Search Results - (Author, Cooperation:A. McMillan)
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1Latest Papers from Table of Contents or Articles in PressChensu Wang; Hanspeter Niederstrasser; Peter M. Douglas; Rueyling Lin; Juan Jaramillo; Yang Li; Nathaniel W. Oswald; Anwu Zhou; Elizabeth A. McMillan; Saurabh Mendiratta; Zhaohui Wang; Tian Zhao; Zhiqaing Lin; Min Luo; Gang Huang; Rolf A. Brekken; Bruce A. Posner; John B. Mac; Millan; Jinming Gao; Michael A. White
Nature Publishing Group (NPG)
Published 2018Staff ViewPublication Date: 2018-05-22Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2041-1723Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-03-28Publisher: Institute of Physics (IOP)Electronic ISSN: 1367-2630Topics: PhysicsPublished by: -
3Latest Papers from Table of Contents or Articles in PressN. Annaluru ; H. Muller ; L. A. Mitchell ; S. Ramalingam ; G. Stracquadanio ; S. M. Richardson ; J. S. Dymond ; Z. Kuang ; L. Z. Scheifele ; E. M. Cooper ; Y. Cai ; K. Zeller ; N. Agmon ; J. S. Han ; M. Hadjithomas ; J. Tullman ; K. Caravelli ; K. Cirelli ; Z. Guo ; V. London ; A. Yeluru ; S. Murugan ; K. Kandavelou ; N. Agier ; G. Fischer ; K. Yang ; J. A. Martin ; M. Bilgel ; P. Bohutski ; K. M. Boulier ; B. J. Capaldo ; J. Chang ; K. Charoen ; W. J. Choi ; P. Deng ; J. E. DiCarlo ; J. Doong ; J. Dunn ; J. I. Feinberg ; C. Fernandez ; C. E. Floria ; D. Gladowski ; P. Hadidi ; I. Ishizuka ; J. Jabbari ; C. Y. Lau ; P. A. Lee ; S. Li ; D. Lin ; M. E. Linder ; J. Ling ; J. Liu ; M. London ; H. Ma ; J. Mao ; J. E. McDade ; A. McMillan ; A. M. Moore ; W. C. Oh ; Y. Ouyang ; R. Patel ; M. Paul ; L. C. Paulsen ; J. Qiu ; A. Rhee ; M. G. Rubashkin ; I. Y. Soh ; N. E. Sotuyo ; V. Srinivas ; A. Suarez ; A. Wong ; R. Wong ; W. R. Xie ; Y. Xu ; A. T. Yu ; R. Koszul ; J. S. Bader ; J. D. Boeke ; S. Chandrasegaran
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-03-29Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Base Sequence ; *Chromosomes, Fungal/genetics/metabolism ; DNA, Fungal/genetics ; Genes, Fungal ; Genetic Fitness ; Genome, Fungal ; Genomic Instability ; Introns ; Molecular Sequence Data ; Mutation ; Polymerase Chain Reaction ; RNA, Fungal/genetics ; RNA, Transfer/genetics ; Saccharomyces cerevisiae/cytology/*genetics/physiology ; Sequence Analysis, DNA ; Sequence Deletion ; Synthetic Biology/*methods ; Transformation, GeneticPublished by: -
4Latest Papers from Table of Contents or Articles in PressBrandt A. Nichols, Nathaniel W. Oswald, Elizabeth A. McMillan, Kathleen McGlynn, Jingsheng Yan, Min S. Kim, Janapriya Saha, Prema L. Mallipeddi, Sydnie A. La; Duke, Pamela A. Villalobos, Jaime Rodriguez-Canales, Ignacio I. Wistuba, Bruce A. Posner, Anthony J. Davis, John D. Minna, John B. Mac; Millan, Angelique W. Whitehurst
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-11-02Publisher: The American Association for Cancer Research (AACR)Print ISSN: 0008-5472Electronic ISSN: 1538-7445Topics: MedicinePublished by: -
5Latest Papers from Table of Contents or Articles in PressEmily A. McMillan, Sheila M. Longo, Michael D. Smith, Sarah Broskin, Baicheng Lin, Nisha K. Singh, Todd I. Strochlic
The American Society for Biochemistry and Molecular Biology (ASBMB)
Published 2018Staff ViewPublication Date: 2018-02-24Publisher: The American Society for Biochemistry and Molecular Biology (ASBMB)Print ISSN: 0021-9258Electronic ISSN: 1083-351XTopics: BiologyChemistry and PharmacologyPublished by: -
6Latest Papers from Table of Contents or Articles in PressCollins, S. L., McMillan, A., Seney, S., van der Veer, C., Kort, R., Sumarah, M. W., Reid, G.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-02-15Publisher: The American Society for Microbiology (ASM)Print ISSN: 0099-2240Electronic ISSN: 1098-5336Topics: BiologyPublished by: -
7Articles: DFG German National LicensesBartkowiak, M. ; Mahan, G. D. ; Modine, F. A. ; Alim, M. A. ; Lauf, R. ; McMillan, A.
[S.l.] : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Electrical transport in zinc oxide varistors is simulated using two-dimensional Voronoi networks. The networks are assumed to contain randomly distributed grain boundaries of three electrical types: (1) high nonlinearity (i.e., "good'') junctions; (2) poor nonlinearity (i.e., "bad'') junctions; and (3) linear with low-resistivity (i.e., ohmic) junctions. These type classifications are those found in experimental measurements. By varying the type concentrations, the simulated current density versus electric field (J–E) characteristics can be made to conform to the different experimentally observed characteristics of ZnO varistors. These characteristics include the sharpness of switching at the transition between ohmic and nonlinear J–E response (i.e., knee region), as well as the degree of nonlinearity. It is shown that the reduction of the nonlinearity coefficient of bulk varistors, relative to that of isolated grain boundaries, can be explained only by the presence of "bad'' varistor junctions. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1468-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Objectives To study the histology of the skin lesions of secondary syphilis.Background Secondary syphilis is becoming less prevalent in developed countries and clinicians not familiar with the condition may resort to biopsy to elucidate the nature of a rash. It is therefore important that Dermatopathologists are aware of the histological features of secondary syphilis.Design Patients with secondary syphilis, who attended clinics held by one of us during a 10 year period and who consented to biopsy, were studied.Subjects Twenty-eight individuals.Methods Skin biopsies of representative lesions. Routine histological processing.Results The most common finding was that of an erythema multiforme pattern of papillary oedema and perivascular lympho-histiocytic infiltration (19 cases including the 2 men with HIV infection). The tissue reaction was mild in patients with macular lesions. Focal lichenoid tissue reaction (4 cases), a pseudolymphomatous appearance (1 case), and granuloma formation (3 cases) were noted in other patients. The histology of a condyloma latum was typical.Conclusions Our study serves to emphasise the importance of clinicopathological correlation in the assessment of a skin rash and to remind pathologists of secondary syphilis as an aetiological factor in macular and papular skin lesions. The mimicry of several other conditions confounds the specificity of the changes and shows that syphilis is a theoretical candidate in considering the aetiology of the changes seen. Careful scrutiny of all the histopathological features may permit a relatively refined differential diagnosis to be established and, either prospectively or retrospectively, alert the clinician to the appropriate additional investigative techniques which will allow a sound diagnosis to be attained.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Using an indirect immunoperoxidase method and a panel of monoclonal antibodies, anogenital warts removed from 86 individuals (28 heterosexual men, 47 homosexual men and 11 women) were studied. A constant feature was the presence of a stromal infiltrate of lymphocytes, in which CD4+ and CD8+ cells appear in a ratio of about 5:1. Cells expressing interleukin-2 receptors were found in the stroma, amounting to 10% of the CD3+ cells. Leu 6+ epidermal dendritic cells (Langerhans' cells) were present in each wart; their density and morphology were similar to that in adjacent, apparently normal, skin. The mean number of Langerhans' cells that expressed HLA-DQ was lower than that of HLA-DR+ cells. In 40 warts. HLA-DR was expressed on the surface of keratinocytes. Leu 7+ and Leu 11b+ cells were found in the epidermis of 17 and five warts, respectively. B-cells were noted in only five warts. These results are discussed in relation to persistence of wart virus infection.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A histological study of the lymphoid tissue of the rectums of 323 homosexual and 30 heterosexual men (including five intravenous drug users seropositive for human immunodeficiency virus, HIV) was undertaken. Marked lymphoid hyperplasia (germinal centre 〉680μm in diameter) was found in 13 men, nine of whom had a sexually transmitted infection of the rectum. Immunocytochemical studies showed that the germinal centres contained B-cells and follicular dendritic cells, surrounded by CD4+ and CD8+ T-cells in a ratio of between 5:1 and 10:1. In HIV-infected men there were decreased numbers of CD4+ cells and increased numbers of CD8+ cells, resulting in a ratio of between 0.8:1 and 2:1. In biopsies from four of seven HIV-infected men the follicular dendritic cell processes appeared shorter and fragmented. The pathogenesis of HIV infection is discussed in the light of these findings.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1365-2621Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyNotes: It is thought that a pre-digested dietary protein could have applications for patients with digestive disorders, and especially for the condition of cystic fibrosis. Enzymic hydrolysis, compared with acid hydrolysis, has the advantage of retaining the nutritional value of the protein, but is often associated with the occurrence of a bitter peptide which makes the product unpalatable. Eggwhite and casein have been investigated as protein substrates and treated with endopeptidases and pig's kidney tissue as a source of exopeptidases; hydrolysates relatively free of bitterness and containing small peptides and over 50% free amino acids have been obtained.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesMCMILLAN, A. S. ; LEUNG, K. C. M. ; POW, E. H. N. ; WONG, M. C. M. ; LI, L. S. W. ; ALLEN, P. F.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2842Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: summary The study aimed to investigate oral health-related quality of life (OHR-QoL) of stroke survivors on hospital discharge after rehabilitation. It was a cross-sectional study involving 43 elderly survivors of mild to moderate stroke about to be discharged from hospital after rehabilitation and a comparison group of 43 community-dwelling elderly people. The Medical Outcomes Short Form 36 (SF-36) measure, the General Oral Health Assessment Index (GOHAI) and an oral health transition scale were administered prior to a dental examination. Median SF-36 subscale scores were significantly different between groups (P 〈 0·05). In physical function, role-physical, role-emotional and mental health domains, stroke survivors had significantly lower scores indicating poorer health. The median GOHAI score for the stroke group was 52 and 54 for the comparison group with no significant difference between groups although more stroke survivors had difficulty speaking compared with the comparison group. About 75% of stroke survivors considered their appearance to be worse, half of them felt that speech was worse and about a third had difficulty chewing hard food compared with the pre-stroke condition (P 〈 0·05). Most participants were partially dentate with no significant difference in DMFT scores or prosthetic status between groups (P 〉 0·05). Health-related quality of life in general was significantly poorer after stroke although patients were considered physically well enough to be discharged from hospital. There was some impairment of OHR-QoL. The nature of the stroke, the hospital environment including diet, coping strategies and elderly Chinese peoples’ perception of health should be taken into account when interpreting measures of health status in stroke survivors.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesMcMillan, A. S. ; Leung, K. C. M. ; Leung, W. K. ; Wong, M. C. M. ; Lau, C. S. ; Mok, T. M. Y.
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-2842Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: summary The effect of oral symptoms of Sjögren's syndrome (SS) on health-related quality of life is presently uncertain. This study aimed to investigate oral health-related quality of life (OHRQOL) among southern Chinese people with SS. Twenty-six primary SS cases, 25 secondary cases and 29 matched controls took part in this cross-sectional study. Each participant completed a SF-36 questionnaire, the Oral Health Impact Profile and a dry mouth measure, assisted by a trained interviewer. Data on socio-demographic variables were also collected. The dry mouth measure revealed that people with primary and secondary SS had significant problems associated with subjective symptoms of dry mouth generally, and dry mouth when eating and speaking (P 〈 0·01). Sticky saliva and coughing were also problems in some primary SS cases. OHIP summary and sub-scale scores did not reveal differences in negative impacts between groups. Mean SF-36 sub-scale scores were significantly different between groups (P 〈 0·05). In physical function, role-physical and general health domains, primary and secondary SS sufferers had lower scores indicating poorer health. Oral symptoms of SS, notably xerostomia, had a negative effect on OHRQOL. Health-related quality of life in general was also impaired in SS sufferers. The OHIP did not appear to discriminate oral problems of concern to SS sufferers.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesMcmillan, A. S. ; Wong, M. C. M. ; Lo, E. C. M. ; Allen, P. F.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2842Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: summary The study aimed to describe and compare the psychosocial and functional impact of oral disease on the quality of life of the institutionalized and non-institutionalized elderly in Hong Kong. A total of 268 institutionalized and 318 non-institutionalized elderly aged 60–80 years took part. The 49-statement Oral Health Impact Profile (OHIP) was administered in a structured interview format and sociodemographic information collected prior to a clinical, oral examination. A greater number of the institutionalized were edentulous (19%); they also had more untreated dental disease. The number of elderly reporting negative impacts was generally low. The percentage of institutionalized elderly reporting a negative impact was significantly lower in one of the OHIP subscales (handicap, P 〈 0·001) and similar in the other six. The main factors affecting the OHIP score were living location, socio-economic status, dental disease and treatment seeking behaviour. In conclusion, the psychosocial and functional impact of oral conditions was low and similar in the institutionalized and non-institutionalized elderly although the pattern of oral disease was different. Life events and socially and culturally derived values appeared to affect the elderly perception of the impact of oral disease.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesMcMillan, A. S. ; Pow, E. H. N. ; Leung, W. K. ; Wong, M. C. M. ; Kwong, D. L. W.
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-2842Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: summary Although the complications of head and neck radiotherapy in the treatment of nasopharyngeal carcinoma (NPC) have been described, there is limited information on the effect of oral complications on oral health related quality of life. The aim of this study was to describe the psychosocial and functional impact of oral conditions in southern Chinese following radiotherapy for NPC. A cross-sectional study design was used with a sample of 109 subjects including NPC survivors, newly diagnosed NPC cases and a control group. Oral health related quality of life was assessed through the SF-36 and the Oral Health Impact Profile measures and a dry mouth measure. Data on socio-demographic variables and treatment seeking were also collected. The psychosocial and functional impact of oral conditions as revealed by the health status measures was significantly greater in NPC survivors than newly diagnosed NPC cases and controls. The oral specific and condition specific measures appeared to discriminate more effectively between groups than the generic measure. NPC survivors sought significantly more dental treatment than the other groups. The oral complications of radiotherapy for NPC, notably sequelae of salivary gland damage, have a significant negative effect on oral health related quality of life and result in an increased burden of dental care in the long-term.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesLeung, K. C. M. ; Pow, E. H. N. ; McMillan, A. S. ; Wong, M. C. M. ; Li, L. S. W. ; Hi, S.-L.
Oxford UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-2842Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Oral perception and oral motor ability were assessed in edentulous patients with stroke, Parkinson's disease, and an age and gender matched control group. Standard stereognosis and oral motor ability tests were performed, with and without complete dentures in situ. Statistical comparisons were made using ANOVA, Levene's test and paired t-tests. Stroke patients had significantly poorer stereognostic measures than Parkinson's disease patients and controls (P 〈 0·02). Stereognostic measures were better in all groups when dentures were worn. There were no differences in oral motor ability between groups. Oral stereognosis was significantly impaired in stroke patients. Oral stereognostic ability was better in all groups when dentures were worn. The oral motor ability test lacked the sensitivity to detect differences in motor ability between experimental groups. Edentulous patients with stroke should be encouraged to wear dentures during the rehabilitation phase as oral stereognosis is then less impaired.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0006-3002Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1600-0501Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: A longitudinal clinical trial involving 103 subjects was undertaken to assess the impact of oral implant therapy on the psychosocial well-being of subjects with complete denture wearing problems. There were four experimental groups: (1) an implant group, where subjects were edentulous/edentate in one jaw and requested and received implants to retain an oral prosthesis (IG); (2) subjects edentulous/edentate in one jaw requesting implants but who received conventional dentures (CDG1); (3) edentulous subjects requesting replacement of their dentures by conventional means (CDG2); (4) dentate subjects requiring routine treatment, who were included for comparison. Data were collected in each group pre- and post-treatment using validated oral specific [the Oral Health Impact Profile (OHIP)], and generic (the SF36) health status measures. Subjects in IG, CDG1 and CDG2 also completed a denture satisfaction scale.IG and CDG1 subjects reported that tooth loss and denture wearing problems had a much greater impact on their quality of life than subjects seeking conventional dentures. Dentate subjects had a much better oral health status compared with denture-wearing subjects. Following treatment, subjects who received implant-retained prostheses (IG) reported a significant improvement in satisfaction and health-related quality of life, as did subjects who requested and received conventional dentures (CDG2). Subjects who requested implants, but received conventional dentures (CDG1), reported little improvement in denture satisfaction and only modest improvement in their quality of life. None of the denture-wearing subjects reported health-related quality of life that was as good as that of dentate subjects. The findings have significant implications in the assessment of outcomes in future clinical trials.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1752-1688Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Architecture, Civil Engineering, SurveyingGeographyNotes: By using the method of successive approximations, the one-dimensional diffusion equation was solved for the distribution of pollutant from an instantaneous point source in a semi-infinite body of water under the influence of wind-generated waves. The solution was obtained with the aid of an expression developed in this study to relate the dispersion coefficient to wind speed, characteristics of a wind-generated wave, and drift current velocities. The results indicate that the wave causes the local concentration to oscillate with respect to time around a mean concentration distribution curve. The period of the oscillation is about that of the wave, and its amplitude is always less than 7 percent of the mean. The effect of a chemical reaction is to reduce the level of pollutant concentration, the magnitude of the reduction being dependent upon both the rate constant and the order of reaction. The case of simultaneous dumping of one pollutant at different sites was also considered.Type of Medium: Electronic ResourceURL: