Search Results - (Author, Cooperation:A. Wessels)
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1Latest Papers from Table of Contents or Articles in PressR. Durst ; K. Sauls ; D. S. Peal ; A. deVlaming ; K. Toomer ; M. Leyne ; M. Salani ; M. E. Talkowski ; H. Brand ; M. Perrocheau ; C. Simpson ; C. Jett ; M. R. Stone ; F. Charles ; C. Chiang ; S. N. Lynch ; N. Bouatia-Naji ; F. N. Delling ; L. A. Freed ; C. Tribouilloy ; T. Le Tourneau ; H. LeMarec ; L. Fernandez-Friera ; J. Solis ; D. Trujillano ; S. Ossowski ; X. Estivill ; C. Dina ; P. Bruneval ; A. Chester ; J. J. Schott ; K. D. Irvine ; Y. Mao ; A. Wessels ; T. Motiwala ; M. Puceat ; Y. Tsukasaki ; D. R. Menick ; H. Kasiganesan ; X. Nie ; A. M. Broome ; K. Williams ; A. Johnson ; R. R. Markwald ; X. Jeunemaitre ; A. Hagege ; R. A. Levine ; D. J. Milan ; R. A. Norris ; S. A. Slaugenhaupt
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-08-11Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Body Patterning/genetics ; Cadherins/deficiency/*genetics/*metabolism ; Cell Movement/genetics ; Chromosomes, Human, Pair 11/genetics ; Female ; Humans ; Male ; Mice ; Mitral Valve/abnormalities/embryology/pathology/surgery ; Mitral Valve Prolapse/*genetics/*pathology ; Mutation/*genetics ; Pedigree ; Phenotype ; Protein Stability ; RNA, Messenger/genetics ; Zebrafish/genetics ; Zebrafish Proteins/genetics/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressZuur, M. A., Ghimire, S., Bolhuis, M. S., Wessels, A. M. A., van Altena, R., de Lange, W. C. M., Kosterink, J. G. W., Touw, D. J., van der Werf, T. S., Akkerman, O. W., Alffenaar, J. W. C.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-04-27Publisher: The American Society for Microbiology (ASM)Print ISSN: 0066-4804Electronic ISSN: 1098-6596Topics: BiologyMedicinePublished by: -
3Articles: DFG German National LicensesWESSELS, A. ; VERMEULEN, J. L. M. ; VIRÁGH, SZ. ; MOORMAN, A. F. M.
Oxford, UK : Blackwell Publishing Ltd
Published 1990Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0362-3319Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: SociologyType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesOosthoek, P.W. ; Gros, D. ; Mijnders, T.A.M. ; Wessels, A. ; Vermeulen, J.L.M. ; Moorman, A.F.M. ; Lamers, W.H.
Amsterdam : ElsevierStaff ViewISSN: 0309-1651Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0309-1651Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesBergwerff, M. ; Gittenberger-de Groot, A.C. ; Wisse, L. J. ; DeRuiter, M. C. ; Wessels, A. ; Martin, J. F. ; Olson, E. N. ; Kern, M. J.
Springer
Published 2000Staff ViewISSN: 1432-2307Keywords: Key words Paired-related homeobox ; Heart development ; Pharyngeal arch arteries ; Vascular matrixSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Prx1 (MHox) and Prx2 (S8) are non-clustered homeobox genes that are expressed in a complex, mostly mesenchyme-specific pattern throughout embryogenesis. The expression pattern and gene-targeted mice previously revealed a major role for Prx1 in skeletogenesis. In addition, specific and high expression of both Prx genes was reported in the developing cardiovascular system, predominantly in prospective connective tissues of the heart and in the great arteries and veins. We examined embryos of previously generated gene-targeted mice. Prx2-/- mutants were viable and did not show cardiovascular malformations. Intracardiac morphology of Prxl-/- and Prx1/Prx2-combined null mutants also appeared normal throughout development. However, the Prx1-/- and Prx1/Prx2 double-null mutants showed a vascular abnormality with an abnormal positioning and awkward curvature of the aortic arch in addition to a misdirected and elongated ductus arteriosus, and in two of seven combined mutants, an anomalous retro-oesophageal right subclavian artery. Generally, all great arteries appeared to run somewhat tortuously through the surrounding mesenchyme. The vascular histology and vessel wall thickness were normal in all mutants. Prx1-/- and Prx double-gene-targeted mice revealed similar spectra of vascular anomalies, but double mutants appeared to be more seriously affected. The current findings suggest that other genes may compensate for the lossof Prx in the heart, but, in contrast, our data support a role for Prx in the development of vascular and perivascular matrix.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary An inverted Y chromosome has been found at a very high frequency in a Muslim Indian community living in the Johannesburg-Witwatersrand area of the Transvaal Province of South Africa: 8 of 141 (5.7%) retrospectively identified Indian males had an inv(Y)(p11.2q11.23) and all were of the Muslim faith. The inversion was found in 22 of 72 (30.5%) prospectively studied normal Muslim Indian males. All the carriers of the inversion were Gujarati-speakers whose families migrated to the Transvaal from the Gujerat Province of India during the first half of this century. The origins of the ancestors of the individuals with inv(Y) were traced to a small village, Kholvad, near the city of Surat, and some neighbouring villages. The polymorphic frequency of the inv(Y) has probably been produced through random genetic drift in a reproductively isolated community, maintained by strict endogamous marriage customs based on religious and linguistic affiliations. There was no indication that the inverted Y was associated with any reproductive disadvantages.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesBredman, J. J. ; Wessels, A. ; Weijs, W. A. ; Korfage, J. A. M. ; Soffers, C. A. S. ; Moorman, A. F. M.
Springer
Published 1991Staff ViewISSN: 1573-6865Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary Human and rabbit masticatory muscles were analyzed immuno-and enzyme-histochemically using antibodies specific to ‘cardiac’ α, slow and fast myosin heavy chain isoforms. In human masseter, temporalis, and lateral pterygoid muscle ‘cardiac’ α myosin heavy chain is found in fibres that contain either fast, or fast and slow myosin heavy chain. In rabbit masseter, temporalis and digastric muscles, fibres are present that express ‘cardiac’ α myosin heavy chain either exclusively, or concomitantly with slow myosin heavy chain or fast myosin heavy chain. Our results demonstrate a much broader distribution of ‘cardiac’ α myosin heavy chain than hitherto recognized and these might explain in part the specific characteristics of masticatory muscles. The ‘cardiac’ α myosin heavy chain is only found in skeletal muscles originating from the cranial part of the embryo (including the heart muscle) suggesting that its expression might be determined by the developmental history of these muscles.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesWessels, A. ; Vermeulen, J. L. M. ; Virágh, S. Z. ; Kálmán, F. ; Lamers, W. H. ; Moorman, A. F. M.
New York, NY [u.a.] : Wiley-Blackwell
Published 1991Staff ViewISSN: 0003-276XKeywords: Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: MedicineNotes: The spatial distribution of α- and β-myosin heavy chain isoforms (MHCs) was investigated immunohistochemically in the embryonic human heart between the 4th and the 8th week of development. The development of the overall MHC isoform expression pattern can be outlined as follows: (1) In all stages examined, β-MHC is the predominant isoform in the ventricles and outflow tract (OFT), while α-MHC is the main isoform in the atria. In addition, α-MHC is also expressed in the ventricles at stage 14 and in the OFT from stage 14 to stage 19. This expression pattern is very reminiscent of that found in chicken and rat. (2) In the early embryonic stages the entire atrioventricular canal (AVC) wall expresses α-MHC whereas only the lower part expresses β-MHC. The separation of atria and ventricles by the fibrous annulus takes place at the ventricular margin of the AVC wall. Hence, the β-MHC expressing part of the AVC wall, including the right atrioventricular ring bundle, is eventually incorporated in the atria. (3) In the late embryonic stages (approx. 8 weeks of development) areas of α-MHC reappear in the ventricular myocardium, in particular in the subendocardial region at the top of the interventricular septum. These coexpressing cells are topographically related to the developing ventricular conduction system. (4) In the sinoatrial junction of all hearts examined α- and β-MHC coexpressing cells are observed. In the older stages these cells are characteristically localized at the periphery of the SA node.Additional Material: 8 Ill.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesWessels, A. ; Vermeulen, J. L. M. ; Virágh, S. Z. ; Kálmán, F. ; Morris, G. E. ; Man, Nguyen Thi ; Lamers, W. H. ; Moorman, A. F. M.
New York, NY [u.a.] : Wiley-Blackwell
Published 1990Staff ViewISSN: 0003-276XKeywords: Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: MedicineNotes: Using monoclonal antibodies against the M and B subunit isoforms of creatine kinase (CK) we have investigated their distribution in developing human skeletal and cardiac muscle immunohistochemically. It is demonstrated that in skeletal muscle, a switch from CK-B to CK-M takes place around the week 8 of development, whereas in the developing heart, CK-M is the predominant isoform from the earliest stage examined onward (i.e., 4½ weeks of development). In all hearts examined, local differences in concentration of the CK isoforms are observed. The CK-M expression in the developing outflow tract (OFT) and conduction system is described in detail. Between the weeks 5 and 7 of development, the distal portion of the OFT is characterized by low CK-M expression, whereas around the week 8-10 of development the myocardium around the developing semilunar valves in the OFT expresses a very high level of CK-M. At all stages examined, a relatively low CK-M level is observed in those regions in which the “slow” components of the conduction system do develop (e.g., the sinoatrial junction and atrioventricular junction), whereas a relatively high concentration of CK-M is observed in those areas that are destined to become the “fast” components, i.e., the subendocardial myocardium of the ventricles. The high expression of CK-M in the developing “fast components” of the conduction system contrasts with the relatively low expression of CK-M in the force-producing myocardium of the interventricular septum and free ventricular wall.Additional Material: 10 Ill.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesWessels, A. ; Vermeulen, J. L. M. ; Verbeek, F. J. ; Virágh, S. Z. ; Kálmán, F. ; Lamers, W. H. ; Moorman, A. F. M.
New York, NY [u.a.] : Wiley-Blackwell
Published 1992Staff ViewISSN: 0003-276XKeywords: Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: MedicineNotes: A monoclonal antibody raised against an extract from the Ganglion Nodosum of the chick and designated GIN2 proves to bind specifically to a subpopulation of cardiomyocytes in the embryonic human heart. In the youngest stage examined (Carnegie stage 14, i. e., 4 1/2 weeks of development) these GIN2-expressing cells are localized in the myocardium that surrounds the foramen between the embryonic left and right ventricle. In the lesser curvature of the cardiac loop this “primary” ring occupies the lower part of the wall of the atrioventricular canal. During subsequent development, GIN2-expressing cells continue to identify the entrance to the right ventricle, but the shape of the ring changes as a result of the tissue remodelling that underlies cardiac septation. During the initial phases of this process the staining remains recognizable as a continuous band of cells in the myocardium that surrounds the developing right portion of the atrioventricular canal, subendocardially in the developing interventricular septum and around the junction of the embryonic left ventricle with the subaortic portion of the outflow tract. During the later stages of cardiac septation, the latter part of the ring discontinues to express GIN2, while upon the completion of septation, no GIN2-expressing cardiomyocytes can be detected anymore. The topographic distribution pattern of GIN suggests that the definitive ventricular conduction system derives from a ring of cells that initially surrounds the “primary” interventricular foramen. The results indicate that the atrioventricular bundle and bundle branches develop from GIN2-expressing myocytes in the interventricular septum, while the “compact” atrioventricular node develops at the junction of the band of GIN2-positive cells in the right atrioventricular junction (the right atrioventricular ring bundle) and the (“pentrating”) atrioventricular bundle. A “dead-end tract” represents remnants of conductive tissue in the anterior part of the top of the interventricular septum. The location of the various components of the avian conduction system is topographically homologous with that of the GIN2-ring in the human embryonic heart, indicating a phylogentically conserved origin of the conduction system in vertebrates.Additional Material: 10 Ill.Type of Medium: Electronic ResourceURL: