Search Results - (Author, Cooperation:A. Leonard)

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  1. 1
    Annetta, Leonard A. [Sonstige] ; Minogue, James [Sonstige]
    Cham : Springer International Publishing
    Published 2016
    Staff View Availability Links
    Person(s):
    Annetta, Leonard A. [Sonstige]; Minogue, James [Sonstige]
    Type of Medium:
    Online Resource
    Pages:
    1 Online-Ressource (XI, 385 p. 75 illus)
    Edition:
    1st ed. 2016
    ISBN:
    9783319163994
    Series Statement:
    Contemporary Trends and Issues in Science Education 44
    URL:
    URL des Erstveröffentlichers
    Inhaltsverzeichnis
    Abstract
    eBook
    Zugang zum eBook-Portal
    DOI:
    10.1007/978-3-319-16399-4
    Language:
    English
    Recall This
    URL des Erstveröffentlichers
    Description / Table of Contents
    Abstract
    eBook
    Zugang zum eBook-Portal

    Printed Books
  2. 2
    Annetta, Leonard A. [Herausgeber] ; Minogue, James [Herausgeber]
    Cham ; Heidelberg ; New York ; Dordrecht ; London : Springer
    Published 2016
    Staff View Availability Links
    Person(s):
    Annetta, Leonard A. [Herausgeber]; Minogue, James [Herausgeber]
    Type of Medium:
    Book
    Pages:
    XI, 385 Seiten :, Illustrationen, Diagramme
    ISBN:
    9783319163987
    Series Statement:
    Contemporary trends and issues in science education Vol. 44
    URL:
    Inhaltsverzeichnis
    Language:
    English
    Recall This
    Description / Table of Contents

    Printed Books
  3. 3
    Staff View
    Publication Date:
    2018-04-25
    Publisher:
    National Academy of Sciences
    Print ISSN:
    0027-8424
    Electronic ISSN:
    1091-6490
    Topics:
    Biology
    Medicine
    Natural Sciences in General
    Published by:
    http://www.nasonline.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Thomas A. Leonard
    National Academy of Sciences
    Published 2018
    Staff View
    Publication Date:
    2018-07-04
    Publisher:
    National Academy of Sciences
    Print ISSN:
    0027-8424
    Electronic ISSN:
    1091-6490
    Topics:
    Biology
    Medicine
    Natural Sciences in General
    Keywords:
    Letters
    Published by:
    http://www.nasonline.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    W. Adam, T. Bergauer, E. Brondolin, M. Dragicevic, M. Friedl, R. Frühwirth, M. Hoch, J. Hrubec, A. König, H. Steininger, W. Treberspurg, W. Waltenberger, S. Alderweireldt, W. Beaumont, X. Janssen, J. Lauwers, P. Van Mechelen, N. Van Remortel, A. Van Spilbeeck, D. Beghin, H. Brun, B. Clerbaux, G. De Lentdecker, H. Delannoy, G. Fasanella, L. Favart, R. Goldouzian, A. Grebenyuk, G. Karapostoli, T. Lenzi, A. Léonard, J. Luetic, T. Maerschalk, A. Marinov, N. Postiau, A. Randle-Conde, T. Seva, P. Vanlaer, D. Vannerom, R. Yonamine, Q. Wang, Y. Yang, F. Zenoni, F. Zhang, S. Abu Zeid, F. Blekman, I. De Bruyn, J. De Clercq, J. D'Hondt, K. Deroover, S. Lowette, S. Moortgat, L. Moreels, Q. Python, K. Skovpen, P. Van Mulders, I. Van Parijs, H. Bakhshiansohi, O. Bondu, S. Brochet, G. Bruno, A. Caudron, C. Delaere, M. Delcourt, S. De Visscher, B. Francois, A. Giammanco, A. Jafari, J. Cabrera Jamoulle, J. De Favereau De Jeneret, M. Komm, G. Krintiras, V. Lemaitre, A. Magitteri, A. Mertens, D. Michotte, M. Musich, K. Piotrzkowski, L. Quertenmont, N. Szilasi, M. Vidal Marono, S. Wertz, N. Beliy, T. Caebergs, E. Daubie, G.H. Hammad, J. Härkönen, T. Lampén, P. Luukka, T. Peltola, E. Tuominen, E. Tuovinen, P. Eerola, G. Baulieu, G. Boudoul, L. Caponetto, C. Combaret, D. Contardo, T. Dupasquier, G. Gallbit, N. Lumb, L. Mirabito, S. Perries, M. Vander Donckt, S. Viret, J.-L. Agram, J. Andrea, D. Bloch, C. Bonnin, J.-M. Brom, E. Chabert, N. Chanon, L. Charles, E. Conte, J.-Ch. Fontaine, L. Gross, J. Hosselet, M. Jansova, D. Tromson, C. Autermann, L. Feld, W. Karpinski, K.M. Kiesel, K. Klein, M. Lipinski, A. Ostapchuk, G. Pierschel, M. Preuten, M. Rauch, S. Schael, C. Schomakers, J. Schulz, G. Schwering, M. Wlochal, V. Zhukov, C. Pistone, G. Fluegge, A. Kuensken, O. Pooth, A. Stahl, M. Aldaya, C. Asawatangtrakuldee, K. Beernaert, D. Bertsche, C. Contreras-Campana, G. Eckerlin, D. Eckstein, T. Eichhorn, E. Gallo, J. Garay Garcia, K. Hansen, M. Haranko, A. Harb, J. Hauk, J. Keaveney, A. Kalogeropoulos, C. Kleinwort, W. Lohmann, R. Mankel, H. Maser, G. Mittag, C. Muhl, A. Mussgiller, D. Pitzl, O. Reichelt, M. Savitskyi, P. Schuetze, R. Walsh, A. Zuber, H. Biskop, P. Buhmann, M. Centis-Vignali, E. Garutti, J. Haller, M. Hoffmann, R. Klanner, M. Matysek, A. Perieanu, Ch. Scharf, P. Schleper, A. Schmidt, J. Schwandt, J. Sonneveld, G. Steinbrück, B. Vormwald, J. Wellhausen, M. Abbas, C. Amstutz, T. Barvich, Ch. Barth, F. Boegelspacher, W. De Boer, E. Butz, M. Casele, F. Colombo, A. Dierlamm, B. Freund, F. Hartmann, S. Heindl, U. Husemann, A. Kornmeyer, S. Kudella, Th. Muller, M. Printz, H.J. Simonis, P. Steck, M. Weber, Th. Weiler, G. Anagnostou, P. Asenov, P. Assiouras, G. Daskalakis, A. Kyriakis , D. Loukas, L. Paspalaki, F. Siklér, V. Veszprémi, A. Bhardwaj, R. Dalal, G. Jain, K. Ranjan, S. Dutta, S. Roy Chowdhury, H. Bakhshiansohl, H. Behnamian, M. Khakzad, M. Naseri, P. Cariola, D. Creanza, M. De Palma, G. De Robertis, L. Fiore, M. Franco, F. Loddo, G. Sala, L. Silvestris, G. Maggi, S. My, G. Selvaggi, S. Albergo, S. Costa, A. Di Mattia, F. Giordano, R. Potenza, M.A. Saizu, A. Tricomi, C. Tuve, G. Barbagli, M. Brianzi, R. Ciaranfi, V. Ciulli, C. Civinini, R. D'Alessandro, E. Focardi, G. Latino, P. Lenzi, M. Meschini, S. Paoletti, L. Russo, E. Scarlini, G. Sguazzoni, D. Strom, L. Viliani, F. Ferro, M. Lo Vetere, E. Robutti, M.E. Dinardo, S. Fiorendi, S. Gennai, S. Malvezzi, R.A. Manzoni, D. Menasce, L. Moroni, D. Pedrini, P. Azzi, N. Bacchetta, D. Bisello, M. Dall'Osso, N. Pozzobon, M. Tosi, F. De Canio, L. Gaioni, M. Manghisoni, B. Nodari, E. Riceputi, V. Re, G. Traversi, D. Comotti, L. Ratti, L. Alunni Solestizi, M. Biasini, G.M. Bilei, C. Cecchi, B. Checcucci, D. Ciangottini, L. Fanò, C. Gentsos, M. Ionica, R. Leonardi, E. Manoni, G. Mantovani, S. Marconi, V. Mariani, M. Menichelli, A. Modak, A. Morozzi, F. Moscatelli, D. Passeri, P. Placidi, V. Postolache, A. Rossi, A. Saha, A. Santocchia, L. Storchi, D. Spiga, K. Androsov, P. Azzurri, S. Arezzini, G. Bagliesi, A. Basti, T. Boccali, L. Borrello, F. Bosi, R. Castaldi, A. Ciampa, M.A. Ciocci, R. Dell'Orso, S. Donato, G. Fedi, A. Giassi, M.T. Grippo, F. Ligabue, T. Lomtadze, G. Magazzu, L. Martini, E. Mazzoni, A. Messineo, A. Moggi, F. Morsani, F. Palla, F. Palmonari, F. Raffaelli, A. Rizzi, A. Savoy-Navarro, P. Spagnolo, R. Tenchini, G. Tonelli, A. Venturi, P.G. Verdini, R. Bellan, M. Costa, R. Covarelli, M. Da Rocha Rolo, N. Demaria, A. Rivetti, G. Dellacasa, G. Mazza, E. Migliore, E. Monteil, L. Pacher, F. Ravera, A. Solano, M. Fernandez, G. Gomez, R. Jaramillo Echeverria, D. Moya, F.J. Gonzalez Sanchez, I. Vila, A.L. Virto, D. Abbaneo, I. Ahmed, E. Albert, G. Auzinger, G. Berruti, G. Bianchi, G. Blanchot, J. Bonnaud, A. Caratelli, D. Ceresa, J. Christiansen, K. Cichy, J. Daguin, A. D'Auria, S. Detraz, D. Deyrail, O. Dondelewski, F. Faccio, N. Frank, T. Gadek, K. Gill, A. Honma, G. Hugo, L.M. Jara Casas, J. Kaplon, A. Kornmayer, L. Kottelat, M. Kovacs, M. Krammer, P. Lenoir, M. Mannelli, A. Marchioro, S. Marconi, S. Mersi, S. Martina, S. Michelis, M. Moll, A. Onnela, S. Orfanelli, S. Pavis, A. Peisert, J.-F. Pernot, P. Petagna, G. Petrucciani, H. Postema, P. Rose, P. Tropea, J. Troska, A. Tsirou, F. Vasey, P. Vichoudis, B. Verlaat, L. Zwalinski, F. Bachmair, R. Becker, D. di Calafiori, B. Casal, P. Berger, L. Djambazov, M. Donega, C. Grab, D. Hits, J. Hoss, G. Kasieczka, W. Lustermann, B. Mangano, M. Marionneau, P. Martinez Ruiz del Arbol, M. Masciovecchio, M. Meinhard, L. Perozzi, U. Roeser, A. Starodumov, V. Tavolaro, R. Wallny, D. Zhu, C. Amsler, K. Bösiger, L. Caminada, F. Canelli, V. Chiochia, A. de Cosa, C. Galloni, T. Hreus, B. Kilminster, C. Lange, R. Maier, J. Ngadiuba, D. Pinna, P. Robmann, S. Taroni, Y. Yang, W. Bertl, K. Deiters, W. Erdmann, R. Horisberger, H.-C. Kaestli, D. Kotlinski, U. Langenegger, B. Meier, T. Rohe, S. Streuli, P.-H. Chen, C. Dietz, U. Grundler, W.-S. Hou, R.-S. Lu, M. Moya, D. Cussans, H. Flacher, J. Goldstein, M. Grimes, J. Jacob, S. Seif El Nasr-Storey, J. Cole, C. Hoad, P. Hobson, A. Morton, I.D. Reid, G. Auzinger, R. Bainbridge, P. Dauncey, J. Fulcher, G. Hall, T. James, A.-M. Magnan, M. Pesaresi, D.M. Raymond, K. Uchida, D. Braga, J.A. Coughlan, K. Harder, L. Jones, J. Ilic, P. Murray, M. Prydderch, I.R. Tomalin, A. Garabedian, U. Heintz, M. Narain, J. Nelson, S. Sagir, T. Speer, J. Swanson, D. Tersegno, J. Watson-Daniels, M. Chertok, J. Conway, R. Conway, C. Flores, R. Lander, D. Pellett, F. Ricci-Tam, M. Squires, J. Thomson, R. Yohay, K. Burt, J. Ellison, G. Hanson, M. Olmedo, W. Si, B.R. Yates, R. Gerosa, V. Sharma, A. Vartak, A. Yagil, G. Zevi Della Porta, V. Dutta, L. Gouskos, J. Incandela, S. Kyre, S. Mullin, H. Qu, D. White, A. Dominguez, R. Bartek, J.P. Cumalat, W.T. Ford, F. Jensen, A. Johnson, M. Krohn, S. Leontsinis, T. Mulholland, K. Stenson, S.R. Wagner, A. Apresyan, G. Bolla, K. Burkett, J.N. Butler, H.W.K. Cheung, J. Chramowicz, D. Christian, W.E. Cooper, G. Deptuch, G. Derylo, C. Gingu, S. Grünendahl, S. Hasegawa, J. Hoff, J. Howell, M. Hrycyk, S. Jindariani, M. Johnson, F. Kahlid, C.M. Lei, R. Lipton, R. Lopes De Sá, T. Liu, S. Los, M. Matulik, P. Merkel, S. Nahn, A. Prosser, R. Rivera, B. Schneider, G. Sellberg, A. Shenai, L. Spiegel, N. Tran, L. Uplegger, E. Voirin, D.R. Berry, X. Chen, L. Ennesser, A. Evdokimov, O. Evdokimov, C.E. Gerber, D.J. Hofman, S. Makauda, C. Mills, I.D. Sandoval Gonzalez, J. Alimena, L.J. Antonelli, B. Francis, A. Hart, C.S. Hill, N. Parashar, J. Stupak, D. Bortoletto, M. Bubna, N. Hinton, M. Jones, D.H. Miller, X. Shi, P. Tan, P. Baringer, A. Bean, S. Khalil, A. Kropivnitskaya, D. Majumder, G. Wilson, A. Ivanov, R. Mendis, T. Mitchell, N. Skhirtladze, R. Taylor, I. Anderson, D. Fehling, A. Gritsan, P. Maksimovic, C. Martin, K. Nash, M. Osherson, M. Swartz, M. Xiao, J.G. Acosta, L.M. Cremaldi, S. Oliveros, L. Perera, D. Summers, K. Bloom, D.R. Claes, C. Fangmeier, R. Gonzalez Suarez, J. Monroy, J. Siado, K. Hahn, S. Sevova, K. Sung, M. Trovato, E. Bartz, Y. Gershtein, E. Halkiadakis, S. Kyriacou, A. Lath, K. Nash, M. Osherson, S. Schnetzer, R. Stone, M. Walker, S. Malik, S. Norberg, J.E. Ramirez Vargas, M. Alyari, J. Dolen, A. Godshalk, C. Harrington, I. Iashvili, A. Kharchilava, D. Nguyen, A. Parker, S. Rappoccio, B. Roozbahani, J. Alexander, J. Chaves, J. Chu, S. Dittmer, K. McDermott, N. Mirman, A. Rinkevicius, A. Ryd, E. Salvati, L. Skinnari, L. Soffi, Z. Tao, J. Thom, J. Tucker, M. Zientek, B. Akgün, K.M. Ecklund, M. Kilpatrick, T. Nussbaum, J. Zabel, B. Betchart, R. Covarelli, R. Demina, O. Hindrichs, G. Petrillo, R. Eusebi, R. Patel, A. Perloff, K.A. Ulmer, A.G. Delannoy, P. D'Angelo and W. Johns
    Institute of Physics Publishing (IOP)
    Published 2018
    Staff View
    Publication Date:
    2018-03-07
    Publisher:
    Institute of Physics Publishing (IOP)
    Electronic ISSN:
    1748-0221
    Topics:
    Physics
    Published by:
    http://www.iop.org/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    Publication Date:
    2013-11-16
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Animals, Domestic/*genetics ; Base Sequence ; Breeding ; Dogs/*genetics ; Europe ; Genome, Mitochondrial/*genetics ; Molecular Sequence Data ; Phylogeny ; Wolves/genetics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  7. 7
    F. Hailer ; V. E. Kutschera ; B. M. Hallstrom ; S. R. Fain ; J. A. Leonard ; U. Arnason ; A. Janke
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-09-18
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; *Biological Evolution ; *Genome ; *Multilocus Sequence Typing ; Ursidae/*genetics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  8. 8
    F. Hailer ; V. E. Kutschera ; B. M. Hallstrom ; D. Klassert ; S. R. Fain ; J. A. Leonard ; U. Arnason ; A. Janke
    American Association for the Advancement of Science (AAAS)
    Published 2012
    Staff View
    Publication Date:
    2012-04-21
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Bayes Theorem ; *Biological Evolution ; Cell Nucleus/genetics ; DNA, Mitochondrial/genetics ; Gene Flow ; Genetic Speciation ; Genetic Variation ; *Genome ; Haplotypes ; Hybridization, Genetic ; Molecular Sequence Data ; *Multilocus Sequence Typing ; Phylogeny ; Ursidae/classification/*genetics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  9. 9
    A. J. Westphal ; R. M. Stroud ; H. A. Bechtel ; F. E. Brenker ; A. L. Butterworth ; G. J. Flynn ; D. R. Frank ; Z. Gainsforth ; J. K. Hillier ; F. Postberg ; A. S. Simionovici ; V. J. Sterken ; L. R. Nittler ; C. Allen ; D. Anderson ; A. Ansari ; S. Bajt ; R. K. Bastien ; N. Bassim ; J. Bridges ; D. E. Brownlee ; M. Burchell ; M. Burghammer ; H. Changela ; P. Cloetens ; A. M. Davis ; R. Doll ; C. Floss ; E. Grun ; P. R. Heck ; P. Hoppe ; B. Hudson ; J. Huth ; A. Kearsley ; A. J. King ; B. Lai ; J. Leitner ; L. Lemelle ; A. Leonard ; H. Leroux ; R. Lettieri ; W. Marchant ; R. Ogliore ; W. J. Ong ; M. C. Price ; S. A. Sandford ; J. A. Sans Tresseras ; S. Schmitz ; T. Schoonjans ; K. Schreiber ; G. Silversmit ; V. A. Sole ; R. Srama ; F. Stadermann ; T. Stephan ; J. Stodolna ; S. Sutton ; M. Trieloff ; P. Tsou ; T. Tyliszczak ; B. Vekemans ; L. Vincze ; J. Von Korff ; N. Wordsworth ; D. Zevin ; M. E. Zolensky
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-08-16
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  10. 10
    S. F. Leiser ; H. Miller ; R. Rossner ; M. Fletcher ; A. Leonard ; M. Primitivo ; N. Rintala ; F. J. Ramos ; D. L. Miller ; M. Kaeberlein
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-11-21
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Caenorhabditis elegans/genetics/metabolism/*physiology ; Caenorhabditis elegans Proteins/chemistry/genetics/metabolism/*physiology ; Diet ; Intestines/*enzymology ; Longevity/genetics/*physiology ; Mice ; Neurons/*metabolism ; Oxygenases/genetics/*physiology ; Protein Stability ; RNA Interference ; Receptors, Serotonin/metabolism ; Signal Transduction ; Transcription Factors/chemistry/*metabolism ; Tryptophan Hydroxylase/metabolism
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  11. 11
    Staff View
    Publication Date:
    2018-09-21
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Geosciences
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Physics
    Published by:
    http://www.aaas.org/

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  12. 12
    E. D. Lorenzen ; D. Nogues-Bravo ; L. Orlando ; J. Weinstock ; J. Binladen ; K. A. Marske ; A. Ugan ; M. K. Borregaard ; M. T. Gilbert ; R. Nielsen ; S. Y. Ho ; T. Goebel ; K. E. Graf ; D. Byers ; J. T. Stenderup ; M. Rasmussen ; P. F. Campos ; J. A. Leonard ; K. P. Koepfli ; D. Froese ; G. Zazula ; T. W. Stafford, Jr. ; K. Aaris-Sorensen ; P. Batra ; A. M. Haywood ; J. S. Singarayer ; P. J. Valdes ; G. Boeskorov ; J. A. Burns ; S. P. Davydov ; J. Haile ; D. L. Jenkins ; P. Kosintsev ; T. Kuznetsova ; X. Lai ; L. D. Martin ; H. G. McDonald ; D. Mol ; M. Meldgaard ; K. Munch ; E. Stephan ; M. Sablin ; R. S. Sommer ; T. Sipko ; E. Scott ; M. A. Suchard ; A. Tikhonov ; R. Willerslev ; R. K. Wayne ; A. Cooper ; M. Hofreiter ; A. Sher ; B. Shapiro ; C. Rahbek ; E. Willerslev
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-11-04
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Bayes Theorem ; *Biota ; Bison ; Climate Change/*history ; DNA, Mitochondrial/analysis/genetics ; Europe ; *Extinction, Biological ; Fossils ; Genetic Variation ; Geography ; History, Ancient ; Horses ; Human Activities/*history ; Humans ; Mammals/genetics/*physiology ; Mammoths ; Molecular Sequence Data ; Population Dynamics ; Reindeer ; Siberia ; Species Specificity ; Time Factors
    Published by:
    http://www.nature.com/

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  13. 13
    Luhby, A. Leonard ; Cooperman, Jack M ; Lopez, Rafael ; Giorgio, Anthony J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1969
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1969.tb27816.x

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    1365-2958
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Notes:
    A novel growth phase-associated two-component-type regulator, Fas (fibronectin/fibrinogen binding/haemolytic activity/streptokinase regulator), of Streptococcus pyogenes was identified in the M1 genome sequence, based on homologies to the histidine protein kinase (HPK) and response regulator (RR) part of the Staphylococcus aureus Agr and Streptococcus pneumoniae Com quorum-sensing systems. The fas operon, present in all 12 tested M serotypes, was transcribed as polycystronic message (fasBCA) and contained genes encoding two potential HPKs (FasB and FasC) and one RR (FasA). Downstream of fasBCA, we identified a small 300 nucleotide monocistronic transcript, designated fasX, that did not appear to encode true peptide sequences. Measurements of luciferase promoter fusions revealed a growth phase-associated transcription of fasBCA and fasX, with peak activities during the late exponential phase. Insertional mutagenesis disrupting fasBCA and fasA led to a phenotype similar to agr-null mutations in S. aureus, with prolonged expression of extracellular matrix protein-binding adhesins and reduced expression of secreted virulence factors such as streptokinase and streptolysin S. In addition, fasX transcription was dependent on the RR FasA; however, deletion mutagenesis of fasX resulted in a similar phenotype to that of the fasBCA or fasA mutants. Complementation of the fasX deletion mutant, with the fasX gene expressed in trans from a plasmid, restored the wild-type fasBCA regulation pattern. This strongly suggested that fasX, a putative non-translated RNA, is the main effector molecule of the fas regulon. However, using spent culture supernatants from wild-type and fas mutant strains, we were not able to show an influence on the logarithmic growth phase expression of fas and dependent genes. Thus, despite structural and functional similarities between fas and agr, to date the fas operon appears not to be involved in group A streptococcal (GAS) quorum-sensing regulation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2958.2001.02226.x

    Articles: DFG German National Licenses
  15. 15
    SHEFFNER, A. LEONARD ; ADACHI, RICHARD ; SPECTOR, HARRY

    Oxford, UK : Blackwell Publishing Ltd
    Published 1957
    Staff View
    ISSN:
    1750-3841
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2621.1957.tb17503.x

    Articles: DFG German National Licenses
  16. 16
    Kartner, Norbert ; Augustinas, Olga ; Jensen, Timothy J. ; Naismith, A. Leonard ; Riordan, John R.

    [s.l.] : Nature Publishing Group
    Published 1992
    Staff View
    ISSN:
    1546-1718
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Medicine
    Notes:
    [Auszug] Misprocessing and mislocalization of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) has been described for the major CF–causing mutation (ΔF508) in heterologous expression systems in vitro. We have generated monoclonal antibodies (mAbs) to CFTR with the aim of ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/ng0892-321

    Articles: DFG German National Licenses
  17. 17
    CAMPBELL, DONALD T. ; MILLER, NORMAN ; DIAMOND, A. LEONARD

    Provincetown, Mass., etc. : Periodicals Archive Online (PAO)
    Published 1960
    Staff View
    ISSN:
    0022-1309
    Topics:
    Psychology
    URL:
    http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:1128-1960-000-00-000043

    Articles: DFG German National Licenses
  18. 18
    SHEFFNER, A. LEONARD

    [s.l.] : Nature Publishing Group
    Published 1953
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] These results confirmed previous ones which indicated that adaptation to the utilization of galactose is not concerned with oxidation or fermentation as such, but rather with an enzyme or series of enzymes which make galactose available to the cell for subsequent oxidation or fermentation1. Since ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/1711073a0

    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1432-1831
    Keywords:
    Key wordsStreptococcus pyogenes ; Group A streptococci ; Cysteine protease ; SpeB ; Virulence factor
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Group A streptococcal (GAS) cysteine protease is a major virulence factor involved in the pathogenesis of purulent and invasive infections. The secreted enzyme cleaves a number of different bacterial and host proteins which could contribute to different stages of the infective processes. It has been proposed that, among these functions, SpeB plays a role in obtaining nutrients during late growth phases. In the present study, speB mutants of various GAS serotypes were found to exhibit unaltered growth characteristics in several complex and chemically defined media (CDM). When amino acid-depleted CDM was prepared, neither SpeB activity on whole proteins added to the medium during incubation nor the addition of SpeB-digested proteins was able to support bacterial growth. SpeB also was unable to liberate iron from iron-containing protein sources added to iron-deficient CDM. However, SpeB levels in culture supernatants changed in response to the protein and glucose content of the media. Using a speB promoter-luciferase reporter, speB expression levels were found to correspond to peptide concentrations in the culture media. The effect appeared to be specific for peptides since addition of peptides derived from various proteins had an affect on expression, while addition of the whole proteins had no effect. Addition of glucose to CDM had no effect on speB expression, while glucose addition to complex medium decreased speB expression. Overall, SpeB did not appear to be directly involved in providing the bacteria with nutritional factors but expression of the speB gene responded to ratios of peptides and carbohydrates in the culture medium.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004300050111

    Articles: DFG German National Licenses
  20. 20
    Staff View
    ISSN:
    1573-2568
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The developmental patterns of secretion of hydrochloric acid, pepsin, and intrinsic factor were studied, following Histalog stimulation, in gastric juice of infants 12 hr to 3 months old. In the first day of life, the outputs of hydrochloric acid, intrinsic factor, and pepsin were very low, but in no instance was achlorhydria found. The outputs of these three glandular secretory components then showed a gradual increase until the third week after birth, followed by a short decline in the third to fourth week, and a second sustained rise continuing into the second and third month of life. A good correlation was observed between the outputs of hydrochloric acid and intrinsic factor in gastric juice of the neonate following Histalog stimulation; and a somewhat poorer correlation between that of intrinsic factor and pepsin. When secretory outputs were recalculated for body weight, those of intrinsic factor in infants 2–3 months old were at levels comparable to that observed in older children and adults; those of hydrochloric acid, at the lower range of normal, or slightly below adult levels; and that of pepsin, well below adult values. On serial determinations, one infant showed intrinsic-factor activity, throughout the period of study, that was well below that of other infants of comparable age. The possible relationship of this case to juvenile pernicious anemia is discussed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02239360

    Articles: DFG German National Licenses