Search Results - (Author, Cooperation:A. Tandon)
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1Latest Papers from Table of Contents or Articles in PressD. Reich ; N. Patterson ; D. Campbell ; A. Tandon ; S. Mazieres ; N. Ray ; M. V. Parra ; W. Rojas ; C. Duque ; N. Mesa ; L. F. Garcia ; O. Triana ; S. Blair ; A. Maestre ; J. C. Dib ; C. M. Bravi ; G. Bailliet ; D. Corach ; T. Hunemeier ; M. C. Bortolini ; F. M. Salzano ; M. L. Petzl-Erler ; V. Acuna-Alonzo ; C. Aguilar-Salinas ; S. Canizales-Quinteros ; T. Tusie-Luna ; L. Riba ; M. Rodriguez-Cruz ; M. Lopez-Alarcon ; R. Coral-Vazquez ; T. Canto-Cetina ; I. Silva-Zolezzi ; J. C. Fernandez-Lopez ; A. V. Contreras ; G. Jimenez-Sanchez ; M. J. Gomez-Vazquez ; J. Molina ; A. Carracedo ; A. Salas ; C. Gallo ; G. Poletti ; D. B. Witonsky ; G. Alkorta-Aranburu ; R. I. Sukernik ; L. Osipova ; S. A. Fedorova ; R. Vasquez ; M. Villena ; C. Moreau ; R. Barrantes ; D. Pauls ; L. Excoffier ; G. Bedoya ; F. Rothhammer ; J. M. Dugoujon ; G. Larrouy ; W. Klitz ; D. Labuda ; J. Kidd ; K. Kidd ; A. Di Rienzo ; N. B. Freimer ; A. L. Price ; A. Ruiz-Linares
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Americas ; Asia ; Cluster Analysis ; Emigration and Immigration/*history/statistics & numerical data ; Gene Flow ; Genetics, Population ; History, Ancient ; Humans ; Indians, North American/*genetics/*history ; Models, Genetic ; *Phylogeny ; Polymorphism, Single Nucleotide/genetics ; SiberiaPublished by: -
2Latest Papers from Table of Contents or Articles in PressM. Meyer ; M. Kircher ; M. T. Gansauge ; H. Li ; F. Racimo ; S. Mallick ; J. G. Schraiber ; F. Jay ; K. Prufer ; C. de Filippo ; P. H. Sudmant ; C. Alkan ; Q. Fu ; R. Do ; N. Rohland ; A. Tandon ; M. Siebauer ; R. E. Green ; K. Bryc ; A. W. Briggs ; U. Stenzel ; J. Dabney ; J. Shendure ; J. Kitzman ; M. F. Hammer ; M. V. Shunkov ; A. P. Derevianko ; N. Patterson ; A. M. Andres ; E. E. Eichler ; M. Slatkin ; D. Reich ; J. Kelso ; S. Paabo
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-09-01Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Animals ; Base Sequence ; Fossils ; Gene Flow ; Gene Library ; *Genetic Variation ; Genome, Human/*genetics ; *Heterozygote ; Humans ; Molecular Sequence Data ; Neanderthals/*genetics ; Sequence Analysis, DNAPublished by: -
3Latest Papers from Table of Contents or Articles in PressK. Prufer ; F. Racimo ; N. Patterson ; F. Jay ; S. Sankararaman ; S. Sawyer ; A. Heinze ; G. Renaud ; P. H. Sudmant ; C. de Filippo ; H. Li ; S. Mallick ; M. Dannemann ; Q. Fu ; M. Kircher ; M. Kuhlwilm ; M. Lachmann ; M. Meyer ; M. Ongyerth ; M. Siebauer ; C. Theunert ; A. Tandon ; P. Moorjani ; J. Pickrell ; J. C. Mullikin ; S. H. Vohr ; R. E. Green ; I. Hellmann ; P. L. Johnson ; H. Blanche ; H. Cann ; J. O. Kitzman ; J. Shendure ; E. E. Eichler ; E. S. Lein ; T. E. Bakken ; L. V. Golovanova ; V. B. Doronichev ; M. V. Shunkov ; A. P. Derevianko ; B. Viola ; M. Slatkin ; D. Reich ; J. Kelso ; S. Paabo
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-12-20Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Africa ; Animals ; Caves ; DNA Copy Number Variations/genetics ; Female ; *Fossils ; Gene Flow/genetics ; Gene Frequency ; Genome/*genetics ; Heterozygote ; Humans ; Inbreeding ; Models, Genetic ; Neanderthals/classification/*genetics ; Phylogeny ; Population Density ; Siberia/ethnology ; Toe Phalanges/anatomy & histologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressA. G. Hinch ; A. Tandon ; N. Patterson ; Y. Song ; N. Rohland ; C. D. Palmer ; G. K. Chen ; K. Wang ; S. G. Buxbaum ; E. L. Akylbekova ; M. C. Aldrich ; C. B. Ambrosone ; C. Amos ; E. V. Bandera ; S. I. Berndt ; L. Bernstein ; W. J. Blot ; C. H. Bock ; E. Boerwinkle ; Q. Cai ; N. Caporaso ; G. Casey ; L. A. Cupples ; S. L. Deming ; W. R. Diver ; J. Divers ; M. Fornage ; E. M. Gillanders ; J. Glessner ; C. C. Harris ; J. J. Hu ; S. A. Ingles ; W. Isaacs ; E. M. John ; W. H. Kao ; B. Keating ; R. A. Kittles ; L. N. Kolonel ; E. Larkin ; L. Le Marchand ; L. H. McNeill ; R. C. Millikan ; A. Murphy ; S. Musani ; C. Neslund-Dudas ; S. Nyante ; G. J. Papanicolaou ; M. F. Press ; B. M. Psaty ; A. P. Reiner ; S. S. Rich ; J. L. Rodriguez-Gil ; J. I. Rotter ; B. A. Rybicki ; A. G. Schwartz ; L. B. Signorello ; M. Spitz ; S. S. Strom ; M. J. Thun ; M. A. Tucker ; Z. Wang ; J. K. Wiencke ; J. S. Witte ; M. Wrensch ; X. Wu ; Y. Yamamura ; K. A. Zanetti ; W. Zheng ; R. G. Ziegler ; X. Zhu ; S. Redline ; J. N. Hirschhorn ; B. E. Henderson ; H. A. Taylor, Jr. ; A. L. Price ; H. Hakonarson ; S. J. Chanock ; C. A. Haiman ; J. G. Wilson ; D. Reich ; S. R. Myers
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Africa, Western/ethnology ; African Americans/*genetics ; Alleles ; Amino Acid Motifs ; Base Sequence ; Chromosome Mapping ; Crossing Over, Genetic/*genetics ; Europe/ethnology ; European Continental Ancestry Group/genetics ; Evolution, Molecular ; Female ; Gene Frequency ; Genetics, Population ; Genome, Human/*genetics ; Genomics ; Haplotypes/genetics ; Histone-Lysine N-Methyltransferase/chemistry/genetics/metabolism ; Humans ; Male ; Molecular Sequence Data ; Pedigree ; Polymorphism, Single Nucleotide/genetics ; ProbabilityPublished by: -
5Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: Prolonged high-frequency orthodromic stimulation of superior cervical ganglia is known to result in increased acetylcholine (ACh) synthesis and ACh content after the period of stimulation. In a previous study, we provided evidence to suggest that adenosine acts as an extracellular signal to activate this increased ACh synthesis and we proposed that the source of that adenosine might be postsynaptic. Thus, the purpose of the present study was to test whether direct stimulation of the postganglionic nerves could affect ganglionic ACh content. Antidromic conditioning of ganglia (15 Hz, 45 min) did not affect significantly their ACh content. However, if ganglia were allowed a 15-min rest period after this antidromic conditioning, their ACh stores were increased by 20%; a similar increase was induced by 4-Hz stimulation before the rest period. During the 15-Hz antidromic stimulation, ACh release was not clearly increased above the basal level, suggesting that preganglionic nerve endings were not stimulated to an extent that could explain the increased ACh content. Orthodromic stimulation (5 Hz) of ganglia 15 min after they had been subjected to antidromic conditioning (15 Hz, 45 min) showed increased ACh release in comparison with that from control unconditioned ganglia. Moreover, the extra ACh released by the conditioned ganglia was quantitatively similar to the increase in the ACh stores, as if most, or all, of the additional ACh was released by preganglionic stimulation. If the antidromic conditioning and the rest period were done during perfusion with Ca2+-free medium, the ganglia did not accumulate extra ACh. The ACh content was also not changed if ganglia were conditioned in the absence of Ca2+ but rested with normal Ca2+. However, ACh content was increased by 23% when the antidromic stimulation was done with normal Ca2+ but the rest period was without Ca2+. To test the role of adenosine in this retrograde effect, the effect of nucleoside transport inhibitors was tested. Dipyridamole blocked the antidromic stimulation-induced increase, but nitrobenzylthioinosine did not. Overall, these results are consistent with the idea that a diffusible retrograde messenger activates ACh synthesis. The sensitivity to blockade by dipyridamole suggests that adenosine might be that signal.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: The present study was initiated to examine the effects of ATP on acetylcholine (ACh) synthesis. The exposure of superior cervical ganglia to ATP increased ACh stores by 25%, but this effect was also evident with ADP, AMP, and adenosine, but not with βγ-methylene ATP, a nonhydrolyzable analogue of ATP, or with inosine, the deaminated product of adenosine. Thus, we attribute the enhanced ACh content caused by ATP to the presence of adenosine derived from its hydrolysis by 5′-nucleotidase. The adenosine-induced increase of tissue ACh was not the consequence of an adenosine-induced decrease of ACh release. The extra ACh remained in the tissue for more than 15 min after the removal of adenosine, but it was not apparent when ganglia were exposed to adenosine in a Ca2+-free medium. Incorporation of radiolabelled choline into [3H]ACh was also enhanced in the presence of adenosine, suggesting an extracellular source of precursor. Moreover, the synthesis of radiolabelled forms of phosphorylcholine and phospholipid was not reduced in adenosine's presence, suggesting that the extra ACh was not likely derived from choline destined for phospholipid synthesis. Aminophylline did not prevent the adenosine effect to increase ACh content; this effect was blocked by dipyridamole, but not by nitrobenzylthioinosine (NBTI). In addition, two benzodiazepine stereoisomers known to inhibit stereoselectively the NBTI-resistant nucleoside transporter displayed a similar stereoselective ability to block the effect of adenosine. Together, these results argue that adenosine is transported through an NBTI-resistant nucleoside transporter to exert an effect on ACh synthesis. The extra ACh accumulated as a result of adenosine's action was releasable during subsequent preganglionic nerve stimulation, but not in the presence of vesamicol, a vesicular ACh transporter inhibitor. We conclude that the mobilization of ACh is enhanced as a result of adenosine pretreatment.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesTandon, A. ; Bachoo, M. ; Weldon, P. ; Polosa, C. ; Collier, B.
Oxford, UK : Blackwell Science Ltd
Published 1996Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: These experiments investigate the effect of block, by colchicine, of fast axonal transport in the cat's cervical sympathetic trunk (CST) on the superior cervical ganglion's choline acetyltransferase (ChAT) enzyme activity, acetylcholine (ACh) content, and ACh release. Electron microscopy on the segment of the CST exposed to colchicine 1 or 4 days earlier showed disappearance of microtubules and accumulation of vesicles and smooth membrane tubules but no disruption of the axonal cytomatrix. At 4 days following colchicine treatment, the number and size of synaptic boutons per grid square in the ganglion ipsilateral to the colchicine-treated CST were similar to those in the control ganglion. At 2 and 4 days following exposure of the CST to colchicine, ChAT activity in the ipsilateral ganglion was reduced to 76 ± 8 and 54 ± 6% of control values, respectively. ACh stores in the ganglia were also reduced (to 81 ± 6% of control values at 2 days and to 51 ± 5% of control values at 4 days). Ganglionic transmission and its sensitivity to blockade by hexamethonium during 2-Hz CST stimulation were not impaired at day 4 postcolchicine. ACh release evoked by 2-Hz stimulation of colchicine-treated axons was similar to release from untreated axons, despite the decrease in the ganglionic ACh content. In contrast, ACh release evoked by 20-Hz stimulation was depressed. The amount of ACh released during 5-Hz stimulation in the presence of vesamicol by the terminals of colchicine-treated axons was similar to that released by the terminals of untreated axons. These results suggest the following conclusions: (a) Colchicine-sensitive fast axonal transport contributes significantly to maintaining ChAT stores in preganglionic axon terminals. (b) The half-life of ChAT in sympathetic preganglionic terminals is ∼4 days. (c) One consequence of colchicine-induced block of axonal transport is a reduced ACh content of preganglionic nerve terminals. (d) This decrease in ACh content appears to be the result of a loss in a reserve transmitter pool, whereas the size of the readily releasable compartment is maintained.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesTakeuchi, T. ; Chang, Y.-L. ; Tandon, A. ; Bour, D. ; Corzine, S. ; Twist, R. ; Tan, M.
Woodbury, NY : American Institute of Physics (AIP)
Published 2002Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: We have achieved 160 A/cm2 threshold current density of a 1.21 μm InGaAs/GaAs quantum well (QW) laser grown under a very low As/III ratio. We investigated the As/III ratio dependence on the optical quality of InGaAs QWs grown with arsine and tertiarybutylarsine (TBA). We found that TBA allows us to grow high quality InGaAs QWs under a very low As/III ratio (∼3), while a higher As/III ratio (∼10) with arsine is necessary to obtain the similar quality QWs. This high quality InGaAs QW grown under the low As/III ratio leads to the realization of high quality InGaAsN QW which should be grown under a low As/III ratio and a high N/V ratio. © 2002 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesTandon, A. ; Collier, B. ; Zhang, Z. W. ; Feltz, P.
Oxford, UK : Blackwell Publishing Ltd
Published 1991Staff ViewISSN: 1365-2826Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Previous pharmacological studies with the pituitary gland have suggested that acetylcholine (ACh) might be involved in the regulation of intermediate lobe (IL) function. Whether ACh is endogenous to the IL cells or provided from an extrinsic source is unclear. The present experiments tested the possibility that the endocrine cells of the IL may be a source of ACh by measuring certain cholinergic markers in a primary culture of dissociated porcine cells. The endogenous ACh content was readily measurable in both the freshly dissociated IL cells and in 2- or 4-day primary cultures. Choline acetyltransferase activity was also measurable in the freshly dissociated and cultured IL cells and was reduced by 53% in the presence of a specific inhibitor, napthylvinylpyridine (50 μM). IL cells incubated in the presence of [14C]choline (1 μM) were able to synthesize [14C]ACh and the accumulation of the new ACh was inhibited by hemicholinium-3 (30 μM), a competitive inhibitor of high affinity choline uptake at cholinergic nerve terminals. In conclusion, these results demonstrate that the endocrine cells of the IL are capable of synthesizing and storing ACh.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0368-1874Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0921-4526Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0921-4526Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0167-2789Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesSrivastava, R. C. ; Madamwar, D. B. ; Sharma, R. K. ; Tandon, A. ; Bhise, S. B.
Springer
Published 1984Staff ViewISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary A new observation on theH. halobium cells is reported. It has been observed that when the cells are exposed to light a volume flow is observed through them. The magnitude of the light-induced volume flow depends on the intensity and wavelength of the exciting light and is also influenced by temperature. The phenomenon appears to be relevant to the physiology of the organism.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Zusammenfassung Nach Knochenverletzung beim Kaninchen kommt es im Blut zu einer drastischen Erhöhung der gesamten Lipide, freien Fettsäuren und des Cholesterols, während die Veränderungen des Serum-Phospholipids nur geringfügig ist. Die Erhöhung bleibt bis zum 9. Tag nach erfolgtem Knochenbruch.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1420-9136Source: Springer Online Journal Archives 1860-2000Topics: GeosciencesPhysicsNotes: Summary The crustal structure beneath the Himalayas has been investigated using body wave data from near earthquakes having epicentres over the Himalayas and recorded by the observatories situated over, or very near, the foothills of the mountains. A three-layered crustal model, without the top sedimentary layer, with velocities for theP wave group in Granite I, Granite II and the Basaltic layer as 5.48, 6.00 and 6.45 and for theS wave group as 3.33, 3.56 and 3.90 km/sec respectively, has been interpreted. The upper mantle velocity for theP wave has been observed to be 8.07 km/sec and for theS wave as 4.57 km/sec. Average thickness for the Granite I layer has been computed as 22.7 km, for the Granite II layer as 16.3 km and for the Basaltic layer as 18.7 km. Crustal and sub-crustal velocities indicate a lower trend under the mountain. A thicker crust has been obtained beneath the Himalayas.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1420-9136Source: Springer Online Journal Archives 1860-2000Topics: GeosciencesPhysicsNotes: Summary Experimental dispersion curves of short-period Love waves due to three small shocks in the Koyna region and recorded at Bombay have been compared with theoretical computed curves. The results indicate that the average thickness of the traps overlying the granitic basement is about 1.25 km.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1420-9136Source: Springer Online Journal Archives 1860-2000Topics: GeosciencesPhysicsNotes: Summary The stress drop and average dislocation of some earthquakes in the Indian sub-continent have been determined after deducing the relationship between the aftershock areaA, and the magnitudeM L of the main shock which is given by $$\log A = 0.89M_L - 2.67 for 5 \leqslant M_L \leqslant 7.$$ It has been found that the stress drop is considerably larger for the great Assam earthquake of 15 August, 1950, occurring near the continent-continent boundary of the Indian-Eurasian plates, compared to that of a similar magnitude earthquake in a continent-island are type collision boundary in the Pacific (near Japan). The stress drop in smaller events of comparative magnitude in different regions are, however, of the same order and thus do not bring out the distinguishing features of the source regions in different kinds of plate boundaries.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1435-1536Keywords: Charge-Transfer ; free radical ; nitrogen donorSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract Polymerization of methylmethacrylate (MMA) with aminoalcohols, namely ethanolamine (EA), diethanolamine (DEA) and triethanolamine (TEA) in the presence of carbontetrachloride (CCl4) has been investigated in the dimethylsulfoxide (DMSO) medium by employing a dilatometric technique. The rate of polymerization (R p) has been evaluated under the conditions $$\tfrac{{{\text{CCl}}4}}{{\left[ {{\text{amine}}} \right]}}〈 1$$ and 〉 1. The kinetic data reveal the possible participation of a charge-transfer complex in the polymerization reaction. In the absence of either CCl4 or amine, no polymerization of MMA was observed under the present experimental conditions. The polymerization of MMA was inhibited by hydroquinone, indicating a free radical initiation.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1432-1955Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Using aLitomosoides carinii adult antigen, time courses of antibody levels were followed by an ELISA inL. carinii, Dipetalonema viteae, Brugia malayi andB. pahangi infectedMastomys natalensis. Using various groups of infected animals, periods up to 400 days after infection were covered. InL. carinii infected Mastomys, antibodies were first detected 11 days p.i. and levels increased rapidly until day 40. Temporarily reduced levels about the beginning of patency were followed by increasing values until about 100 days p.i. Then the antibody content of the sera remained more or less constant until about 250 days p.i. although maximum levels were found at day 170. Thereafter, the antibody concentration in the sera declined slowly but high levels were still observed 390 days p.i. The antibody content was usually higher in animals with high microfilariae densities than in those with low microfilariae counts but relations could not be proven statistically. InD. viteae infected Mastomys, maximum antibody values were reached within the beginning of patency. Levels were not altered markedly until about 110 days p.i. Thereafter they decreased slightly but then remained constant until the end of the investigation period 350 days p.i. B. malayi infected animals showed a rapid increase of the antibody content in the sera; a maximum was reached by 20 days after the infection. Thereafter, somewhat constant levels were found for 4–5 months. After 200 days p.i. the antibody levels declined progressively, accompanied with increasing parasitaemia densities; after 380 days the levels reached about 2/3 of the maximum. However, despite this, no relation was found between the levels of parasitaemia and antibody in individual animals. InB. pahangi infections the main prepatent antibody increase occurred during week 5 p.i., when maximum values were observed. The beginning of patency and the early patency were accompanied with slightly declining antibody levels. From 150 days p.i. until the end of the investigation 400 days p.i., the antibody content of the sera was fairly constant.Type of Medium: Electronic ResourceURL: