Search Results - (Author, Cooperation:B. Melin)
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1Latest Papers from Table of Contents or Articles in PressH. F. Zheng ; V. Forgetta ; Y. H. Hsu ; K. Estrada ; A. Rosello-Diez ; P. J. Leo ; C. L. Dahia ; K. H. Park-Min ; J. H. Tobias ; C. Kooperberg ; A. Kleinman ; U. Styrkarsdottir ; C. T. Liu ; C. Uggla ; D. S. Evans ; C. M. Nielson ; K. Walter ; U. Pettersson-Kymmer ; S. McCarthy ; J. Eriksson ; T. Kwan ; M. Jhamai ; K. Trajanoska ; Y. Memari ; J. Min ; J. Huang ; P. Danecek ; B. Wilmot ; R. Li ; W. C. Chou ; L. E. Mokry ; A. Moayyeri ; M. Claussnitzer ; C. H. Cheng ; W. Cheung ; C. Medina-Gomez ; B. Ge ; S. H. Chen ; K. Choi ; L. Oei ; J. Fraser ; R. Kraaij ; M. A. Hibbs ; C. L. Gregson ; D. Paquette ; A. Hofman ; C. Wibom ; G. J. Tranah ; M. Marshall ; B. B. Gardiner ; K. Cremin ; P. Auer ; L. Hsu ; S. Ring ; J. Y. Tung ; G. Thorleifsson ; A. W. Enneman ; N. M. van Schoor ; L. C. de Groot ; N. van der Velde ; B. Melin ; J. P. Kemp ; C. Christiansen ; A. Sayers ; Y. Zhou ; S. Calderari ; J. van Rooij ; C. Carlson ; U. Peters ; S. Berlivet ; J. Dostie ; A. G. Uitterlinden ; S. R. Williams ; C. Farber ; D. Grinberg ; A. Z. LaCroix ; J. Haessler ; D. I. Chasman ; F. Giulianini ; L. M. Rose ; P. M. Ridker ; J. A. Eisman ; T. V. Nguyen ; J. R. Center ; X. Nogues ; N. Garcia-Giralt ; L. L. Launer ; V. Gudnason ; D. Mellstrom ; L. Vandenput ; N. Amin ; C. M. van Duijn ; M. K. Karlsson ; O. Ljunggren ; O. Svensson ; G. Hallmans ; F. Rousseau ; S. Giroux ; J. Bussiere ; P. P. Arp ; F. Koromani ; R. L. Prince ; J. R. Lewis ; B. L. Langdahl ; A. P. Hermann ; J. E. Jensen ; S. Kaptoge ; K. T. Khaw ; J. Reeve ; M. M. Formosa ; A. Xuereb-Anastasi ; K. Akesson ; F. E. McGuigan ; G. Garg ; J. M. Olmos ; M. T. Zarrabeitia ; J. A. Riancho ; S. H. Ralston ; N. Alonso ; X. Jiang ; D. Goltzman ; T. Pastinen ; E. Grundberg ; D. Gauguier ; E. S. Orwoll ; D. Karasik ; G. Davey-Smith ; A. V. Smith ; K. Siggeirsdottir ; T. B. Harris ; M. C. Zillikens ; J. B. van Meurs ; U. Thorsteinsdottir ; M. T. Maurano ; N. J. Timpson ; N. Soranzo ; R. Durbin ; S. G. Wilson ; E. E. Ntzani ; M. A. Brown ; K. Stefansson ; D. A. Hinds ; T. Spector ; L. A. Cupples ; C. Ohlsson ; C. M. Greenwood ; R. D. Jackson ; D. W. Rowe ; C. A. Loomis ; D. M. Evans ; C. L. Ackert-Bicknell ; A. L. Joyner ; E. L. Duncan ; D. P. Kiel ; F. Rivadeneira ; J. B. Richards
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-09-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bone Density/*genetics ; Bone and Bones/metabolism ; Disease Models, Animal ; Europe/ethnology ; European Continental Ancestry Group/genetics ; Exome/genetics ; Female ; Fractures, Bone/*genetics ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Genetic Variation/genetics ; Genome, Human/*genetics ; Genomics ; Genotype ; Homeodomain Proteins/*genetics ; Humans ; Mice ; Sequence Analysis, DNA ; Wnt Proteins/geneticsPublished by: -
2Articles: DFG German National LicensesMartigne, M. ; Melin, B. ; Mahlberg, F. ; Domingo, N. ; Chanussot, F. ; Lafont, H. ; Hauton, J.C.
Amsterdam : ElsevierStaff ViewISSN: 0005-2736Keywords: (Rat liver) ; Anionic polypeptide fraction ; Cholesterol ; Protein bindingSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0005-2760Keywords: (Rat hepatocyte) ; Albumin ; HDL ; Lipoprotein secretion ; Monensin ; VLDLSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0005-2760Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0009-8981Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0022-3999Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicinePsychologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesMelin, B. ; Eclache, J. P. ; Geelen, G. ; Annat, G. ; Allevard, A. M. ; Jarsaillon, E. ; Zebidi, A. ; Legros, J. J. ; Gharib, Cl.
Springer
Published 1980Staff ViewISSN: 1439-6327Keywords: Exercise ; Plasma renin activity ; Aldosterone ; Vasopressin ; NeurophysinSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The effect of intense muscular work (80% of maximal oxygen uptake) on responses of plasma hormones involved in electrolyte and water balance were measured in 14 male subjects. They were divided into three groups according to their maximal oxygen uptake and the duration of exercise performed until exhaustion: well trained subjects (group I), trained subjects (group II), and untrained subjects (group III). Pulmonary gas exchange, heart rate, rectal and skin temperature, and weight loss were measured as well as hematocrit and plasma and urine sodium and potassium concentrations. Rectal temperature increased significantly in all subjects after exhaustion. The variation of hematocrit was smallest and the weight loss greatest in the well-trained subjects. Plasma aldosterone, renin activity (PRA), vasopressin (AVP), and neurophysin (Np) displayed highly significant increases after exercise in all three groups: PRA was increased 4.5 times (p〈0.01), aldosterone 13 times (p〈0.05), Np 2.6 times (p〈0.05), and AVP 4.8 times (p〈0.05). Nevertheless, there was no correlation between the changes in PRA and those in plasma aldosterone, nor between aldosterone and plasma sodium or potassium. At the urinary level, the only striking observation was that free water clearance tends to become positive after exercise. Our results provide evidence that this kind of exercise produces a highly significant increase in plasma levels of the hormones involved in electrolyte and water balance. They also indicate that it is among the well-trained subjects that sweat loss is highest though the hematocrit increase is the smallest; this suggests that water is shifted more efficiently from the extravascular compartment.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesMelin, B. ; Curé, M. ; Jimenez, C. ; Koulmann, N. ; Savourey, G. ; Bittel, J.
Springer
Published 1994Staff ViewISSN: 1439-6327Keywords: Exercise ; Dehydration ; Rehydration ; Cardiovascular responses ; Body temperaturesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Six male volunteers performed three tests, each comprising a passive heating session to obtain dehydration (loss of 2.6% body mass), followed by exercise on a treadmill until exhaustion (50% of maximal oxygen consumption) in a warm environment (dry bulb temperature 35° C, relative humidity 20%–30%). In one test, the subjects exercised without rehydration (Dh). In the two other tests, 50% of the fluid lost in the dehydration session was replaced by drinking mineral water given either in one amount [913 (SEM 23) ml] before the exercise (Rh1) or divided into four equal portions [228 (SEM 5) ml] before the exercise and on three occasions at 15-min intervals during exercise (Rh4). Rehydration increased exercise duration in Rh1 compared to Dh [112 (SEM 7) min and 82 (SEM 3) min, respectively;P 〈 0.05]. The difference was not significant with Rh4 [103 (SEM 9) min]. A restoration of the time course of changes in plasma volume, plasma osmolality, heart rate and rectal temperature occurred immediately in Rh1 and was delayed in Rh4 until after 60 min of exercise. Our results demonstrated that the swift replacement of the fluid loss in the dehydrated subjects was beneficial to exercise performance by rapidly correcting the disturbances in body fluid balance.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesKoulmann, N. ; Melin, B. ; Jimenez, C. ; Charpenet, A. ; Savourey, G. ; Bittel, J.
Springer
Published 1997Staff ViewISSN: 1439-6327Keywords: Key words Rehydration ; Deuterium ; Body fluids ; Cardiovascular responses ; Body temperaturesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract To determine whether different forms of glucose (free and polymer) associated with sodium chloride influence the rate of water absorption during exercise in the heat, six men took part in five trials. Each trial included a passive heating session which resulted in a 2% loss of body mass, followed by 1h of treadmill exercise (at 50% of maximal oxygen uptake) in warm conditions (dry bulb temperature 35°C, relative humidity 20%–30%). Immediately before exercise, the subjects were given either no fluid or a volume equal to 50% of the fluid previously lost (about 650 ml), chosen from among four D2O-labelled beverages : mineral water, a 6% glucose-electrolyte solution (GS), a 6% maltodextrin solution and a 6% maltodextrin-electrolyte solution. No significant differences were observed among these various beverages so far as temporal accumulation of deuterium in plasma, sweat and urine was concerned. During GS, the plasma volume was completely restored and the drifts of heart rate and rectal temperature were less marked than during other trials. These results would suggest that rehydration with GS was more efficient, probably because of an internal redistribution of water. The proportion of ingested water was twice as high in sweat as it was in urine. These findings may reflect the essential part played by circulatory adjustments in the transfer of plasma water into sweat and urine.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesJimenez, C. ; Melin, B. ; Koulmann, N. ; Allevard, A. M. ; Launay, J. C. ; Savourey, G.
Springer
Published 1999Staff ViewISSN: 1439-6327Keywords: Key words Exercise ; Glycerol hyperhydration ; Heat exposure ; Dehydration ; Plasma volumeSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract This study examined plasma volume changes (ΔPV) in humans during periods with or without changes in body hydration: exercise-induced dehydration, heat-induced dehydration and glycerol hyperhydration. Repeated measurements of plasma volume were made after two injections of Evans blue. Results were compared to ΔPV calculated from haematocrit (Hct) and blood haemoglobin concentration ([Hb]). Eight well-trained men completed four trials in randomized order: euhydration (control test C), 2.8% dehydration of body mass by passive controlled hyperthermia (D) and by treadmill exercise (60% of their maximal oxygen uptake, V˙O2max) (E), and hyperhydration (H) by glycerol ingestion. The Hct, [Hb], plasma protein concentrations and plasma osmolality were measured before, during and after the changes in body hydration. Different Hct and [Hb] reference values were obtained to allow for posture-induced variations between and during trials. The ΔPV values calculated after two Evans blue injections were in good agreement with ΔPV calculated from Hct and [Hb]. Compared to the control test, mean plasma volume declined markedly during heat-induced dehydration [−11.4 (SEM 1.7)%] and slightly during exercise-induced dehydration [−4.2 (SEM 0.9)%] (P 〈 0.001 compared to D), although hyperosmolality was similar in these two trials. Conversely, glycerol hyperhydration induced an increase in plasma volume [+7.5 (SEM 1.0)%]. These results would indicate that, for a given level of dehydration, plasma volume is dramatically decreased during and after heat exposure, while it is better maintained during and after exercise.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesJimenez, C. ; Melin, B. ; Koulmann, N. ; Charpenet, A. ; Cottet-Emard, J. M. ; Péquignot, J. M. ; Savourey, G. ; Bittel, J.
Springer
Published 1997Staff ViewISSN: 1439-6327Keywords: Key words Dehydration ; Exercise ; Heat ; Hormones ; RehydrationSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The objective of our study was to examine the effects of beverage content on hormone responses involved in fuel substrate metabolism (catecholamines, insulin and glucagon) in previously dehydrated subjects exercising at a moderate intensity in the heat. Six healthy men walked for 60-min on five occasions at 50% maximal oxygen uptake in a warm environment (dry bulb temperature 35 ± 0.2°C, relative humidity 20%). On each occasion, the subjects were dehydrated before exercise (loss of 2% body mass) by passive controlled hyperthermia, which led to a reduction in plasma volume (PV) of about −5% to −9%. In one session, the subjects exercised without rehydration (Dh). In the other sessions, four beverages (650 ml) were given just before the exercise: mineral water (W), a 60 g · l−1 glucose and 1.2 g · l−1 NaCl solution (GS), a 60 g · l−1 maltodextrin solution, and a 60 g · l−1 maltodextrin and 1.2 g · l−1 NaCl solution. Compared to Dh and W, carbohydrate supply with or without NaCl induced a higher glycaemia (P 〈 0.05), a reduced increase in plasma adrenaline concentration (P 〈 0.05) and a higher plasma insulin concentration (P 〈 0.05), which lowered plasma free fatty acids and glycerol concentrations (P 〈 0.05). The lesser increase in plasma noradrenaline concentrations observed during GS compared to Dh and W sessions can be explained by a larger correction in PV which might have induced better haemodynamic conditions. However, the increase in plasma glucagon with carbohydrate supply – compared to Dh and W (P 〈 0.05) – remains unexplained.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesKoulmann, N. ; Melin, B. ; Bourdon, L. ; Péronnet, F. ; Jimenez, C. ; Pouzeratte, N. ; Savourey, G. ; Launay, J-C. ; Bittel, J.
Springer
Published 1999Staff ViewISSN: 1439-6327Keywords: Key words Hypoxia ; Exercise ; Rehydration ; Body fluids ; NoradrenalineSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract To determine whether or not acute hypobaric hypoxia alters the rate of water absorption from a carbohydrate beverage ingested during exercise, six men cycled for 80 min on three randomly assigned different occasions. In one trial, exercise was performed in hypoxia (barometric pressure, P B = 594 hPa, altitude 4 400 m) at an exercise intensity selected to elicit 75% of the individual's maximal oxygen uptake (V˙O2max) previously determined in such conditions. In the two other experiments, the subjects cycled in normoxia (P B = 992 hPa) at the same absolute and the same relative intensities as in hypoxia, which corresponded to 55% and 75%, respectively, of their V˙O2max determined in normoxia. The subjects consumed 400 ml of a 12.5% glucose beverage just prior to exercise, and 250 ml of the same drink at 20, 40 and 60 min from the beginning of exercise. The first drink contained 20 ml of deuterium oxide to serve as a tracer for the entry of water into body fluids. The heart rate (HR) during exercise was higher in hypoxia than in normoxia at the same absolute exercise intensity, whereas it was similar to HR measured in normoxia at the same relative exercise intensity. Both in normoxia and hypoxia, plasma noradrenaline concentrations were related to the relative exercise intensity up to 40 min of exercise. Beyond that duration, when exercise was performed at the highest absolute power in normoxia, the noradrenaline response was higher than in hypoxia at the same relative exercise intensity. No significant differences were observed among experimental conditions, either in temporal profiles of plasma D accumulation or in elimination of water ingested in sweat. Conversely, elimination in urine of the water ingested appeared to be related to the severity of exercise, either high absolute power or the same relative power combined with hypoxia. We concluded that water absorption into blood after drinking a 12.5% glucose beverage is not altered during cycling exercise in acute hypobaric hypoxia. It is suggested that the elimination of water ingested in sweat and urine may be dependent on local circulatory adjustments during exercise.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1439-6327Keywords: Plasma prolactin ; Plasma norepinephrine ; Body temperature ; Exercise ; DehydrationSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The effects of euhydration (Eh) and light (Dh1) and moderate (Dh2) dehydrations on plasma prolactin (PRL) levels were studied in 5 young male volunteers at rest and during exercise to exhaustion (50% of $$\dot V_{{\text{O}}_{{\text{2}} {\text{max}}} } $$ ) in a warm environment (Tdb=35° C, rh=20–30%). Light and moderate dehydrations (loss of 1.1 and 1.8% body respectively) were obtained before exercise by controlled hyperthermia. Compared to Eh, time for exhaustion was reduced in Dh1 and Dh2 (p〈0.01) and rectal temperature (Tre) rose faster in Dh2 (p〈0.05). Both venous plasma PRL and norepinephrine (NE) increased during exercise at any hydration level (p〈0.05). Plasma PRL reached higher values after 40 and 60 min in Dh2 and Dh1 (p〈0.05). Plasma NE values were higher in Dh2 at rest and at the 40th min during exercise (p〈0.05). Plasma PRL was linearly correlated to Tre and plasma NE (p〈0.001) but unrelated to plasma volume variation and osmolality. Our results provide further evidence for the major effect of body temperature in exercise-induced PRL changes. Moreover, the plasma PRL-NE relationship suggests that these changes may result from central noradrenergic activation.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesMelin, B. ; Jimenez, C. ; Savourey, G. ; Bittel, J. ; Cottet-Emard, J. M. ; Pequignot, J. M. ; Allevard, A. M. ; Gharib, C.
Springer
Published 1997Staff ViewISSN: 1439-6327Keywords: Key words Exercise ; Hydration state ; Catecholamines Fluid-regulating hormones ; Renal responsesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The effects of hydromineral hormones and catecholamines on renal concentrating ability at different hydration states were examined in five male volunteers while they performed three trials. Each of these trials comprised a 60-min exercise bout on a treadmill (at 50% of maximal oxygen uptake) in a warm environment (dry bulb temperature, 35°C; relative humidity, 20–30%). In one session, subjects were euhydrated before exercise (C). In the two other sessions, after thermal dehydration (loss of 3% body mass) which markedly reduced plasma volume (PV) and increased plasma osmolality (osmpl), the subjects exercised either not rehydrated (Dh) or rehydrated (Rh) by drinking 600 ml of mineral water before and 40 min after the onset of exercise. During exercise in the Dh compared to C state, plasma renin, aldosterone, arginine vasopressin (AVP), noradrenaline and adrenaline concentrations were increased (P 〈 0.05). A reduction in creatinine clearance and urine flow was also observed (P 〈 0.05) together with a decrease in urine osmolality, osmolar clearance and sodium excretion, while free water clearance increased (P 〈 0.05). However, compared to Dh, Rh partially restored PV and osmpl and induced a marked reduction in the time courses of both the plasma AVP and catecholamine responses (P 〈 0.05). Values for renal water and electrolyte excretion were intermediate between those of Dh and C. Plasma atrial natriuretic peptide presented similar changes whatever the hydration state. These results demonstrate that during moderate exercise in the heat, renal concentrating ability is paradoxically reduced by prior dehydration in spite of high plasma AVP levels, and might be the result of marked activation of the sympatho-adrenal system. Rehydration, by reducing this activation, could partially restore the renal concentrating ability despite the lowered plasma AVP.Type of Medium: Electronic ResourceURL: