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1Articles: DFG German National LicensesFadzlina, Zainal A. Noor ; Karim, Alias A. ; Teng, Tjoon T.
Oxford, UK : Blackwell Publishing Ltd
Published 2005Staff ViewISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: : Carboxymethyl starch (CMS) with degree of substitution (DS) ranging from 0.1 to 0.32 was prepared from sago (Metroxylon sagu) starch in non-aqueous medium using isopropanol as a solvent. The physico-chemical, rheological, and thermal properties of the starches were investigated. At room temperature (25 °C), CMS hydrated readily, resulting in higher swelling power compared with native (unmodified) starch. Light microscopy revealed that CMS granules imbibed more water than native starch at room temperature and thus caused a larger increase in granule size. Some of the CMS granules lost their integrity. Scanning electron microscopic observation revealed fine fissures on the surface of CMS (DS 0.32) granules compared with a relatively smooth surface of native starch granules. Carboxymethylated sago starch exhibited excellent dispersibility and cold water solubility as judged by the absence of peak viscosity in the pasting profile (determined by Rapid ViscoAnalyzer). Pasting profile of CMS was qualitatively similar to pregelatinized starch. Despite exhibiting greater swelling power, CMS showed significantly lower pasting viscosity compared with the native starch. Intrinsic viscosity was also greatly reduced by carboxymethylation. Studies using differential scanning calorimetry (DSC) showed that transition temperatures and enthalpies decreased with an increase of degree of substitution. CMS at higher substitution levels (DS 0.27 and 0.32) showed significantly lower retrogradation tendency, as indicated by lower setback, absence of DSC endotherm upon storage at 4 °C and lower syneresis upon repeated freeze-thaw cycles. The results suggested that retrogradation might be effectively retarded by the presence of the bulky carboxymethyl group.Type of Medium: Electronic ResourceURL: -
2Articles: DFG German National LicensesStaff View
ISSN: 1432-1955Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Invermectin at single doses of 0.2–1.0 mg/kg body weight reduced the microfilarial counts of subperiodic Brugia malayi in Presbytis cristata by 59.9%–89.6% of initial counts, 4 weeks after treatment. Adult filaricidal activity was poor, live adult worms being recovered from all animals at autopsy. There was no serious side effect at these doses.Type of Medium: Electronic ResourceURL: -
3Latest Papers from Table of Contents or Articles in PressP. H. Sudmant ; T. Rausch ; E. J. Gardner ; R. E. Handsaker ; A. Abyzov ; J. Huddleston ; Y. Zhang ; K. Ye ; G. Jun ; M. Hsi-Yang Fritz ; M. K. Konkel ; A. Malhotra ; A. M. Stutz ; X. Shi ; F. Paolo Casale ; J. Chen ; F. Hormozdiari ; G. Dayama ; K. Chen ; M. Malig ; M. J. Chaisson ; K. Walter ; S. Meiers ; S. Kashin ; E. Garrison ; A. Auton ; H. Y. Lam ; X. Jasmine Mu ; C. Alkan ; D. Antaki ; T. Bae ; E. Cerveira ; P. Chines ; Z. Chong ; L. Clarke ; E. Dal ; L. Ding ; S. Emery ; X. Fan ; M. Gujral ; F. Kahveci ; J. M. Kidd ; Y. Kong ; E. W. Lameijer ; S. McCarthy ; P. Flicek ; R. A. Gibbs ; G. Marth ; C. E. Mason ; A. Menelaou ; D. M. Muzny ; B. J. Nelson ; A. Noor ; N. F. Parrish ; M. Pendleton ; A. Quitadamo ; B. Raeder ; E. E. Schadt ; M. Romanovitch ; A. Schlattl ; R. Sebra ; A. A. Shabalin ; A. Untergasser ; J. A. Walker ; M. Wang ; F. Yu ; C. Zhang ; J. Zhang ; X. Zheng-Bradley ; W. Zhou ; T. Zichner ; J. Sebat ; M. A. Batzer ; S. A. McCarroll ; R. E. Mills ; M. B. Gerstein ; A. Bashir ; O. Stegle ; S. E. Devine ; C. Lee ; E. E. Eichler ; J. O. Korbel
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-10-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Genetic Predisposition to Disease ; Genetic Variation/*genetics ; Genetics, Medical ; Genetics, Population ; Genome, Human/*genetics ; Genome-Wide Association Study ; Genomics ; Genotype ; Haplotypes/genetics ; Homozygote ; Humans ; Molecular Sequence Data ; Mutation Rate ; *Physical Chromosome Mapping ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics ; Sequence Analysis, DNA ; Sequence Deletion/geneticsPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-05-05Publisher: Institute of Physics (IOP)Print ISSN: 1755-1307Electronic ISSN: 1755-1315Topics: GeographyGeosciencesPhysicsPublished by: -
5Articles: DFG German National LicensesStaff View
ISSN: 0360-1315Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: EducationType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0360-1315Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: EducationType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0219-175XKeywords: convex sublattice ; standard n-ideal ; neutral element ; homomorphism n-kernel ; boolean algebraSource: Springer Online Journal Archives 1860-2000Topics: MathematicsNotes: Abstract An n-ideal of a lattice L is a convex sublattice containing a fixed element n ∈ L and it is called standard if it is a standard element of the lattice of n-ideals In(L). In this paper we have shown that, for a neutral element n of a lattice L, the principal n-ideal 〈a〉n of a lattice L is a standard n-ideal if and only if a ∨ n is standard and a ∧ n is dual standard. We have also shown that if n is a neutral element and (n] and [n) are relatively complemented, then every homomorphism n-kernels of L is a standard n-ideal and every standard n-ideal is the n-kernel of precisely one congruence relation. Finally, we have shown that, for a relatively complemented lattice L with 0 and 1, C(L) is a Boolean algebra if and only if every standard n-ideal of L is a principal n-ideal.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesGraham, Alexander ; Kalsheker, Noor A. ; Newton, Clive R. ; Bamforth, Fiona J. ; Powell, Steven J. ; Markham, Alexander F.
Springer
Published 1989Staff ViewISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary Three mutations causing alpha-1-antitrypsin defiiency have been identified by gene amplification and direct DNA sequencing. In the Pi (proteinase-inhibitor) nullcardiff gene, the codon for aspartate at position 256 has mutated to encode valine. In Pi Mmalton and Pi I, the respective mutations are the deletion of the codon for a phenylalanine residue at position 51 or 52, and a single base substitution resulting in arginine being replaced by cysteine at position 39. Examination of the protein tertiary structure suggests that all of these mutations are likely to result in folding abnormalities that may explain the deficiency states.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesGraham, Alexander ; Hayes, Karen ; Weidinger, Sebastian ; Newton, Clive R. ; Markham, Alexander F. ; Kalsheker, Noor A.
Springer
Published 1990Staff ViewISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary By sequence analysis of the complete proteincoding region of the human alpha-1-antitrypsin gene using polymerase chain reaction techniques, we have characterised one of the normal variants, M3. We have identified a single point mutation between M1 Va1213 and M3 at codon position 376 which is a GAA(Glu) to GAC(Asp) transversion.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesGraham, Alexander ; Kalsheker, Noor A. ; Bamforth, Fiona J. ; Newton, Clive R. ; Markham, Alexander F.
Springer
Published 1990Staff ViewISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary Two single point mutations in the alpha-1-antitrypsin gene, resulting in AAT deficiency, have been characterised in heterozygotes by DNA amplification and direct sequencing. The mutations result in amino acid substitutions, Gly115→Ser and Ser−19→Leu, in the leader sequence, respectively, and have been designated Pi NullNewport and Pi Z Wrexham. In the two families studied the mutations occur on chromosomes which also carry the common mutation causing Z deficiency. Individuals with such a deficiency are, therefore, compound heterozygotes. It is not known if these particular mutations would only cause a mild form of AAT deficiency in the absence of the Z mutation as they do not appear to cause predictable folding abnormalities. They do, however, result in severe deficiency when the Z mutation occurs in the same gene.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-0924Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract A study is made of the effects of variation in the lamination and geometric parameters, and boundary conditions of multi-layered composite panels on the accuracy of the detailed response characteristics obtained by five different modeling approaches. The modeling approaches considered include four two-dimensional models, each with five parameters to characterize the deformation in the thickness direction, and a predictor-corrector approach with twelve displacement parameters. The two-dimensional models are first-order shear deformation theory, third-order theory; a theory based on trigonometric variation of the transverse shear stresses through the thickness, and a discrete layer theory. The combination of the following four key elements distinguishes the present study from previous studies reported in the literature: (1) the standard of comparison is taken to be the solutions obtained by using three-dimensional continuum models for each of the individual layers; (2) both mechanical and thermal loadings are considered; (3) boundary conditions other than simply supported edges are considered; and (4) quantities compared include detailed through-the-thickness distributions of transverse shear and transverse normal stresses. Based on the numerical studies conducted, the predictor-corrector approach appears to be the most effective technique for obtaining accurate transverse stresses, and for thermal loading, none of the two-dimensional models is adequate for calculating transverse normal stresses, even when used in conjunction with three-dimensional equilibrium equations.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1573-4919Keywords: glycogen phosphorylase ; glycogen synthase ; insulin signaling ; HepG2 cellsSource: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyMedicineNotes: Abstract The effect of insulin on glycogen synthesis and key enzymes of glycogen metabolism, glycogen phosphorylase and glycogen synthase, was studied in HepG2 cells. Insulin stimulated glycogen synthesis 1.83-3.30 fold depending on insulin concentration in the medium. Insulin caused a maximum of 65% decrease in glycogen phosphorylase 'a' and 110% increase in glycogen synthase activities in 5 min. Although significant changes in enzyme activities were observed with as low as 0.5 nM insulin level, the maximum effects were observed with 100 nM insulin. There was a significant inverse correlation between activities of glycogen phosphorylase 'a' and glycogen synthase 'a' (R2 = 0.66, p 〈 0.001). Addition of 30 mM glucose caused a decrease in phosphorylase 'a' activity in the absence of insulin and this effect was additive with insulin up to 10 nM concentration. The inactivation of phosphorylase 'a' by insulin was prevented by wortmannin and rapamycin but not by PD98059. The activation of glycogen synthase by insulin was prevented by wortmannin but not by PD98059 or rapamycin. In fact, PD98059 slightly stimulated glycogen synthase activation by insulin. Under these experimental conditions, insulin decreased glycogen synthase kinase-3β activity by 30-50% and activated more than 4-fold particulate protein phosphatase-1 activity and 1.9-fold protein kinase B activity; changes in all of these enzyme activities were abolished by wortmannin. The inactivation of GSK-3β and activation of PKB by insulin were associated with their phosphorylation and this was also reversed by wortmannin. The addition of protein phosphatase-1 inhibitors, okadaic acid and calyculin A, completely abolished the effects of insulin on both enzymes. These data suggest that stimulation of glycogen synthase by insulin in HepG2 cells is mediated through the PI-3 kinase pathway by activating PKB and PP-1G and inactivating GSK-3β. On the other hand, inactivation of phosphorylase by insulin is mediated through the PI-3 kinase pathway involving a rapamycin-sensitive p70s6k and PP-1G. These experiments demonstrate that insulin regulates glycogen phosphorylase and glycogen synthase through (i) a common signaling pathway at least up to PI-3 kinase and bifurcates downstream and (ii) that PP-1 activity is essential for the effect of insulin.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-0878Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Zusammenfassung Im Pankreas ausgewachsener Ratten wurden nach Alloxanschädigung Regenerationsherde beobachtet und beschrieben. Sie bestehen in einem büschelförmigen Aussprossen kleiner Gänge an umschriebenen Stellen des Organes, die in ein retikuläres Bindegewebe eingebettet sind. In analoger Weise wie bei der ontogenetischen Entwicklung des Pankreas aus den primitiven Drüsenschläuchen, kommt es auch im Bereiche der Gangwucherungen zur Neubildung von Inselgewebe.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesEl-Refaee, M. M. ; Elsayed, M. M. ; Al-Najem, N. M. ; Noor, A. A.
Chichester : Wiley-Blackwell
Published 1998Staff ViewISSN: 0271-2091Keywords: natural convection ; tilted cavity ; partial cooling ; storage tanks ; Engineering ; Numerical Methods and ModelingSource: Wiley InterScience Backfile Collection 1832-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Two-dimensional numerical simulations of laminar natural convection in a partially cooled, differentially heated inclined cavities are performed. One of the cavity walls is entirely heated to a uniformly high temperature (heat source) while the opposite wall is partially cooled to a lower temperature (heat sink). The remaining walls are adiabatic. The tilt angle of the cavity is varied from 0° (heated from left) to -90° (heated from top). The fast false implicit transient scheme (FITS) algorithm, developed earlier by the same authors, is modified to solve the derived variables vorticity-streamfunction formulation. The effects of aspect ratio (AR), sink-source ratio and tilt angle on the average Nusselt number are examined through a parametric study; solutions are obtained for two Grashof numbers, 105 and 107. Flow patterns and isotherms are used to investigate the heat transfer and fluid flow mechanisms inside the cavity. © 1998 John Wiley & Sons, Ltd.Additional Material: 9 Ill.Type of Medium: Electronic Resource -
16Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-06-19Publisher: MDPIElectronic ISSN: 2078-2489Topics: Computer SciencePublished by: -
17Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-05-15Publisher: Institute of Physics (IOP)Print ISSN: 1757-8981Electronic ISSN: 1757-899XTopics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPublished by: