Search Results - (Author, Cooperation:B. M. Spiegelman)
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1A. S. Banks ; F. E. McAllister ; J. P. Camporez ; P. J. Zushin ; M. J. Jurczak ; D. Laznik-Bogoslavski ; G. I. Shulman ; S. P. Gygi ; B. M. Spiegelman
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-11-20Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adipocytes/enzymology/metabolism ; Adipose Tissue/cytology/enzymology/metabolism ; Animals ; Cell Proliferation ; Cells, Cultured ; Cyclin-Dependent Kinase 5/deficiency/*metabolism ; Diabetes Mellitus/*metabolism ; Diet, High-Fat ; Extracellular Signal-Regulated MAP Kinases/*metabolism ; Humans ; Insulin Resistance ; MAP Kinase Kinase 2/antagonists & inhibitors/metabolism ; MAP Kinase Signaling System ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; PPAR gamma/chemistry/*metabolism ; PhosphorylationPublished by: -
2E. T. Chouchani ; L. Kazak ; M. P. Jedrychowski ; G. Z. Lu ; B. K. Erickson ; J. Szpyt ; K. A. Pierce ; D. Laznik-Bogoslavski ; R. Vetrivelan ; C. B. Clish ; A. J. Robinson ; S. P. Gygi ; B. M. Spiegelman
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-03-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adipose Tissue, Brown/chemistry/cytology/metabolism ; Animals ; Cell Respiration ; Cysteine/*chemistry/genetics/metabolism ; *Energy Metabolism/drug effects ; Female ; Humans ; Ion Channels/*chemistry/deficiency/genetics/*metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects/*metabolism ; Mitochondrial Proteins/*chemistry/deficiency/genetics/*metabolism ; Mutant Proteins/chemistry/genetics/metabolism ; Oxidation-Reduction ; Reactive Oxygen Species/*metabolism ; Sulfhydryl Compounds/metabolism ; *Thermogenesis/drug effectsPublished by: -
3A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesisP. Bostrom ; J. Wu ; M. P. Jedrychowski ; A. Korde ; L. Ye ; J. C. Lo ; K. A. Rasbach ; E. A. Bostrom ; J. H. Choi ; J. Z. Long ; S. Kajimura ; M. C. Zingaretti ; B. F. Vind ; H. Tu ; S. Cinti ; K. Hojlund ; S. P. Gygi ; B. M. Spiegelman
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-01-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adipocytes/cytology/drug effects/metabolism ; Adipose Tissue, Brown/*cytology/drug effects/metabolism ; Adipose Tissue, White/*cytology/drug effects/metabolism ; Animals ; Cell Respiration/drug effects ; Cells, Cultured ; Culture Media, Conditioned/pharmacology ; Energy Metabolism/drug effects/genetics/physiology ; Exercise/physiology ; Gene Expression Regulation/drug effects/genetics ; Hormones/metabolism/secretion ; Humans ; Insulin Resistance/physiology ; Intracellular Signaling Peptides and Proteins/genetics/metabolism ; Ion Channels/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Mitochondrial Proteins/metabolism ; Models, Animal ; Muscle Cells/metabolism ; Obesity/blood/chemically induced/prevention & control ; Physical Conditioning, Animal/physiology ; Plasma/chemistry ; Subcutaneous Fat/cytology/drug effects/metabolism ; *Thermogenesis/drug effects/genetics ; Trans-Activators/deficiency/genetics/*metabolism/secretion ; Transcription FactorsPublished by: -
4J. H. Choi ; A. S. Banks ; T. M. Kamenecka ; S. A. Busby ; M. J. Chalmers ; N. Kumar ; D. S. Kuruvilla ; Y. Shin ; Y. He ; J. B. Bruning ; D. P. Marciano ; M. D. Cameron ; D. Laznik ; M. J. Jurczak ; S. C. Schurer ; D. Vidovic ; G. I. Shulman ; B. M. Spiegelman ; P. R. Griffin
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-09-06Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: 3T3-L1 Cells ; Adipocytes/drug effects/metabolism ; Adipose Tissue, White/drug effects/metabolism ; Animals ; Biphenyl Compounds/chemistry/pharmacology ; Body Fluids/drug effects ; COS Cells ; Cercopithecus aethiops ; Cyclin-Dependent Kinase 5/*antagonists & inhibitors ; Dietary Fats/pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Hypoglycemic Agents/adverse effects/chemistry/*pharmacology ; Ligands ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Models, Molecular ; Obesity/chemically induced/metabolism ; Osteogenesis/drug effects ; PPAR gamma/agonists/chemistry/*metabolism ; Phosphorylation/drug effects ; Phosphoserine/metabolism ; Thiazolidinediones/adverse effects/pharmacology ; Transcription, Genetic/drug effects ; Tumor Necrosis Factor-alpha/pharmacology ; Weight Gain/drug effectsPublished by: -
5S. Kir ; J. P. White ; S. Kleiner ; L. Kazak ; P. Cohen ; V. E. Baracos ; B. M. Spiegelman
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adipose Tissue, Brown/cytology/drug effects/*metabolism/pathology ; Animals ; Cachexia/*metabolism/pathology ; Carcinoma, Lewis Lung/genetics/*metabolism/*pathology ; Culture Media, Conditioned/pharmacology ; Energy Metabolism/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Male ; Mice ; Muscle, Skeletal/metabolism/pathology ; Organ Size/drug effects ; Parathyroid Hormone-Related Protein/antagonists & inhibitors/*metabolism ; Thermogenesis/drug effects/geneticsPublished by: -
6Choi, S. H., Bylykbashi, E., Chatila, Z. K., Lee, S. W., Pulli, B., Clemenson, G. D., Kim, E., Rompala, A., Oram, M. K., Asselin, C., Aronson, J., Zhang, C., Miller, S. J., Lesinski, A., Chen, J. W., Kim, D. Y., van Praag, H., Spiegelman, B. M., Gage, F. H., Tanzi, R. E.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-09-07Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Medicine, Diseases, Neuroscience, Online OnlyPublished by: -
7Honrado, G. I. ; Johnson, Randall S. ; Golombek, D. A. ; Spiegelman, B. M. ; Papaioannou, V. E. ; Ralph, M. R.
Springer
Published 1996Staff ViewISSN: 1432-1351Keywords: Circadian rhythm ; Gene targeting ; Phase shift ; Entrainment ; Light cycleSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract We examined the role of c-fos in the synchronization of circadian rhythms to environmental light cycles using a line of gene-targeted mice carrying a null mutation at this locus. Circadian locomotor rhythms in mutants had similar periods as wild-type controls but took significantly longer than controls to entrain to 12:12 light-dark cycles. Light-induced phase shifts of rhythms in constant dark were attenuated in mutants although the circadian timing of phase delays and advances was not changed. A functional retinohypothalamic projection was indicated from behavioral results and light-induced jun-B expression in the SCN. The results indicate that while c-fos activation is not an absolute requirement for rhythm generation nor photic responses, it is required for normal entrainment of the mammalian biological clock.Type of Medium: Electronic ResourceURL: