Search Results - (Author, Cooperation:A. Wald)
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1Latest Papers from Table of Contents or Articles in PressSilver, S. A., Saragosa, M., Adhikari, N. K., Bell, C. M., Harel, Z., Harvey, A., Kitchlu, A., Neyra, J. A., Wald, R., Jeffs, L.
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-06-17Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Renal medicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressJ. Zhu ; T. Peng ; C. Johnston ; K. Phasouk ; A. S. Kask ; A. Klock ; L. Jin ; K. Diem ; D. M. Koelle ; A. Wald ; H. Robins ; L. Corey
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-05-10Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; CD8-Positive T-Lymphocytes/cytology/*immunology ; Clone Cells/cytology/immunology ; Herpes Genitalis/*immunology/virology ; Herpesvirus 2, Human/*immunology ; Humans ; Immunologic Memory/immunology ; *Immunologic Surveillance ; Receptors, Antigen, T-Cell, alpha-beta/immunology/metabolism ; Skin/*cytology/*immunologyPublished by: -
3Latest Papers from Table of Contents or Articles in PressSchiffer, J. T., Swan, D. A., Roychoudhury, P., Lund, J. M., Prlic, M., Zhu, J., Wald, A., Corey, L.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-08-21Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
4Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract— The relationship between sodium ion (Na+) influx and vol. flow of fluid into the cerebral ventricles was measured during ventriculocisternal perfusion with sucrose solutions of various concentrations. The vol. flow of fluid into the ventricles of cats varied linearly from 0 to 90 μl/min with sucrose solutions of 6 to 780 mOsm/l. In the vol. flow range of 0 to 35 μl/min, Na+ influx was essentially constant independent of vol. flow rate with a mean value of 6.95 μEq/min. In the vol. flow range of 25 to 90 μl/min, Na+ influx increased linearly with flow rate. Under all conditions, Na+ influx was greater than that corresponding to newly formed fluid with a normal spinal fluid Na+ concentration. The virtual Na+ concentration of nascent fluid was effectively infinite when vol. flow was zero and had an asymptotic minimum value of 109 mEq/l as vol. flow increased above normal. These results demonstrate that Na+ influx into the ventricles may occur by diffusion from the surrounding brain and also with vol. flow of nascent fluid.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Anorectal disorders, such as faecal incontinence, defecation difficulty and conditions associated with anorectal pain, are commonly encountered in the practices of gastroenterologists, urogynaecologists and colorectal surgeons. The evaluation of these disorders has been very much improved by the development and wider availability of diagnostic tests, such as manometry, endo-anal ultrasound, static and dynamic pelvic magnetic resonance imaging and electromyography. After briefly reviewing the normal anatomy and physiology of the anorectum, the pathophysiology and diagnostic approaches to faecal incontinence, defecation disorders and functional anorectal pain are discussed. Until recently, the management of these disorders has been largely anecdotal. However, our therapeutic armamentarium has been expanded by pharmacological agents, such as nitrates, calcium channel blockers and botulinum toxin, as well as the development of novel techniques, such as sacral nerve stimulation. These and other pharmacological, behavioural and surgical approaches are reviewed with respect to the robustness of evidence to support their efficacy in patients with these disorders.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0019-1035Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-2307Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0931-8658Topics: EconomicsDescription / Table of Contents: Statistik und BevölkerungslehreNotes: EinzelbesprechungenURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0931-8658Topics: EconomicsURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0931-8658Topics: EconomicsURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0931-8658Topics: EconomicsDescription / Table of Contents: Statistik und BevölkerungslehreNotes: EinzelbesprechungenURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-1106Keywords: CSF bulk flow ; CSF osmolality ; Brain water content ; Ventriculocisternal perfusion ; Acetazolamide and CSF formationSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The effects of ventricular fluid osmolality on the bulk flow of nascent fluid into the cerebral ventricles of anesthetized cats was measured during ventriculocisternal perfusion. This nascent fluid consists of both cerebrospinal fluid (CSF) and fluid which results from an osmotic gradient between ventricular fluid and the blood and/or brain. Perfusions were carried out with both mock CSF and with solutions containing either sucrose, urea, or NaCl. Differences between the normal bulk flow rate of nascent CSF and bulk flow rate measured during perfusion with anisotonic solutions were linearly related to corresponding differences in osmolality of the effluent fluid from the ventricles. The coefficients of osmotic flow using sucrose (0.231 μl/min per mOsm) and NaCl (0.224) were similar, and greater than that using urea (0.156). During perfusion with sucrose when effluent osmolality increased by 200 mOsm (63% of normal), bulk flow rate of nascent fluid increased by 50 μl/min (200% of normal). Flow was undetectable when the effluent osmolality was 190 mOsm (decrease of 135 mOsm), although osmotically active particles continued to enter the ventricular system. Intravenous injection of acetazolamide reduced these coefficients to similar values of 0.0963 for NaCl, and 0.0955 for urea. In all experimental conditions no changes were found in cerebral water content. These results suggest that the increased bulk flow which occurs during perfusion with hypertonic solutions originates from the choroid plexus.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-1807Source: Springer Online Journal Archives 1860-2000Topics: MathematicsType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesReisch, R. ; Tintner, G. ; Bilimovič, A. ; Fraser, L. M. ; Fubini, R. ; Mossé, R. ; Machlup, F. ; Wagner, V. F. ; Knoblich, A. ; Veit, O. ; Kuffler, E. ; Steindl, J. ; Cabiati, A. ; Rizzi, H. ; Harsin, P. ; Zassenhaus, H. ; Goetz-Girey, R. ; Roll, E. ; Winkler, W. ; Nusko, H. ; Smith, Vera C. ; Varga, St. ; Giretti, E. ; Dolinski, N. W. ; Wald, A.
Springer
Published 1937Staff ViewISSN: 1617-7134Source: Springer Online Journal Archives 1860-2000Topics: EconomicsType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1617-7134Source: Springer Online Journal Archives 1860-2000Topics: EconomicsType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesFossati, E. ; Lovasy, G. ; Bode, K. ; Nurkse, R. ; Tintner, G. ; Papi, G. U. ; Pflug, General O. ; Lederer, M. ; Anderson, O. ; Wald, A. ; Simon, W. ; Schiff, E. ; Fischer, G.
Springer
Published 1937Staff ViewISSN: 1617-7134Source: Springer Online Journal Archives 1860-2000Topics: EconomicsType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesEinaudi, L. ; Egner, E. ; Lovasy, G. ; Steindl, J. ; Röpke, W. ; Peter, H. ; Josephy, B. ; Ellis, Howard S. ; Brunner, O. ; Mitić, M. ; Anderson, O. ; Wald, A. ; Tintner, G. ; Fischer, G.
Springer
Published 1936Staff ViewISSN: 1617-7134Source: Springer Online Journal Archives 1860-2000Topics: EconomicsType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1617-7134Source: Springer Online Journal Archives 1860-2000Topics: EconomicsType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1573-2649Keywords: Cross-cultural ; genital herpes ; health-related quality of life ; reliability ; validationSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract A disease-specific measure was needed for use in an international clinical trial to evaluate an investigational drug for genital herpes. A new measure was developed initially in the UK and translated and adapted for use in France, Italy, Germany, Denmark, Spain and the USA. This paper describes the translation and adaptation of the USA measure. It also describes the assessment of internal consistency, reproducibility, content validity, and construct validity (convergent and discriminant) of the measure. Two outcome measures of the final genital herpes-specific measure were developed: (1) a 21-item symptoms subscale; and (2) a 20-item HRQOL subscale. Each measure was scored and analyzed separately; the psychometric testing discussed in this paper refers to the HRQOL subscale only. The internal consistency of the HRQOL subscale is high (r=0.93), as is the reproducibility measured with a two week interval (r=0.85). Convergent validity is moderate to high. (Fleming Self-Regard subscale,r=0.48; SF-36 Social Functioning dimensionr=0.59; SF-36 Mental Health dimensionr=0.50). The number of herpes outbreaks in the past year was a significant predictor of scores on the HRQOL subscale (0–1 outbreaks, mean=82.1; 2+ outbreaks, mean=72.1,p=0.058) suggesting discriminant validity. The measure is currently in a phase III clinical trial including anti-viral therapy where the question of responsiveness can be addressed.Type of Medium: Electronic ResourceURL: