Search Results - (Author, Cooperation:B. A. Yankner)
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1Latest Papers from Table of Contents or Articles in PressC. Kang ; Q. Xu ; T. D. Martin ; M. Z. Li ; M. Demaria ; L. Aron ; T. Lu ; B. A. Yankner ; J. Campisi ; S. J. Elledge
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-09-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Aging/*genetics/metabolism ; Animals ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Autophagy/*genetics ; Brain/metabolism ; Cell Aging/*genetics ; Cell Cycle/genetics ; Cells, Cultured ; Cyclin-Dependent Kinase Inhibitor p16 ; *DNA Damage ; Fibroblasts ; GATA4 Transcription Factor/genetics/*metabolism ; Gene Expression Profiling ; Humans ; Inflammation/*genetics ; Interleukin-1alpha/genetics/metabolism ; Mice ; Mice, Inbred C57BL ; MicroRNAs/genetics/metabolism ; NF-kappa B/metabolism ; Phenotype ; Promoter Regions, Genetic ; Tumor Necrosis Factor Receptor-Associated Peptides and ; Proteins/genetics/metabolism ; Tumor Suppressor Protein p53/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressT. Lu ; L. Aron ; J. Zullo ; Y. Pan ; H. Kim ; Y. Chen ; T. H. Yang ; H. M. Kim ; D. Drake ; X. S. Liu ; D. A. Bennett ; M. P. Colaiacovo ; B. A. Yankner
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-03-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aged ; Aged, 80 and over ; Aging/genetics/*metabolism/pathology ; Alzheimer Disease/genetics/*metabolism/pathology ; Amyloid beta-Peptides/antagonists & inhibitors/toxicity ; Animals ; Autophagy ; Brain/cytology/metabolism/pathology ; Caenorhabditis elegans Proteins/metabolism ; Cell Death/genetics ; Cell Nucleus/metabolism ; Chromatin Immunoprecipitation ; Cognition ; DNA-Binding Proteins/metabolism ; Down-Regulation ; Frontotemporal Dementia/metabolism/pathology ; Gene Expression Regulation ; Humans ; Lewy Body Disease/metabolism/pathology ; Longevity ; Mice ; Mild Cognitive Impairment/metabolism ; Neurons/cytology/metabolism/pathology ; Neuroprotective Agents/metabolism ; *Oxidative Stress/genetics/physiology ; Phagosomes ; Repressor Proteins/deficiency/genetics/*metabolism ; Transcription Factors/metabolism ; Up-Regulation ; Wnt Signaling Pathway ; Young AdultPublished by: -
3Latest Papers from Table of Contents or Articles in PressF. Sun ; K. K. Park ; S. Belin ; D. Wang ; T. Lu ; G. Chen ; K. Zhang ; C. Yeung ; G. Feng ; B. A. Yankner ; Z. He
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-11-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Axons/pathology/*physiology ; Cell Growth Processes/genetics ; Gene Expression Regulation ; Mice ; Mice, Inbred C57BL ; Nerve Crush ; Nerve Regeneration/*physiology ; Optic Nerve/cytology/growth & development/pathology ; Optic Nerve Injuries/genetics/metabolism/pathology ; PTEN Phosphohydrolase/*deficiency/genetics ; Retinal Ganglion Cells/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Suppressor of Cytokine Signaling Proteins/*deficiency/geneticsPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2013-05-03Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aging/*physiology ; Animals ; Female ; Gonadotropin-Releasing Hormone/*metabolism ; Hypothalamus/*physiology ; I-kappa B Kinase/*metabolism ; Male ; NF-kappa B/*metabolismPublished by: -
5Articles: DFG German National LicensesStaff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralNotes: Several lines of evidence suggest that amyloid deposition in the brain contributes to neuronal degeneration in Alzheimer's disease (AD). In the AD brain, diffuse plaques composed mostly of amorphous β amyloid (Am-βA) are inert, whereas compact plaques composed of β amyloid fibrils (Fib-βA) are associated with neurodegenerative changes. The effects of these two types of amyloid were tested on primary rat hippocampal neurons. Fib-βA induced the formation of dystrophic neurites and caused neuronal cell death, whereas Am-βA was not toxic. In addition, Fib-βA caused synapse loss in the remaining viable neurons, whereas Am-βA did not significantly affect synapse number. We also examined the effects of amylin, the primary constituent of the amyloid fibrils that form in the pancreas in adult-onset diabetes. Amylin was toxic to rat and human insulin-producing islet cells in the concentration range of fibril formation. The relative toxic potencies of amylin peptides of different species correlated with their fibril-forming capacity. Soluble amylin was not toxic. The amyloid fibril-binding dye Congo red inhibited the toxicity of both βA and amylin. Congo red afforded protection against toxicity by a dual mechanism. When present during the phase of fibril polymerization, Congo red could inhibit fibril formation from some peptides. When added to preformed fibrils, Congo red bound to fibrils rendering them nontoxic. These results suggest that fibril formation is necessary for both βA and amylin toxicity. Congo red appears to be a general inhibitor of amyloid fibril toxicity and may therefore be a useful prototype for drugs targeted to the amyloid pathology of AD and adult-onset diabetes.Type of Medium: Electronic ResourceURL: