Search Results - (Author, Cooperation:A. Maschio)

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  1. 1
    Staff View
    Publication Date:
    2013-08-03
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adult ; Chromosomes, Human, Y/*classification/*genetics ; European Continental Ancestry Group/*genetics ; *Evolution, Molecular ; Haplotypes ; Humans ; Italy ; Male ; Phylogeny ; Polymorphism, Single Nucleotide
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    C. Gieger ; A. Radhakrishnan ; A. Cvejic ; W. Tang ; E. Porcu ; G. Pistis ; J. Serbanovic-Canic ; U. Elling ; A. H. Goodall ; Y. Labrune ; L. M. Lopez ; R. Magi ; S. Meacham ; Y. Okada ; N. Pirastu ; R. Sorice ; A. Teumer ; K. Voss ; W. Zhang ; R. Ramirez-Solis ; J. C. Bis ; D. Ellinghaus ; M. Gogele ; J. J. Hottenga ; C. Langenberg ; P. Kovacs ; P. F. O'Reilly ; S. Y. Shin ; T. Esko ; J. Hartiala ; S. Kanoni ; F. Murgia ; A. Parsa ; J. Stephens ; P. van der Harst ; C. Ellen van der Schoot ; H. Allayee ; A. Attwood ; B. Balkau ; F. Bastardot ; S. Basu ; S. E. Baumeister ; G. Biino ; L. Bomba ; A. Bonnefond ; F. Cambien ; J. C. Chambers ; F. Cucca ; P. D'Adamo ; G. Davies ; R. A. de Boer ; E. J. de Geus ; A. Doring ; P. Elliott ; J. Erdmann ; D. M. Evans ; M. Falchi ; W. Feng ; A. R. Folsom ; I. H. Frazer ; Q. D. Gibson ; N. L. Glazer ; C. Hammond ; A. L. Hartikainen ; S. R. Heckbert ; C. Hengstenberg ; M. Hersch ; T. Illig ; R. J. Loos ; J. Jolley ; K. T. Khaw ; B. Kuhnel ; M. C. Kyrtsonis ; V. Lagou ; H. Lloyd-Jones ; T. Lumley ; M. Mangino ; A. Maschio ; I. Mateo Leach ; B. McKnight ; Y. Memari ; B. D. Mitchell ; G. W. Montgomery ; Y. Nakamura ; M. Nauck ; G. Navis ; U. Nothlings ; I. M. Nolte ; D. J. Porteous ; A. Pouta ; P. P. Pramstaller ; J. Pullat ; S. M. Ring ; J. I. Rotter ; D. Ruggiero ; A. Ruokonen ; C. Sala ; N. J. Samani ; J. Sambrook ; D. Schlessinger ; S. Schreiber ; H. Schunkert ; J. Scott ; N. L. Smith ; H. Snieder ; J. M. Starr ; M. Stumvoll ; A. Takahashi ; W. H. Tang ; K. Taylor ; A. Tenesa ; S. Lay Thein ; A. Tonjes ; M. Uda ; S. Ulivi ; D. J. van Veldhuisen ; P. M. Visscher ; U. Volker ; H. E. Wichmann ; K. L. Wiggins ; G. Willemsen ; T. P. Yang ; J. Hua Zhao ; P. Zitting ; J. R. Bradley ; G. V. Dedoussis ; P. Gasparini ; S. L. Hazen ; A. Metspalu ; M. Pirastu ; A. R. Shuldiner ; L. Joost van Pelt ; J. J. Zwaginga ; D. I. Boomsma ; I. J. Deary ; A. Franke ; P. Froguel ; S. K. Ganesh ; M. R. Jarvelin ; N. G. Martin ; C. Meisinger ; B. M. Psaty ; T. D. Spector ; N. J. Wareham ; J. W. Akkerman ; M. Ciullo ; P. Deloukas ; A. Greinacher ; S. Jupe ; N. Kamatani ; J. Khadake ; J. S. Kooner ; J. Penninger ; I. Prokopenko ; D. Stemple ; D. Toniolo ; L. Wernisch ; S. Sanna ; A. A. Hicks ; A. Rendon ; M. A. Ferreira ; W. H. Ouwehand ; N. Soranzo
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-12-06
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Blood Platelets/*cytology/metabolism ; Cell Size ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Europe ; Gene Expression Profiling ; Gene Silencing ; Genome, Human/genetics ; Genome-Wide Association Study ; Hematopoiesis/*genetics ; Humans ; Megakaryocytes/*cytology/metabolism ; Platelet Count ; Protein Interaction Maps ; Transcription, Genetic/genetics ; Zebrafish/genetics ; Zebrafish Proteins/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Landoni, F. ; Pellegrino, A. ; Cormio, G. ; Zanetta, G. ; Del Maschio, A. ; Vanzulli, A. ; Mangioni, C.

    Suite 500, 5th Floor, 238 Main Street, Cambridge, Massachusetts, 02142, USA : Blackwell Science Inc.
    Published 1996
    Staff View
    ISSN:
    1525-1438
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    The sensitivity of magnetic resonance (MR) imaging in predicting extracervical tumor invasion on the basis of the detection of a thinning of the uninvolved cervical stromal ring (3 mm or less) was compared to the sensitivity achieved by visualization of a complete stromal interruption. Fifty-seven consecutive patients with squamous carcinoma of the uterine cervix (FIGO stage IB-IIA), scheduled for radical surgery, were examined with axial and sagittal weighted MR sequences. The sensitivity in predicting extracervical involvement on the basis of the MR imaging visualization of a thinned stroma was 87.5%, whereas the sensitivity obtained by detection of a complete stromal interruption was 70%. Among women with a spared cervical stroma of more than 3 mm at MR imaging, only two had microscopic extracervical involvement at pathologic examination, accounting for a negative predictive value of 92.8%. The results of our study show a high concordance between MR imaging and pathologic findings, and indicate that the detection of an intact cervical stromal ring exceeding 3 mm at MR imaging is related to a very low risk of extracervical seeding of tumor. On the other hand, the detection of a thinned stromal ring is related to a high incidence of microscopic parametrial invasion. The information obtained by this imaging technique may therefore be extremely useful in accurate treatment planning for these patients.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1525-1438.1996.06010049.x

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    0090-6980
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0090-6980(88)90200-6

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    0090-6980
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0090-6980(82)90123-X

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    0090-6980
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0090-6980(84)90162-X

    Articles: DFG German National Licenses
  7. 7
    Maschio, A. ; Dejana, E. ; Bazzoni, G.
    Springer
    Published 1993
    Staff View
    ISSN:
    1432-0584
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01709662

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Type 1 (insulin-dependent) diabetes mellitus ; diabetic nephropathy ; microalbuminuria ; magnetic resonance ; chronic renal failure
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Reductions in the physiological cortical to medullary signal intensity ratio are found in magnetic resonance scans of the kidney in non-diabetic glomerular disease. Whether this abnormality can also characterise patients with Type 1 (insulin-dependent) diabetes mellitus and nephropathy is not known. We measured the cortical to medullary signal intensity ratio in magnetic resonance images of the kidney in 34 patients with Type 1 diabetes (ten with either clinical proteinuria or raised serum creatinine or both, nine with microalbuminuria, seven with normal urinary albumin excretion and long duration of diabetes and eight with Type 1 diabetes of short duration). The cortical to medullary signal intensity ratio showed a trend to cluster at lower values in the normoalbuminuric patients with normal serum creatinine rather than in the nine healthy individuals, independent of Type 1 diabetes duration (1.47 ± 0.06 and 1.41 ± 0.13 vs 1.63 ± 0.16; five groups-Scheffé F-test p = 0.05–0.1). Among the Type 1 diabetic patients, significant reductions in the cortical to medullary signal intensity ratio characterised overt nephropathy (1.19 ± 0.15, p 〈0.05 vs all groups), but not microalbuminuria (1.47 ± 0.13, p = NS), concomitantly with low glomerular filtration rate and elevated fractional excretion of uric acid, but independent of glycaemic control. The determinants of the renal cortical to medullary signal intensity ratio in Type 1 diabetes are uncertain. Reductions in the cortical to medullary signal intensity ratio may be a late finding in diabetic nephropathy, and parallel the accompanying impairment in kidney haemodynamics. Magnetic resonance imaging of the kidney may not offer clues in the early diagnosis of diabetic nephropathy.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00401433

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    1432-0509
    Keywords:
    Gastrointestinal tract, motility-Glucagon, applications
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract In the present study, following a double-blind, double placebo protocol vs. placebo, we compared the hypotonic effect of intranasal and intravenous glucagon during a double-contrast barium meal examination of the stomach. We found a statistically significant difference between placebo and intranasal or intravenous glucagon in inducing gastric hypomotility, with no significant differences between IN and IV glucagon. The intranasal administration of glucagon has the advantage of being noninvasive and well tolerated by the patients, and might be a valuable aid in upper gastrointestinal examination as well as in CT scan or magnetic resonance imaging of the abdomen.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00199643

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1432-0509
    Keywords:
    Key words: Liver neoplasm, chemotherapeutic infusion—Liver neoplasm, MR—Liver neoplasm, therapy.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract. Background: To assess unenhanced and gadolinium-enhanced magnetic resonance (MR) imaging patterns of hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). Methods: Thirty-two patients with 48 HCC lesions underwent MR imaging before and 15 days after TACE. Fifteen lesions were then surgically resected. The remaining 33 lesions were not removed and were followed up with MR imaging at 3, 6, 12, and 18 months after treatment. Spin echo (SE) T1- and T2-weighted and gadolinium-enhanced SE T1-weighted sequences were employed. Qualitative evaluation of signal intensity pattern of the treated lesions was performed in all cases. Histological evaluation and selective hepatic arteriography were considered the gold standard of the study for the 15 resected lesions and the 33 unresected lesions, respectively. Results: On follow-up enhanced T1-weighted images of the 15 resected lesions, seven showed no area of enhancement corresponding to complete necrosis at histologic examination. The remaining eight resected lesions showed areas of enhancement; in six of these cases, viable tumor tissue was found at histology; in the other two lesions, histologic examination revealed the presence of complete tumor necrosis. In the group of resected lesions, T2-weighted images showed no pattern characteristic of necrosis. In 24 of 33 unresected lesions, loss of enhancement on follow-up enhanced T1-weighted images was a characteristic finding, which correlated to devascularization at arteriography. Of these 24 lesions, 17 were completely hypointense on follow-up T2-weighted images; the remaining seven showed small foci of hyperintensity. The other nine unresected lesions showed enhanced portions on follow-up enhanced T1-weighted images, which corresponded to hyperintense areas on T2-weighted images. These findings correlated to persistence of hypervascular areas at arteriography. Conclusion: Gadolinium-enhanced T1-weighted MR imaging is a reliable method for evaluating the outcome of TACE treatment and is more accurate than unenhanced T2-weighted MR imaging.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002619900110

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1432-0509
    Keywords:
    Key words: Pancreatic neoplasms—Insulinoma—Comparative studies—Pancreas, US studies—Pancreas, MRI
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract. Background: Abdominal sonography, computed tomography (CT), angiography, and magnetic resonance (MR) imaging are the most widely used modalities for preoperative localization of insulinomas. CT and angiography are generally considered the techniques of reference, and the role of sonography and MR imaging in these patients is controversial. The purpose of this study was to compare these four modalities in a group of patients with pancreatic insulinoma and determine an effective radiological approach to this disease. Methods: Twenty-eight patients with clinical and biochemical signs of pancreatic insulinoma underwent abdominal sonography, MR imaging at 0.5 T (spin echo technique), bolus dynamic CT, and digital subtraction angiography. Examinations were evaluated independently for the presence, size, and location of the lesions; preoperative diagnoses were compared with surgical findings based on palpation and intraoperative sonography. Tumoral vascularity was histologically graded. Sensitivities of the four imaging techniques were calculated and compared with the size, location, and vascularity of the tumors. Detection rates of combined techniques were finally determined. Results: At surgery, 29 lesions in the 28 patients were found (range = 0.8–4.3 cm, average = 1.65 cm). Sensitivities of abdominal sonography, MR imaging, CT, and angiography were 79.3%, 65.5%, 44.8%, and 69% respectively. Correct localization of tumor was achieved in 96.6% of cases by a combination of sonography and MR imaging and in 72.4% of cases by using CT with angiography. Conclusion: In our experience, sonography and MR imaging performed well in the preoperative detection of pancreatic insulinoma. Therefore, we believe that the combination of abdominal sonography and MR imaging may represent the first radiological approach in clinically suspected insulinomas and that CT and angiography should be reserved for negative and/or doubtful cases.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002619900193

    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1432-1920
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Résumé Les auteurs rapportent un cas d'hémangiome du rachis dorsal chez un adolescent de 11 ans, devenu paraparétique après un léger traumatisme. La myélographie montrait un arrêt complet du produit opaque au niveau de la vertèbre angiomateuse. L'angiographie médullaire sélective permettait d'opacifier l'hémangiome et ses pédicules vasseaux provenant des artères intercostales ge droite et gauche. — Après la visualisation de l'artère de Adamkiewicz, provenant de la 7eartère intercostale gauche, une embolisation pré-opératoire de l'hémangiome est réalisée. L'intervention chirurgicale de laminectomie s'est révélée simple et peu hémorragique. L'enfant marchait correctement 2 mois après l'operation.
    Abstract:
    Zusammenfassung Die Autoren berichten über einen Fall mit einem Hämangiom der Brustwirbelsäule bei einem elfjährigen Kind, das nach einem leichten Trauma paraparetisch geworden war. Eine Myelographie ergab einen kompletten Stop des Kontrastmittels in der Höhe des angiomatösen Wirbels. Mit einer selektiven Rückenmark-Angiographie wurden das Hämangiom und seine Versorgungsgefäße aus der linken und rechten 9. Interkostalarterie dargestellt. Darauf wurde nach Darstellung der Arterie von Adamkiewicz mit ihrem Ursprung aus der linken 7. Interkostalarterie die präoperative Embolisierung des Hämangioms durchgeführt. Der darauffolgende chirurgische Eingriff, eine Laminektomie, war einfach und ging ohne nennenswerten Blut verlust vor sich. Zwei Monate nach der Operation hatte sich das Kind gut erholt und begann normal zu gehen.
    Notes:
    Summary The authors report one case of dorsal haemangioma in an eleven year old boy who became paraparetic following slight trauma. Myelography revealed a complete block at the level of the angiomatous vertebra. — Selective medullary angiography gave complete visualization of the haemangioma and of its vascular peduncles which started from the right and left 9th inter costal arteries. After having visualized Adamkiewicz's artery, which started from Th7 on the left, the angioma was embolised with sponge fragments. This made decompressive laminectomy much easier since it reduced the risk of profuse bleeding. The child was walking normally two months after operation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00344326

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1432-1459
    Keywords:
    Multiple sclerosis ; Diagnosis ; Electrophysiological tests ; Magnetic resonance imaging
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Sixty multiple sclerosis (MS) patients (33 definite, 13 probale and 14 suspected were investigated by computed tomography (CT), magnetic resonance imaging (MRI), multimodality evoked potentials (EPs) and cerebrospinal fluid (CSF) electrophoresis. MRI abnormalities were found in 50 cases, while at least one abnormal evoked potential was detected in each of 52 cases. Brain-stem auditory evoked potentials were more sensitive than MRI for the detection of brainstem involvement. All the patients with oligoclonal bands had abnormal MRI and none of the patients with normal MRI had oligoclonal bands in the CSF. The number and the extent of MRI lesions were significantly correlated with the duration of disease and with the degree of disability. Our observations stress the importance of the combined use of MRI and EPs in detecting silent CNS lesions in MS patients.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00314209

    Articles: DFG German National Licenses
  14. 14
    Beltramello, A. ; Benati, A. ; Perini, S. ; Maschio, A.
    Springer
    Published 1989
    Staff View
    ISSN:
    1433-0350
    Keywords:
    Interventional angiography ; Embolization ; Head and neck angiomas ; Aneurysmal bone cyst ; Vertebral hemangioma ; Spinal cord angioma
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Since the introduction of non-invasive imaging techniques (CT, US, MRI), superselective cerebrospinal angiography has been playing a major role as a diagnostic tool as well as a therapeutic procedure prior to surgery or as an alternative. Surgical neuroangiography is now also a well-established therapeutic technique in neuropediatrics. Lesions fed by the external carotid artery and spinal cord lesions are the main indications. The first group consists of maxillofacial vascular malformations, nasopharyngeal angiofibromas, and vascularized tumors of the facioorbital area (hemangiopericytoma, angiosarcoma ...). Spinal lesions for which embolization can be considered are benign tumors of the vertebral column (vertebral hemangioma, aneurysmal bone cyst ...) and vascular malformations intrinsic to the spinal cord. Particles (Ivalon, dura) are the safest embolization materials and have a wide range of possible applications; glues such as IBC have defined but limited indications. Digital subtraction angiography is crucial during the procedure and in determining the overall doses of contrast medium to be administered. Furthermore, decisions can be made more rapidly and precisely, with a definite improvement in the therapeutic results.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00571116

    Articles: DFG German National Licenses
  15. 15
    Sansone, V. ; Ponti, A ; Paluello, G. Minio ; Maschio, A.
    Springer
    Published 1995
    Staff View
    ISSN:
    1432-5195
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Résumé Nous avons examiné les caractéristiques épidémiologiques du kyste poplité chez l'adulte et la fréquence des pathologies intra-articulaires du genou associées à celui-ci dans une population de 1001 patients qui se sont adressés à notre hôpital pour exécuter une resonance magnétique nucléaire du genou. Les images qui montraient la présence d'un kyste poplité ont été réexaminées par 2 d'entre nous pour déterminer la présence d'autres pathologies intra-articulaires du genou. L'incidence du kyste poplité dans la population étudiée (4.7%) était moindre par rapport à ce qui a été décrit dans des études précédentes, où le diagnostique était posé par des techniques différentes. Nous avons toujour observé la présence d'une communication entre le kyste et la cavité articulaire. Nous avons constaté que le kyste poplité est associé à une autre pathologie intra-articulaire, mise en évidence par la resonance magnétique nucléaire, dans 94% des cas. Les pathologies plus fréquement associées sont: lésions méniscales (83%), intéressant généralement la corne postérieure du ménisque interne, lésions chondrales (43%), et rupture du ligament croisé antérieur (32%). Bien que la relation entre kyste et pathologie intra-articulaire du genou mérite d' être approfondi, nos données suggèrent, que la pathologie intra-articulaire puisse jouer un rôle fondamental dans la pathogenèse du kyste poplité de l'adulte.
    Notes:
    Summary We have studied retrospectively the epidemiological features of popliteal cysts in adults and the incidence of associated intra-articular disorders in a series of 1001 patients undergoing magnetic resonance imaging who had been randomly referred to our institution. Images of popliteal cysts were seen in 4.7% of this group which is lower than in other studies with different imaging techniques. A communication with the joint was invariably found. The cysts were associated with one, or more, disorders detected by MRI in 94%. The commonest lesions were meniscal (83%), frequently involving the posterior horn of the medial meniscus, chondral (43%), and anterior cruciate ligament tears. Our data suggest that intra-articular disorders may play an important role in the pathogenesis of popliteal cysts in adults.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00181107

    Articles: DFG German National Licenses