Search Results - (Author, Cooperation:B. Jacobsson)

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  1. 1
    C. A. Rietveld ; S. E. Medland ; J. Derringer ; J. Yang ; T. Esko ; N. W. Martin ; H. J. Westra ; K. Shakhbazov ; A. Abdellaoui ; A. Agrawal ; E. Albrecht ; B. Z. Alizadeh ; N. Amin ; J. Barnard ; S. E. Baumeister ; K. S. Benke ; L. F. Bielak ; J. A. Boatman ; P. A. Boyle ; G. Davies ; C. de Leeuw ; N. Eklund ; D. S. Evans ; R. Ferhmann ; K. Fischer ; C. Gieger ; H. K. Gjessing ; S. Hagg ; J. R. Harris ; C. Hayward ; C. Holzapfel ; C. A. Ibrahim-Verbaas ; E. Ingelsson ; B. Jacobsson ; P. K. Joshi ; A. Jugessur ; M. Kaakinen ; S. Kanoni ; J. Karjalainen ; I. Kolcic ; K. Kristiansson ; Z. Kutalik ; J. Lahti ; S. H. Lee ; P. Lin ; P. A. Lind ; Y. Liu ; K. Lohman ; M. Loitfelder ; G. McMahon ; P. M. Vidal ; O. Meirelles ; L. Milani ; R. Myhre ; M. L. Nuotio ; C. J. Oldmeadow ; K. E. Petrovic ; W. J. Peyrot ; O. Polasek ; L. Quaye ; E. Reinmaa ; J. P. Rice ; T. S. Rizzi ; H. Schmidt ; R. Schmidt ; A. V. Smith ; J. A. Smith ; T. Tanaka ; A. Terracciano ; M. J. van der Loos ; V. Vitart ; H. Volzke ; J. Wellmann ; L. Yu ; W. Zhao ; J. Allik ; J. R. Attia ; S. Bandinelli ; F. Bastardot ; J. Beauchamp ; D. A. Bennett ; K. Berger ; L. J. Bierut ; D. I. Boomsma ; U. Bultmann ; H. Campbell ; C. F. Chabris ; L. Cherkas ; M. K. Chung ; F. Cucca ; M. de Andrade ; P. L. De Jager ; J. E. De Neve ; I. J. Deary ; G. V. Dedoussis ; P. Deloukas ; M. Dimitriou ; G. Eiriksdottir ; M. F. Elderson ; J. G. Eriksson ; D. M. Evans ; J. D. Faul ; L. Ferrucci ; M. E. Garcia ; H. Gronberg ; V. Guethnason ; P. Hall ; J. M. Harris ; T. B. Harris ; N. D. Hastie ; A. C. Heath ; D. G. Hernandez ; W. Hoffmann ; A. Hofman ; R. Holle ; E. G. Holliday ; J. J. Hottenga ; W. G. Iacono ; T. Illig ; M. R. Jarvelin ; M. Kahonen ; J. Kaprio ; R. M. Kirkpatrick ; M. Kowgier ; A. Latvala ; L. J. Launer ; D. A. Lawlor ; T. Lehtimaki ; J. Li ; P. Lichtenstein ; P. Lichtner ; D. C. Liewald ; P. A. Madden ; P. K. Magnusson ; T. E. Makinen ; M. Masala ; M. McGue ; A. Metspalu ; A. Mielck ; M. B. Miller ; G. W. Montgomery ; S. Mukherjee ; D. R. Nyholt ; B. A. Oostra ; L. J. Palmer ; A. Palotie ; B. W. Penninx ; M. Perola ; P. A. Peyser ; M. Preisig ; K. Raikkonen ; O. T. Raitakari ; A. Realo ; S. M. Ring ; S. Ripatti ; F. Rivadeneira ; I. Rudan ; A. Rustichini ; V. Salomaa ; A. P. Sarin ; D. Schlessinger ; R. J. Scott ; H. Snieder ; B. St Pourcain ; J. M. Starr ; J. H. Sul ; I. Surakka ; R. Svento ; A. Teumer ; H. Tiemeier ; F. J. van Rooij ; D. R. Van Wagoner ; E. Vartiainen ; J. Viikari ; P. Vollenweider ; J. M. Vonk ; G. Waeber ; D. R. Weir ; H. E. Wichmann ; E. Widen ; G. Willemsen ; J. F. Wilson ; A. F. Wright ; D. Conley ; G. Davey-Smith ; L. Franke ; P. J. Groenen ; M. Johannesson ; S. L. Kardia ; R. F. Krueger ; D. Laibson ; N. G. Martin ; M. N. Meyer ; D. Posthuma ; A. R. Thurik ; N. J. Timpson ; A. G. Uitterlinden ; C. M. van Duijn ; P. M. Visscher ; D. J. Benjamin ; D. Cesarini ; P. D. Koellinger
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-06-01
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Cognition ; *Educational Status ; Endophenotypes ; Female ; Genetic Loci ; *Genome-Wide Association Study ; Humans ; Male ; Multifactorial Inheritance ; *Polymorphism, Single Nucleotide
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    A. Okbay ; J. P. Beauchamp ; M. A. Fontana ; J. J. Lee ; T. H. Pers ; C. A. Rietveld ; P. Turley ; G. B. Chen ; V. Emilsson ; S. F. Meddens ; S. Oskarsson ; J. K. Pickrell ; K. Thom ; P. Timshel ; R. de Vlaming ; A. Abdellaoui ; T. S. Ahluwalia ; J. Bacelis ; C. Baumbach ; G. Bjornsdottir ; J. H. Brandsma ; M. Pina Concas ; J. Derringer ; N. A. Furlotte ; T. E. Galesloot ; G. Girotto ; R. Gupta ; L. M. Hall ; S. E. Harris ; E. Hofer ; M. Horikoshi ; J. E. Huffman ; K. Kaasik ; I. P. Kalafati ; R. Karlsson ; A. Kong ; J. Lahti ; S. J. van der Lee ; C. deLeeuw ; P. A. Lind ; K. O. Lindgren ; T. Liu ; M. Mangino ; J. Marten ; E. Mihailov ; M. B. Miller ; P. J. van der Most ; C. Oldmeadow ; A. Payton ; N. Pervjakova ; W. J. Peyrot ; Y. Qian ; O. Raitakari ; R. Rueedi ; E. Salvi ; B. Schmidt ; K. E. Schraut ; J. Shi ; A. V. Smith ; R. A. Poot ; B. St Pourcain ; A. Teumer ; G. Thorleifsson ; N. Verweij ; D. Vuckovic ; J. Wellmann ; H. J. Westra ; J. Yang ; W. Zhao ; Z. Zhu ; B. Z. Alizadeh ; N. Amin ; A. Bakshi ; S. E. Baumeister ; G. Biino ; K. Bonnelykke ; P. A. Boyle ; H. Campbell ; F. P. Cappuccio ; G. Davies ; J. E. De Neve ; P. Deloukas ; I. Demuth ; J. Ding ; P. Eibich ; L. Eisele ; N. Eklund ; D. M. Evans ; J. D. Faul ; M. F. Feitosa ; A. J. Forstner ; I. Gandin ; B. Gunnarsson ; B. V. Halldorsson ; T. B. Harris ; A. C. Heath ; L. J. Hocking ; E. G. Holliday ; G. Homuth ; M. A. Horan ; J. J. Hottenga ; P. L. de Jager ; P. K. Joshi ; A. Jugessur ; M. A. Kaakinen ; M. Kahonen ; S. Kanoni ; L. Keltigangas-Jarvinen ; L. A. Kiemeney ; I. Kolcic ; S. Koskinen ; A. T. Kraja ; M. Kroh ; Z. Kutalik ; A. Latvala ; L. J. Launer ; M. P. Lebreton ; D. F. Levinson ; P. Lichtenstein ; P. Lichtner ; D. C. Liewald ; A. Loukola ; P. A. Madden ; R. Magi ; T. Maki-Opas ; R. E. Marioni ; P. Marques-Vidal ; G. A. Meddens ; G. McMahon ; C. Meisinger ; T. Meitinger ; Y. Milaneschi ; L. Milani ; G. W. Montgomery ; R. Myhre ; C. P. Nelson ; D. R. Nyholt ; W. E. Ollier ; A. Palotie ; L. Paternoster ; N. L. Pedersen ; K. E. Petrovic ; D. J. Porteous ; K. Raikkonen ; S. M. Ring ; A. Robino ; O. Rostapshova ; I. Rudan ; A. Rustichini ; V. Salomaa ; A. R. Sanders ; A. P. Sarin ; H. Schmidt ; R. J. Scott ; B. H. Smith ; J. A. Smith ; J. A. Staessen ; E. Steinhagen-Thiessen ; K. Strauch ; A. Terracciano ; M. D. Tobin ; S. Ulivi ; S. Vaccargiu ; L. Quaye ; F. J. van Rooij ; C. Venturini ; A. A. Vinkhuyzen ; U. Volker ; H. Volzke ; J. M. Vonk ; D. Vozzi ; J. Waage ; E. B. Ware ; G. Willemsen ; J. R. Attia ; D. A. Bennett ; K. Berger ; L. Bertram ; H. Bisgaard ; D. I. Boomsma ; I. B. Borecki ; U. Bultmann ; C. F. Chabris ; F. Cucca ; D. Cusi ; I. J. Deary ; G. V. Dedoussis ; C. M. van Duijn ; J. G. Eriksson ; B. Franke ; L. Franke ; P. Gasparini ; P. V. Gejman ; C. Gieger ; H. J. Grabe ; J. Gratten ; P. J. Groenen ; V. Gudnason ; P. van der Harst ; C. Hayward ; D. A. Hinds ; W. Hoffmann ; E. Hypponen ; W. G. Iacono ; B. Jacobsson ; M. R. Jarvelin ; K. H. Jockel ; J. Kaprio ; S. L. Kardia ; T. Lehtimaki ; S. F. Lehrer ; P. K. Magnusson ; N. G. Martin ; M. McGue ; A. Metspalu ; N. Pendleton ; B. W. Penninx ; M. Perola ; N. Pirastu ; M. Pirastu ; O. Polasek ; D. Posthuma ; C. Power ; M. A. Province ; N. J. Samani ; D. Schlessinger ; R. Schmidt ; T. I. Sorensen ; T. D. Spector ; K. Stefansson ; U. Thorsteinsdottir ; A. R. Thurik ; N. J. Timpson ; H. Tiemeier ; J. Y. Tung ; A. G. Uitterlinden ; V. Vitart ; P. Vollenweider ; D. R. Weir ; J. F. Wilson ; A. F. Wright ; D. C. Conley ; R. F. Krueger ; G. Davey Smith ; A. Hofman ; D. I. Laibson ; S. E. Medland ; M. N. Meyer ; M. Johannesson ; P. M. Visscher ; T. Esko ; P. D. Koellinger ; D. Cesarini ; D. J. Benjamin
    Nature Publishing Group (NPG)
    Published 2016
    Staff View
    Publication Date:
    2016-05-27
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2018-01-25
    Publisher:
    BMJ Publishing
    Electronic ISSN:
    2044-6055
    Topics:
    Medicine
    Keywords:
    Open access
    Published by:
    http://group.bmj.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    JACOBSSON, B. ; LIGNELID, H. ; BERGERHEIM, U.S.R.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1365-2559
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Ten human kidney specimens and thirty-two renal cell carcinomas were investigated for the presence of transthyretin mRNA and cystatin C mRNA using Northern blot analysis. Five of ten kidney specimens and 15 of 32 renal carcinomas were also immunohistochemically investigated for the presence of the corresponding proteins. Transthyretin mRNA could not be detected in any of the normal or neoplastic tissue preparations, whereas low amounts of cystatin C mRNA were found in nine of ten normal kidneys and in 24 of 32 renal cell carcinomas. Immunoreactive transthyretin and cystatin C were present in proximal tubular epithelial cells of all kidney specimens, whereas neither of the proteins was detected in the tumour cells of the renal carcinomas. Immunoreactive cystatin C was, however, demonstrated in scattered monocyte/macrophage-like cells. We conclude that the presence of immunoreactive transthyretin and cystatin C in proximal tubular cells of the kidney is most likely due to reabsorption of the proteins from the primary urine. The small amounts of cystatin C mRNA in some of the normal and neoplastic renal preparations are probably due to cystatin C synthesis in macrophages. Transthyretin has been recommended as an immunohistochemical marker for renal cell carcinomas. Our results, however, clearly indicate that neither transthyretin nor cystatin C constitutes a useful marker for such neoplasms.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2559.1995.tb00275.x

    Articles: DFG German National Licenses
  5. 5
    Jacobsson, B. ; Nordstroom, B. ; Lundstrom, R.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0925-7535
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Technology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0925-7535(92)90025-U

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    0022-2828
    Keywords:
    Adenylate cyclase ; Carbachol ; Muscarinic receptors ; Oxotremorine ; Phosphatidylinositol
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0022-2828(86)80955-5

    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    0022-2828
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0022-2828(84)80436-8

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    0022-2828
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0022-2828(84)80404-6

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    0375-9474
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0375-9474(92)90571-Z

    Articles: DFG German National Licenses
  10. 10
    Lignelid, Helén ; Collins, V. Peter ; Jacobsson, B.
    Springer
    Published 1997
    Staff View
    ISSN:
    1432-0533
    Keywords:
    Key words Cystatins ; Transthyretin ; Brain tumors ; Pituitary adenomas ; Human
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The localization of cystatin C (CC) and transthyretin (TTR) synthesis was studied using Northern blot and immunohistochemical methods. Normal brain tissues from all sites studied contained CC mRNA. Immunoreactive CC was present in the choroid plexus epithelial cells, cerebral and cerebellar neurons, astrocytes, ependymal cells, macrophage-like cells of the arachnoid membrane and in neuroendocrine cells of the anterior pituitary lobe. TTR mRNA and TTR were restricted to the choroid plexus. In primary brain tumors, the transcript for CC was found in all 39 tumors examined, while the protein could only be demonstrated in 3/5 choroid plexus papillomas, 8/8 astrocytomas, 7/23 anaplastic astrocytomas and glioblastomas, 1/6 oligodendrogliomas, 1/1 oligoastrocytoma, 1/4 anaplastic oligodendrogliomas, 3/7 ependymomas, 0/1 anaplastic ependymoma, 0/5 primitive neuroectodermal tumors, 0/1 neuroblastoma, 3/11 meningiomas and 16/16 pituitary adenomas. CC cannot be used as a marker for any specific brain tumor type but the fact that the protein could be demonstrated more frequently in astrocytomas than in their more malignant counterparts suggests that the cellular production and secretion of CC changes with the malignant progression of these tumors. TTR mRNA and TTR were present only in the choroid plexus papillomas, indicating that TTR synthesis is mainly restricted to such brain neoplasms.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004010050644

    Articles: DFG German National Licenses
  11. 11
    Jacobsson, B. ; Holm, G. ; Björntorp, P. ; Smith, U.
    Springer
    Published 1976
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Human adipose tissue ; lipolysis ; noradrenaline ; insulin
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary In the present study dose-response relationships of the effects of noradrenaline and insulin on fat cells of different sizes were performed. Adipose cells larger than 100 μm were more responsive (expressed as absolute effects) to the lipolytic action of noradrenaline as well as to the antilipolytic effect of insulin. This suggests that in the larger cells thecapacity, i. e. the sum of factors contributing to the ability to stimulate or inhibit the metabolic rates, was greater than in the smaller ones. In contrast thesensitivity to these agents, i.e. the readiness to respond, was not different between small and large cells. It is shown that the concentrations of insulin needed to obtain an antilipolytic effect is far below that needed to stimulate glucose incorporation. This discrepancy in insulin concentrations required may be due to binding of insulin to receptors with different affinity.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01221967

    Articles: DFG German National Licenses
  12. 12
    Jacobsson, B.
    Springer
    Published 1989
    Staff View
    ISSN:
    1432-119X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary In situ hybridization with 35S-labeled single stranded RNA probes was used on sections from formaldehyde-fixed and paraffin-embedded tissue specimens to provide semiquantitative data on the occurrence of transthyretin(TTR)-mRNA in human liver, choroid plexus and pancreatic islets as well as in 15 endocrine tumours of the pancreas and gut. A monoclonal antibody to TTR was used for immunocytochemical identification of the protein in consecutive sections. The amount of TTR-mRNA in hepatocytes was found to be much less than that in epithelial cells of the choroid plexus. Glucagon cells of the pancreatic islets were also specifically labeled and the level of TTR-mRNA in these cells was intermediate between that of hepatocytes and choroid plexus epithelial cells. Four glucagonomas, one malignant insulinoma and two midgut carcinoids were shown to contain TTR-mRNA. The ‘in situ’ labeled cells were also found to be TTR immunoreactive. These findings present the first conclusive evidence for TTR synthesis in pancreatic islets and in endocrine tumours. They also establish that the high serum concentration of TTR found in some patients with endocrine tumours (notably glucagonomas) is most likely due to tumour production of TTR.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00493004

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1432-1998
    Keywords:
    Children ; catheterisation ; adverse effects-thrombosis-atrophy
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Thirty-three 6 month to 13 year (average 9 years) old children subjected to femoral artery catheterisation in the 1960s were reviewed 2–9 years (average 5 years) later. They were then 7–18 years old (average 14 years). The review included measurement of the circumference of each calf and oscillography. Of the patients in whom either of these methods had suggested obstruction of the circulation, 10 were selected at random and examined with plethysmography and/or arteriography. The relatively high frequency of impaired circulation and growth of the limb found, appeared to warrant the conclusion that vascular catheterisation of children should always be followed by careful investigation for vascular obstruction, preferably with oscillography, and, if thrombosis is suspected by supplementary arteriography. A firm diagnosis of thromboembolism after catheterisation with occlusion of a major limb artery motivates thromboectomy.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00973222

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    1432-198X
    Keywords:
    Key words Females ; Urinary tract infection ; Renal scarring ; Vesicoureteral reflux ; Follow-up
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  We report the detection and progression of renal scars in girls prospectively followed from their first recognized urinary tract infection. There were 107 infection-prone subjects with a median age of 7.1 years at the first and 21.7 years at the last urography. Of 51 females who ultimately had lesions, 38 had established scars at the first urography. In 18 subjects, new scars were found in previously undamaged kidneys, 5 already with unilateral scarring. There had been a normal urography after the 5th birthday in 8 of those with later scarring. Worsening of scarring was seen in 10 of the 38 subjects with established scars. The renal damage was in most cases slight or moderate. By stepwise logistic regression analysis, grade of reflux and number of pyelonephritic attacks correlated with scarring, and number of pyelonephritic attacks with new scars and worsening of the lesions. In summary, of the females who ultimately had renal lesions, one-third developed new scars. In most of those with established scars at the first urography, the focal character of lesions suggests that most were also acquired. Since reflux and number of pyelonephritic attacks were identified as risk factors, prevention of renal deterioration should be possible.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004670050063

    Articles: DFG German National Licenses
  15. 15
    Claësson, I. ; Jacobsson, B. ; Riha, M.
    Springer
    Published 1987
    Staff View
    ISSN:
    1432-1998
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The size of a kidney, as measured on a urogram, is a sensitive indicator of renal damage in a child with urinary tract infection and renal surface area correlates well with glomerular filtration rate. Sequential measurements can be invaluable in evaluating the efficacy of a regimen of treatment. A system utilizing a personal microcomputer has been developed to facilitate the measuring procedure and the handling and analysis of data.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02388278

    Articles: DFG German National Licenses
  16. 16
    Crankson, S. ; Nazer, H. ; Jacobsson, B.
    Springer
    Published 1992
    Staff View
    ISSN:
    1432-1076
    Keywords:
    Gallbladder hydrops ; Ultrasonography ; Abdominal mass
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Acute hydrops of the gallbladder (AHGB) is a rare paediatric disease being diagnosed with increased frequency due to its association with other illnesses and the availability of ultrasonography. The symptoms and signs of AHGB include abdominal pain, vomiting, abdominal mass and/or tenderness. As these clinical features mimic the more common surgical conditions such as acute appendicitis, intussusception and volvulus, some cases are still diagnosed only at laparotomy. diagnosis is established by ultrasonography of the abdomen demonstrating normal biliary ducts and a distended gallbladder without calculi or congenital malformation. The aetiology of acute hydrops of the gallbladder is unknown but may be multifactorial. Treatment varies from non-operative management to surgical intervention.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02113247

    Articles: DFG German National Licenses
  17. 17
    Jacobsson, B. ; Dalén, N. ; Tjörnstrand, B.
    Springer
    Published 1987
    Staff View
    ISSN:
    1432-5195
    Keywords:
    Ostearthritis ; Hip ; Aetiology ; Labour
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Résumé Pour savoir si les contraintes extérieures peuvent contribuer au déveleloppement de la coxarthrose, on a interrogé au sujet de leur métier 85 malades atteints de coxarthrose primitive ainsi que 262 malades urologiques masculins. L'importance de l'atteinte de leurs hanches a été appréciée sur les radiographies. Les malades présentant une coxarthrose avaient exercé plus fréquemment des travaux de force, avec soulèvement de poids lourds et pour beaucoup conduite de tracteurs. Nos résultats montrent que les efforts entraînés par les modes de vie et les métiers divers peuvent jouer un rôle dans l'apparitation de la coxarthrose.
    Notes:
    Summary To investigate whether environmentally associated stress may contribute to the development of coxarthrosis, 85 males with primary coxarthrosis and 262 male urological patients were questioned about their occupation, and their hips were graded radiologically. Patients with coxarthrosis had been more frequently exposed to heavy labour, heavy lifting, and much tractor driving. Our results indicate that environmentally associated stress, as reflected by a varied life style or occupation, may contribute to the development of coxarthrosis.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00271306

    Articles: DFG German National Licenses
  18. 18
    Dalen, N. ; Jacobsson, B.
    Springer
    Published 1985
    Staff View
    ISSN:
    1432-5195
    Keywords:
    Femoral head viability ; Femoral neck fractures ; Fracture displacement ; impaction ; Osteoporosis ; osteosynthesis ; Reoperation
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Résumé Ce travail compare deux groupes de malades présentant une fracture du col du fémur: 22 ayant dû être réopérés et 72 non. On a particulièrement étudié l'ostéoporose, le redéplacement de la fracture, la vitalité de la tête fémorale, la réduction avec compression peropératoire et le type d'ostéosynthèse: par un clou de Thornton ou trois broches de Scand. On a mis en évidence une différence significative (p〈0.01) entre les deux groupes en ce qui concerne l'ostéoporose, le redéplacement de la fracture et la vitalité de la tête du fémur. Les broches de Scand comparées aux clous de Thornton ont montré une tendance (p〈0.1) à déterminer moins de réinterventions. La compression ou l'absence de compression peropératoire n'ont entraîné aucune différence.
    Notes:
    Summary This investigation compares two groups of patients with fractures of the femoral neck: 22 required a further operation and 72 did not. Special attention was paid to osteoporosis, the displacement of the fracture, viability of the femoral head, operative impaction and osteosynthesis with a Thornton nail or three Scand hip pins. There was a significant (p〈0.01) difference between the two groups with regard to osteoporosis, fracture displacement and viability of the femoral head. Scand hip pins, as compared to Thornton nails, showed a tendency (p〈0.1) to need a smaller number of reoperations. Operative impaction compared with no impaction showed no difference.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00266509

    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1434-9949
    Keywords:
    Osteoarthritis ; Piroxicam ; Indometacin ; Suppositories ; Efficacy ; Side Effects
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Six orthopaedic clinics in Sweden made a comparison of the effects and side effects of Piroxicam (20mg) and Indometacin (100mg) suppositories in 261 patients with painful coxarthrosis on the waiting list for total hip replacement (THR). The study was designed as a single blind study over 4 weeks. Amount of pain and range of motion was registered before the trial and compared with findings after 4 weeks, including reported side effects. Both drugs gave satisfactory pain relief without any appreciable variation on weightbearing or at rest. On the other hand, the trial showed a significant difference (p=0.0033, Student's-test) between the two drugs as regards the frequency of side effects from the lower gastrointestinal tract, where piroxicam had a lower rate compared with indometacin. No serious complications occurred; 16 patients dropped out, 8 in each group.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02207081

    Articles: DFG German National Licenses
  20. 20
    Staff View
    ISSN:
    1439-0973
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Zusammenfassung Es wird von 70 männlichen Säuglingen mit klinisch manifesten, möglichen Erstinfektionen der Harnwege berichtet, die zwischen dem zweiten und zwölften Lebensmonat auftraten. Im Laufe der Untersuchungszeit lag die Häufigkeit scheinbar bei 1,2‰ der Geburten. Acht (11%) Säuglinge wiesen obstruktive Harnwegsanomalien auf und wurden bei den folgenden Untersuchungen nicht berücksichtigt. 51 der 62 Fälle ohne Obstruktionen wurden von zwei bis 12 Jahren verfolgt. Hohes Fieber und Reizbarkeit waren stark hervortretende Symptome. Eine Gedeihstörung wurde nur bei einem Kind beobachtet. Fieberanfälle traten häufig in dem Monat vor der ersten Urinuntersuchung auf und deuteten auf eine mögliche unerkannte Harnwegsinfektion (HWI) hin. Für 87% der Infektionen war E. coli ätiologisch verantwortlich. Eine Pyurie bestand bei 97% der Kinder. Auf die Schwierigkeiten der bakteriologischen Diagnostik von HWI bei Jungen im ersten Lebensjahr wird hingewiesen. Bei den meisten Fällen wurde die Konzentrationskapazität vorübergehend herabgesetzt. Die Harnstoff-N-Werte im Blut waren bei allen untersuchten Fällen normal. Eine Elimination der Bakterien wurde mit einer 10tägigen Behandlung erreicht. Mit einer Ausnahme traten die Rezidive bei 20% der Fälle innerhalb eines Jahres nach der Erstinfektion auf. Es wird daraus geschlossen, daß Jungen mit einer möglichen Erstinfektion innerhalb des ersten Lebensjahres nur ein halbes Jahr lang beobachtet werden müssen. Bei sechs Fällen wurden Narbenbildungen entweder sicher nachgewiesen oder vermutet; vier Fälle waren ohne ausgeprägten Reflux. Daraus kann geschlossen werden, daß das Risiko von Nierenparenchymzerstörung in dieser Altersgruppe hoch zu sein scheint, sogar wenn die Diagnose frühzeitig gestellt wird und es gelingt, die Bakterien zu eliminieren. Eine Blasenausgangsstenose wurde bei sieben Patienten gefunden, doch es bestand keine Beziehung zum Reflux. Es wird vor chirurgischen Maßnahmen ohne dringenden Anlaß gewarnt, da dies zur andauernden und schwer zu behandelnden Infektion führen kann.
    Notes:
    Summary This study describes consecutive observations made on 70 boys with a symptomatic urinary tract infection occurring apparently for the first time with onset between the second and twelfth month of life. During the observation period the apparent frequency was 1.2 per 1,000 births. Eight cases (11%) had obstructive malformations and were excluded from the following analysis. Fifty-one of the 62 cases without obstruction were followed up for two to twelve years. High fever and irritability were conspicuous symptoms; “failure to thrive“ was seen in only one infant. Attacks of fever during the month preceeding the first urine examination were common and were possibly indicative of unrecognised urinary infection. E. coli caused 87% of the infections; pyuria was demonstrated in 97%. The difficulties in the bacteriological diagnosis of UTI in young boys are emphasized. A temporary decrease in the concentrating capacity was seen in most cases. The blood urea nitrogen concentration was normal in all cases investigated. Elimination of bacteriuria was achieved easily with ten days' treatment. Recurrences occurred in 20% and within a year of the first infection except in one case. It is concluded that follow-up for one year may be sufficient in males with an apparent first infection during the first year of life. Scarring was confirmed or strongly suspected in six cases (10%), four without gross reflux. The risk of renal damage thus seems to be high in males of this age group even when diagnosis is made early on and bacteria are rapidly eliminated. Calcyceal cysts not seen at first examination appeared later in four patients. Narrowing of the outflow region of the bladder was seen in seven patients. There was no relation to reflux. We would warn against surgical intervention without strict indication as it may be followed by prolonged infection which is difficult to treat.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01639648

    Articles: DFG German National Licenses