Search Results - (Author, Cooperation:B. O. Williams)

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    Staff View
    Publication Date:
    2011-05-31
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Blood Vessels/growth & development ; Endothelial Cells/metabolism ; Fibroblasts ; Intracellular Signaling Peptides and Proteins/genetics/metabolism ; LDL-Receptor Related Proteins/genetics/metabolism ; Ligands ; Low Density Lipoprotein Receptor-Related Protein-5 ; Mice ; Myeloid Cells/*metabolism ; Neovascularization, Physiologic/*physiology ; Receptors, G-Protein-Coupled ; Retina/*cytology ; *Signal Transduction ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor ; Receptor-1/deficiency/genetics/*metabolism/secretion ; Wnt Proteins/deficiency/genetics/*metabolism
    Published by:
    Latest Papers from Table of Contents or Articles in Press
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    Williams, B. O.

    Chapel Hill, N.C. : Periodicals Archive Online (PAO)
    Published 1938
    Articles: DFG German National Licenses
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    Staff View
    ISSN:
    1439-6327
    Keywords:
    Exercise ; Ischaemic heart disease ; Metabolism ; Lactate
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Nineteen patients who had recovered from a mild to moderately severe myocardial infraction 6–18 months previously were studied in order to investigate the relationship between the severity of myocardial insufficiency and metabolic changes developing during and after exercise. The patients were compared with six controls by means of a graded exercise test on a treadmill. Electrocardiographic records were made and blood pressure measured during and after the exercise and venous blood samples were taken for measurement of lactate, pyruvate, glycerol and free fatty acids. In five patients with moderate or advanced ischaemic electrocardiograph changes the blood lactate and pyruvate mean concentrations continued to rise up to a further 50% after they stopped exercising. The other patients, including some who developed symptoms suggestive of myocardial ischaemia, and all the controls, failed to show these marked increases in blood concentrations after the exercise. We conclude that the development of myocardial insufficiency during exercise is associated with marked increases in lactate and pyruvate concentrations in the peripheral blood particularly after the exercise has ceased.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses