Search Results - (Author, Cooperation:A. Miners)

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  1. 1
    Staff View
    Publication Date:
    2015-12-04
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adolescent ; Adult ; Africa ; Aged ; Anti-HIV Agents/economics/pharmacology/therapeutic use ; Cost-Benefit Analysis ; HIV Infections/diagnosis/*drug therapy/economics/*virology ; Humans ; Middle Aged ; Precision Medicine/economics/*methods ; *Viral Load/drug effects ; Young Adult
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Miners, A. H. ; Lee, C. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 2004
    Staff View
    ISSN:
    1365-2516
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Summary.  Primary prophylaxis with clotting factor is the clinical treatment of choice for people with severe haemophilia, as evidence suggests it can prevent the onset and progression of joint- and muscle-related problems caused by bleeding episodes. However, the major limitation of this approach is that it requires considerably more clotting factor compared with treating on-demand. Thus, there is a need to establish its cost-effectiveness. The aim of this paper is to review the published evidence on the cost-effectiveness of prophylaxis and to highlight areas for future research that would decrease the uncertainty around these findings.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1355-0691.2004.00880.x

    Articles: DFG German National Licenses
  3. 3
    YEE, T. T. ; BEETON, K. ; GRIFFIOEN, A. ; HARRINGTON, C. ; MINERS, A. ; LEE, C. A. ; BROWN, S. A.

    Oxford UK : Blackwell Science Ltd
    Published 2002
    Staff View
    ISSN:
    1365-2516
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    The practice of prophylactic treatment of boys with severe haemophilia has been evaluated in our centre. Prophylaxis was started at the median age of 3.7 years (range 0.4–12.7 years) in 38/41 children (93%) under 17 years of age. Median follow-up was 4.1 years (range 0.4–12.7 years). The criteria of primary prophylaxis according to the definition by the European Paediatric Network of Haemophilia Management was fulfilled by 9/38 (24%). Although a majority [76%, 29/38] of the children started prophylaxis after a median number of joint bleeds of 3.5, 70% of the children in this group had clinical joint scores of 0. Intravenous catheter insertion was required at a median age of 15.5 months (range 5–36 months) in 21% of the children, resulting in a catheter infection rate of 1.74 per 1000 catheter days. None developed an inhibitor on prophylaxis and three patients who had low-titre inhibitors (〈 5 Bethesda units) prior to prophylaxis had undetectable inhibitors after prophylaxis. The home-treatment training programme required considerable time and cost. As a result, 87% of the children used peripheral venous access and hospital visits declined as prophylaxis became established. Parents' incentives for prophylaxis were that the children undertook many physical activities and sports previously not recommended, there was less parental anxiety and an overall improvement in the quality of life for the whole family.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2516.2002.00630.x

    Articles: DFG German National Licenses
  4. 4
    Miners, A. H. ; Sabin, C. A. ; Tolley, K. H. ; Parnaby, A. ; Lee, C. A.

    Oxford UK : Blackwell Science Ltd
    Published 2001
    Staff View
    ISSN:
    1365-2516
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    In this study, we assessed whether severity of haemophilia was associated with levels of productivity. Productivity levels were assessed by sending a ‘time-use’ questionnaire to 228 individuals with mild, moderate and severe haemophilia. The results showed that, after adjusting for differences in age and HIV serostatus, there were no differences between individuals with severe and mild/moderate haemophilia in terms of completed levels of education, employment status, absenteeism from work over the previous 2 weeks, the number of hours each week spent performing unpaid tasks and how efficiently individuals performed these tasks. The data did suggest, however, that a significantly larger proportion of individuals with severe haemophilia (32%) required help from family or friends to perform routine household tasks each week than individuals with mild/moderate haemophilia (13%). In conclusion, it is possible that individuals with severe haemophilia have similar levels of productivity compared to individuals with mild/moderate haemophilia or that treatment with secondary prophylaxis has helped to reduce differences between the two patient groups.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2516.2001.00547.x

    Articles: DFG German National Licenses