Search Results - (Author, Cooperation:B. Knowles)

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  1. 1
    D. M. Messerschmidt ; W. de Vries ; M. Ito ; D. Solter ; A. Ferguson-Smith ; B. B. Knowles
    American Association for the Advancement of Science (AAAS)
    Published 2012
    Staff View
    Publication Date:
    2012-03-24
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Blastocyst/physiology ; DNA Methylation ; Down-Regulation ; *Embryo Loss ; Embryo, Mammalian/*physiology ; Embryonic Development ; *Epigenesis, Genetic ; Female ; Gene Expression Regulation, Developmental ; *Genomic Imprinting ; Insulin-Like Growth Factor II/genetics/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Nuclear Proteins/*genetics/*physiology ; Oligonucleotide Array Sequence Analysis ; Oocytes/*physiology ; Phenotype ; RNA, Long Noncoding ; RNA, Untranslated/genetics/metabolism ; Repressor Proteins/*genetics/*physiology
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2016-03-17
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Anthozoa/physiology/*virology ; Bacteriophages/pathogenicity/physiology ; Coral Reefs ; *Ecosystem ; Genes, Viral/genetics ; *Host-Pathogen Interactions ; Lysogeny ; Models, Biological ; Virulence/genetics ; Viruses/genetics/isolation & purification/*pathogenicity
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2018-02-16
    Publisher:
    American Heart Association (AHA)
    Print ISSN:
    0009-7330
    Electronic ISSN:
    1524-4571
    Topics:
    Medicine
    Keywords:
    Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Physiology, Vascular Biology, Thrombosis
    Published by:
    http://www.americanheart.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2018-05-11
    Publisher:
    American Heart Association (AHA)
    Print ISSN:
    0009-7330
    Electronic ISSN:
    1524-4571
    Topics:
    Medicine
    Keywords:
    Biomarkers, Vascular Biology, Thrombosis
    Published by:
    http://www.americanheart.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2018-09-14
    Publisher:
    Nature Publishing Group (NPG)
    Electronic ISSN:
    2041-1723
    Topics:
    Biology
    Chemistry and Pharmacology
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    C. Lorthongpanich ; L. F. Cheow ; S. Balu ; S. R. Quake ; B. B. Knowles ; W. F. Burkholder ; D. Solter ; D. M. Messerschmidt
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-09-07
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Blastocyst/*metabolism ; Cellular Reprogramming/*genetics ; *Chimerism ; *DNA Methylation ; *Epigenesis, Genetic ; Gene Deletion ; *Gene Expression Regulation, Developmental ; Genetic Loci ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Nuclear Proteins/genetics ; Repressor Proteins/genetics ; Single-Cell Analysis
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  7. 7
    Knowles, B. H. ; Ellar, D. J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1988
    Staff View
    ISSN:
    1365-2958
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Notes:
    Bacillus thuringlensis var. aizawai HD–249 produces more than one protein of 130–135 kD in its insecticidal crystal δ-endotoxin. We describe an indirect method of assessing the relative contribution to toxicity of two of these protoxins using monospecific antibodies directed against their active proteolytic products. Our results show that one toxin is active against Spodoptera frugiperda but not Choristoneura fumiferana cells in vitro, while the other lyses C. fumiferana but not S. frugiperda cells. There is no indication of synergism between these toxins in vitro.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2958.1988.tb00016.x

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    0005-2760
    Keywords:
    (Human HepG2 cell) ; Apolipoprotein ; Cholesterol synthesis ; LDL ; Lipoprotein receptor
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0005-2760(84)90003-1

    Articles: DFG German National Licenses
  9. 9
    Knowles, B. B. ; Pan, S. ; Solter, D. ; Linnenbach, A. ; Croce, C. ; Huebner, K.

    [s.l.] : Nature Publishing Group
    Published 1980
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] F9 12-1 cells are morphologically identical to murine ECCs. In our experiments (Table 1), we were unable to find any unequivocably SV40 T antigen-positive nuclei; however, because it is difficult to estimate nuclear fluorescence in ECCs due to their characteristic growth in clumps of rounded cells, ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/288615a0

    Articles: DFG German National Licenses
  10. 10
    PFIZENMAIER, K. ; TRINCHIERI, G. ; SOLTER, D. ; KNOWLES, B. B.

    [s.l.] : Nature Publishing Group
    Published 1978
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] B1O and BALB/c mice were immunised with SV40 (legend to Fig. 1). The kinetics of the CTL generation were studied by varying the time of in vivo immunisation (Fig. 1) as well as the in vitro culture period (Fig. 2). Antigenic specificity of the CTL was investigated using SV40- and adenovirus ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/274691a0

    Articles: DFG German National Licenses
  11. 11
    Gooi, H. C. ; Feizi, T. ; Kapadia, A. ; Knowles, B. B. ; Solter, D. ; Evans, M. J.

    [s.l.] : Nature Publishing Group
    Published 1981
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] A relationship between the stage-specific embryonic antigen, SSEA-1, and blood group I antigen was suggested by: (1) some similarities in the distribution of these two antigens in early post-implantation embryos and teratocarcinomas5'11, and (2) the reactivities of anti-I and -SSEA-1 reagents with ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/292156a0

    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1432-041X
    Keywords:
    Key words Mouse chromosome 10 and 14 ; Maternal transcript ; Mouse Expressed Sequence Tag (EST)
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Abstract  As part of a large scale mouse Expressed Sequence Tag (EST) project to identify molecules involved in the initiation of mammalian development, a homolog of the Drosophila cornichon gene was detected as a mouse maternal transcript present in the two-cell embryo. Cornichon is a multigene family in the mouse: the new gene, Cnih, maps to mouse chromosome 10, another cornichon homolog, Cnil, maps to chromosome 14 and two additional cornichon-related loci, possibly pseudogenes, localize to chromosomes 3 and 10, respectively. Cnih encodes an open reading frame (ORF) of 144 amino acids that is 93% homologous (68% identical) to the Drosophila protein, whereas the ORF of Cnil contains two extra polypeptide regions not found in these other proteins. Transcripts of Cnih are highly abundant in the full grown oocyte and the ovulated unfertilized egg, while Cnil message is only detectable after activation of the embryonic genome at the eight-cell stage. In situ hybridization shows specific localization of Cnih transcripts to ovarian oocytes. The lack of cytoplasmic polyadenylation of the maternally inherited Cnih transcript suggests that Cnih mRNA is translated in the full grown oocyte before, but not after, ovulation. In Drosophila, cornichon is involved in the establishment of both anterior-posterior and dorso-ventral polarity via the epidermal growth factor (EGF)-receptor signaling pathway. Finding Cnih in the mammalian oocyte opens a new perspective on the investigation of EGF-signaling in the oocyte.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004270050234

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1432-1211
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract An antigen reactive with antisera to a human chromosome 7-coded cell-surface antigen can be extracted from human cells with the nonionic detergent NP-40. Immune complexes of radiolabeled cell extracts analyzed on SDS polyacrylamide gels showed a single protein with an apparent M.W. of approximately 165,000. This protein was immunoprecipitated from extracts of hybrid cells containing chromosome 7 and human cell extracts, but not from mouse cell extracts or from extracts of a hybrid clone without human chromosome 7. The data presented here indicate that the protein identified on the gels is a cell-surface glycoprotein coded for by human chromosome 7.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01563921

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    1572-9931
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract We have mapped two new genes to chromosome 11 which control the cell-surface expression of two distinct antigens defined by monoclonal antibodies. One of the antigens has a general tissue distribution and is associated with a molecular complex of two polypeptides of 80,000 dalton and 40,000 dalton molecular weight. The second antigen has a restricted tissue distribution and is carried on a polypeptide of 100,000 daltons. We have used a combination of genetic and biochemical techniques to demonstrate that these new markers are distinct from the antigens defined by the monoclonal antibodies F10.44.2 and W6/34 which are also encoded by genes on chromosome 11. It is concluded that human chromosome 11 carries at least four distinct genes controlling cell-surface antigen expression.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01574263

    Articles: DFG German National Licenses
  15. 15
    Dennis, R. D. ; Wiegandt, H. ; Haustein, D. ; Knowles, B. H. ; Ellar, D. J.

    New York, NY : Wiley-Blackwell
    Published 1986
    Staff View
    ISSN:
    0269-3879
    Keywords:
    Chemistry ; Analytical Chemistry and Spectroscopy
    Source:
    Wiley InterScience Backfile Collection 1832-2000
    Topics:
    Medicine
    Notes:
    The hypothesis tested was that a particular glycoconjugate(s) in the exposed cell-surface membrane of susceptible insect cells acts as a receptor and/or modulator for the specific interaction with the protoxin/activated toxin of the δ-endotoxin of Bacillus thuringiensis var. kurstaki. As candidates, the total neutral and acidic fraction glycolipids, and the isolated neutral glycosphingolipid components, were screened for binding activity by the thin layer chromatogram overlay technique. The main protoxin/activated toxin-binding glycolipid in the neutral fraction (5B) had the structure: Gal(α1-3)GalNAc(β1-4)GlcNAc(β1-3)Man(β1-4)Glc(β1-1)Cer. The main protoxin/activated toxin-binding glycolipid in the acidic fraction was designated band 1, the structure of which is at present unknown. The possibility that the component 5B carbohydrate sequence may also function as a toxin-binding site of relevant insect plasma membrane glycoproteins is discussed.
    Additional Material:
    5 Ill.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1002/bmc.1130010108

    Articles: DFG German National Licenses