Search Results - (Author, Cooperation:B. H. Ye)
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1Latest Papers from Table of Contents or Articles in PressC. Duy ; C. Hurtz ; S. Shojaee ; L. Cerchietti ; H. Geng ; S. Swaminathan ; L. Klemm ; S. M. Kweon ; R. Nahar ; M. Braig ; E. Park ; Y. M. Kim ; W. K. Hofmann ; S. Herzog ; H. Jumaa ; H. P. Koeffler ; J. J. Yu ; N. Heisterkamp ; T. G. Graeber ; H. Wu ; B. H. Ye ; A. Melnick ; M. Muschen
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-05-20Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: ADP-Ribosylation Factor 1/metabolism ; Animals ; Cell Survival/drug effects ; DNA-Binding Proteins/biosynthesis/deficiency/genetics/*metabolism ; *Drug Resistance, Neoplasm ; Fusion Proteins, bcr-abl/*antagonists & inhibitors ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug ; therapy/genetics/metabolism/*pathology ; Protein Kinase Inhibitors/*pharmacology/therapeutic use ; Transcription, Genetic ; Tumor Suppressor Protein p53/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressKuo, P.-Y., Jatiani, S. S., Rahman, A. H., Edwards, D., Jiang, Z., Ahr, K., Perumal, D., Leshchenko, V. V., Brody, J., Shaknovich, R., Ye, B. H., Parekh, S.
American Society of Hematology (ASH)
Published 2018Staff ViewPublication Date: 2018-05-18Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Lymphoid NeoplasiaPublished by: -
3Latest Papers from Table of Contents or Articles in PressShah, U. A., Chung, E. Y., Giricz, O., Pradhan, K., Kataoka, K., Gordon-Mitchell, S., Bhagat, T. D., Mai, Y., Wei, Y., Ishida, E., Choudhary, G. S., Joseph, A., Rice, R., Gitego, N., Parrish, C., Bartenstein, M., Goel, S., Mantzaris, I., Shastri, A., Derman, O., Binder, A., Gritsman, K., Kornblum, N., Braunschweig, I., Bhagat, C., Hall, J., Graber, A., Ratner, L., Wang, Y., Ogawa, S., Verma, A., Ye, B. H., Janakiram, M.
American Society of Hematology (ASH)
Published 2018Staff ViewPublication Date: 2018-10-05Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Lymphoid NeoplasiaPublished by: -
4Articles: DFG German National LicensesStaff View
ISSN: 0277-5387Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0162-0134Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesLiu, J.-G. ; Ye, B.-H. ; Zhang, Q.-L. ; Zou, X.-H. ; Zhen, Q.-X. ; Tian, X. ; Ji, L.-N.
Springer
Published 2000Staff ViewISSN: 1432-1327Keywords: Syntheses ; Enantiomeric ruthenium complexes ; DNA binding modes ; EnantioselectivitySource: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNotes: Δ - and Λ-[Ru(bpy)2(HPIP)](PF6)2 (Δ-1 and Λ-1; bpy =2,2′-bipyridine, HPIP=2-(2-hydroxyphenyl)imidazo[4,5-f][1,10]phenan-throline), Δ- and Λ-[Ru(bpy)2(HNAIP)](PF6)2 (Δ-2 and Λ-2; HNAIP=2-(2-hydroxy-1-naphthyl)imidazo[4,5-f][1,10]phenanthroline), Δ- and Λ-[Ru(bpy)2 (HNOIP)](PF6)2 (Δ-3 and Λ-3; HNOIP=2-(2-hydroxy-5-nitrophenyl)imidazo[4,5-f][1,10]phenanthroline), and Δ- and Λ-[Ru(bpy)2(DPPZ)](PF6)2 (Δ-4 and Λ-4; DPPZ=dipyridophenazine), have been synthesized. Binding behavior of these chiral complexes to calf thymus DNA (CT-DNA) has been investigated by electronic absorption, steady-state emission, and circular dichroism spectroscopies, as well as by viscosity measurements and equilibrium dialysis binding studies. Several points came from the results. (1) The DNA-binding properties were distinctly different for the [Ru(bpy)2L]2+ (L=HPIP, HNAIP, HNOIP) series of ruthenium(II) complexes, which indicates that the photophysical behavior of the complexes on binding to DNA can be modulated through ligand design. (2) Different binding rates of individual enantiomers of complexes 1 and 4 to DNA were observed through dialysis experiments. The Λ enantiomer bound more rapidly than the Δ enantiomer and their different intercalative binding geometries were suggested to be responsible. (3) Both Δ-2 and Λ-2 bound weakly to CT-DNA; Δ-2 may bind through a partial intercalation mode, whereas Λ-2 may bind in the DNA groove. (4) There was no noticeable enantioselectivity for complexes 1, 3, and 4 on binding to CT-DNA. Both of their enantiomers can intercalate into DNA base pairs. It is noted that Δ-3 and Λ-3 exhibited almost identical spectral changes on addition of CT-DNA, and a similar binding manner of the isomers to the double helix was proposed.Type of Medium: Electronic ResourceURL: