Search Results - (Author, Cooperation:A. Lei)
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1Latest Papers from Table of Contents or Articles in PressA. Adhikari ; T. N. Lerner ; J. Finkelstein ; S. Pak ; J. H. Jennings ; T. J. Davidson ; E. Ferenczi ; L. A. Gunaydin ; J. J. Mirzabekov ; L. Ye ; S. Y. Kim ; A. Lei ; K. Deisseroth
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-11-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amygdala/cytology/*physiology ; Animals ; Anxiety/*physiopathology/psychology ; Extinction, Psychological/physiology ; Fear/*physiology/psychology ; Female ; Freezing Reaction, Cataleptic/physiology ; Learning/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Neural Pathways/*physiology ; Prefrontal Cortex/cytology/physiology ; Stress, Psychological/physiopathologyPublished by: -
2Articles: DFG German National LicensesKuiken, S. D. ; Lei, A. ; Tytgat, G. N. J. ; Holman, R. ; Boeckxstaens, G. E. E.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background : The use of N-methyl-d-aspartate (NMDA) receptor antagonists may hold promise for the treatment of pain of visceral origin, in particular in conditions characterized by visceral hypersensitivity.Aim : To study the effect of dextromethorphan, a low affinity, non-competitive NMDA receptor antagonist, on visceral perception in healthy volunteers.Methods : Nine healthy volunteers (5 female, median age 22 years) underwent a gastric barostat study after oral administration of placebo, dextromethorphan 10 mg or dextromethorphan 30 mg, on three separate days in a double-blind, randomised order. Sensations induced by step-wise isobaric gastric distension (2 mmHg/2 min) were studied during fasting and 30 min after a meal. In addition, proximal gastric tone was measured during fasting and postprandially.Results : Compared to placebo, dextromethorphan 30 mg significantly increased the distension-evoked sensation scores for nausea (P=0.004) and satiation (P=0.004) during fasting; and for bloating (P= 0.001), nausea (P=0.000) and satiation (P=0.01) 30 min postprandially. Dextromethorphan did not alter pain scores, proximal gastric tone or gastric compliance.Conclusions : Dextromethorphan increases the perception of non-painful sensations during gastric distension, without altering the perception of pain. Therefore, application of dextromethorphan as a visceral analgesic is questionable. Future studies with more specific NMDA receptor antagonist are warranted.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0022-4073Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
4Latest Papers from Table of Contents or Articles in PressElectrochemical oxidative oxysulfenylation and aminosulfenylation of alkenes with hydrogen evolutionYuan, Y., Chen, Y., Tang, S., Huang, Z., Lei, A.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-08-02Publisher: American Association for the Advancement of Science (AAAS)Electronic ISSN: 2375-2548Topics: Natural Sciences in GeneralPublished by: -
5Latest Papers from Table of Contents or Articles in PressLei, A.-H., Xiao, Q., Liu, G.-Y., Shi, K., Yang, Q., Li, X., Liu, Y.-F., Wang, H.-K., Cai, W.-P., Guan, Y.-J., Gabrilovich, D. I., Zhou, J.
Rockefeller University Press
Published 2018Staff ViewPublication Date: 2018-08-07Publisher: Rockefeller University PressPrint ISSN: 0022-1007Electronic ISSN: 1540-9538Topics: MedicineKeywords: Innate Immunity and InflammationPublished by: