Search Results - (Author, Cooperation:A. Ordonez)

2018-08-15

National Academy of Sciences

0027-8424

1091-6490

Biology

Medicine

Natural Sciences in General

2011-10-14

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Cell Line ; DNA Transposable Elements/genetics ; Hepatocytes/metabolism/transplantation ; Humans ; Induced Pluripotent Stem Cells/*physiology ; Liver/cytology ; Mice ; Serum Albumin/genetics/metabolism ; *Targeted Gene Repair ; Time Factors ; alpha 1-Antitrypsin/*genetics/metabolism ; alpha 1-Antitrypsin Deficiency/*genetics

2018-11-02

The Society of Nuclear Medicine (SNM)

0022-3123

Medicine

1745-4549

Blackwell Publishing Journal Backfiles 1879-2005

Process Engineering, Biotechnology, Nutrition Technology

Utilization of ultrafiltered (UF) milk for the manufacture of frozen yogurt was investigated. Three basic frozen yogurt mixes (0, 2, and 4% milk fat) were formulated using ultrafiltered skim milk as a base material and fermented with Lactobacillus acidophilus, Bifidobacterium bifidum, and a mixed yogurt culture of Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus. the cultured mixes were frozen using a continuous freezer and evaluated for product stability. Results suggest that culture organisms grew well during fermentation and produced acids continuously in the UF mixes, which became excessively viscous at a TA of 0.40% or higher. Therefore, all mixes were fermented to 0.30% TA (±4h) and rapidly cooled to 10C or lower to prevent excessive viscosity development. the finished products contained high levels of protein and calcium as well as good flavor and textural quality. In addition, the culture organisms were stable during six weeks of frozen storage.

Electronic Resource

1432-0843

Key words Gastric cancer ; Chemotherapy ; Toxicity

Springer Online Journal Archives 1860-2000

Medicine

Abstract  A phase II study was performed to assess the efficacy and toxicity of the combination of 5-fluorouracil (5-FU), leucovorin (LV), etoposide, and cisplatin (FLEP) in patients with advanced gastric carcinoma. A total of 46 consecutive, previously untreated patients with unresectable, measurable gastric carcinoma were treated with 300 mg/m2 LV, 100 mg/m2 etoposide, 500 mg/m2 5-FU, and 30 mg/m2 cisplatin on days 1–3 every 28 days. All courses were given on an outpatient basis. A total of 169 courses of treatment were given. In all, 18 of the 46 patients (39%) had an objective response [95% confidence interval (CI), 25%–54%] and 2 (4%) patients experienced a clinical complete response. The median duration of response was 5 months. The main side effects were hematological and gastrointestinal. Grade 3–4 toxicity was encountered as follows: leukopenia, in 9.5% of the courses; anemia, in 3%; thrombocytopenia, in 3%; nausea/ vomiting, in 4%; and diarrhea, in 5%. Hospitalization due to fever and granulocytopenia was required in 5 patients, 3 of whom died of sepsis. In conclusion, FLEP shows moderate activity in patients with advanced gastric carcinoma, albeit at the cost of a high degree of toxicity. For this reason we do not recommend its use.

Electronic Resource

1432-0843

Gastric cancer ; Chemotherapy ; Toxicity

Springer Online Journal Archives 1860-2000

Medicine

Abstract A phase II study was performed to assess the efficacy and toxicity of the combination of 5-fluorouracil (5-FU), leucovorin (LV), etoposide, and cisplatin (FLEP) in patients with advanced gastric carcinoma. A total of 46 consecutive, previously untreated patients with unresectable, measurable gastric carcinoma were treated with 300 mg/m2 LV, 100 mg/m2 etoposide, 500 mg/m2 5-FU, and 30 mg/m2 cisplatin on days 1–3 every 28 days. All courses were given on an outpatient basis. A total of 169 courses of treatment were given. In all, 18 of the 46 patients (39%) had an objective response [95% confidence interval (CI), 25%–54%] and 2 (4%) patients experienced a clinical complete response. The median duration of response was 5 months. The main side effects were hematological and gastrointestinal. Grade 3–4 toxicity was encountered as follows: leukopenia, in 9.5% of the courses; anemia, in 3%; thrombocytopenia, in 3%; nausea/vomiting, in 4%; and diarrhea, in 5%. Hospitalization due to fever and granulocytopenia was required in 5 patients, 3 of whom died of sepsis. In conclusion, FLEP shows moderate activity in patients with advanced gastric carcinoma, albeit at the cost of a high degree of toxicity. For this reason we do not recommend its use.

Electronic Resource

0160-2527

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Psychology

Law

Electronic Resource

0160-2527

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Psychology

Law

Electronic Resource

1432-0843

Key words Malignant melanoma ; Chemotherapy ; Cisplatin ; Tamoxifen

Springer Online Journal Archives 1860-2000

Medicine

Abstract  A phase II study was performed to assess the efficacy and toxicity of the combination of cisplatin (CDDP) and tamoxifen (TAM) in patients with metastatic malignant melanoma (MM). A total of 31 consecutive previously untreated patients with unresectable measurable MM were given 100 mg/m2 CDDP every 21 days and 60 mg TAM every 12 h daily. All courses were given on an outpatient basis. A total of 119 courses of treatment were given. In all, 5 of the 31 patients (16%) had an objective response (95% confidence interval 5.3 – 34%) and 2 (6%) achieved a clinical complete response. The median duration of response was 7 months. The main side effect was gastrointestinal: 13% of the patients experienced grade 3/4 nausea/vomiting. Hematological or neurological toxicities were mild and rare. In conclusion, the combination CDDP-TAM has limited activity in MM, although its toxicity is tolerable. Our results do not allow us to recommend its use for the treatment of MM.

Electronic Resource

1433-7339

Truth disclosure ; Cancer communication ; Psychological stress in doctors

Springer Online Journal Archives 1860-2000

Medicine

Abstract Giving bad news to patients with cancer may generate stress in doctors, who use distancing tactics. The causes of this anxiety come from social conventions and its consequences affect both doctors and their patients. There is no “gold standard” by which stress may be overcome during the interview but we offer some suggestions that may help.

Electronic Resource

1573-6903

Springer Online Journal Archives 1860-2000

Medicine

Abstract Isolated frog rod outer segments (ROS) with a leaky plasma membrane showed a bicarbonate-dependent, ATP-activated45Ca accumulation. This calcium uptake requires magnesium and is specific for ATP; Other nucleotides, ITP, GTP, UTP and the non-hydrolysable analogue of ATP β-γ-methylene ATP did not substitute for ATP.45Ca accumulation was inhibited by mersalyl, ethylmaleimide, ruthenium red, oligomycin and dicyclohexylcarbodiimide and was unaffected by ouabain. Addition of taurine to the incubation medium enhanced45Ca uptake in a concentration-dependent manner; increases of more than 100% being produced by 25 mM taurine. The taurine-induced stimulation of45Ca uptake was also sensitive to the tested inhibitors. The effect of taurine was only exerted on the bicarbonate-dependent, ATP-activated45Ca uptake. Calcium accumulation observed in the absence of ATP or in a tris-buffered medium was unaffected by taurine. Other amino acids, glycine, GABA, β-alanine, glutamic acid and the taurine analogue guanidinoethyl-sulfonate did not stimulate45Ca uptake. These results suggest that taurine is affecting a Mg-ATPase activity responsible for calcium accumulation in frog ROS.

Electronic Resource

1572-9575

Springer Online Journal Archives 1860-2000

Physics

Abstract We discuss the validity of a relation betweenfunctionals in quantum resonance scattering which isoften used in the current literature.

Electronic Resource