Search Results - (Author, Cooperation:A. R. Atkins)
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1J. M. Suh ; J. W. Jonker ; M. Ahmadian ; R. Goetz ; D. Lackey ; O. Osborn ; Z. Huang ; W. Liu ; E. Yoshihara ; T. H. van Dijk ; R. Havinga ; W. Fan ; Y. Q. Yin ; R. T. Yu ; C. Liddle ; A. R. Atkins ; J. M. Olefsky ; M. Mohammadi ; M. Downes ; R. M. Evans
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Blood Glucose/metabolism ; Body Weight/drug effects ; Diabetes Mellitus, Experimental/drug therapy/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Diet, High-Fat ; Dose-Response Relationship, Drug ; Fibroblast Growth Factor 1/administration & dosage/adverse effects/*pharmacology ; Glucose/*metabolism ; Glucose Tolerance Test ; Humans ; Insulin/*metabolism ; Insulin Resistance ; Liver/drug effects/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Mitogens/pharmacology ; Muscle, Skeletal/drug effects/metabolism ; Receptor, Fibroblast Growth Factor, Type 1/metabolismPublished by: -
2J. W. Jonker ; J. M. Suh ; A. R. Atkins ; M. Ahmadian ; P. Li ; J. Whyte ; M. He ; H. Juguilon ; Y. Q. Yin ; C. T. Phillips ; R. T. Yu ; J. M. Olefsky ; R. R. Henry ; M. Downes ; R. M. Evans
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-04-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adipocytes/drug effects/metabolism/pathology ; Animals ; Base Sequence ; Cell Size/drug effects ; Diabetes Mellitus, Experimental/chemically induced/genetics/pathology ; Diet, High-Fat/adverse effects ; Fibroblast Growth Factor 1/deficiency/*genetics/*metabolism ; *Homeostasis/drug effects ; Humans ; Inflammation/genetics ; Insulin/metabolism ; Insulin Resistance ; Intra-Abdominal Fat/drug effects/*metabolism/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Necrosis/enzymology ; PPAR gamma/*metabolism ; Promoter Regions, Genetic/genetics ; Response Elements/geneticsPublished by: -
3J. M. Suh ; J. W. Jonker ; M. Ahmadian ; R. Goetz ; D. Lackey ; O. Osborn ; Z. Huang ; W. Liu ; E. Yoshihara ; T. H. van Dijk ; R. Havinga ; W. Fan ; Y. Q. Yin ; R. T. Yu ; C. Liddle ; A. R. Atkins ; J. M. Olefsky ; M. Mohammadi ; M. Downes ; R. M. Evans
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-03-06Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
4S. P. Bapat ; J. Myoung Suh ; S. Fang ; S. Liu ; Y. Zhang ; A. Cheng ; C. Zhou ; Y. Liang ; M. LeBlanc ; C. Liddle ; A. R. Atkins ; R. T. Yu ; M. Downes ; R. M. Evans ; Y. Zheng
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-11-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adipose Tissue/*cytology/*immunology ; Aging/*immunology ; Animals ; Diabetes Mellitus, Type 2/metabolism ; Glucose/metabolism ; Inflammation/immunology/metabolism ; Insulin Resistance/*immunology ; Macrophages/immunology ; Male ; Metabolic Syndrome X/immunology/metabolism ; Mice ; Obesity/metabolism ; T-Lymphocytes, Regulatory/*cytology/*immunologyPublished by: -
5H. Cho ; X. Zhao ; M. Hatori ; R. T. Yu ; G. D. Barish ; M. T. Lam ; L. W. Chong ; L. DiTacchio ; A. R. Atkins ; C. K. Glass ; C. Liddle ; J. Auwerx ; M. Downes ; S. Panda ; R. M. Evans
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-03-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Biological Clocks/drug effects/genetics ; Circadian Rhythm/genetics/*physiology ; Cryptochromes/deficiency/genetics/metabolism ; *Energy Metabolism/genetics ; Feedback, Physiological ; Gene Expression Regulation ; Gene Regulatory Networks/genetics ; Homeostasis/genetics ; *Lipid Metabolism/genetics ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Sequence Data ; Motor Activity/genetics/physiology ; Nuclear Receptor Subfamily 1, Group D, Member 1/deficiency/genetics/*metabolism ; Period Circadian Proteins/deficiency/genetics/metabolism ; Receptors, Cytoplasmic and Nuclear/deficiency/genetics/*metabolism ; Repressor Proteins/deficiency/genetics/*metabolism ; Transcriptome/geneticsPublished by: -
6Staff View
ISSN: 0008-199XTopics: Linguistics and Literary StudiesURL: -
7Staff View
ISSN: 0008-199XTopics: Linguistics and Literary StudiesNotes: REVIEWSURL: -
8Staff View
ISSN: 0008-199XTopics: Linguistics and Literary StudiesNotes: REVIEWSURL: -
9Staff View
ISSN: 0008-199XTopics: Linguistics and Literary StudiesNotes: REVIEWSURL: -
10Staff View
ISSN: 0307-1847Topics: Political ScienceURL: -
11Staff View
ISSN: 1432-1254Source: Springer Online Journal Archives 1860-2000Topics: GeographyPhysicsType of Medium: Electronic ResourceURL: -
12Mitchell, Duncan ; Wyndham, C. H. ; Atkins, A. R. ; Vermeulen, A. J. ; Hofmeyr, H. S. ; Strydom, N. B. ; Hodgson, T.
Springer
Published 1968Staff ViewISSN: 1432-2013Keywords: Thermal Exchanges ; Heat Balance ; Thermoregulation ; Responses to Heat and Cold ; Wärmeaustausch ; Wärmeausgleich ; Wärmeregulierung ; Hitze- und KältereaktionenSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Two nude resting men were exposed for two-hour periods to each of 25 dry environments, with air temperatures ranging between 12.8° C and 49.1° C and wind speeds between 0.67 m/sec and 4.94 m/sec. The mean radiant temperature of the surroundings was kept equal to the air temperature. Rates of radiant and convective heat exchange were measured directly, separately and continuously. The men had reached a thermal steady state after 105 min in the warm environments, but not in the cold environments. Graphs are presented to show the effect of ambient temperature and wind speed on the radiation and convection rates attained after 105 min, as well as on metabolic rate, sweat evaporation rate, rectal temperature and mean skin temperature. These graphs revealed some important aspects of the behaviour of man's thermal control system. In particular the physiological conductance increased with increasing ambient temperature and then “saturated” at an ambient temperature near 35° C. This saturation resulted in a constant difference between rectal temperature and mean skin temperature irrespective of the environmental conditions.Type of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 1432-2013Keywords: Fever ; Thermoregulation ; Set-Point ; Physiological Control ; Fieber ; “Set”-Punkt ; Physiologische KontrolleSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Thermoregulation during fever is generally described in terms of a change in the level of the reference signal in the control system. This paper presents an alternative postulate, namely that during fever the thermoregulatory control centre undergoes a pyrogen-induced change in sensitivity, or gain. This postulate is supported strongly by the behaviour of thermoregulatory neurones. Febrile and afebrile thermoregulation can be described by means of a model with no reference signal at all, but with opposing warm and cold stimuli to the control centre.Type of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 1432-2013Keywords: Body Temperature ; Physiological Scheme ; Mathematical Model ; Temperature Regulation ; Temperature ReceptorsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Mean skin temperatures, rectal temperatures and sweat rates were measured on four highly acclimatised subjects. They were exposed for 180 min to 16 different combinations of 4 metabolic rates and 4 air temperatures, ranging from cold (10°C) to hot (49°C). Mean sweat rates for the second hour were plotted against mean rectal temperaturesfor 4 different levels of skin temperature and viceversa. These graphs indicate, firstly, that sweat rate does not increase until rectal temperature rises above a threshold value of 36.5°C; thereafter the increase in sweat rate depends upon the level of mean skin temperature, being greater the higher the mean skin temperature is. Secondly, sweat rate does not increase markedly until mean skin temperature rises above 33°C but the increase in sweat rate above 33°C depends upon the level of rectal temperature, being greater the higher the rectal temperature is. The interrelated effects upon sweat rate of mean skin temperature and core temperature can be explained by means of a relatively simple physiological system, comprising temperature sensors in the hypothalamus and skin, and a heat loss and a heat conservation integrating centre. Mathematical equations have been developed to express the relationships between sweat rate, core, and mean skin temperature for cool conditions, but these relationships are so complex that it is preferable to use an analogue computer for these purposes.Type of Medium: Electronic ResourceURL: -
15Staff View
ISSN: 1432-2013Keywords: Simulation of Control Characteristics ; Thermal Control in the Body ; Computer Model of Man's Thermal Behaviour ; Thermal ResponseSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary To be able to predict man's thermal response to any given environment it is essential to have a thorough understanding of man's thermo-regulatory mechanism. The mechanism is dependant on a number of highly non-linear variables. An analogue computer can be of great value with such a problem as non-linear control characteristics are easily incorporated into its programme. The computer is used as a model to reproduce man's thermal behaviour. This paper describes the application of such a computer. A number of tests were made to study some thermal control characteristics and the results are compared with those of a series of experiments performed on two resting subjects who were exposed to various environmental conditions in a climatic chamber.Type of Medium: Electronic ResourceURL: