Search Results - (Author, Cooperation:B. A. Webb)

Showing 1 - 3 results of 3, query time: 0.12s Refine Results
  1. 1
    B. A. Webb ; F. Forouhar ; F. E. Szu ; J. Seetharaman ; L. Tong ; D. L. Barber
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-05-20
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Enzyme Activation ; Humans ; Microscopy, Electron, Transmission ; *Models, Molecular ; Mutation/genetics ; Neoplasms/*enzymology/genetics ; Phosphofructokinase-1/*chemistry/*genetics/ultrastructure ; Protein Structure, Tertiary ; Recombinant Proteins/chemistry/genetics/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Webb, B. A. ; Summers, M. D.
    Springer
    Published 1992
    Staff View
    ISSN:
    1420-9071
    Keywords:
    Hymenopteran endoparasites ; ecdysteroids ; developmental regulation ; virus replication ; polydnaviruses
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract During oviposition the endoparasitic waspCampoletis sonorensis, introduces a polydnavirus into parasitized insects where viral gene expression is required for endoparasite survival. The polydnavirus is integrated into wasp chromosomal DNA and replicates only in the ovary. Ecdysteroids regulate the developmental expression of many insect genes and may regulate polydnavirus replication. Direct verification of viral replication was performed by dot blot hybridization and by amplifying DNA sequences containing the viral integration site; this ‘junction’ fragment cannot be amplified from integrated virus. Thoracic ligations and in vitro ecdysteroid treatments of wasp ovaries support the hypothesis that polydnavirus DNA replication is regulated by ecdysteroid during parasite development.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01919157

    Articles: DFG German National Licenses
  3. 3
    Staff View
    ISSN:
    1432-136X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary Manduca sexta larvae accumulate large amounts of iron during their larval feeding period. When59Fe was fed to 5th instar larvae, it was evenly distributed among the hemolymph, gut and carcass until the cessation of feeding. By pupation 95% of the labelled iron was found in the fat body. In the adult a significant portion of this iron was found in flight muscle. Studies of the hemolymph disclosed two ironcontaining proteins. The first was composed of a single polypeptide chain of 80 kD, containing one atom of iron. This protein bound ionic iron in vitro and was able to transfer this iron to ferritin when incubated with fat body in vitro. Therefore, it appeared to serve a transport function. The second protein had a molecular weight of 490 kD with subunits of 24 and 26 kD and contained 220 μg of iron/mg protein. Its chemical and ultrastructural characteristics were those of ferritin. These studies demonstrate the presence of both a transport protein and a unique circulating ferritin inManduca sexta, the latter serving a storage function during development and possibly also a transport function.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00695327

    Articles: DFG German National Licenses