Search Results - (Author, Cooperation:A. M. Kelly)
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1Latest Papers from Table of Contents or Articles in PressL. Chen ; M. Kostadima ; J. H. Martens ; G. Canu ; S. P. Garcia ; E. Turro ; K. Downes ; I. C. Macaulay ; E. Bielczyk-Maczynska ; S. Coe ; S. Farrow ; P. Poudel ; F. Burden ; S. B. Jansen ; W. J. Astle ; A. Attwood ; T. Bariana ; B. de Bono ; A. Breschi ; J. C. Chambers ; F. A. Choudry ; L. Clarke ; P. Coupland ; M. van der Ent ; W. N. Erber ; J. H. Jansen ; R. Favier ; M. E. Fenech ; N. Foad ; K. Freson ; C. van Geet ; K. Gomez ; R. Guigo ; D. Hampshire ; A. M. Kelly ; H. H. Kerstens ; J. S. Kooner ; M. Laffan ; C. Lentaigne ; C. Labalette ; T. Martin ; S. Meacham ; A. Mumford ; S. Nurnberg ; E. Palumbo ; B. A. van der Reijden ; D. Richardson ; S. J. Sammut ; G. Slodkowicz ; A. U. Tamuri ; L. Vasquez ; K. Voss ; S. Watt ; S. Westbury ; P. Flicek ; R. Loos ; N. Goldman ; P. Bertone ; R. J. Read ; S. Richardson ; A. Cvejic ; N. Soranzo ; W. H. Ouwehand ; H. G. Stunnenberg ; M. Frontini ; A. Rendon
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-09-27Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: *Alternative Splicing ; Cell Lineage/*genetics ; Genetic Variation ; Hematopoiesis/*genetics ; Hematopoietic Stem Cells/*cytology/metabolism ; Humans ; NFI Transcription Factors/genetics/metabolism ; RNA-Binding Proteins/metabolism ; Thrombopoiesis/genetics ; TranscriptomePublished by: -
2Latest Papers from Table of Contents or Articles in PressV. M. Narasimhan ; K. A. Hunt ; D. Mason ; C. L. Baker ; K. J. Karczewski ; M. R. Barnes ; A. H. Barnett ; C. Bates ; S. Bellary ; N. A. Bockett ; K. Giorda ; C. J. Griffiths ; H. Hemingway ; Z. Jia ; M. A. Kelly ; H. A. Khawaja ; M. Lek ; S. McCarthy ; R. McEachan ; A. O'Donnell-Luria ; K. Paigen ; C. A. Parisinos ; E. Sheridan ; L. Southgate ; L. Tee ; M. Thomas ; Y. Xue ; M. Schnall-Levin ; P. M. Petkov ; C. Tyler-Smith ; E. R. Maher ; R. C. Trembath ; D. G. MacArthur ; J. Wright ; R. Durbin ; D. A. van Heel
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-03-05Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; *Consanguinity ; DNA Mutational Analysis ; Drug Prescriptions ; Exome/genetics ; Female ; Fertility ; Gene Knockout Techniques ; Genes, Lethal ; Genetic Loci ; Genome, Human ; Great Britain ; *Health ; Histone-Lysine N-Methyltransferase/*genetics ; Homologous Recombination ; Homozygote ; Humans ; Male ; Mothers ; Pakistan/ethnology ; PhenotypePublished by: -
3Articles: DFG German National LicensesBURROWS, D. ; KELLY, A. M. T. ; BRIDGES, J. M. ; CONNOLLY, J. H.
Oxford, UK : Blackwell Publishing Ltd
Published 1970Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: SUMMARY.— Six cases of Letterer-Siwe disease occurring in a population of 1,500,000 over a period of 10 years are described. Five have died and 1 survives 2 years after cessation of therapy and 4 years after diagnosis. Of those who died, in 2 the terminal event was measles infection, in 1 surgical emphysema consequent on rupture of a lung cyst and in 2 death followed progression of the disease.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesKelly, A. M. Clare ; Hester, Robert ; Murphy, Kevin ; Javitt, Daniel C. ; Foxe, John J. ; Garavan, Hugh
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Using event-related fMRI, this study investigated the neural dynamics of response inhibition under fluctuating task demands. Fourteen participants performed a GO/NOGO task requiring inhibition of a prepotent motor response to NOGO events that occurred as part of either a Fast or Slow presentation stream of GO stimuli. We compared functional activations associated with correct withholds (Stops) required during the Fast presentation stream of stimuli to Stops required during the Slow presentation stream. A predominantly right hemispheric network was activated across conditions, consistent with previous studies. Furthermore, a functional dissociation of activations between conditions was observed. Slow Stops elicited additional activation in anterior dorsal and polar prefrontal cortex and left inferior parietal cortex. Fast Stops showed additional activation in a network that included right dorsolateral prefrontal cortex, insula and dorsal striatum. These results are discussed in terms of our understanding of the impact of preparation on the distributed network underlying response inhibition and the contribution of subcortical areas, such as the basal ganglia, to executive control processes.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesDawson, P. M. ; Blair, S. D. ; Begent, R. H. J. ; Kelly, A. M. B. ; Boxer, G. M. ; Theodorou, N. A.
Springer
Published 1991Staff ViewISSN: 1530-0358Keywords: Radioimmunoguided surgery ; Colorectal cancerSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Radioimmunoguided surgery (RIGS) using an anti-CEA (A5B7) monoclonal antibody has been assessed in 52 patients (43 primary excisions and nine second look procedures) undergoing surgery for colorectal carcinoma. The antibody localized in 97.8 percent of primary tumours and in 88.8 percent of the principal tumor in second look procedures. Additional information concerning the extent of primary tumor was obtained in 11 of 43 patients (25.5 percent) undergoing excision of primary carcinoma and five of nine patients (55 percent) in the second look series. Incorrect information was obtained about the extent of the primary tumour in six patients (11.3 percent), whereas no incorrect information was obtained during second look procedures. RIGS correctly predicted the subsequent Dukes' staging in 77 percent of first look cases (sensitivity 65 percent, specificity 90 percent), although accurate identification of individual nodes was impossible. The technique influenced the surgical procedure performed in 2 of 43 cases (4.6 percent) in primary surgery and in three of nine patients undergoing second look laparotomy (33 percent). RIGS in primary colorectal carcinoma may provide additional information concerning extent of locally advanced tumors in particular and the principle that the subsequent surgery may be influenced has been established. The technique appears to have a greater role in second look procedures where it may help determine the extent of recurrent tumour. Larger follow-up series are required to define how the additional information provided by this technique may best be exploited.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStedman, H. H. ; Sweeney, H. L. ; Shrager, J. B. ; Maguire, H. C. ; Panettieri, R. A. ; Petrof, B. ; Narusawa, M. ; Leferovich, J. M. ; Sladky, J. T. ; Kelly, A. M.
[s.l.] : Nature Publishing Group
Published 1991Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Histopathological changes in the mdx diaphragm are rare before 25 days of age. At 30 days, foci of myofibre degeneration, necrosis, mineralization and regeneration are present but are not extensive. Similar changes are present in limb muscles. We find no evidence that the initial lesions of the ...Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Serial, frozen sections were prepared from the extensor digi-torum longus (EDL) and soleus muscle of fetal, neonatal and adult rats. At 16 days gestation primordia of the EDL and soleus stain with anti-fast myosin and the reaction with anti-slow is equivocal. Specification into fibre types in the ...Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesTao, Y. Z. ; Henzell, R. G. ; Jordan, D. R. ; Butler, D. G. ; Kelly, A. M. ; McIntyre, C. L.
Springer
Published 2000Staff ViewISSN: 1432-2242Keywords: Key words Sorghum ; Genome mapping ; Stay green ; Marker-assisted selection ; Multi-environment testingSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract Stay green is an important drought resistance trait for sorghum production. QTLs for this trait with consistent effects across a set of environments would increase the efficiency of selection because of its relatively low heritability. One hundred and sixty recombinant inbreds, derived from a cross between QL39 and QL41, were used as a segregating population for genome mapping and stay green evaluation. Phenotypic data were collected in replicated field trials from five sites and in three growing seasons, and analysed by fitting appropriate models to account for spatial variability and to describe the genotype by environment interaction. Interval mapping and non-parametric mapping identified three regions, each in a separate linkage group, associated with stay green in more than one trial, and two regions in single trial. The regions on linkage groups B and I were both consistently identified from three trials. The multiple environment testing was very helpful for correctly identifying QTLs associated with the trait. The utilisation of molecular markers for stay green in sorghum breeding is also discussed.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1573-2657Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary The present study examines the developmental accumulation of slow myosin heavy chain in the extensor digitorum longus, soleus and plantaris muscles of rats after early post-natal imposition of mechanical overload by removal of synergistic muscles. The proportions of slow and fast myosin heavy chain were measured in each muscle by ELISA. Fibres expressing slow myosin were examined immunocytochemically using a monoclonal antibody specific for slow MHC. Between 30 and 60 days of age, MHC increases by 15% (p〈0.001) in the soleus and by 27% (p〈0.001) in the plantaris of normally developing, unoperated animals. The effect of overload on the soleus and plantaris is to accelerate the rate of increase in slow MHC accumulation so that levels are respectively 16 and 39% higher than controls by 30 days of age (p〈0.001). By 60 days, the control soleus and plantaris attain levels of slow MHC roughly equivalent to their overloaded counterparts. In overloaded plantaris, the increase in levels of slow myosin does not occur at the expense of fast myosin expression. In the EDL there is a normal developmentally regulated decrease in slow MHC accumulation, reflected by a 40% decrease in levels of slow MHC (p〈0.0001) and a 50% decrease in the number of slow fibres (p〈0.001), between 30 days and 20 weeks of age. This elimination of slow myosin accumulation in the EDL is unimpeded by chronic overload. Thus, muscles react to mechanical overload in a tissue specific manner. The pattern of response is conservative and potentiates normal, long term maturational shifts in myosin heavy chain expression characteristic of each muscle.Type of Medium: Electronic ResourceURL: