Search Results - (Author, Cooperation:A. Singer)
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1Mezei, A. K., Pedersen, H. N., Sy, S., Regan, C., Mitchell-Foster, S. M., Byamugisha, J., Sekikubo, M., Armstrong, H., Rawat, A., Singer, J., Ogilvie, G. S., Kim, J. J., Campos, N. G.
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-06-13Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Global health, Screening (epidemiology)Published by: -
2K. L. Silver ; P. A. Singer
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-07-12Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Child ; *Child Development ; Humans ; Organizational Objectives ; Poverty ; United NationsPublished by: -
3A. Ulvestad ; A. Singer ; J. N. Clark ; H. M. Cho ; J. W. Kim ; R. Harder ; J. Maser ; Y. S. Meng ; O. G. Shpyrko
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-06-20Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
4M. F. Berger ; E. Hodis ; T. P. Heffernan ; Y. L. Deribe ; M. S. Lawrence ; A. Protopopov ; E. Ivanova ; I. R. Watson ; E. Nickerson ; P. Ghosh ; H. Zhang ; R. Zeid ; X. Ren ; K. Cibulskis ; A. Y. Sivachenko ; N. Wagle ; A. Sucker ; C. Sougnez ; R. Onofrio ; L. Ambrogio ; D. Auclair ; T. Fennell ; S. L. Carter ; Y. Drier ; P. Stojanov ; M. A. Singer ; D. Voet ; R. Jing ; G. Saksena ; J. Barretina ; A. H. Ramos ; T. J. Pugh ; N. Stransky ; M. Parkin ; W. Winckler ; S. Mahan ; K. Ardlie ; J. Baldwin ; J. Wargo ; D. Schadendorf ; M. Meyerson ; S. B. Gabriel ; T. R. Golub ; S. N. Wagner ; E. S. Lander ; G. Getz ; L. Chin ; L. A. Garraway
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-05-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Chromosome Breakpoints/radiation effects ; DNA Damage ; DNA Mutational Analysis ; Gene Expression Regulation, Neoplastic ; Genome, Human/*genetics ; Guanine Nucleotide Exchange Factors/*genetics/metabolism ; Humans ; Melanocytes/metabolism/pathology ; Melanoma/*genetics/pathology ; Mutagenesis/radiation effects ; Mutation/*genetics/radiation effects ; Oncogenes/genetics ; Sunlight/*adverse effects ; Ultraviolet Rays/adverse effectsPublished by: -
5P. Y. Collins ; V. Patel ; S. S. Joestl ; D. March ; T. R. Insel ; A. S. Daar ; W. Anderson ; M. A. Dhansay ; A. Phillips ; S. Shurin ; M. Walport ; W. Ewart ; S. J. Savill ; I. A. Bordin ; E. J. Costello ; M. Durkin ; C. Fairburn ; R. I. Glass ; W. Hall ; Y. Huang ; S. E. Hyman ; K. Jamison ; S. Kaaya ; S. Kapur ; A. Kleinman ; A. Ogunniyi ; A. Otero-Ojeda ; M. M. Poo ; V. Ravindranath ; B. J. Sahakian ; S. Saxena ; P. A. Singer ; D. J. Stein
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-07-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Global Health ; Humans ; Mental Disorders/economics/epidemiology/prevention & control ; Mental Health/*statistics & numerical data ; Substance-Related Disorders/economics/epidemiology ; World Health OrganizationPublished by: -
6Ikomi, A. ; Anson, K. ; Tiernan, C. ; Singer, A. ; Miller, R.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
7Staff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
8Mansell, M. E. ; Ho, L. ; Terry, G. ; Singer, A. ; Cuzick, J.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
9Staff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
10Staff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. A semiquantitative immunocytochemical study of natural killer (NK) cells in cervical mucosa was performed by the immuno-peroxidase technique using anti-Leu-7 and anti-Leu-11 monoclonal antibodies. NK cells were present in two of the five normal controls and five of six specimens showing human papillomavirus (HPV) infection. Of the 12 CIN studied, six were positive for both Leu-7 and Leu-11 staining and three were positive for Leu-11 alone. NK cells were found predominantly in the subepithelial stroma. The frequency and pattern of distribution of these cells were similar in all grades of CIN. The number of NK cells present was usually small but the degree of infiltration by Leu-11 positive cells was pronounced in two HPV infections and in one CIN 1. NK cells may have a role in surveillance against HPV infection and the development and progression of CIN.Type of Medium: Electronic ResourceURL: -
11TAY, S. K. ; JENKINS, D. ; MADDOX, P. ; CAMPION, M. ; SINGER, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1987Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. Multiple markers were used to count Langerhans’ cells in the cervix. In the normal cervix, thymocyte antigen (T6) and adenosine triphosphatase (ATPase) demonstrated the largest population of Langerhans’ cells. MHC Class II positive cells were equivalent to 60%, and S100 positive cells were equivalent to 35% of T6 or ATPase positive cells. Whereas Langerhans’ cells demonstrated by T6, ATPase, and MHC Class II antigen were evenly distributed throughout the epithelium, the S100 positive cells were seen predominantly near lymphocytic aggregates and capillaries. In human papillomavirus infection and cervical intraepithelial neoplasia the numbers of T6, ATPase, or MHC Class II positive Langerhans’ cells were reduced by 60% but the S100 positive cells were almost completely depleted. These findings suggested that there were different subpopulations of Langerhans’ cells in the cervical epithelium. The depletion of Langerhans’ cells, particularly the selective depletion of the S100 positive subpopulation, might cause a localized immunodeficiency that impairs immune surveillance and the cell-mediated immune response to human papillomavirus infection and cervical intraepithelial neoplasia.Type of Medium: Electronic ResourceURL: -
12McCANCE, D. J. ; CAMPION, M. J. ; CLARKSON, P. K. ; CHESTERS, P. M. ; JENKINS, D. ; SINGER, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1985Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. The frequency of human papillomavirus (HPV) type 16 in premalignant and malignant lesions of the cervix was investigated and compared with the detection of HPV type 6. In cervical intraepithelial neoplasia (CIN) grades I-III HPV 6 was detected in 28% and HPV 16 in 62% of patients whereas 90% of malignant lesions contained HPV 16 only. In the CIN lesions there was an increase in HPV 16 detection as the severity of disease increased while the level of detection of HPV 6 decreased. Only three (18%) of the cervices that were colposcnpically and histologically normal contained HPV genomes: although two of these three women had either a history of genital warts or a sexual partner with penile warts.Type of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Thirty patients with abnormal cervical cytology had a colposcopy during pregnancy. Their management during and after pregnancy is described and supports the contention that the introduction of a colposcopy service safely permits a greater selectivity in management without recourse to operative intervention during pregnancy. In one patient a preclinical invasive squamous carcinoma of the cervix was diagnosed by colposcopy, and in another three, in whom colposcopy could not exclude the presence of invasion, a wedge biopsy under anaesthesia and two punch biopsies without anaesthesia had to be performed. In the remaining 26 patients, the possibility of invasion could be excluded by colposcopy and further treatment deferred until after pregnancy.Type of Medium: Electronic ResourceURL: -
14CAMPION, M. J. ; BROWN, J. R. ; MCCANCE, D. J. ; ATIA, W. ; EDWARDS, R. ; CUZICK, J. ; SINGER, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1988Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. The psychosexual sequelae of diagnosis and treatment of pre-invasive cervical atypia were assessed in three groups of women. The first group included 30 women referred to a colposcopy clinic with an abnormal cervical smear indicating cervical intraepithelial neoplasia (CIN), the second comprised 50 women who were traced as sexual partners of men with penile human papillomavirus (HPV) infection; 26 of them had histologically proven cervical atypia and 24 had no such evidence. The third group included 25 women traced as partners of men with non-specific urethritis and who did not have cervical disease. Before and after questionnaires assessed six aspects of sexual behaviour and responses before diagnosis and 6 months after treatment in women with cervical atypia. These were compared with answers given by women investigated and treated, if necessary, as partners of men with sexually transmitted disease (control group). There were statistically significant adverse psychosexual sequelae associated with diagnosis and treatment of pre-invasive cervical epithelial disease.Type of Medium: Electronic ResourceURL: -
15RUSTIN, G. J. S. ; NEWLANDS, E. S. ; SOUTHCOTT, B. M. ; SINGER, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1987Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. Chemotherapy was given as initial therapy to 12 women with very advanced squamous cell carcinoma of the cervix and to 19 women with recurrent disease. They received a median of four courses of POMB which comprised vincristine 1.0 mg/m2 and methotrexate 300 mg/m2 followed by folinic acid rescue, bleomycin 30 mg as a 48-h infusion or intramuscular injection and cisplatin 100 mg/m2 as a 12-h infusion. Two of the 14 assessable patients with recurrent disease (14%) had a complete response with no disease found histologically in one, and seven (50%) had a partial response. Although the actuarial median survival of all 19 patients with recurrent disease was 8 months, five patients have remained free from tumour progression for a median of 17 months from start of chemotherapy. Six of the 10 assessable patients receiving initial chemotherapy (60%) had a complete response (confirmed histologically in two) and two (20%) had a partial response. Nine patients had additional treatment with radiotherapy and or surgery. Although only four of the patients remain disease-free at 61, 51, 7 and 4 months, all but two were initially FIGO stage IV. Although cisplatin-induced emesis is controllable and the side-effects of methotrexate can be avoided, the POMB regimen remains potentially toxic. The small number of patients with very advanced disease who are long-term survivors prompts us to study further the role of aggressive chemotherapy as the initial treatment of patients with visceral or nodal involvement from carcinoma of the cervix.Type of Medium: Electronic ResourceURL: -
16TAY, S. K. ; JENKINS, D. ; MADDOX, P. ; SINGER, A. ; HOGG, N.
Oxford, UK : Blackwell Publishing Ltd
Published 1987Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. Tissue macrophages in the uterine cervix were studied immunocytochemically with monoclonal antibody (MoAb) 3.9 which reacts with the majority of macrophages, and Ell which is specific for the C3b receptor, CR1. Samples from five normal women, six with human papillomavirus (HPV) infection and 10 with cervical intraepithelial neoplasia (CIN) were tested. A small population of MoAb 3.9 positive and only occasional MoAb Ell positive macrophages were found in the normal cervix. In HPV infection and CIN there was a significant infiltration of MoAb 3.9 positive and MoAb Ell positive macrophages in both the epithelium and the stroma. The pattern of infiltration in these groups of women suggests that these macrophages were most likely to be functioning as the first line of defence against the spread of the virus infection, either through a direct anti-virus mechanism or non-specific phagocytosis.Type of Medium: Electronic ResourceURL: -
17McCANCE, D. J. ; CLARKSON, P. K. ; DYSON, J. L. ; WALKER, P. G. ; SINGER, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1985Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. Five women with multifocal intraepithelial neoplasia of the lower genital tract were investigated for the presence of human papillomavirus (HPV) infection by the method of DNA-DNA hybridization which detects the viral DNA. The DNA sequences of HPV types 6 and 16 were detected in each of the five patients and in each of the areas biopsied: cervix, vagina and vulva. DNA sequences of both viral types were also found in vulval intraepithelial neoplasia grades I-III and in cervical intraepithelial neoplasia grades I and III. The detection of HPV DNAs in multifocal letions suggests a possible common aetiology for the lower genital tract intraepithelial neoplasias.Type of Medium: Electronic ResourceURL: -
18Staff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We compared the histological diagnoses of premalignant/malignant lesions of the cervix obtained examining colposcopically directed biopsy material from 201 outpatients with those obtained examining tissues from a subsequent, more extensive operative procedure. In all, 98 per cent of operative diagnoses were never more than one degree in advance of diagnoses made colposcopic biopsy. In all seven patients with invasive or microinvasive squamous carcinoma, the lesion Was suspect at colposcopy and confirmed directed biopsy.Type of Medium: Electronic ResourceURL: -
19JARMULOWICZ, M. R. ; JENKINS, D. ; BARTON, S. E. ; GOODALL, A. L. ; HOLLINGWORTH, A. ; SINGER, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1989Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. Quantitative histological study of 84 laser cone biopsies showed a highly significant correlation between the grade of a cervical smear and the size of the lesion for all grades of cervical intraepithelial neoplasia (CIN) (CIN 1 P= 0·004; CIN II P= 0·0001; C1N 111 P= 0·003; total CIN P〈 0·0001); 10 of 34 (29%) of women with CIN III and mild dyskaryosis or less had significantly smaller lesions than 23 of 36 (63%) of women with CIN III and moderate or severe dyskaryosis. Repeat cytology identified as severe dyskaryosis all those with large CIN III lesions. Lesion size has been neglected in studies of the natural history of CIN and in the assessment of cytological screening, but offers an explanation for the apparent discrepancies between cytological, colposcopic and histological assessment of progression of CIN.Type of Medium: Electronic ResourceURL: -
20BARTON, S. E. ; SINGER, A. ; JENKINS, D. ; HOLLINGWORTH, A. ; CUZICK, J.
Oxford, UK : Blackwell Publishing Ltd
Published 1989Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. False-negative cervical cytology due to sampling error is a well-recognized problem. Forty-seven women with histologically proven cervical intraepithelial neoplasia (CIN) were studied. All had two cervical smears performed at a mean interval of 3 months. At the time of the second smear, cervicography, colposcopy and biopsy were performed. The area of acctowhite cervical lesions and of the total visible atypical transformation zone (ATZ) were measurcd from the cervical photographs. The 17 women in whom one or both smears showed no dyskaryosis were found to have a significantly smaller proportion of their ATZ affected by CIN. It is suggested that this finding can account for the sampling error which causes false-negative cervical cytology. New screening techniques, such as cervicography, may offer a method of detecting and assessing these relatively smaller cervical lesions.Type of Medium: Electronic ResourceURL: