Search Results - (Author, Cooperation:B. Melegh)

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  1. 1
    I. Lazaridis ; N. Patterson ; A. Mittnik ; G. Renaud ; S. Mallick ; K. Kirsanow ; P. H. Sudmant ; J. G. Schraiber ; S. Castellano ; M. Lipson ; B. Berger ; C. Economou ; R. Bollongino ; Q. Fu ; K. I. Bos ; S. Nordenfelt ; H. Li ; C. de Filippo ; K. Prufer ; S. Sawyer ; C. Posth ; W. Haak ; F. Hallgren ; E. Fornander ; N. Rohland ; D. Delsate ; M. Francken ; J. M. Guinet ; J. Wahl ; G. Ayodo ; H. A. Babiker ; G. Bailliet ; E. Balanovska ; O. Balanovsky ; R. Barrantes ; G. Bedoya ; H. Ben-Ami ; J. Bene ; F. Berrada ; C. M. Bravi ; F. Brisighelli ; G. B. Busby ; F. Cali ; M. Churnosov ; D. E. Cole ; D. Corach ; L. Damba ; G. van Driem ; S. Dryomov ; J. M. Dugoujon ; S. A. Fedorova ; I. Gallego Romero ; M. Gubina ; M. Hammer ; B. M. Henn ; T. Hervig ; U. Hodoglugil ; A. R. Jha ; S. Karachanak-Yankova ; R. Khusainova ; E. Khusnutdinova ; R. Kittles ; T. Kivisild ; W. Klitz ; V. Kucinskas ; A. Kushniarevich ; L. Laredj ; S. Litvinov ; T. Loukidis ; R. W. Mahley ; B. Melegh ; E. Metspalu ; J. Molina ; J. Mountain ; K. Nakkalajarvi ; D. Nesheva ; T. Nyambo ; L. Osipova ; J. Parik ; F. Platonov ; O. Posukh ; V. Romano ; F. Rothhammer ; I. Rudan ; R. Ruizbakiev ; H. Sahakyan ; A. Sajantila ; A. Salas ; E. B. Starikovskaya ; A. Tarekegn ; D. Toncheva ; S. Turdikulova ; I. Uktveryte ; O. Utevska ; R. Vasquez ; M. Villena ; M. Voevoda ; C. A. Winkler ; L. Yepiskoposyan ; P. Zalloua ; T. Zemunik ; A. Cooper ; C. Capelli ; M. G. Thomas ; A. Ruiz-Linares ; S. A. Tishkoff ; L. Singh ; K. Thangaraj ; R. Villems ; D. Comas ; R. Sukernik ; M. Metspalu ; M. Meyer ; E. E. Eichler ; J. Burger ; M. Slatkin ; S. Paabo ; J. Kelso ; D. Reich ; J. Krause
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-09-19
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Agriculture/history/manpower ; Asia/ethnology ; Europe ; European Continental Ancestry Group/*classification/*genetics ; Genome, Human/*genetics ; History, Ancient ; Humans ; Population Dynamics ; Principal Component Analysis
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Kispal, G. ; Melegh, B. ; Alkonyi, I. ; Sandor, A.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0005-2736
    Keywords:
    (Rat liver) ; Carnitine transport ; Liver perfusion ; Starvation
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0005-2736(87)90360-9

    Articles: DFG German National Licenses
  3. 3
    Sandor, A. ; Kispal, G. ; Melegh, B. ; Alkonyi, I.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0005-2760
    Keywords:
    (Rat liver) ; Carnitine
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0005-2760(85)90033-5

    Articles: DFG German National Licenses
  4. 4
    Sumegi, B. ; Melegh, B. ; Adamovich, K. ; Trombitas, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0009-8981
    Keywords:
    Actin ; Complex I ; Cytochrome oxidase ; Mitochondrial myopathy ; Mitochondrial structure ; Mutation ; Myofiber ; Respiratory defect
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0009-8981(90)90266-U

    Articles: DFG German National Licenses
  5. 5
    Kispal, G. ; Melegh, B. ; Sandor, A.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0167-4889
    Keywords:
    (Rat liver) ; Carnitine transport ; Glucagon ; Insulin
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0167-4889(87)90180-7

    Articles: DFG German National Licenses
  6. 6
    Weisenbach, J. ; Melegh, B.
    Springer
    Published 1996
    Staff View
    ISSN:
    1432-1998
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The case of two sisters with Larsen's syndrome is presented. In addition to typical features of the syndrome, “multiple coronal cleft vertebrae” of the lumbar vertebral bodies were seen in both sibs. The extremities were conspicuously short.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01356836

    Articles: DFG German National Licenses
  7. 7
    Fazekas, I. Gy. ; Felkai, B. ; Melegh, B.
    Springer
    Published 1953
    Staff View
    ISSN:
    1432-2307
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Zusammenfassung 1. Wir erzielten bei Kaninchen durch subcutane Einspritzung wÄ\riger BaCl2-Lösung akute (0,05 g/kg), und durch tÄgliche Verabreichung chronische Vergiftung (0,01–0,002–0,005 g/kg). Infolge der akuten Vergiftung gingen die Versuchstiere nach 2 Std 20 min bzw. 2 Std 30 min ein. Die andauernd behandelten Kaninchen wurden nach 98–193 Tage durch Luftembolie getötet. Gehirn und Rückenmark beider Tiergruppen wurden histologisch in Serienschnitten untersucht. 2. Sowohl in den akuten als in den chronischen BaCl2-VergiftungsfÄllen zeigten sich diffuse GefÄ\- und GanglienzellenverÄnderungen. Am schwersten waren die letzteren im Bereich der Area temporalis, Ganglia olfactoria Luysi, Lamina ganglionaris und Lamina multiformis, ferner am Thalamus, Hypothalamus, Corp. quadrigem. posterior und in den unteren Segmenten der Vorderhörner des Rückenmarks. 3. Da wir sog. ischÄmische GanglienzellenverÄnderungen nicht beobachteten, führen wir die vorgefundenen GanglienzellenverÄnderungen in erster Linie auf die schÄdliche Einwirkung des Ba-ions zurück. Unserer Ansicht nach haben die von den GefÄ\verÄnderungen verursachten Blutkreislaufstörungen im Zustandekommen der GanglienzellenverÄnderungen nur eine sekundÄre Rolle. 4. Da im Zentralnervensystem der lÄngere Zeit hindurch mit BaCl2 behandelten Kaninchen auch infolge der verwendeten kleinen Dosen beachtenswerte GanglienzellenverÄnderungen einsetzten, ist die andauerndere Behandlung mit Bariumchlorid für therapeutische Zwecke sehr zu bedenken.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00948098

    Articles: DFG German National Licenses
  8. 8
    Stankovics, J. ; Nagy, Ágnes ; Méhes, K. ; Melegh, B.
    Springer
    Published 1998
    Staff View
    ISSN:
    1432-1076
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004310050914

    Articles: DFG German National Licenses
  9. 9
    Melegh, B. ; Pap, M. ; Molnár, D. ; Masszi, G. ; Kopcsányi, G.
    Springer
    Published 1997
    Staff View
    ISSN:
    1432-1076
    Keywords:
    Key words Pivampicillin ; Energy metabolism ; Carnitine ; Pivalate ; Fat oxidation
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Ten children receiving pivampicillin for 8 days were studied. On the first 4 days the drug was given alone (4 × 500 mg/day), and on the last 4 days in combination with carnitine (4 × 1 g/day). Pivampicillin treatment was associated with formation and urinary excretion of pivaloylcarnitine and administration of carnitine aided the elimination of pivalate as its carnitine ester. The resting respiratory quotient increased from 0.86 ± 0.01 to 0.96 ± 0.01 on the 4th day of pivampicillin treatment. A shift was observed in the metabolic fuel consumption: a significant decrease was found in the amount of fats oxidized (0.31 ± 0.17 vs 1.27 ± 0.17 g · kg−1 · 24 h−1), while the utilization of carbohydrates increased (6.20 ± 0.51 vs 4.00 ± 0.50 g kg−1 · 24 h−1). Administration of carnitine decreased the respiratory quotient to 0.90 ± 0.01 on the 8th day of treatment, consumption of fats increased, and the oxidation of carbohydrates decreased. The resting energy expenditure was not affected by the treatment. Conclusion Pivampicillin treatment results in inhibited oxidation of fats as metabolic fuel. This drug effect was partially reversed by carnitine which promotes the elimination of the pivaloyl moiety from the body.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004310050716

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1573-2665
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Profound decrease of the carnitine acetyltransferase activity (0.08 U/g wet weight; 1.67% of control) and carnitine deficiency (total carnitine was 230 nmol/g wet weight in the patient vs 2730 in the controls) was detected in the skeletal muscle of a female paediatric patient. She died of her illness, which included cerebellar symptoms and slight muscle spasticity affecting mainly the lower extremities, at 1 year of age. Histological examination of the autopsy specimens revealed a selective Purkinje cell degeneration in the cerebellum: the cells had abnormal position, were shrunken and decreased in number, and displayed abnormal dendritic trees and fragmented, disorganized axons. Electron microscopy revealed mitochondrial abnormalities in skeletal and cardiac muscle and also in the Purkinje cells. Deletions of the mitochondrial DNA were detected in the muscle in heteroplasmic form (up to 7%). Mainly the ND4-ND4L region was affected, as evidenced by the PCR; however, other regions of the mitochondrial genome also showed deletions of varying size and extent, suggesting multiple deletions of the mitochondrial DNA.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1023/A:1005562209034

    Articles: DFG German National Licenses