Search Results - (Author, Cooperation:A. R. Young)

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  1. 1
    M. Narita ; A. R. Young ; S. Arakawa ; S. A. Samarajiwa ; T. Nakashima ; S. Yoshida ; S. Hong ; L. S. Berry ; S. Reichelt ; M. Ferreira ; S. Tavare ; K. Inoki ; S. Shimizu
    American Association for the Advancement of Science (AAAS)
    Published 2011
    Staff View
    Publication Date:
    2011-04-23
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Amino Acids/metabolism ; Animals ; *Autophagy ; *Cell Aging ; Cell Line ; Cytoplasm/metabolism ; Cytoplasmic Vesicles/*metabolism/ultrastructure ; Endoplasmic Reticulum, Rough/ultrastructure ; Genes, ras ; Golgi Apparatus/ultrastructure ; HL-60 Cells ; Humans ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Lysosomes/metabolism/ultrastructure ; Mice ; Monomeric GTP-Binding Proteins/genetics/metabolism ; Nocodazole/pharmacology ; Phagosomes/metabolism/ultrastructure ; Phenotype ; Podocytes/metabolism/ultrastructure ; Protein Biosynthesis ; Proteins/*secretion ; TOR Serine-Threonine Kinases/*metabolism ; Vacuoles/ultrastructure ; trans-Golgi Network/metabolism/ultrastructure
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-07-12
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    0031-9007
    Electronic ISSN:
    1079-7114
    Topics:
    Physics
    Keywords:
    Nuclear Physics
    Published by:
    http://www.aps.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2014-07-22
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Core Binding Factor Alpha 2 Subunit/metabolism ; Cyclin-Dependent Kinases/antagonists & inhibitors ; Cysteine/metabolism ; Enzyme Inhibitors/*pharmacology ; Gene Expression Regulation, Neoplastic/*drug effects ; Humans ; Jurkat Cells ; Phenylenediamines/*pharmacology ; Phosphorylation/drug effects ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*enzymology ; Pyrimidines/*pharmacology
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2016-04-21
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; Brain/metabolism ; CRISPR-Cas Systems/genetics ; Enhancer Elements, Genetic/*genetics ; Epigenesis, Genetic/genetics ; *Gene Expression Regulation ; Genetic Engineering ; Genetic Predisposition to Disease/*genetics ; Genome, Human/genetics ; Homeodomain Proteins/metabolism ; Humans ; Models, Genetic ; Parkinson Disease/*genetics ; Pluripotent Stem Cells/metabolism ; Risk ; Transcription Factors/metabolism ; alpha-Synuclein/*genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2011-03-25
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Age of Onset ; Amino Acid Substitution ; Animals ; Animals, Genetically Modified ; Cell Transformation, Neoplastic/genetics ; Chromatin Immunoprecipitation ; Chromosomes, Human, Pair 1/genetics ; DNA Copy Number Variations/*genetics ; Disease Models, Animal ; Gene Amplification/*genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/genetics ; Genes, Homeobox/genetics ; Histone-Lysine N-Methyltransferase/*genetics/metabolism ; Humans ; Melanocytes/cytology/enzymology/metabolism/pathology ; Melanoma/enzymology/*genetics/*pathology ; Nevus/enzymology ; Oncogenes/genetics ; Protein Methyltransferases/*genetics/*metabolism ; Proto-Oncogene Proteins B-raf/chemistry/genetics/metabolism ; Zebrafish/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    Publication Date:
    2015-11-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Acetylation ; Alleles ; Allelic Imbalance ; Binding Sites ; DNA-Binding Proteins/*genetics ; Enhancer Elements, Genetic/*genetics ; Epigenomics ; GATA3 Transcription Factor/metabolism ; Gene Expression Regulation, Neoplastic/genetics ; Genetic Predisposition to Disease/*genetics ; Genome-Wide Association Study ; Genotype ; Histones/chemistry/metabolism ; Humans ; Introns/genetics ; LIM Domain Proteins/*genetics ; Lysine/metabolism ; Neuroblastoma/*genetics ; Organ Specificity ; Polymorphism, Single Nucleotide/*genetics ; Reproducibility of Results ; Transcription Factors/*genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  7. 7
    Staff View
    Publication Date:
    2016-01-07
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  8. 8
    K. E. Karlstrom ; J. Lee ; S. Kelley ; R. Crow ; R. A. Young ; I. Lucchitta ; L. S. Beard ; R. Dorsey ; J. W. Ricketts ; W. R. Dickinson ; L. Crossey
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-04-17
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  9. 9
    D. Hnisz ; A. S. Weintraub ; D. S. Day ; A. L. Valton ; R. O. Bak ; C. H. Li ; J. Goldmann ; B. R. Lajoie ; Z. P. Fan ; A. A. Sigova ; J. Reddy ; D. Borges-Rivera ; T. I. Lee ; R. Jaenisch ; M. H. Porteus ; J. Dekker ; R. A. Young
    American Association for the Advancement of Science (AAAS)
    Published 2016
    Staff View
    Publication Date:
    2016-03-05
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    *Chromosome Aberrations ; Chromosome Mapping ; *Gene Expression Regulation, Leukemic ; HEK293 Cells ; Humans ; Mutation ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*genetics ; Proto-Oncogenes/*genetics ; *Sequence Deletion ; Transcriptional Activation ; *Translocation, Genetic
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  10. 10
    M. R. Mansour ; B. J. Abraham ; L. Anders ; A. Berezovskaya ; A. Gutierrez ; A. D. Durbin ; J. Etchin ; L. Lawton ; S. E. Sallan ; L. B. Silverman ; M. L. Loh ; S. P. Hunger ; T. Sanda ; R. A. Young ; A. T. Look
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-11-15
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Acetylation ; Base Sequence ; Basic Helix-Loop-Helix Transcription Factors/*genetics ; Binding Sites ; Cell Line, Tumor ; *DNA, Intergenic ; *Enhancer Elements, Genetic ; *Gene Expression Regulation, Neoplastic ; Histones/metabolism ; Humans ; *INDEL Mutation ; Molecular Sequence Data ; *Mutation ; Oncogenes ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*genetics ; Protein Interaction Domains and Motifs ; Proto-Oncogene Proteins/*genetics ; Proto-Oncogene Proteins c-myb/metabolism
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  11. 11
    A. A. Sigova ; B. J. Abraham ; X. Ji ; B. Molinie ; N. M. Hannett ; Y. E. Guo ; M. Jangi ; C. C. Giallourakis ; P. A. Sharp ; R. A. Young
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-10-31
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Base Sequence ; Binding Sites ; Cell Line ; Consensus Sequence ; DNA/metabolism ; Embryonic Stem Cells/metabolism ; *Enhancer Elements, Genetic ; *Gene Expression Regulation ; Mice ; *Promoter Regions, Genetic ; RNA, Messenger/*metabolism ; *Transcription, Genetic ; YY1 Transcription Factor/*metabolism
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  12. 12
    Staff View
    Publication Date:
    2016-01-30
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Animals, Genetically Modified ; Carcinogenesis/*genetics ; Embryonic Stem Cells/metabolism ; Enhancer Elements, Genetic ; *Gene Expression Regulation, Developmental ; *Gene Expression Regulation, Neoplastic ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Melanocytes/metabolism ; Melanoma/*genetics ; Melanoma, Experimental/*genetics ; Mutation ; Nerve Tissue Proteins/genetics ; Neural Crest/*metabolism ; Proto-Oncogene Proteins B-raf/genetics ; SOXE Transcription Factors/genetics ; Skin Neoplasms/*genetics ; Tumor Suppressor Protein p53/genetics ; *Zebrafish ; Zebrafish Proteins/genetics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  13. 13
    W. A. Whyte ; S. Bilodeau ; D. A. Orlando ; H. A. Hoke ; G. M. Frampton ; C. T. Foster ; S. M. Cowley ; R. A. Young
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-02-03
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Cell Differentiation/*genetics ; Embryonic Stem Cells/*cytology/*metabolism ; Enhancer Elements, Genetic/*genetics ; Fibroblasts ; *Gene Silencing ; Histone Demethylases ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Mice ; Oxidoreductases, N-Demethylating/antagonists & inhibitors/*metabolism ; Promoter Regions, Genetic/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  14. 14
    Staff View
    Publication Date:
    2011-03-25
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Amino Acid Substitution ; Animals ; Animals, Genetically Modified ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Lineage/drug effects ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic ; Genes, p53/genetics ; Humans ; Isoxazoles/pharmacology/therapeutic use ; Melanoma/drug therapy/enzymology/*genetics/*pathology ; Mice ; Neural Crest/drug effects/*enzymology/metabolism/pathology ; Oxidoreductases Acting on CH-CH Group Donors/antagonists & inhibitors/*metabolism ; Proto-Oncogene Proteins B-raf/antagonists & ; inhibitors/chemistry/genetics/metabolism ; Rats ; Stem Cells/cytology/drug effects/pathology ; *Transcription, Genetic/drug effects/physiology ; Xenograft Model Antitumor Assays ; Zebrafish/embryology/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  15. 15
    Staff View
    Publication Date:
    2018-05-11
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Geosciences
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  16. 16
    Savin, D. W. ; Gardner, L. D. ; Reisenfeld, D. B. ; Young, A. R. ; Kohl, J. L.

    [S.l.] : American Institute of Physics (AIP)
    Published 1995
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    A technique has been developed to determine the absolute single particle counting efficiency of a channel electron multiplier (CEM) for positively charged ions at keV energies. The calibration technique is applicable to positive ion detectors in general. Ion beam currents of C2+ were created by charge transfer of C3+ on H2 in the thin target regime. By adjusting the H2 pressure in the beam scattering chamber from 10−10 to 10−6 Torr, C2+ currents could be created either low enough to be detected by the CEM in the particle counting mode or high enough to be measured as a current using the CEM as a Faraday cup. The CEM counting efficiency was determined by comparing the C2+ count rate to the C2+ current, scaling by the change in H2 pressure, and also scaling by the incident C3+ current for each C2+ measurement. This method, which effectively uses the charge transfer cross section as a "transfer standard,'' allows the CEM counting efficiency to be determined in situ and to be monitored accurately over extended periods of time. The calibration requires that only the relative, not the absolute, pressure change be known. The technique does not require the value of the charge transfer cross section to be known. The accuracy of the calibration technique for the present results was 10% at a confidence level considered to be equivalent to a statistical 90% confidence level. For the present work, the peak counting efficiency of a Galileo 4039 CEM for 32.5 keV C2+ ions was determined to be 96%. © 1995 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.1146531

    Articles: DFG German National Licenses
  17. 17
    Gardner, L. D. ; Kohl, J. L. ; Lafyatis, G. P. ; Young, A. R. ; Chutjian, A.

    [S.l.] : American Institute of Physics (AIP)
    Published 1986
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    An inclined beams apparatus for the measurement of absolute cross sections for dielectronic recombination between free electrons and singly or multiply charged ions is described. The collision products, a photon and a lower-charge-state ion, are detected in delayed coincidence. Measurements of dielectronic recombination in C3+ are described to illustrate the use of the apparatus and techniques. Verification of the calibrations and operation of the apparatus is demonstrated through measurements of charge transfer and electron impact excitation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.1138694

    Articles: DFG German National Licenses
  18. 18
    Young, A. R. ; Appelt, S. ; Ben-Amar Baranga, A. ; Erickson, C. ; Happer, W.

    Woodbury, NY : American Institute of Physics (AIP)
    Published 1997
    Staff View
    ISSN:
    1077-3118
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    We present detailed images of the Rb polarization in a high-pressure optical pumping cell. Images taken at high magnetic field strengths ((approximate)37 G) yield precise information on the relative occupation probability of the hyperfine Zeeman sublevels. Low-field (≤4 G) images yield very high resolution (less than 1 mm) maps of the spatial distribution of the Rb polarization. For optical pumping in the presence of high-pressure buffer gases, the measured populations of the hyperfine magnetic sublevels are shown to be well described by a spin temperature, even though the Rb–Rb spin exchange rate is much smaller than the rates of optical pumping or electron-randomizing Rb–Xe collisions in the buffer gas. © 1997 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.119097

    Articles: DFG German National Licenses
  19. 19
    Smith, H. R. ; Kelly, D. A. ; Young, A. R. ; Basketter, D. B. ; McFadden, J. P.

    Oxford, UK : Blackwell Science, Ltd
    Published 2002
    Staff View
    ISSN:
    1600-0536
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Contact dermatitis shows significant interindividual variation. We studied the relationship between an individual's irritant threshold and the elicitation of experimentally induced allergic sensitization. The results suggest that there is an association between reactivity to an irritant and the likelihood of positive elicitation reactions to lower hapten concentrations. This novel finding would be compatible with the proposal that contact allergy is best explained using a danger model with cutaneous irritancy determining sensitization. However, the enhanced allergic reactivity of individuals with a lower irritant threshold was not apparent on visual inspection, suggesting that the determinants of skin reactivity to haptens are multifactorial.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1034/j.1600-0536.2002.460207.x

    Articles: DFG German National Licenses
  20. 20
    Zaidman, M. D. ; Keller, V. ; Young, A. R. ; Wall, A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 2003
    Staff View
    ISSN:
    1747-6593
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Energy, Environment Protection, Nuclear Power Engineering
    Notes:
    Low-flow frequency analysis techniques are robust only where the flow record is relatively long and the flow regime is known to be stationary over time. If applied to short-period flow records. low-flow frequency analysis can give poor or misleading results. This paper examines the effectiveness of data-transfer methods for improving the characterisation of low-flow frequency relationships for gauged sites with flow records of less than fifteen years.Two transfer methods were considered. In each case the sequence of annual minimum flows from an analogue catchment was used to provide extra information about the sequence of flows at the site of interest. Transposing the standardised probability distribution function of annual minima between analogue sites worked where their flow records were highly correlated. However, better results were obtained where recurrence intervals for observations at the subject site were estimated from recurrence intervals for the same years in the analogue record.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1747-6593.2003.tb00437.x

    Articles: DFG German National Licenses