Search Results - (Author, Cooperation:A. R. Morgan)

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  1. 1
    L. Jostins ; S. Ripke ; R. K. Weersma ; R. H. Duerr ; D. P. McGovern ; K. Y. Hui ; J. C. Lee ; L. P. Schumm ; Y. Sharma ; C. A. Anderson ; J. Essers ; M. Mitrovic ; K. Ning ; I. Cleynen ; E. Theatre ; S. L. Spain ; S. Raychaudhuri ; P. Goyette ; Z. Wei ; C. Abraham ; J. P. Achkar ; T. Ahmad ; L. Amininejad ; A. N. Ananthakrishnan ; V. Andersen ; J. M. Andrews ; L. Baidoo ; T. Balschun ; P. A. Bampton ; A. Bitton ; G. Boucher ; S. Brand ; C. Buning ; A. Cohain ; S. Cichon ; M. D'Amato ; D. De Jong ; K. L. Devaney ; M. Dubinsky ; C. Edwards ; D. Ellinghaus ; L. R. Ferguson ; D. Franchimont ; K. Fransen ; R. Gearry ; M. Georges ; C. Gieger ; J. Glas ; T. Haritunians ; A. Hart ; C. Hawkey ; M. Hedl ; X. Hu ; T. H. Karlsen ; L. Kupcinskas ; S. Kugathasan ; A. Latiano ; D. Laukens ; I. C. Lawrance ; C. W. Lees ; E. Louis ; G. Mahy ; J. Mansfield ; A. R. Morgan ; C. Mowat ; W. Newman ; O. Palmieri ; C. Y. Ponsioen ; U. Potocnik ; N. J. Prescott ; M. Regueiro ; J. I. Rotter ; R. K. Russell ; J. D. Sanderson ; M. Sans ; J. Satsangi ; S. Schreiber ; L. A. Simms ; J. Sventoraityte ; S. R. Targan ; K. D. Taylor ; M. Tremelling ; H. W. Verspaget ; M. De Vos ; C. Wijmenga ; D. C. Wilson ; J. Winkelmann ; R. J. Xavier ; S. Zeissig ; B. Zhang ; C. K. Zhang ; H. Zhao ; M. S. Silverberg ; V. Annese ; H. Hakonarson ; S. R. Brant ; G. Radford-Smith ; C. G. Mathew ; J. D. Rioux ; E. E. Schadt ; M. J. Daly ; A. Franke ; M. Parkes ; S. Vermeire ; J. C. Barrett ; J. H. Cho
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-11-07
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Colitis, Ulcerative/genetics/immunology/microbiology/physiopathology ; Crohn Disease/genetics/immunology/microbiology/physiopathology ; Genetic Predisposition to Disease/*genetics ; Genome, Human/genetics ; *Genome-Wide Association Study ; Haplotypes/genetics ; *Host-Pathogen Interactions/genetics/immunology ; Humans ; Inflammatory Bowel Diseases/*genetics/immunology/*microbiology/physiopathology ; Mycobacterium/*immunology/pathogenicity ; Mycobacterium Infections/genetics/microbiology ; Mycobacterium tuberculosis/immunology/pathogenicity ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Reproducibility of Results
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Abbasakoor, F. ; Beynon, A. R. Morgan J. ; Carr, N. D.
    Springer
    Published 1998
    Staff View
    ISSN:
    1432-1262
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s003840050133

    Articles: DFG German National Licenses
  3. 3
    P. Bailey ; D. K. Chang ; K. Nones ; A. L. Johns ; A. M. Patch ; M. C. Gingras ; D. K. Miller ; A. N. Christ ; T. J. Bruxner ; M. C. Quinn ; C. Nourse ; L. C. Murtaugh ; I. Harliwong ; S. Idrisoglu ; S. Manning ; E. Nourbakhsh ; S. Wani ; L. Fink ; O. Holmes ; V. Chin ; M. J. Anderson ; S. Kazakoff ; C. Leonard ; F. Newell ; N. Waddell ; S. Wood ; Q. Xu ; P. J. Wilson ; N. Cloonan ; K. S. Kassahn ; D. Taylor ; K. Quek ; A. Robertson ; L. Pantano ; L. Mincarelli ; L. N. Sanchez ; L. Evers ; J. Wu ; M. Pinese ; M. J. Cowley ; M. D. Jones ; E. K. Colvin ; A. M. Nagrial ; E. S. Humphrey ; L. A. Chantrill ; A. Mawson ; J. Humphris ; A. Chou ; M. Pajic ; C. J. Scarlett ; A. V. Pinho ; M. Giry-Laterriere ; I. Rooman ; J. S. Samra ; J. G. Kench ; J. A. Lovell ; N. D. Merrett ; C. W. Toon ; K. Epari ; N. Q. Nguyen ; A. Barbour ; N. Zeps ; K. Moran-Jones ; N. B. Jamieson ; J. S. Graham ; F. Duthie ; K. Oien ; J. Hair ; R. Grutzmann ; A. Maitra ; C. A. Iacobuzio-Donahue ; C. L. Wolfgang ; R. A. Morgan ; R. T. Lawlor ; V. Corbo ; C. Bassi ; B. Rusev ; P. Capelli ; R. Salvia ; G. Tortora ; D. Mukhopadhyay ; G. M. Petersen ; D. M. Munzy ; W. E. Fisher ; S. A. Karim ; J. R. Eshleman ; R. H. Hruban ; C. Pilarsky ; J. P. Morton ; O. J. Sansom ; A. Scarpa ; E. A. Musgrove ; U. M. Bailey ; O. Hofmann ; R. L. Sutherland ; D. A. Wheeler ; A. J. Gill ; R. A. Gibbs ; J. V. Pearson ; A. V. Biankin ; S. M. Grimmond
    Nature Publishing Group (NPG)
    Published 2016
    Staff View
    Publication Date:
    2016-02-26
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Carcinoma, Pancreatic ; Ductal/classification/genetics/immunology/metabolism/pathology ; Cell Line, Tumor ; DNA Methylation ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Genes, Neoplasm/*genetics ; Genome, Human/*genetics ; *Genomics ; Hepatocyte Nuclear Factor 3-beta/genetics ; Hepatocyte Nuclear Factor 3-gamma/genetics ; Histone Demethylases/genetics ; Homeodomain Proteins/genetics ; Humans ; Mice ; Mutation/*genetics ; Nuclear Proteins/genetics ; Pancreatic Neoplasms/*classification/*genetics/immunology/metabolism/pathology ; Prognosis ; Receptors, Cytoplasmic and Nuclear/genetics ; Survival Analysis ; Trans-Activators/genetics ; Transcription Factors/genetics ; Transcription, Genetic ; Transcriptome ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Proteins/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    N. Waddell ; M. Pajic ; A. M. Patch ; D. K. Chang ; K. S. Kassahn ; P. Bailey ; A. L. Johns ; D. Miller ; K. Nones ; K. Quek ; M. C. Quinn ; A. J. Robertson ; M. Z. Fadlullah ; T. J. Bruxner ; A. N. Christ ; I. Harliwong ; S. Idrisoglu ; S. Manning ; C. Nourse ; E. Nourbakhsh ; S. Wani ; P. J. Wilson ; E. Markham ; N. Cloonan ; M. J. Anderson ; J. L. Fink ; O. Holmes ; S. H. Kazakoff ; C. Leonard ; F. Newell ; B. Poudel ; S. Song ; D. Taylor ; S. Wood ; Q. Xu ; J. Wu ; M. Pinese ; M. J. Cowley ; H. C. Lee ; M. D. Jones ; A. M. Nagrial ; J. Humphris ; L. A. Chantrill ; V. Chin ; A. M. Steinmann ; A. Mawson ; E. S. Humphrey ; E. K. Colvin ; A. Chou ; C. J. Scarlett ; A. V. Pinho ; M. Giry-Laterriere ; I. Rooman ; J. S. Samra ; J. G. Kench ; J. A. Pettitt ; N. D. Merrett ; C. Toon ; K. Epari ; N. Q. Nguyen ; A. Barbour ; N. Zeps ; N. B. Jamieson ; J. S. Graham ; S. P. Niclou ; R. Bjerkvig ; R. Grutzmann ; D. Aust ; R. H. Hruban ; A. Maitra ; C. A. Iacobuzio-Donahue ; C. L. Wolfgang ; R. A. Morgan ; R. T. Lawlor ; V. Corbo ; C. Bassi ; M. Falconi ; G. Zamboni ; G. Tortora ; M. A. Tempero ; A. J. Gill ; J. R. Eshleman ; C. Pilarsky ; A. Scarpa ; E. A. Musgrove ; J. V. Pearson ; A. V. Biankin ; S. M. Grimmond
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-02-27
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adenocarcinoma/drug therapy/genetics ; Animals ; Carcinoma, Pancreatic Ductal/drug therapy/genetics ; *DNA Mutational Analysis ; DNA Repair/genetics ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Markers/genetics ; Genome, Human/*genetics ; Genomic Instability/genetics ; *Genomics ; Genotype ; Humans ; Mice ; Mutation/*genetics ; Pancreatic Neoplasms/classification/drug therapy/*genetics ; Platinum/pharmacology ; Point Mutation/genetics ; Poly(ADP-ribose) Polymerase Inhibitors ; Xenograft Model Antitumor Assays
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    A. V. Biankin ; N. Waddell ; K. S. Kassahn ; M. C. Gingras ; L. B. Muthuswamy ; A. L. Johns ; D. K. Miller ; P. J. Wilson ; A. M. Patch ; J. Wu ; D. K. Chang ; M. J. Cowley ; B. B. Gardiner ; S. Song ; I. Harliwong ; S. Idrisoglu ; C. Nourse ; E. Nourbakhsh ; S. Manning ; S. Wani ; M. Gongora ; M. Pajic ; C. J. Scarlett ; A. J. Gill ; A. V. Pinho ; I. Rooman ; M. Anderson ; O. Holmes ; C. Leonard ; D. Taylor ; S. Wood ; Q. Xu ; K. Nones ; J. L. Fink ; A. Christ ; T. Bruxner ; N. Cloonan ; G. Kolle ; F. Newell ; M. Pinese ; R. S. Mead ; J. L. Humphris ; W. Kaplan ; M. D. Jones ; E. K. Colvin ; A. M. Nagrial ; E. S. Humphrey ; A. Chou ; V. T. Chin ; L. A. Chantrill ; A. Mawson ; J. S. Samra ; J. G. Kench ; J. A. Lovell ; R. J. Daly ; N. D. Merrett ; C. Toon ; K. Epari ; N. Q. Nguyen ; A. Barbour ; N. Zeps ; N. Kakkar ; F. Zhao ; Y. Q. Wu ; M. Wang ; D. M. Muzny ; W. E. Fisher ; F. C. Brunicardi ; S. E. Hodges ; J. G. Reid ; J. Drummond ; K. Chang ; Y. Han ; L. R. Lewis ; H. Dinh ; C. J. Buhay ; T. Beck ; L. Timms ; M. Sam ; K. Begley ; A. Brown ; D. Pai ; A. Panchal ; N. Buchner ; R. De Borja ; R. E. Denroche ; C. K. Yung ; S. Serra ; N. Onetto ; D. Mukhopadhyay ; M. S. Tsao ; P. A. Shaw ; G. M. Petersen ; S. Gallinger ; R. H. Hruban ; A. Maitra ; C. A. Iacobuzio-Donahue ; R. D. Schulick ; C. L. Wolfgang ; R. A. Morgan ; R. T. Lawlor ; P. Capelli ; V. Corbo ; M. Scardoni ; G. Tortora ; M. A. Tempero ; K. M. Mann ; N. A. Jenkins ; P. A. Perez-Mancera ; D. J. Adams ; D. A. Largaespada ; L. F. Wessels ; A. G. Rust ; L. D. Stein ; D. A. Tuveson ; N. G. Copeland ; E. A. Musgrove ; A. Scarpa ; J. R. Eshleman ; T. J. Hudson ; R. L. Sutherland ; D. A. Wheeler ; J. V. Pearson ; J. D. McPherson ; R. A. Gibbs ; S. M. Grimmond
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-10-30
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Axons/*metabolism ; Carcinoma, Pancreatic Ductal/*genetics/*pathology ; Gene Dosage ; Gene Expression Regulation, Neoplastic ; Genome/*genetics ; Humans ; Kaplan-Meier Estimate ; Mice ; Mutation ; Pancreatic Neoplasms/*genetics/*pathology ; Proteins/genetics ; Signal Transduction
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Islet beta cells ; cytokines ; interleukin 1 ; tumour necrosis factor ; interferon gamma ; DNA damage
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The cytokines, interleukin 1, tumour necrosis factor, and interferon gamma are cytotoxic to islet beta cells, however, their mechanisms of beta-cell killing are not fully characterized. Since DNA damage is a mechanism of cytokine-induced cell death in some cell types, we sought evidence for cytotoxic effects of cytokines at a nuclear level in islet beta cells by measuring DNA fragmentation in rat islets and islet beta-cell lines. The individual cytokines, interleukin 1 (10 U/ml), tumour recrosis factor (103 U/ml) and interferon gamma (103 U/ml) inhibited insulin release from rat islets, but did not cause DNA fragmentation or destroy islet cells; by contrast, combination of the three cytokines induced DNA fragmentation and islet-cell death. Cytokine-induced DNA fragmentation preceded cell lysis in islet beta-cell lines (RINm5F, rat insulinoma cells; and NIT-1, NOD/Lt mouse transgenic beta cells), whereas in non-islet cell lines (GH-3, rat pituitary; and PC-12, rat adrenal) the cytokines induced cell lysis and no or late DNA fragmentation. Nicotinamide prevented both DNA fragmentation and destruction of RINm5F islet cells by the cytokines. These findings identify DNA as an early target of cytokine action in islet beta cells, and implicate DNA fragmentation as a mechanism of cytokine-induced beta-cell destruction.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00404328

    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Key words Islet beta cells, cytokines, interleukin 1, tumour necrosis factor, interferon gamma, DNA damage.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The cytokines, interleukin 1, tumour necrosis factor, and interferon gamma are cytotoxic to islet beta cells, however, their mechanisms of beta-cell killing are not fully characterized. Since DNA damage is a mechanism of cytokine-induced cell death in some cell types, we sought evidence for cytotoxic effects of cytokines at a nuclear level in islet beta cells by measuring DNA fragmentation in rat islets and islet beta-cell lines. The individual cytokines, interleukin 1 (10 U/ml), tumour recrosis factor (103 U/ml) and interferon gamma (103 U/ml) inhibited insulin release from rat islets, but did not cause DNA fragmentation or destroy islet cells; by contrast, combination of the three cytokines induced DNA fragmentation and islet-cell death. Cytokine-induced DNA fragmentation preceded cell lysis in islet beta-cell lines (RINm5F, rat insulinoma cells; and NIT-1, NOD/Lt mouse transgenic beta cells), whereas in non-islet cell lines (GH-3, rat pituitary; and PC-12, rat adrenal) the cytokines induced cell lysis and no or late DNA fragmentation. Nicotinamide prevented both DNA fragmentation and destruction of RINm5F islet cells by the cytokines. These findings identify DNA as an early target of cytokine action in islet beta cells, and implicate DNA fragmentation as a mechanism of cytokine-induced beta-cell destruction. [Diabetologia (1994) 37: 733–738]
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001250050172

    Articles: DFG German National Licenses
  8. 8
    Kössel, H. ; Büchi, H. ; Jacob, T. M. ; Morgan, A. R. ; Narang, S. A. ; Ohtsuka, E. ; Wells, R. D. ; Khorana, H. G.

    Weinheim : Wiley-Blackwell
    Published 1969
    Staff View
    ISSN:
    0044-8249
    Keywords:
    Chemistry ; General Chemistry
    Source:
    Wiley InterScience Backfile Collection 1832-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1002/ange.19690810922

    Articles: DFG German National Licenses