Sobolev ; B. Zafirova ; B. Polic ; A. Hayday
    American Association for the Advancement of Science (AAAS)
    Published 2011
    Staff View
    Publication Date:
    2011-12-07
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Epidermis/*immunology ; Hypersensitivity, Immediate/*immunology ; Ligands ; Lymphoid Tissue/*immunology ; Membrane Proteins/immunology/metabolism ; Mice ; Mice, Transgenic ; NK Cell Lectin-Like Receptor Subfamily K/immunology/*metabolism ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; Stress, Physiological ; T-Lymphocyte Subsets/*immunology ; Th2 Cells/*immunology ; Up-Regulation
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Weiss, T., Schneider, H., Silginer, M., Steinle, A., Pruschy, M., Polic, B., Weller, M., Roth, P.
    The American Association for Cancer Research (AACR)
    Published 2018
    Staff View
    Publication Date:
    2018-02-16
    Publisher:
    The American Association for Cancer Research (AACR)
    Print ISSN:
    1078-0432
    Electronic ISSN:
    1557-3265
    Topics:
    Medicine
    Published by:
    http://www.aacr.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    ISSN:
    1432-8798
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary.  Salivary gland-derived murine cytomegalovirus (SGV) infections of mice have been widely used as models of human cytomegalovirus infections and in the study of CMV biology. Still, many aspects of SGV pathogenesis are not clearly defined. Fatal and non-fatal SGV infections were investigated to characterize pathogenetic correlates of mortality and to assess the role of the immune response in disease progression. Suppression of immune responses was observed in both lethal and sublethal infections. Depletion of immune cell populations in spleen, however, correlated with severe CMV-induced hepatitis and mortality. In addition, T cell depletion studies indicated a requirement for this immune cell subset in control of liver damage and survival of infected mice. Examination of cytokine responses revealed a previously undescribed shock-like syndrome in lethally-infected mice characterized by high levels of tumor necrosis factor α and interferon γ. Furthermore, the sites of tumor necrosis factor α gene induction did not strictly correlate with either viral load or the sites of tissue damage during infection. Taken together, these findings define the pathogenetic progression of disease as it relates to disease outcome and suggests that organ-specific differences in cytokine induction play a significant role in the late stages of acute lethal MCMV infections.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s007050070010

    Articles: DFG German National Licenses