Search Results - (Author, Cooperation:A. M. Brown)
-
1Grunwell, J. R., Yeligar, S. M., Stephenson, S., Ping, X. D., Gauthier, T. W., Fitzpatrick, A. M., Brown, L. A. S.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-03-07Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
2L. I. Shlush ; S. Zandi ; A. Mitchell ; W. C. Chen ; J. M. Brandwein ; V. Gupta ; J. A. Kennedy ; A. D. Schimmer ; A. C. Schuh ; K. W. Yee ; J. L. McLeod ; M. Doedens ; J. J. Medeiros ; R. Marke ; H. J. Kim ; K. Lee ; J. D. McPherson ; T. J. Hudson ; A. M. Brown ; F. Yousif ; Q. M. Trinh ; L. D. Stein ; M. D. Minden ; J. C. Wang ; J. E. Dick
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-02-14Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Differentiation ; Cell Division ; Cell Lineage ; Clone Cells/cytology/metabolism/pathology ; DNA (Cytosine-5-)-Methyltransferase/genetics/metabolism ; Drug Resistance, Neoplasm/drug effects ; Female ; Hematopoiesis ; Hematopoietic Stem Cells/*cytology/drug effects/metabolism/pathology ; Heterografts ; Humans ; Isocitrate Dehydrogenase/genetics ; Leukemia, Myeloid, Acute/diagnosis/drug therapy/genetics/*pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mutation/genetics ; Neoplasm Transplantation ; Neoplastic Stem Cells/*cytology/drug effects/metabolism/pathology ; Nuclear Proteins/genetics ; Remission Induction ; T-Lymphocytes/metabolism/pathologyPublished by: -
3M. G. Aartsen ; R. Abbasi ; Y. Abdou ; M. Ackermann ; J. Adams ; J. A. Aguilar ; M. Ahlers ; D. Altmann ; J. Auffenberg ; X. Bai ; M. Baker ; S. W. Barwick ; V. Baum ; R. Bay ; J. J. Beatty ; S. Bechet ; J. Becker Tjus ; K. H. Becker ; M. L. Benabderrahmane ; S. BenZvi ; P. Berghaus ; D. Berley ; E. Bernardini ; A. Bernhard ; D. Bertrand ; D. Z. Besson ; G. Binder ; D. Bindig ; M. Bissok ; E. Blaufuss ; J. Blumenthal ; D. J. Boersma ; S. Bohaichuk ; C. Bohm ; D. Bose ; S. Boser ; O. Botner ; L. Brayeur ; H. P. Bretz ; A. M. Brown ; R. Bruijn ; J. Brunner ; M. Carson ; J. Casey ; M. Casier ; D. Chirkin ; A. Christov ; B. Christy ; K. Clark ; F. Clevermann ; S. Coenders ; S. Cohen ; D. F. Cowen ; A. H. Cruz Silva ; M. Danninger ; J. Daughhetee ; J. C. Davis ; M. Day ; C. De Clercq ; S. De Ridder ; P. Desiati ; K. D. de Vries ; M. de With ; T. DeYoung ; J. C. Diaz-Velez ; M. Dunkman ; R. Eagan ; B. Eberhardt ; B. Eichmann ; J. Eisch ; R. W. Ellsworth ; S. Euler ; P. A. Evenson ; O. Fadiran ; A. R. Fazely ; A. Fedynitch ; J. Feintzeig ; T. Feusels ; K. Filimonov ; C. Finley ; T. Fischer-Wasels ; S. Flis ; A. Franckowiak ; K. Frantzen ; T. Fuchs ; T. K. Gaisser ; J. Gallagher ; L. Gerhardt ; L. Gladstone ; T. Glusenkamp ; A. Goldschmidt ; G. Golup ; J. G. Gonzalez ; J. A. Goodman ; D. Gora ; D. T. Grandmont ; D. Grant ; A. Gross ; C. Ha ; A. Haj Ismail ; P. Hallen ; A. Hallgren ; F. Halzen ; K. Hanson ; D. Heereman ; D. Heinen ; K. Helbing ; R. Hellauer ; S. Hickford ; G. C. Hill ; K. D. Hoffman ; R. Hoffmann ; A. Homeier ; K. Hoshina ; W. Huelsnitz ; P. O. Hulth ; K. Hultqvist ; S. Hussain ; A. Ishihara ; E. Jacobi ; J. Jacobsen ; K. Jagielski ; G. S. Japaridze ; K. Jero ; O. Jlelati ; B. Kaminsky ; A. Kappes ; T. Karg ; A. Karle ; J. L. Kelley ; J. Kiryluk ; J. Klas ; S. R. Klein ; J. H. Kohne ; G. Kohnen ; H. Kolanoski ; L. Kopke ; C. Kopper ; S. Kopper ; D. J. Koskinen ; M. Kowalski ; M. Krasberg ; K. Krings ; G. Kroll ; J. Kunnen ; N. Kurahashi ; T. Kuwabara ; M. Labare ; H. Landsman ; M. J. Larson ; M. Lesiak-Bzdak ; M. Leuermann ; J. Leute ; J. Lunemann ; J. Madsen ; G. Maggi ; R. Maruyama ; K. Mase ; H. S. Matis ; F. McNally ; K. Meagher ; M. Merck ; T. Meures ; S. Miarecki ; E. Middell ; N. Milke ; J. Miller ; L. Mohrmann ; T. Montaruli ; R. Morse ; R. Nahnhauer ; U. Naumann ; H. Niederhausen ; S. C. Nowicki ; D. R. Nygren ; A. Obertacke ; S. Odrowski ; A. Olivas ; A. O'Murchadha ; L. Paul ; J. A. Pepper ; C. Perez de los Heros ; C. Pfendner ; D. Pieloth ; E. Pinat ; J. Posselt ; P. B. Price ; G. T. Przybylski ; L. Radel ; M. Rameez ; K. Rawlins ; P. Redl ; R. Reimann ; E. Resconi ; W. Rhode ; M. Ribordy ; M. Richman ; B. Riedel ; J. P. Rodrigues ; C. Rott ; T. Ruhe ; B. Ruzybayev ; D. Ryckbosch ; S. M. Saba ; T. Salameh ; H. G. Sander ; M. Santander ; S. Sarkar ; K. Schatto ; F. Scheriau ; T. Schmidt ; M. Schmitz ; S. Schoenen ; S. Schoneberg ; A. Schonwald ; A. Schukraft ; L. Schulte ; O. Schulz ; D. Seckel ; Y. Sestayo ; S. Seunarine ; R. Shanidze ; C. Sheremata ; M. W. Smith ; D. Soldin ; G. M. Spiczak ; C. Spiering ; M. Stamatikos ; T. Stanev ; A. Stasik ; T. Stezelberger ; R. G. Stokstad ; A. Stossl ; E. A. Strahler ; R. Strom ; G. W. Sullivan ; H. Taavola ; I. Taboada ; A. Tamburro ; A. Tepe ; S. Ter-Antonyan ; G. Tesic ; S. Tilav ; P. A. Toale ; S. Toscano ; E. Unger ; M. Usner ; N. van Eijndhoven ; A. Van Overloop ; J. van Santen ; M. Vehring ; M. Voge ; M. Vraeghe ; C. Walck ; T. Waldenmaier ; M. Wallraff ; C. Weaver ; M. Wellons ; C. Wendt ; S. Westerhoff ; N. Whitehorn ; K. Wiebe ; C. H. Wiebusch ; D. R. Williams ; H. Wissing ; M. Wolf ; T. R. Wood ; K. Woschnagg ; D. L. Xu ; X. W. Xu ; J. P. Yanez ; G. Yodh ; S. Yoshida ; P. Zarzhitsky ; J. Ziemann ; S. Zierke ; M. Zoll
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-11-23Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
4A. Kreso ; C. A. O'Brien ; P. van Galen ; O. I. Gan ; F. Notta ; A. M. Brown ; K. Ng ; J. Ma ; E. Wienholds ; C. Dunant ; A. Pollett ; S. Gallinger ; J. McPherson ; C. G. Mullighan ; D. Shibata ; J. E. Dick
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-12-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Lineage ; Cell Tracking ; Clonal Evolution/*genetics ; Clone Cells ; Colorectal Neoplasms/*drug therapy/genetics/*pathology ; DNA Copy Number Variations ; Drug Resistance, Neoplasm/*genetics ; Humans ; Lentivirus ; Mice ; Neoplasm Transplantation ; Transcriptome ; Transduction, Genetic ; Tumor Cells, CulturedPublished by: -
5M. T. Sheldon ; J. van de Groep ; A. M. Brown ; A. Polman ; H. A. Atwater
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-11-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
6Y. Okada ; D. Wu ; G. Trynka ; T. Raj ; C. Terao ; K. Ikari ; Y. Kochi ; K. Ohmura ; A. Suzuki ; S. Yoshida ; R. R. Graham ; A. Manoharan ; W. Ortmann ; T. Bhangale ; J. C. Denny ; R. J. Carroll ; A. E. Eyler ; J. D. Greenberg ; J. M. Kremer ; D. A. Pappas ; L. Jiang ; J. Yin ; L. Ye ; D. F. Su ; J. Yang ; G. Xie ; E. Keystone ; H. J. Westra ; T. Esko ; A. Metspalu ; X. Zhou ; N. Gupta ; D. Mirel ; E. A. Stahl ; D. Diogo ; J. Cui ; K. Liao ; M. H. Guo ; K. Myouzen ; T. Kawaguchi ; M. J. Coenen ; P. L. van Riel ; M. A. van de Laar ; H. J. Guchelaar ; T. W. Huizinga ; P. Dieude ; X. Mariette ; S. L. Bridges, Jr. ; A. Zhernakova ; R. E. Toes ; P. P. Tak ; C. Miceli-Richard ; S. Y. Bang ; H. S. Lee ; J. Martin ; M. A. Gonzalez-Gay ; L. Rodriguez-Rodriguez ; S. Rantapaa-Dahlqvist ; L. Arlestig ; H. K. Choi ; Y. Kamatani ; P. Galan ; M. Lathrop ; S. Eyre ; J. Bowes ; A. Barton ; N. de Vries ; L. W. Moreland ; L. A. Criswell ; E. W. Karlson ; A. Taniguchi ; R. Yamada ; M. Kubo ; J. S. Liu ; S. C. Bae ; J. Worthington ; L. Padyukov ; L. Klareskog ; P. K. Gregersen ; S. Raychaudhuri ; B. E. Stranger ; P. L. De Jager ; L. Franke ; P. M. Visscher ; M. A. Brown ; H. Yamanaka ; T. Mimori ; A. Takahashi ; H. Xu ; T. W. Behrens ; K. A. Siminovitch ; S. Momohara ; F. Matsuda ; K. Yamamoto ; R. M. Plenge
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-01-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Animals ; Arthritis, Rheumatoid/*drug therapy/*genetics/metabolism/pathology ; Asian Continental Ancestry Group/genetics ; Case-Control Studies ; Computational Biology ; *Drug Discovery ; Drug Repositioning ; European Continental Ancestry Group/genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genome-Wide Association Study ; Hematologic Neoplasms/genetics/metabolism ; Humans ; Male ; Mice ; Mice, Knockout ; *Molecular Targeted Therapy ; Polymorphism, Single Nucleotide/geneticsPublished by: -
7H. F. Zheng ; V. Forgetta ; Y. H. Hsu ; K. Estrada ; A. Rosello-Diez ; P. J. Leo ; C. L. Dahia ; K. H. Park-Min ; J. H. Tobias ; C. Kooperberg ; A. Kleinman ; U. Styrkarsdottir ; C. T. Liu ; C. Uggla ; D. S. Evans ; C. M. Nielson ; K. Walter ; U. Pettersson-Kymmer ; S. McCarthy ; J. Eriksson ; T. Kwan ; M. Jhamai ; K. Trajanoska ; Y. Memari ; J. Min ; J. Huang ; P. Danecek ; B. Wilmot ; R. Li ; W. C. Chou ; L. E. Mokry ; A. Moayyeri ; M. Claussnitzer ; C. H. Cheng ; W. Cheung ; C. Medina-Gomez ; B. Ge ; S. H. Chen ; K. Choi ; L. Oei ; J. Fraser ; R. Kraaij ; M. A. Hibbs ; C. L. Gregson ; D. Paquette ; A. Hofman ; C. Wibom ; G. J. Tranah ; M. Marshall ; B. B. Gardiner ; K. Cremin ; P. Auer ; L. Hsu ; S. Ring ; J. Y. Tung ; G. Thorleifsson ; A. W. Enneman ; N. M. van Schoor ; L. C. de Groot ; N. van der Velde ; B. Melin ; J. P. Kemp ; C. Christiansen ; A. Sayers ; Y. Zhou ; S. Calderari ; J. van Rooij ; C. Carlson ; U. Peters ; S. Berlivet ; J. Dostie ; A. G. Uitterlinden ; S. R. Williams ; C. Farber ; D. Grinberg ; A. Z. LaCroix ; J. Haessler ; D. I. Chasman ; F. Giulianini ; L. M. Rose ; P. M. Ridker ; J. A. Eisman ; T. V. Nguyen ; J. R. Center ; X. Nogues ; N. Garcia-Giralt ; L. L. Launer ; V. Gudnason ; D. Mellstrom ; L. Vandenput ; N. Amin ; C. M. van Duijn ; M. K. Karlsson ; O. Ljunggren ; O. Svensson ; G. Hallmans ; F. Rousseau ; S. Giroux ; J. Bussiere ; P. P. Arp ; F. Koromani ; R. L. Prince ; J. R. Lewis ; B. L. Langdahl ; A. P. Hermann ; J. E. Jensen ; S. Kaptoge ; K. T. Khaw ; J. Reeve ; M. M. Formosa ; A. Xuereb-Anastasi ; K. Akesson ; F. E. McGuigan ; G. Garg ; J. M. Olmos ; M. T. Zarrabeitia ; J. A. Riancho ; S. H. Ralston ; N. Alonso ; X. Jiang ; D. Goltzman ; T. Pastinen ; E. Grundberg ; D. Gauguier ; E. S. Orwoll ; D. Karasik ; G. Davey-Smith ; A. V. Smith ; K. Siggeirsdottir ; T. B. Harris ; M. C. Zillikens ; J. B. van Meurs ; U. Thorsteinsdottir ; M. T. Maurano ; N. J. Timpson ; N. Soranzo ; R. Durbin ; S. G. Wilson ; E. E. Ntzani ; M. A. Brown ; K. Stefansson ; D. A. Hinds ; T. Spector ; L. A. Cupples ; C. Ohlsson ; C. M. Greenwood ; R. D. Jackson ; D. W. Rowe ; C. A. Loomis ; D. M. Evans ; C. L. Ackert-Bicknell ; A. L. Joyner ; E. L. Duncan ; D. P. Kiel ; F. Rivadeneira ; J. B. Richards
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-09-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bone Density/*genetics ; Bone and Bones/metabolism ; Disease Models, Animal ; Europe/ethnology ; European Continental Ancestry Group/genetics ; Exome/genetics ; Female ; Fractures, Bone/*genetics ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Genetic Variation/genetics ; Genome, Human/*genetics ; Genomics ; Genotype ; Homeodomain Proteins/*genetics ; Humans ; Mice ; Sequence Analysis, DNA ; Wnt Proteins/geneticsPublished by: -
8E. Ruark ; K. Snape ; P. Humburg ; C. Loveday ; I. Bajrami ; R. Brough ; D. N. Rodrigues ; A. Renwick ; S. Seal ; E. Ramsay ; V. Duarte Sdel ; M. A. Rivas ; M. Warren-Perry ; A. Zachariou ; A. Campion-Flora ; S. Hanks ; A. Murray ; N. Ansari Pour ; J. Douglas ; L. Gregory ; A. Rimmer ; N. M. Walker ; T. P. Yang ; J. W. Adlard ; J. Barwell ; J. Berg ; A. F. Brady ; C. Brewer ; G. Brice ; C. Chapman ; J. Cook ; R. Davidson ; A. Donaldson ; F. Douglas ; D. Eccles ; D. G. Evans ; L. Greenhalgh ; A. Henderson ; L. Izatt ; A. Kumar ; F. Lalloo ; Z. Miedzybrodzka ; P. J. Morrison ; J. Paterson ; M. Porteous ; M. T. Rogers ; S. Shanley ; L. Walker ; M. Gore ; R. Houlston ; M. A. Brown ; M. J. Caufield ; P. Deloukas ; M. I. McCarthy ; J. A. Todd ; C. Turnbull ; J. S. Reis-Filho ; A. Ashworth ; A. C. Antoniou ; C. J. Lord ; P. Donnelly ; N. Rahman
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-12-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Breast Neoplasms/*genetics ; Cluster Analysis ; Exons ; Female ; Genetic Predisposition to Disease/*genetics ; Humans ; Isoenzymes/genetics ; Lymphocytes/metabolism ; *Mosaicism ; *Mutation ; Ovarian Neoplasms/*genetics ; Phosphoprotein Phosphatases/*genetics ; Sequence Analysis, DNA ; Tumor Suppressor Protein p53/metabolismPublished by: -
9S. Sawcer ; G. Hellenthal ; M. Pirinen ; C. C. Spencer ; N. A. Patsopoulos ; L. Moutsianas ; A. Dilthey ; Z. Su ; C. Freeman ; S. E. Hunt ; S. Edkins ; E. Gray ; D. R. Booth ; S. C. Potter ; A. Goris ; G. Band ; A. B. Oturai ; A. Strange ; J. Saarela ; C. Bellenguez ; B. Fontaine ; M. Gillman ; B. Hemmer ; R. Gwilliam ; F. Zipp ; A. Jayakumar ; R. Martin ; S. Leslie ; S. Hawkins ; E. Giannoulatou ; S. D'Alfonso ; H. Blackburn ; F. Martinelli Boneschi ; J. Liddle ; H. F. Harbo ; M. L. Perez ; A. Spurkland ; M. J. Waller ; M. P. Mycko ; M. Ricketts ; M. Comabella ; N. Hammond ; I. Kockum ; O. T. McCann ; M. Ban ; P. Whittaker ; A. Kemppinen ; P. Weston ; C. Hawkins ; S. Widaa ; J. Zajicek ; S. Dronov ; N. Robertson ; S. J. Bumpstead ; L. F. Barcellos ; R. Ravindrarajah ; R. Abraham ; L. Alfredsson ; K. Ardlie ; C. Aubin ; A. Baker ; K. Baker ; S. E. Baranzini ; L. Bergamaschi ; R. Bergamaschi ; A. Bernstein ; A. Berthele ; M. Boggild ; J. P. Bradfield ; D. Brassat ; S. A. Broadley ; D. Buck ; H. Butzkueven ; R. Capra ; W. M. Carroll ; P. Cavalla ; E. G. Celius ; S. Cepok ; R. Chiavacci ; F. Clerget-Darpoux ; K. Clysters ; G. Comi ; M. Cossburn ; I. Cournu-Rebeix ; M. B. Cox ; W. Cozen ; B. A. Cree ; A. H. Cross ; D. Cusi ; M. J. Daly ; E. Davis ; P. I. de Bakker ; M. Debouverie ; B. D'Hooghe M ; K. Dixon ; R. Dobosi ; B. Dubois ; D. Ellinghaus ; I. Elovaara ; F. Esposito ; C. Fontenille ; S. Foote ; A. Franke ; D. Galimberti ; A. Ghezzi ; J. Glessner ; R. Gomez ; O. Gout ; C. Graham ; S. F. Grant ; F. R. Guerini ; H. Hakonarson ; P. Hall ; A. Hamsten ; H. P. Hartung ; R. N. Heard ; S. Heath ; J. Hobart ; M. Hoshi ; C. Infante-Duarte ; G. Ingram ; W. Ingram ; T. Islam ; M. Jagodic ; M. Kabesch ; A. G. Kermode ; T. J. Kilpatrick ; C. Kim ; N. Klopp ; K. Koivisto ; M. Larsson ; M. Lathrop ; J. S. Lechner-Scott ; M. A. Leone ; V. Leppa ; U. Liljedahl ; I. L. Bomfim ; R. R. Lincoln ; J. Link ; J. Liu ; A. R. Lorentzen ; S. Lupoli ; F. Macciardi ; T. Mack ; M. Marriott ; V. Martinelli ; D. Mason ; J. L. McCauley ; F. Mentch ; I. L. Mero ; T. Mihalova ; X. Montalban ; J. Mottershead ; K. M. Myhr ; P. Naldi ; W. Ollier ; A. Page ; A. Palotie ; J. Pelletier ; L. Piccio ; T. Pickersgill ; F. Piehl ; S. Pobywajlo ; H. L. Quach ; P. P. Ramsay ; M. Reunanen ; R. Reynolds ; J. D. Rioux ; M. Rodegher ; S. Roesner ; J. P. Rubio ; I. M. Ruckert ; M. Salvetti ; E. Salvi ; A. Santaniello ; C. A. Schaefer ; S. Schreiber ; C. Schulze ; R. J. Scott ; F. Sellebjerg ; K. W. Selmaj ; D. Sexton ; L. Shen ; B. Simms-Acuna ; S. Skidmore ; P. M. Sleiman ; C. Smestad ; P. S. Sorensen ; H. B. Sondergaard ; J. Stankovich ; R. C. Strange ; A. M. Sulonen ; E. Sundqvist ; A. C. Syvanen ; F. Taddeo ; B. Taylor ; J. M. Blackwell ; P. Tienari ; E. Bramon ; A. Tourbah ; M. A. Brown ; E. Tronczynska ; J. P. Casas ; N. Tubridy ; A. Corvin ; J. Vickery ; J. Jankowski ; P. Villoslada ; H. S. Markus ; K. Wang ; C. G. Mathew ; J. Wason ; C. N. Palmer ; H. E. Wichmann ; R. Plomin ; E. Willoughby ; A. Rautanen ; J. Winkelmann ; M. Wittig ; R. C. Trembath ; J. Yaouanq ; A. C. Viswanathan ; H. Zhang ; N. W. Wood ; R. Zuvich ; P. Deloukas ; C. Langford ; A. Duncanson ; J. R. Oksenberg ; M. A. Pericak-Vance ; J. L. Haines ; T. Olsson ; J. Hillert ; A. J. Ivinson ; P. L. De Jager ; L. Peltonen ; G. J. Stewart ; D. A. Hafler ; S. L. Hauser ; G. McVean ; P. Donnelly ; A. Compston
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-08-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Cell Differentiation/immunology ; Europe/ethnology ; Genetic Predisposition to Disease/*genetics ; Genome, Human/genetics ; Genome-Wide Association Study ; HLA-A Antigens/genetics ; HLA-DR Antigens/genetics ; HLA-DRB1 Chains ; Humans ; Immunity, Cellular/genetics/*immunology ; Major Histocompatibility Complex/genetics ; Multiple Sclerosis/*genetics/*immunology ; Polymorphism, Single Nucleotide/genetics ; Sample Size ; T-Lymphocytes, Helper-Inducer/cytology/immunologyPublished by: -
10Losa, M., Risolino, M., Li, B., Hart, J., Quintana, L., Grishina, I., Yang, H., Choi, I. F., Lewicki, P., Khan, S., Aho, R., Feenstra, J., Vincent, C. T., Brown, A. M. C., Ferretti, E., Williams, T., Selleri, L.
The Company of Biologists
Published 2018Staff ViewPublication Date: 2018-03-15Publisher: The Company of BiologistsPrint ISSN: 0950-1991Electronic ISSN: 1477-9129Topics: BiologyKeywords: Musculoskeletal systemPublished by: -
11BROWN, A. M. ; YATANI, A. ; IMOTO, Y. ; CODINA, J. ; MATTERA, R. ; BIRNBAUMER, L.
Oxford, UK : Blackwell Publishing Ltd
Published 1989Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
12Pratt, C. ; Brown, A. M. ; Rampe, D. ; Mason, J. ; Russell, T. ; Reynolds, R. ; Ahlbrandt, R.
Oxford BSL : Blackwell Science Ltd
Published 1999Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Certain first- and second-generation H1-receptor antagonists are associated with prolongation of the corrected QT interval (QTc) and, in rare instances, with ventricular dysrhythmias, including torsades de pointes ventricular tachycardia.〈section xml:id="abs1-2"〉〈title type="main"〉ObjectiveTo assess the effect of fexofenadine HCl, a new non-sedating antihistamine, on QTc.〈section xml:id="abs1-3"〉〈title type="main"〉MethodsDose-tolerance, safety, and drug-interaction studies with healthy volunteers; and clinical efficacy studies with seasonal allergic rhinitis patients were conducted. Twelve-lead ECG data were collected pre- and postdosing or serially throughout these studies. Outliers were defined as QTc 〉440 msec with a ≥10 msec increase from baseline.〈section xml:id="abs1-4"〉〈title type="main"〉ResultsFexofenadine HCl at single doses up to 800 mg q.d. (once daily) and multiple doses up to 690 mg b.d. for 28 days in healthy volunteers resulted in no increases in QTc (recommended dose range is 120–180 mg daily); QTc changes were similar to placebo. Compared with placebo, there were no statistically significant QTc increases in patients receiving fexofenadine HCl 80 mg b.d. for 3 months, 60 mg b.d. for 6 months, or 240 mg q.d. for 12 months. No statistically significant increases in QTc were detected when fexofenadine HCl 120 mg b.d. was administered in combination with erythromycin (500 mg t.d.) or ketoconazole (400 mg q.d.) after dosing to steady-state (6.5 days). In seasonal allergic rhinitis patients (n = 1160) treated with 40, 60, 120, or 240 mg b.d. fexofenadine HCl for 2 weeks, there were no dose-related increases in QTc and no significant increases in mean QTc compared with placebo. Frequency and magnitude of QTc outliers with fexofenadine HCl and placebo were similar in all studies. No case of fexofenadine-associated torsades de pointes has been observed in controlled trial experience with more than 6000 patients.〈section xml:id="abs1-5"〉〈title type="main"〉ConclusionFexofenadine HCl has been investigated more extensively for possible electrophysiological effects than any other antihistamine. Fexofenadine HCl has no significant effect on QTc, even at doses much higher than those used in clinical practice.Type of Medium: Electronic ResourceURL: -
13Williams, H. K. ; Brown, A. M. S. ; Barber, P. C.
Oxford, UK : Blackwell Publishing Ltd
Published 1997Staff ViewISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Oligodendrogliomas are uncommon intracranial glial tumours in which extracranial spread is only rarely reported. Similarly, both intracranial and ocular medulloepkheliomas are also rare, with metastatic spread from the ocular neoplasm being less common than its intracranial counterpart. We report cases of an intracranial oligodendroglioma and an ocular medulloepithelioma both of which metastasised to the parotid gland. To our knowledge these are only the second oligodendroglioma and the third ocular medulloepithelioma to be reported as metastasising to this site.Type of Medium: Electronic ResourceURL: -
14Williams, H. K. ; Sanders, D. S. A. ; Jankowski, J. A. Z. ; Landini, G. ; Brown, A. M. S.
Oxford, UK : Blackwell Publishing Ltd
Published 1998Staff ViewISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The immunocytochemical expression of cadherins and catenins was examined during the process of oral carcinogenesis by comparing their expression in normal and dysplastic epithelium with primary and metastatic carcinomas. While control epithelium showed normal distribution for P and E cadherin and the catenins, in severe dysplasia P-cadherin was upregulated. In other cases and in carcinoma-in-situ adjacent to infiltrating carcinomas, membranous expression of the cadherins and catenins was reduced or lost. The changes in expression of E-cadherin and the catenins suggest that disruption of the E-cadherin/catenin complex is a late event associated with invasion. In primary carcinomas reduced membranous and cytoplasmic staining were observed for both cadherins and catenins. Abnormal localisation of E-cadherin occurred in the more superficial parts of the better differentiated carcinomas, suggesting abnormality to the E-cadherin complex(es). In contrast, membranous expression of cadherins and catenins was reduced or lost in the deep invasive margin of primary carcinomas and in most poorly differentiated carcinomas. For E-cadherin at least, this reduction appears associated with differentiation, invasion and possibly prognosis. Possible mechanisms involved for changes in expression of the cadherins and associated catenins and areas for further study are discussed.Type of Medium: Electronic ResourceURL: -
15BROWN, A. M. ; DREWE, J. A. ; HARTMANN, H. A. ; TAGLIALATELA, M. ; BIASI, M. De ; SOMAN, K. ; Kirsch, G. E.
Oxford, UK : Blackwell Publishing Ltd
Published 1993Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
16Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Morphology of Acetobacter acetigenum and Cellulose Synthesis IN the course of a systematic study of cellulose biosynthesis by the bacterium Acetobacter acetigenum our attention has turned to the possible function of the cell wall and capsule (that is, a distinct envelope of polysaccharide ...Type of Medium: Electronic ResourceURL: -
17LEE, K. S. ; WEEKS, T. A. ; KAO, R. L. ; AKAIKE, N. ; BROWN, A. M.
[s.l.] : Nature Publishing Group
Published 1979Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The suction pipette method is similar to that used in snail neurones and the details have been published elsewhere10. The main difference in the present experiments is that the tip diameter of the suction pipette was smaller, about 20 ??, and the measured tip resistances ranged from 150 to 250 kfl. ...Type of Medium: Electronic ResourceURL: -
18AKAIKE, N. ; FISHMAN, H. M. ; LEE, K. S. ; MOORE, L. E. ; BROWN, A. M.
[s.l.] : Nature Publishing Group
Published 1978Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Neurones from the circumoesophageal ganglia of Helix aspersa were exposed by removing the capsule of the ganglion. Part of a neurone of about 100 |xm diameter was sucked into the tip of a 50-|xm diameter suction pipette and removed from adjacent neurones and its own axon by pulling it free of the ...Type of Medium: Electronic ResourceURL: -
19Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] We have developed a simple suction pipette method with which individual nerve cell bodies can be isolated, perfused internally and voltage clamped. This method will be valuable in the study of individual cell membranes of excitable or inexcitable tissues. Fig. 1 Schematic of experimental setup. D1 ...Type of Medium: Electronic ResourceURL: -
20Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The experiments were performed on identifiable neurones from the suboesophageal ganglia of Helix aspersa, usually Fl, F2 and El, E2 according to Kerkut et al.5. The nerve cell bodies were isolated by dissection and aspirated into a suction pipette for internal perfusion and voltage clamp6'8. A ...Type of Medium: Electronic ResourceURL: