Search Results - (Author, Cooperation:A. Morandi)

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  1. 1
    Staff View
    Publication Date:
    2012-02-22
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adipocytes/metabolism/pathology ; Adipogenesis ; Adipose Tissue/metabolism/pathology ; Animals ; Calcium Signaling ; Cell Differentiation ; DNA Mutational Analysis ; Diet, High-Fat ; Energy Metabolism ; Europe/ethnology ; European Continental Ancestry Group/genetics ; Exons/genetics ; Fatty Liver/complications/genetics ; Gene Expression Regulation ; Glucagon-Like Peptide 1/secretion ; Glucose/metabolism ; Glucose Intolerance/complications ; Humans ; Insulin/metabolism ; Insulin Resistance ; Lipogenesis ; Liver/metabolism ; Macrophages/metabolism ; Mice ; Mutation/genetics ; Obesity/complications/genetics/*metabolism/pathology ; Receptors, G-Protein-Coupled/deficiency/genetics/*metabolism ; Signal Transduction/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    ISSN:
    0014-5793
    Keywords:
    (Cell culture) ; Alzheimer's disease ; Amyloid ; Amyloid precursor protein
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0014-5793(88)81038-X

    Articles: DFG German National Licenses
  3. 3
    Staff View
    ISSN:
    1590-3478
    Keywords:
    Nerve growth factor (NGF) ; cerebrospinal fluid (CSF) ; neurological diseases ; multiple sclerosis (MS) ; amyotrophic lateral sclerosis (ALS)
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Sommario È stato recentemente dimostrato che l'NGF non è solamente coinvolto nella sopravvivenza e lo sviluppo dei neuroni del sistema simpatico e in quelli sensitivi derivati dalla cresta neurale, ma anche in alcuni meccanismi del sistema immunitario. Per questo motivo abbiamo studiato il contenuto di NGF nel liquor di pazienti affetti da malattie quali la sclerosi multipla, la sclerosi laterale amiotrofica, la malattia di Alzheimer, le polineuropatie croniche recidivanti, la sindrome di Guillain-Barré e i tumori del sistema nervoso, nelle quali meccanismi neuroimmunologici paiono essere coinvolti, ed inoltre in un gruppo di soggetti neurologicamente sani presi come controlli. Abbiamo messo a punto una metodica ELISA per dosare la subunità beta dell'NGF, ottenendo buoni test di validazione e sensibilità fino a 28 pg βNGF per ml. Nessuno dei campioni conteneva livelli misurabili di NGF. Abbiamo quindi concentrato i campioni, ma soltanto un paziente ha presentato livelli significativi. Questo probabilmente mostra che l'NGF non è coinvolto nei meccanismi neuroimmunologici che potrebbero essere alla base di alcune malattie degenerative ed infiammatorie del sistema nervoso.
    Notes:
    Abstract It has been recently shown that NGF is not only involved in the survival and development of sympathetic and neural crest-derived sensory neurons, but also in some mechanisms of the immune system. For this reason, we studied the content of NGF in CSF samples from patients with diseases in which neuroimmonological mechanisms seem to be involved (multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer disease, chronic relapsing polyradiculoneuritis, Guillain-Barré syndrome, and tumors of the nervous system), as well as from a number of normal control subjects. We setup an ELISA aimed at the beta subunit of NGF, obtaining good validation tests and a detection limit of 28 pg βNGF per ml. None of the samples was found to contain detectable levels of NGF and, when a concentration method for sample enrichment was used, only one patient was NGF-positive. This suggests that NGF is probably not involved in the neuroimmunological mechanisms underlying some inflammatory and degenerative diseases of the nervous system.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02340121

    Articles: DFG German National Licenses