Search Results - (Author, Cooperation:A. M. Edwards)
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1A. Quigley ; Y. Y. Dong ; A. C. Pike ; L. Dong ; L. Shrestha ; G. Berridge ; P. J. Stansfeld ; M. S. Sansom ; A. M. Edwards ; C. Bountra ; F. von Delft ; A. N. Bullock ; N. A. Burgess-Brown ; E. P. Carpenter
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-03-30Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Catalytic Domain ; Crystallography, X-Ray ; Humans ; Lamin Type A ; Membrane Proteins/*chemistry/genetics ; Metabolism, Inborn Errors/genetics/*metabolism ; Metalloendopeptidases/*chemistry/genetics ; Molecular Sequence Data ; Nuclear Proteins/chemistry/genetics/*metabolism ; Progeria/genetics/metabolism ; Protein Conformation ; Protein Precursors/chemistry/genetics/*metabolism ; Substrate Specificity ; Thermolysin/chemistryPublished by: -
2Staff View
Publication Date: 2014-01-10Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Female ; Humans ; *Internationality ; Male ; Research Personnel/*statistics & numerical data ; Sexism/*statistics & numerical dataPublished by: -
3A. M. Edwards ; R. Isserlin ; G. D. Bader ; S. V. Frye ; T. M. Willson ; F. H. Yu
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-02-11Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Bibliometrics ; Biomedical Research/*instrumentation/methods/*statistics & numerical data/trends ; Human Genome Project ; Humans ; Ion Channels ; Protein Kinases ; Receptors, Cytoplasmic and NuclearPublished by: -
4Edwards, A. M. ; Dao, Y. ; Nemanich, R. J. ; Sayers, D. E.
[S.l.] : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: A structural study of the initial interface region formed by titanium on silicon (111) was undertaken. Thin films (100 A(ring)) of titanium were deposited in ultrahigh vacuum (UHV) conditions onto atomically clean silicon(111) wafers and annealed in situ at 25 °C intervals between 300 and 475 °C. Structural characterization of the evolving interface was performed primarily via extended x-ray absorption fine structure (EXAFS) measurements. Results indicate that a major structural rearrangement takes place between 400 and 425 °C. EXAFS fitting analysis reveals this transition to be from a disordered TiSi-like phase to a more ordered C49-like disilicide state. The results are compared with those previously reported for the zirconium:silicon system. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
5Edwards, A. M. ; Dao, Y. ; Nemanich, R. J. ; Sayers, D. E. ; Kemner, K. M.
[S.l.] : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: A structural study of the initial interface region formed by zirconium on silicon (111) was undertaken. Thin films (100 A(ring)) of zirconium were deposited in ultrahigh-vacuum conditions onto atomically, clean silicon (111) wafers and annealed in situ at 25 °C intervals between 300 and 425 °C, over which range Auger spectroscopy indicated silicon diffusion to the surface. Structural characterization of the evolving interface was performed primarily via extended x-ray-absorption fine-structure (EXAFS) measurements. Results indicate that a major structural rearrangement takes place between 350 and 375 °C. EXAFS fitting analysis reveals this transition to be from a disordered-intermixed phase to a more ordered state having interatomic distances closely resembling those of ZrSi, but lower coordination numbers. Ordering continues with progressively higher annealing temperatures until the interface region assumes the ZrSi structure at ∼425 °C. The results are discussed in terms of the free energy and strain of the interface film.Type of Medium: Electronic ResourceURL: -
6Dao, Y. ; Edwards, A. M. ; Ying, H. ; Chen, Y. L. ; Sayers, D. E. ; Nemanich, R. J.
Woodbury, NY : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: Alloy films of Ti and up to 20% Zr were prepared by codeposition onto Si(111) surfaces in ultrahigh vacuum. After in situ thermal annealing at temperatures of ∼600 °C, the films form the C49 phase and are stable in this phase up to at least 910 °C. In contrast, Ti films on Si(111) initially react to form the C49 phase and transform to the C54 phase at ∼700 °C. The surfaces of the (Ti0.9Zr0.1)Si2 alloy films are studied by atomic force microscopy and are shown to be smoother than the surfaces of TiSi2 films on Si substrates. In addition the tendency to island formation is also not observed for annealing temperatures less than 910 °C. The sheet resistivity of the (Ti0.9Zr0.1)Si2 alloy films is found to be ∼46 μΩ cm for annealing temperatures from 600 to 910 °C. © 1994 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
7Staff View
ISSN: 1365-2427Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Water samples collected weekly from the rivers Yare, Tud, Wensum and Tas in Norfolk, England, displayed marked depletions in the spring and summer of the concentration of dissolved silicon. These were unconnected with any hydrological event and were assumed to be due to the assimilation of silicon by diatoms. Equilibrium concentrations were maintained in the Yare and Tud during the weeks prior to and following the spring bloom. It was estimated that 35 Mg (51%) of the predicted load were removed from the Yare during the 11 weeks of this depletion and 6-0 Mg (45%) from the Tud. The lowest observed concentration (0-4 mg/l) occurred during the first week in May when over 90% of the silicon had been removed. However, the maximum amount of removal and hence maximum diatom productivity occurred earlier at a time of higher water discharge. A similar pattern was observed in the Yare during the spring of 1971. Two small blooms occurred later in the summer of 1970 in the Yare and Tud. It was estimated that 15% ofthe Yare's dissolved silicon load of 263 Mg was in the assimilated form and 12-5%of the Tud's output of 56-6 Mg. The weathering of silicate minerals was probably the source of almost all the silicon and the outputs represented a silicon erosion rate of 1-15 Mg/km2/year for the Yare and 0-77 Mg/kmVyear for the Tud.Type of Medium: Electronic ResourceURL: -
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ISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
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ISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
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ISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
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ISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
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ISSN: 1747-6593Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Energy, Environment Protection, Nuclear Power EngineeringNotes: The reduction of the waste of raw materials at source using clean technologies, recycling, and good housekeeping has considerable benefits for both the environment and industry. A demonstration project on wastewater minimization was completed in 1995 in the Aire and Calder catchments of West Yorkshire. The findings indicated cost savings for eleven firms of over $3 million/annum and further opportunities which, when implemented, could realize another $1 million/annum. The reduction in the amount of wastewater discharged either to sewer or river was 27%, with a potential to increase to over 40%. The payback period for 63% of the waste minimization opportunities is less than one year and many involve only a small initial investment. Waste minimization when widely adopted has prospects for cutting industry's costs, reducing demand for water and reducing the volume of effluent produced.Type of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Livingstone4, in the most extensive compilation of river water analyses to date, obtains a worldwide mean dissolved silicon concentration of 13.1 mg SiO2 1?1. These data show that the concentration of silicon in rivers is remarkably constant compared with other major dissolved constituents (for ...Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-2099Source: Springer Online Journal Archives 1860-2000Topics: BiologyPhysicsNotes: Summary The fluorescent behaviour and the photodynamic effect was studied in native and structurally modified lysozyme andα-lactalbumin. The Tyr residues in lysozyme andα-lactalbumin show different sensitivities to the photodynamic effect. The effect is zero in the case of Tyr from native lysozyme. In contrast, the Tyr residues inα-lactalbumin are susceptible to photooxidation, which indicates a greater degree of exposure to the solvent. The three His residues ofα-lactalbumin have different degrees of exposure and show two different kinetics of photooxidation whereas the His residue of lysozyme is photooxidized with a single kinetic. Two photooxidation kinetics were obtained for the Trp residues of both native proteins, an indication that in both cases there are Trp residues that are differently exposed to the solvent. The wavelengths of maximum fluorescent emission of the Trp residues were different for the two proteins, an effect which can also be explained in terms of a difference in the environment of these residues. The modified form of these proteins emit at wavelengths longer than those of the native forms. When modified the proteins photooxidize with noticeably greater quantum yields.Type of Medium: Electronic ResourceURL: -
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ISSN: 1573-6903Keywords: Model ; cocaine ; DA uptake ; Na ; rat ; synaptosomesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Initial velocity of uptake of dopamine (DA) has been measured in the presence of 1μM cocaine as a function of both [DA] and [Na]. Although DA uptake is overwhelmingly dependent on sodium, it appears that a small amount of DA uptake takes place in the absence of sodium. This contrasts with a previous study of the sodium dependence of uptake without cocaine (referred to below as control), in which uptake was found to be 100% sodium dependent. The data were fitted to several rapid equilibrium models and the minimal best fit model identified. The interaction of transporter (C), DA (S), and Na+ (Na) in this present model is identical to the reaction scheme found previously to fit control data (no cocaine). Whereas the control model required translocation only as CNa2S, in the presence of cocaine (I), two additional translocated species are required to fit the data (CS and CNaS). Another previous study of the interaction of carrier and cocaine at a constant [Na]0 predicted that cocaine interacts with a transporter site other than the DA binding site and that uptake takes place as CS and CSI. The present results are consistent with the assumption that the CS and CNaS forms of the present model are actually CSI and CNaSI, since they are required to fit a model of the sodium dependence in the presence of cocaine, but are not required in the absence of cocaine.Type of Medium: Electronic ResourceURL: -
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ISSN: 1573-6903Keywords: Dopamine ; uptake ; synaptosomes ; sodium dependenceSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Initial velocity of uptake of dopamine (DA) has been measured in rat striatal synaptosomes as a function of both [DA] and [Na]. Carrier mediated uptake is totally dependent on external sodium. The data were fitted to a rapid equilibrium model which has been found in previous studies to fit, with appropriate simplification, uptake data for glutamate, GABA, and choline in several brain regions under varying conditions. This model also gives a good fit to the dopamine data. The minimal best fit simplification of this model allows for DA uptake along with two sodium ions and predicts that apparent maximal velocity of uptake should increase with [Na], while the Michaelis-Menten constant should decrease. The minimal best fit model for DA, and a number of kinetic parameters which quantitate the model, are compared to those for the GABA, glutamate, and choline transporters. The results are consistent with a symmetrical, rapid equilibrium model, which has been presented previously for other neurotransmitters and precursors (18). This model offers a unifying basis for understanding the sodium and membrane potential dependence of neurotransmitter transport and the possible participation of transporters in depolarization induced release throughout the CNS.Type of Medium: Electronic ResourceURL: -
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ISSN: 1741-2765Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract This paper presents the results of a series of experiments on the progressive plastic buckling of cylindrical shells under axial compressive load. It shows that, for shell bodies with anR/t less than 100, the normal axisymmetric ring buckling will develop into nonsymmetric patterns. We demonstrate that there exists also a class of shells within this thickness-radius range for which nonsymmetric plastic buckling always occurs without the prior formation of a ring. It appears from the limited number of tests made that, for a particularR, R/t, material and rate of loading, there is a critical value ofL, above which there is a high probability of the buckle pattern developing in a nonsymmetric fashion. It seems probable, too, that there are bands ofR/t for a particularL/R, R, material and rate of loading for which the buckle number will be constant. The experiments tend to indicate that the postbuckling efficiency of the shell decreases with increasing buckle number. The nonsymmetric patterns demonstrated appear to be inextensional deformations. They are very similar in character to the Yoshimura pattern which occurs as the limiting case for thin shells in axial compression and, under impact loading. Load-displacement histories are presented for some of the various modes of failure demonstrated.Type of Medium: Electronic ResourceURL: