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1Latest Papers from Table of Contents or Articles in PressS. Nik-Zainal ; H. Davies ; J. Staaf ; M. Ramakrishna ; D. Glodzik ; X. Zou ; I. Martincorena ; L. B. Alexandrov ; S. Martin ; D. C. Wedge ; P. Van Loo ; Y. S. Ju ; M. Smid ; A. B. Brinkman ; S. Morganella ; M. R. Aure ; O. C. Lingjaerde ; A. Langerod ; M. Ringner ; S. M. Ahn ; S. Boyault ; J. E. Brock ; A. Broeks ; A. Butler ; C. Desmedt ; L. Dirix ; S. Dronov ; A. Fatima ; J. A. Foekens ; M. Gerstung ; G. K. Hooijer ; S. J. Jang ; D. R. Jones ; H. Y. Kim ; T. A. King ; S. Krishnamurthy ; H. J. Lee ; J. Y. Lee ; Y. Li ; S. McLaren ; A. Menzies ; V. Mustonen ; S. O'Meara ; I. Pauporte ; X. Pivot ; C. A. Purdie ; K. Raine ; K. Ramakrishnan ; F. G. Rodriguez-Gonzalez ; G. Romieu ; A. M. Sieuwerts ; P. T. Simpson ; R. Shepherd ; L. Stebbings ; O. A. Stefansson ; J. Teague ; S. Tommasi ; I. Treilleux ; G. G. Van den Eynden ; P. Vermeulen ; A. Vincent-Salomon ; L. Yates ; C. Caldas ; L. V. Veer ; A. Tutt ; S. Knappskog ; B. K. Tan ; J. Jonkers ; A. Borg ; N. T. Ueno ; C. Sotiriou ; A. Viari ; P. A. Futreal ; P. J. Campbell ; P. N. Span ; S. Van Laere ; S. R. Lakhani ; J. E. Eyfjord ; A. M. Thompson ; E. Birney ; H. G. Stunnenberg ; M. J. van de Vijver ; J. W. Martens ; A. L. Borresen-Dale ; A. L. Richardson ; G. Kong ; G. Thomas ; M. R. Stratton
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-05-03Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. The effects of a 13-day intraperitoneal (i.p.) infusion of bromocriptine, delivered by osmotic pump, on plasma and pituitary thyroid-stimulating hormone (TSH) levels were investigated in New Zealand genetically hypertensive (GH) rats and their normotensive (NT) controls.2. In both the GH and NT rats, bromocriptine significantly reduced plasma TSH level but did not have any significant effect on pituitary TSH content.3. No significant difference was found in the plasma TSH level and pituitary TSH content between the vehicle-treated GH and NT rats.4. These results suggest that there are no differences between the GH and NT rats with regard to the activity of the central dopaminergic system influencing TSH release and also that TSH does not play a role in the hypertension of the GH rats.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. We have previously reported on the effects of a 13-day intraperitoneal infusion of bromocriptine delivered by osmotic pump on blood pressure, plasma and pituitary PRL levels in genetically hypertensive (GH) rats and their normotensive (NT) controls. This paper reports further on that study in describing the changes in saline and water intakes in rats as a result of bromocriptine (BRC) treatment.2. In the GH rats, bromocriptine did not have any significant effect on saline or water intake.3. In the NT rats, bromocriptine significantly decreased saline intake and increased water intake.4. The saline intake in the vehicle-treated GH rats was significantly lower than that in the vehicle-treated NT rats while the water intake was not significantly different.5. These results indicate that differences exist between the GH and NT rats with regard to their saline and water intakes and their responses to chronic bromocriptine treatment. The changes in saline and water intakes in the GH rats seem to be different from those seen in the spontaneously hypertensive rat in another study.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. The effects on blood pressure (BP), plasma and pituitary prolactin (PRL) of a 13 day intraperitoneal infusion of bromocriptine (BRC) delivered by osmotic minipump were investigated in genetically hypertensive rats (GHR) and their normotensive (NT) controls.2. In the GHR, the mean BP in the BRC-treated group over the 13 day period of study was significantly lower than in the vehicle-treated group. In the NT rats, the mean BP in the BRC-treated group over the 13 day period was also significantly lower than in the vehicle-treated group.3. Mean plasma PRL concentration in the GHR and NT rats were comparable. In the GHR, the mean plasma PRL concentration taken on day 13 was significantly lower in the BRC-treated group than in the vehicle-treated group. In the NT rats, the mean plasma PRL concentration taken on day 13 in the BRC-treated group was, however, not significantly different from that in the vehicle-treated group.4. The mean pituitary PRL content was not significantly different in the GH and NT rats. There was a greater suppression of pituitary PRL content in the BRC-treated GHR than in the BRC-treated NT rats compared with their respective vehicle-treated groups.5. The results raise the possibility that PRL may have an indirect role in the pathogenesis of the hypertension of the GHR.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. The effects on blood pressure (BP) and plasma and pituitary prolactin (PRL) of a 13 day intraperitoneal infusion of bromocriptine delivered by osmotic minipump were investigated in spontaneously hypertensive rats (SHR) and their normotensive controls, the Wistar-Kyoto rats (WKY).2. In the SHR, a fall in BP which was steepest over the initial few days and sustained up to day 12 was observed in the bromocriptine-treated group compared with the lack of a change in BP observed in the vehicle-treated group. The plasma PRL level taken on day 13 was found to be significantly lower in the bromocriptine-treated group than in the vehicle-treated group.3. In the WKY, bromocriptine had no significant effect on either BP or plasma PRL.4. Pituitary PRL content was significantly lower in the SHR than in the WKY. The suppression by bromocriptine treatment was greater in the SHR than in the WKY.5. These results provide further evidence for a central dopaminergic insufficiency in the SHR and raise the possibility that PRL may, either directly or indirectly by interacting with other factors in the SHR, influence BP.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesMøller, S. E. ; Beurs, P. ; Timmerman, L. ; Tan, B. K. ; Leijnse-Ybema, H. J. ; Cohen Stuart, M. H. ; Høpfner Petersen, H. E.
Springer
Published 1986Staff ViewISSN: 1432-2072Keywords: Depressive disorder ; Tryptophan ratio ; Tyrosine ratio ; Response prediction ; Citalopram ; MaprotilineSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Pretreatment plasma ratios of tryptophan (Trp) and tyrosine (Tyr) to other large neutral amino acids were determined in 27 depressed patients who completed a double-blind trial of citalopram, a selective serotonin uptake inhibitor, against maprotiline, a selective noradrenaline uptake inhibitor. The Trp ratio and the Tyr ratio were decreased in the total patient sample as compared with healthy controls. Plasma Tyr ratio was normal in the endogenous, but significantly decreased in the non-endogenous depressives. There was no significant relationship between the plasma Trp ratio and the probenecid-induced accumulation of 5-HIAA in the CSF, or between the plasma Tyr ratio and HVA level in CSF, whereas the CSF level of MHPG correlated significantly with the plasma Tyr ratio. There was a significantly positive correlation between the Trp ratio, the Tyr ratio, their sum and the final Hamilton depression score in 14 patients treated with citalopram; on the whole, this association was evident also in the endogenous and non-endogenous subgroups. In 13 patients on maprotiline there was a significantly positive correlation between the plasma Tyr ratio and the percent reduction of Hamilton depression score; this association was poor in the endogenous, whereas a trend towards a correlation remained in the non-endogenous subgroup. The results suggest that the plasma Trp and Tyr ratios may be determinants of clinical improvement in depressed patients to treatment with citalopram and maprotiline. However, further studies are needed on larger patient samples to allow a firm conclusion.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0021-8995Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: The scorch property of accelerated sulfur vulcanization of three grades of expoxidized natural rubber (viz. ENR 10, ENR 25, and ENR 50) was studied by using Mooney Shearing Disk Viscometer in the temperature range of 100-180°C. Effects of accelerator types, concentration of accelerator, and carbon black on ENR 10 were also determined. Results obtained indicate a similar scorch behavior as that reported earlier for SMR L. However, some differences in the magnitude of scorch times in the temperature and concentration studies are observed between ENR and SMR L. These differences are attributed to the activation of a double bond by the adjacent epoxide group in ENR, the effect being more significant for a higher degree of epoxidation of natural rubber. In the case of ENR 50, differential scanning calorimetry measurement suggests that additional crosslink occurs via a ring-opening reaction at about 155°C. Based on first-order reaction kinetics, the apparent activation energy of vulcanization for the rubbers studied is estimated and discussed.Additional Material: 9 Ill.Type of Medium: Electronic ResourceURL: