Search Results - (Author, Cooperation:A. Manglik)
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1Latest Papers from Table of Contents or Articles in PressS. Granier ; A. Manglik ; A. C. Kruse ; T. S. Kobilka ; F. S. Thian ; W. I. Weis ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-05-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Animals ; Binding Sites ; Conserved Sequence ; Crystallography, X-Ray ; Mice ; Models, Molecular ; Molecular Sequence Data ; Naltrexone/*analogs & derivatives/chemistry/metabolism/pharmacology ; Protein Structure, Tertiary ; Receptors, Opioid, delta/antagonists & inhibitors/*chemistry/metabolism ; Reproducibility of Results ; Structure-Activity Relationship ; Substrate SpecificityPublished by: -
2Latest Papers from Table of Contents or Articles in PressA. Manglik ; A. C. Kruse ; T. S. Kobilka ; F. S. Thian ; J. M. Mathiesen ; R. K. Sunahara ; L. Pardo ; W. I. Weis ; B. K. Kobilka ; S. Granier
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-03-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Binding Sites ; Crystallography, X-Ray ; Ligands ; Mice ; Models, Molecular ; Morphinans/*chemistry/metabolism/pharmacology ; Protein Conformation ; Protein Multimerization ; Receptors, Opioid, mu/*antagonists & inhibitors/*chemistry/metabolism ; Solvents/chemistryPublished by: -
3Latest Papers from Table of Contents or Articles in PressR. O. Dror ; T. J. Mildorf ; D. Hilger ; A. Manglik ; D. W. Borhani ; D. H. Arlow ; A. Philippsen ; N. Villanueva ; Z. Yang ; M. T. Lerch ; W. L. Hubbell ; B. K. Kobilka ; R. K. Sunahara ; D. E. Shaw
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-06-20Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: GTP-Binding Protein alpha Subunits, Gi-Go/*chemistry ; GTP-Binding Protein alpha Subunits, Gs/*chemistry ; Guanine Nucleotide Exchange Factors/*chemistry ; Humans ; Models, Chemical ; Molecular Dynamics Simulation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Receptors, G-Protein-Coupled/*chemistry ; Signal TransductionPublished by: -
4Latest Papers from Table of Contents or Articles in PressA. M. Ring ; A. Manglik ; A. C. Kruse ; M. D. Enos ; W. I. Weis ; K. C. Garcia ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-09-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adrenergic beta-2 Receptor Agonists/*pharmacology ; Benzoxazines/pharmacology ; Binding Sites/drug effects ; Crystallography, X-Ray ; Directed Molecular Evolution ; Epinephrine/*pharmacology ; Humans ; Hydrogen Bonding/drug effects ; Isoproterenol/analogs & derivatives/pharmacology ; Ligands ; Models, Molecular ; *Protein Engineering ; Protein Stability/drug effects ; Receptors, Adrenergic, beta-2/*chemistry/drug effects/*metabolism ; Single-Chain Antibodies/genetics/*pharmacology ; Tyrosine/chemistry/metabolism ; Water/chemistry/pharmacologyPublished by: -
5Latest Papers from Table of Contents or Articles in PressA. C. Kruse ; A. M. Ring ; A. Manglik ; J. Hu ; K. Hu ; K. Eitel ; H. Hubner ; E. Pardon ; C. Valant ; P. M. Sexton ; A. Christopoulos ; C. C. Felder ; P. Gmeiner ; J. Steyaert ; W. I. Weis ; K. C. Garcia ; J. Wess ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-11-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Allosteric Regulation ; Binding Sites ; Cytoplasm/metabolism ; Humans ; Isoxazoles/chemistry/metabolism ; *Models, Molecular ; Protein Binding ; Protein Structure, Tertiary ; Quaternary Ammonium Compounds/chemistry/metabolism ; Receptors, Muscarinic/*chemistry/*metabolismPublished by: -
6Latest Papers from Table of Contents or Articles in PressR. Sounier ; C. Mas ; J. Steyaert ; T. Laeremans ; A. Manglik ; W. Huang ; B. K. Kobilka ; H. Demene ; S. Granier
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-08-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Allosteric Regulation ; Animals ; Binding Sites ; Heterotrimeric GTP-Binding Proteins/metabolism ; Lysine/metabolism ; Mice ; Models, Molecular ; Morphinans/chemistry/metabolism/pharmacology ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Conformation/drug effects ; Pyrroles/chemistry/metabolism/pharmacology ; Receptors, Adrenergic, beta-2/chemistry ; Receptors, Opioid, mu/*chemistry/*metabolism ; Single-Chain Antibodies/chemistry/metabolism/pharmacology ; Structure-Activity Relationship ; Substrate SpecificityPublished by: -
7Latest Papers from Table of Contents or Articles in PressA. K. Shukla ; A. Manglik ; A. C. Kruse ; K. Xiao ; R. I. Reis ; W. C. Tseng ; D. P. Staus ; D. Hilger ; S. Uysal ; L. Y. Huang ; M. Paduch ; P. Tripathi-Shukla ; A. Koide ; S. Koide ; W. I. Weis ; A. A. Kossiakoff ; B. K. Kobilka ; R. J. Lefkowitz
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-04-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Arrestins/*chemistry/immunology/*metabolism ; Crystallography, X-Ray ; Humans ; Immunoglobulin Fab Fragments/chemistry/immunology/metabolism ; Models, Molecular ; Phosphopeptides/*chemistry/*metabolism ; Phosphorylation ; Protein Binding ; Protein Conformation ; Protein Stability ; Rats ; Receptors, Vasopressin/*chemistry ; RotationPublished by: -
8Latest Papers from Table of Contents or Articles in PressW. Huang ; A. Manglik ; A. J. Venkatakrishnan ; T. Laeremans ; E. N. Feinberg ; A. L. Sanborn ; H. E. Kato ; K. E. Livingston ; T. S. Thorsen ; R. C. Kling ; S. Granier ; P. Gmeiner ; S. M. Husbands ; J. R. Traynor ; W. I. Weis ; J. Steyaert ; R. O. Dror ; B. K. Kobilka
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-08-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Allosteric Regulation ; Animals ; Binding Sites ; Crystallography, X-Ray ; Heterotrimeric GTP-Binding Proteins/chemistry/metabolism ; Mice ; Models, Molecular ; Molecular Dynamics Simulation ; Morphinans/chemistry/metabolism/pharmacology ; Protein Stability/drug effects ; Protein Structure, Tertiary ; Pyrroles/chemistry/metabolism/pharmacology ; Receptor, Muscarinic M2/chemistry ; Receptors, Adrenergic, beta-2/chemistry ; Receptors, Opioid, mu/agonists/*chemistry/*metabolism ; Single-Chain Antibodies/chemistry/pharmacology ; Structure-Activity RelationshipPublished by: -
9Latest Papers from Table of Contents or Articles in PressH. R. Schmidt ; S. Zheng ; E. Gurpinar ; A. Koehl ; A. Manglik ; A. C. Kruse
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-04-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Benzamides/chemistry/metabolism ; Binding Sites ; Crystallography, X-Ray ; Endoplasmic Reticulum/metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Intracellular Membranes/metabolism ; Isoxazoles/chemistry/metabolism ; Ligands ; Models, Molecular ; Piperidines/chemistry/metabolism ; Protein Structure, Tertiary ; Pyridines/chemistry/metabolism ; Receptors, sigma/*chemistry/metabolism ; Substrate SpecificityPublished by: -
10Articles: DFG German National LicensesStaff View
ISSN: 1365-246XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesNotes: Models of retrograde metamorphism in many orogenic belts are based on crustal thickening and erosion of continental lithosphere. The pressure and temperature evolutions in such models are generally obtained by solving the advection diffusion equation with the lithosphere-asthenosphere boundary (LAB) either fixed at a specified depth or moving downwards at the same rate as erosion from the surface. However, this boundary is defined as a solid-partial-melt boundary in many geophysical interpretations. In the present work, we discuss a solution of the above problem considering the LAB as a phase boundary that moves. This solution is obtained by the Fourier series approach for a general case of surface erosion and basal heat transport. The results obtained for different models of crustal thickening show a significant movement of the LAB in response to erosion from the surface. A corresponding variation in the lithospheric thickness is also a significant result of this analysis. The earlier notion of a fixed-base lithosphere seems to be a good approximation when analysing metamorphic data, as we obtain nearly the same temperature profile in the crust as after including the LAB motion effect. However, the erosion of thickened crust is found to affect the lithospheric growth. These results indicate that metamorphic data (sampling the thermal structure of the upper lithosphere) do not preserve the signatures of such boundary motion.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1573-1650Keywords: unconfined aquifer ; transient recharge ; water table ; analytical solutionSource: Springer Online Journal Archives 1860-2000Topics: Architecture, Civil Engineering, SurveyingGeographyNotes: Abstract A prior knowledge of the water table fluctuations, in response to the proposed recharge scheme, is essential to achieve the preset objectives of ground water resources management. In this paper an analytical solution of the linearised Boussinesq's equation is presented to predict the spatio-temporal variation of the water table in an aquifer system in response to time-varying recharge applied through a rectangular basin. The recharge function is approximated by introducing a number of line segments depending on its nature of variation. The solution is obtained by using finite Fourier sine transform and its application is demonstrated for a case of periodically applied recharge.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1573-1650Keywords: Transient recharge ; water-table ; analytical solution ; aquifer ; predictionSource: Springer Online Journal Archives 1860-2000Topics: Architecture, Civil Engineering, SurveyingGeographyNotes: Abstract A problem of water-table fluctuation in a finite two-dimensional aquifer system in response to transient recharge from an overlying rectangular area is studied. An analytical solution is obtained by using the method of finite Fourier transform to predict the transient position of the water-table. The solution for constant rate of recharge is shown as a special case of the present solution. Effects of variation in the rate of recharge on the growth of two-dimensional groundwater mound is illustrated with the help of a numerical example.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1573-1650Keywords: Unconfined aquifer ; transient recharge ; water table ; analytical solutionSource: Springer Online Journal Archives 1860-2000Topics: Architecture, Civil Engineering, SurveyingGeographyNotes: Abstract An analytical solution is developed to predict spatio-temporal variation of the water table in a 2-D aquifer system which is receiving transient recharge from an overlying basin of rectangular shape. The transient recharge function is approximated by a number of line segments. Application of the solution is demonstrated with the help of an example problem.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1573-1650Keywords: linearized Boussinesq equation ; time-varying recharge and pumping ; unconfined aquiferSource: Springer Online Journal Archives 1860-2000Topics: Architecture, Civil Engineering, SurveyingGeographyNotes: Abstract An analytical solution of a two-dimensional linearized Boussinesqequation is presented to predict the water table fluctuations in anunconfined aquifer due to time-varying recharge and withdrawal frommultiple basins and wells, respectively. This solution is obtainedby using the finite Fourier sine transform. The time-varying recharge(discharge) rate is approximated by a number of piecewisse linearelements of different lengths and slopes depending on the nature ofthe variation in recharge (discharge) rate. Application of thesolution for the prediction of water table fluctuations and in thesensitivity analysis is demonstrated in an example.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1588-2837Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyDescription / Table of Contents: Abstract Кинетика окисления изопропанола водным иодом была исследована при pH=9,18. Реакция имеет первый и нулевой порядок по отношению к субстрату и иоду, соответственно. Молекулярный иод является более эффективным в окислении алкоксидного иона, нежели для ROH. Было исследовано влияние различных факторов, таких как ионная сила, неорганические соли, D2O и температуры на начальную скорость и был предложен механизм отщепления гидрида.Notes: Abstract Kinetics of oxidation of isopropyl alcohol by aqueous iodine has been investigated at pH 9. 18. The reaction is first and zero order with respect to substrate and iodine, respectively. Molecular iodine is more effective in oxidizing alkoxide ion than ROH. The influence of various factors such as ionic strength, inorganic salts, D2O and temperature on the initial rate has been studied and a hydride abstraction mechanism is suggested for the reaction.Type of Medium: Electronic ResourceURL: