Search Results - (Author, Cooperation:A. W. Purcell)
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1Latest Papers from Table of Contents or Articles in PressP. T. Illing ; J. P. Vivian ; N. L. Dudek ; L. Kostenko ; Z. Chen ; M. Bharadwaj ; J. J. Miles ; L. Kjer-Nielsen ; S. Gras ; N. A. Williamson ; S. R. Burrows ; A. W. Purcell ; J. Rossjohn ; J. McCluskey
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-06-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Antigen Presentation/*drug effects ; Autoimmunity/*drug effects/*immunology ; Binding Sites ; Blood Donors ; CD8-Positive T-Lymphocytes/drug effects/immunology ; Carbamazepine/pharmacology ; Dideoxynucleosides/*pharmacology ; Drug Hypersensitivity ; HLA-B Antigens/chemistry/*immunology ; Humans ; Models, Molecular ; Protein Conformation ; Syndrome ; T-Lymphocytes/*drug effects/*immunologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressB. Gerlach ; S. M. Cordier ; A. C. Schmukle ; C. H. Emmerich ; E. Rieser ; T. L. Haas ; A. I. Webb ; J. A. Rickard ; H. Anderton ; W. W. Wong ; U. Nachbur ; L. Gangoda ; U. Warnken ; A. W. Purcell ; J. Silke ; H. Walczak
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-04-02Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; CD40 Ligand/metabolism ; Carrier Proteins/chemistry/metabolism ; Cell Line ; Humans ; I-kappa B Kinase/metabolism ; Immunity/*immunology ; Inflammation/*metabolism/pathology/prevention & control ; Interleukin-1beta/metabolism ; Mice ; Multiprotein Complexes/chemistry/metabolism ; NF-kappa B/metabolism ; Nerve Tissue Proteins/chemistry/genetics/metabolism ; Phenotype ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Receptors, Tumor Necrosis Factor/deficiency/genetics/metabolism ; *Signal Transduction ; Skin/cytology/immunology/metabolism/pathology ; Tumor Necrosis Factor-alpha/deficiency/genetics ; Ubiquitin/chemistry/metabolism ; Ubiquitin-Protein Ligase Complexes/chemistry/metabolism ; Ubiquitin-Protein Ligases/chemistry/metabolism ; *UbiquitinationPublished by: -
3Latest Papers from Table of Contents or Articles in PressL. Kjer-Nielsen ; O. Patel ; A. J. Corbett ; J. Le Nours ; B. Meehan ; L. Liu ; M. Bhati ; Z. Chen ; L. Kostenko ; R. Reantragoon ; N. A. Williamson ; A. W. Purcell ; N. L. Dudek ; M. J. McConville ; R. A. O'Hair ; G. N. Khairallah ; D. I. Godfrey ; D. P. Fairlie ; J. Rossjohn ; J. McCluskey
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-10-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Antigen Presentation ; Bacterial Infections/immunology/microbiology ; Binding Sites ; Cell Line ; Crystallography, X-Ray ; Folic Acid/chemistry/immunology/*metabolism ; Histocompatibility Antigens/chemistry/immunology ; Histocompatibility Antigens Class I/*chemistry/*immunology/metabolism ; Humans ; Immunologic Surveillance/immunology ; Jurkat Cells ; Ligands ; Lymphocyte Activation ; Models, Molecular ; Protein Refolding/drug effects ; Pterins/*chemistry/*immunology/metabolism/pharmacology ; Salmonella/immunology/metabolism ; Salmonella Infections/immunology/microbiology ; Static Electricity ; T-Lymphocytes/*immunology ; beta 2-Microglobulin/immunology/metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressRowntree, L. C., Nguyen, T. H. O., Halim, H., Purcell, A. W., Rossjohn, J., Gras, S., Kotsimbos, T. C., Mifsud, N. A.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-06-05Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
5Articles: DFG German National LicensesGORDON, T. P. ; KINOSHITA, G. ; CAVILL, D. ; KEECH, C. ; FARRIS, A. D. ; KAUFMAN, K. ; McCLUSKEY, J. ; PURCELL, A. W.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Intermolecular spreading of humoral autoimmunity to different components of the Ro (SS-A) and La (SS-B) ribonucleoprotein (RNP) complex has been reported following immunization with a single component of the complex. Although the immune response to the immunizing antigen is polyclonal and diversified, little is known about the specificity of the recruited autoimmune responses to the endogenous Ro and La antigens which drive B-cell spreading. To determine the specificity of intermolecular spreading to La, we examined sera from 52 kDa Ro (Ro52)- and 60 kDa Ro (Ro60)-immunized C3H/HeJ mice for reactivity with recombinant fragments spanning endogenous mouse (m)La by enzyme-linked immunosorbent assay (ELISA) and immunoblotting. Sera from mice primed and boosted with recombinant Ro52 and Ro60 showed reactivity restricted to the COOH-terminal fragment of mLa (aa361–415). The recruited anti-La response was species-specific, cross-reacting weakly with the corresponding region on the human La molecule, and was abrogated by the preabsorption of the Ro-immune sera with mLa 361–415. Analogous experiments using recombinant mRo60 fragments spanning the mRo60 molecule revealed a similar pattern of oligoclonality in the specificity of anti-Ro60 autoimmunity following active immunization with La and Ro52. These results suggest that intermolecular–intrastructural T–B help is limiting in this model, and reveal unsuspected immunodominance of selected Ro–La epitopes in the spreading of the autoantibody response to these structures. The focusing of the recruited autoantibody response to these COOH-terminal regions of the Ro and La polypeptides may also reflect the surface accessibility of these regions in La–Ro RNP.Type of Medium: Electronic ResourceURL: