Search Results - (Author, Cooperation:A. Pena)

2018-02-15

Wiley-Blackwell

0148-0227

Geosciences

Physics

2018-07-07

American Physical Society (APS)

0031-9007

1079-7114

Physics

Atomic, Molecular, and Optical Physics

2018-11-20

The American Association of Immunologists (AAI)

0022-1767

1550-6606

Medicine

2011-04-15

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Aquatic Organisms/growth & development/*isolation & purification/metabolism ; Atlantic Ocean ; Bias (Epidemiology) ; Biomass ; Chlorophyll/analysis ; Data Collection/methods ; *Ecosystem ; Fisheries ; Phytoplankton/growth & development/*isolation & purification/metabolism ; Reproducibility of Results ; Seawater/chemistry/microbiology ; Time Factors

2018-08-23

Nature Publishing Group (NPG)

2041-1723

Biology

Chemistry and Pharmacology

Natural Sciences in General

Physics

1432-2307

Springer Online Journal Archives 1860-2000

Medicine

Electronic Resource

1432-0568

Cerebellum ; Development ; Cortex ; Fissures ; Chick

Springer Online Journal Archives 1860-2000

Medicine

Summary We have studied the chronology of appearance and the cortical changes which precede the fissures appearing between stages 34 to 40. In this paper we demonstrate the structural modifications of the cerebellar cortex defined as the anlagen of the fissures. The analage of a fissure begins in a well-determined place of the cerebellar cortex. It begins with a thickening of the internal cortical cell layer, which finally folds. These modifications precede other similar ones which occur in the overlying external granular layer. On the other hand, these cortical structural modifications precede the transversal projection of the fissures. Chronological order of appearance of the anlagen of the fissures, related to the appearance of fissures on the surface of the cerebellum is also given.

Electronic Resource

1432-0568

Cerebellum ; Development ; Lectin ; Chick

Springer Online Journal Archives 1860-2000

Medicine

Abstract We studied the binding distribution of several lectins, Con A, DBA, UEA and WGA, in the embryonic development of the chick cerebellum between stages 18 to 45 of Hamburger and Hamilton. We observed a differential labeling (in intensity and distribution) in the migratory and cortical layers of the cerebellum anlage with these different lectins. The different distributions and modifications in the labeling pattern suggest intense variations of the glycoproteins and glycosaminoglycans in the extracellular matrix during development. These variations coincide with cellular and organizational phenomena in the migratory and cortical layers, and suggest compartmentalization of the Purkinje cell labeling.

Electronic Resource

1573-2568

Springer Online Journal Archives 1860-2000

Medicine

Summary The principle of effective broad-spectrum anthelmintic activity against human intestinal nematode infections has been demonstrated by the therapeutic results obtained with dithiazanine. In proper dosage, this polyvermicide is therapeutic for trichuriasis, strongyloidiasis, ascariasis and enterobiasis. The drug has only moderate anthelmintic activity against the hookworm,Necator americanus. It fills a need for a therapeutic for trichuriasis and strongyloidiasis. Dithiazanine is useful for the treatment of patients with either single or multiple intestinal helminthic infections. The indications for use of dithiazanine iodide are: 1. Trishuriasis 2. Strongyloidiasis 3. Mixed infections with trichuriasis and ascariasis 4. Other mixed infections with intestinal nematodes when either trichuriasis or strongyloidiasis is present.

Electronic Resource

0031-9422

Labiatae ; S. hyssopifolia ; S. luteola ; Sideritis chamaedryfolia ; ent-15-kaurene and ent-16-kaurene derivatives.

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Electronic Resource

2018-03-06

The Society of Nuclear Medicine (SNM)

0022-3123

Medicine

2018-03-29

The American Society for Microbiology (ASM)

0022-538X

1098-5514

Medicine

2018-11-30

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Geosciences

Computer Science

Medicine

Natural Sciences in General

Physics

Biochemistry, Online Only

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

The fabrication of boring tools (burrs) for dentistry with the use of a hot-filament chemical vapor deposition (CVD) system, to form the diamond abrading structure, is reported here. The diamond was synthesized from a methane/freon gas mixture diluted in hydrogen. Comparative drilling tests with conventional diamond burrs and the CVD diamond burrs in borosilicate glasses demonstrated a lifetime more than 20 times larger for the CVD diamond burrs. Also, heat flow experiments in dentine showed that the CVD diamond burrs induce temperature gradients of the same order as the conventional ones. These characteristics of the CVD diamond burrs are highly desirable for odontological applications where the burrs' lifetime and the low temperature processing are essential to the quality and comfort of the treatment. © 1996 American Institute of Physics.

Electronic Resource

1469-8986

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Psychology

Literature review suggested that certain properties of the REMs of wakefulness and REM sleep show changes with experience and/or maturation. A positive correlation was predicted to obtain between measures of REM sleep intensity and waking information search organization/activity in normal human adults. A correlational study of the REMs of sleep and wakefulness in 9 college-age Ss corroborated the hypothesis. Percentage REM sleep did not correlate significantly with any of the waking REM measures. Implications of the results for current theories and future research on REM sleep–waking perception interrelationships were described.

Electronic Resource

1744-313X

Blackwell Publishing Journal Backfiles 1879-2005

Biology

Medicine

Recent studies have reported the association of a pro-inflammatory profile of genetic polymorphisms in IL-1B, IL-1RN, TNF-A, and IL-10 genes with an increased risk of non-cardia gastric cancer. Because gastric cancer and duodenal ulcer are mutually exclusive outcomes of Helicobacter pylori infection, we aimed to investigate possible allelic variant associations of several functional polymorphisms in the IL-1B, IL-1RN, TNFA, and LTA genes in the susceptibility to duodenal ulcer. Genomic DNA from 118 patients with duodenal ulcer and 97 healthy controls was typed for the IL-1B polymorphisms at positions −511, −31, and +3954, the VNTR polymorphism in intron 2 of the IL-1RN gene, the TNFA−308, TNFA −238, and the NcoI and BsI LTA polymorphisms by PCR, SSCP and TaqMan assays. H. pylori infection and non-steroidal anti-inflammatory drugs (NSAIDs) use was investigated in patients and controls. Logistic regression analysis identified H. pylori infection (OR: 12.86; 95%CI: 3.85–43), NSAID use (OR: 11.95; 95%CI: 4.19–34.05), and family history-ulcer (OR: 3.79; 95%CI: 1.68–8.54) as independent risk factors for duodenal ulcer. When the effect of the combinations of IL-1 and TNF genotypes was studied we found that the distribution of all possible combinations of these eight polymorphisms was similar in duodenal ulcer patients and controls. The simultaneous carriage of alleles IL-1RN*2/IL-1B −31T/IL-1B −511C/IL-IB +3954C/TNF-HaplotypeE negative (termed in some studies as ‘low-producing’ alleles) was increased in H. pylori-positive duodenal ulcer patients compared to H. pylori-infected healthy controls (10.5% vs. 5.9%) although the difference did not reach statistical significance (OR: 1.85; 95%CI: 0.57–5.99, P = 0.41). Moreover, no differences were found with respect to H. pylori status, NSAID use, age, gender, smoking habit, type of complication, recurrence of the ulcer, and need for surgical treatment. Our data show no association between allelic variants of IL-1 and TNF gene polymorphisms in the susceptibility to and final outcome of duodenal ulcer.

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1365-3083

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

The genes for tumour necrosis factor alpha (TNFα) and lymphotoxin alpha (LTα; TNFβ) are tandemly arranged in the central region of the MHC. They may, therefore, be of importance for the aetiology of MHC-associated diseases. The authors have prospectively studied the secretion of TNFα and LTα in relation to polymorphisms at positions -308 and -238 in the TNFα gene (TNFA), and two polymorphisms in the first intron of the LTα gene (LTA), as well as HLA-DR in 30 patients with chronic inflammatory bowel diseases (IBD) and 12 healthy controls. In the Dutch population, the alleles of these four polymorphisms are present in only five combinations, called TNF-haplotypes: TNF-C, -E, -H, -I, and -P. Significant associations between TNF haplotypes and TNFα and LTα secretion were found when PBMC were cultured with T-cell activators, irrespective of disease. Mean TNFα secretion of individuals carrying the HLA-DR3 associated TNF-E haplotype was significantly higher, as compared to individuals without this haplotype (26 441 pg/ml versus 19 629 pg/ml; P = 0.014). Individuals carrying the TNF-C haplotype produced the lowest amount of TNFα (17 408 pg/ml; P = 0.022). The TNF-C and TNF-E haplotypes differ only at position -308 in the promoter of TNFA. Individuals carrying the HLA-DR1 associated TNF-I haplotype produced significantly less LTα when compared to those who lack this haplotype (1979 pg/ml versus 3462 pg/ml; P = 0.006). As the TNF-I haplotype is also associated with low TNFα secretion, this haplotype thus defines a ‘low secretor phenotype’. In conclusion, this is the first study to show associations between TNF haplotypes and TNFα and LTα secretion when T-cell stimulators are used. These findings will contribute to define disease heterogeneity in IBD and may be of relevance for understanding the pathogenesis of autoimmune diseases.

Electronic Resource

1365-2826

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Until recently, pharmacological studies dealing with vasopressin receptor isoforms were severely hampered by the lack of selective agonists or antagonists that recognize the pituitary V1b vasopressin receptor. By contrast, many selective vasopressin-related compounds are available for characterization of the vasopressor (V1a) or antidiuretic (V2) vasopressin receptor subtypes. Recently, SSR149415, a selective nonpeptide molecule, was discovered with nanomolar affinity for mammalian V1b receptors and good selectivity for the other vasopressin and oxytocin receptor isoforms. This molecule exhibits potent antagonist properties both in vitro and in vivo. We also designed synthetic peptides derived from [deaminocysteine1,arginine8]vasopressin (dAVP), modified in position 4 by various amino acid residues. Some of these, d[cyclohexylalanine4]AVP or d[lysine4]AVP, have a high affinity and an excellent selectivity for the human V1b receptor subtype. However, they exhibit a mixed V1b/V2 pharmacological profile for the rat vasopressin receptor isoforms. Whatever the species considered, these peptides behave as agonists both in bioassays performed in vitro and in vivo. The d[cyclohexylalanine4]AVP was tritiated and represents the first selective radiolabelled ligand available for studying the human V1b receptors. The discovery of these new selective V1b agonists and V1b antagonist allows an accurate pharmacological characterization of all the vasopressin receptor isoforms. As emphasized in this review, attention to the vasopressin and oxytocin receptor species differences is of critical importance in studies with all vasopressin and oxytocin ligands.

Electronic Resource

1365-2516

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Summary. An orthopaedic assessment of the joint status of seven severe haemophiliacs (mean age 12.5 y – range 8.9–15.5) on prophylactic treatment (PT) by magnetic resonance imaging (MRI) and physical examination was carried out. Median duration of PT of these patients was 84 months (range 32–107). A locally designed MRI joint score considering seven parameters (1 – joint effusion,2 – synovial membrane thickening, 3 – haemosiderin deposits, 4 – joint cartilage injury, 5 – subchondral bone erosion, 6 – subchondral bone cysts,7 – osteonecrosis) was used (maximum score = 13 points). MRI scans were performed in 17 joints (nine ankles, seven knees and one elbow): mean MRI scores for the affected joints was 5.1. A poor consistency between physical examination and MRI findings or the real extent of joint damage was found (Cohen kappa index 0.320). MRI is a precise non-invasive tool for the assessment of early joint cartilage and synovium pathological changes still undetectable by physical examination or conventional X-rays in the haemophilic setting.

Electronic Resource