Search Results - (Author, Cooperation:A. Jeffreys)

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  1. 1
    M. Manske ; O. Miotto ; S. Campino ; S. Auburn ; J. Almagro-Garcia ; G. Maslen ; J. O'Brien ; A. Djimde ; O. Doumbo ; I. Zongo ; J. B. Ouedraogo ; P. Michon ; I. Mueller ; P. Siba ; A. Nzila ; S. Borrmann ; S. M. Kiara ; K. Marsh ; H. Jiang ; X. Z. Su ; C. Amaratunga ; R. Fairhurst ; D. Socheat ; F. Nosten ; M. Imwong ; N. J. White ; M. Sanders ; E. Anastasi ; D. Alcock ; E. Drury ; S. Oyola ; M. A. Quail ; D. J. Turner ; V. Ruano-Rubio ; D. Jyothi ; L. Amenga-Etego ; C. Hubbart ; A. Jeffreys ; K. Rowlands ; C. Sutherland ; C. Roper ; V. Mangano ; D. Modiano ; J. C. Tan ; M. T. Ferdig ; A. Amambua-Ngwa ; D. J. Conway ; S. Takala-Harrison ; C. V. Plowe ; J. C. Rayner ; K. A. Rockett ; T. G. Clark ; C. I. Newbold ; M. Berriman ; B. MacInnis ; D. P. Kwiatkowski
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-06-23
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; *Biodiversity ; Genome, Protozoan ; Genotype ; *High-Throughput Nucleotide Sequencing ; Humans ; Malaria, Falciparum/*parasitology ; Phylogeny ; Plasmodium falciparum/classification/*genetics ; Polymorphism, Single Nucleotide ; Principal Component Analysis
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Jeffreys, A. J.

    Oxford, UK : Blackwell Science Ltd
    Published 2001
    Staff View
    ISSN:
    1365-2044
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2044.2001.01870-25.x

    Articles: DFG German National Licenses
  3. 3
    JEFFREYS, A. J. ; CRAIG, I. W.

    [s.l.] : Nature Publishing Group
    Published 1976
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] It is widely assumed that the proteins synthesised in cells treated with inhibitors of cytoplasmic protein synthesis are of mitochondrial origin. We have shown previously that about ten major proteins are selectively labelled by cultur-ing cells in the presence of 35S-methionine and the inhibitor ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/259690a0

    Articles: DFG German National Licenses
  4. 4
    Bois, P. ; Jeffreys, A. J.
    Springer
    Published 1999
    Staff View
    ISSN:
    1420-9071
    Keywords:
    Key words. Minisatellite; mutation; instability; recombination; conversion; model; disease; VNTR.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract. Tandem-repeat DNA actively turns over in the genome by a variety of poorly understood dynamic mechanisms. Minisatellites, a class of tandem repeats, have been shown to cause disease by influencing gene expression, modifying coding sequences within genes or generating fragile sites. There has been recent rapid progress towards understanding molecular turnover processes at human minisatellites. Instability at GC-rich minisatellites appears to involve distinct mutation processes operating in somatic and germline cells. In the germline, complex conversion-like events occur, probably during meiosis. Repeat turnover appears to be controlled by intense recombinational activity in DNA flanking the repeat array, suggesting that minisatellites might evolve as by-products of localised meiotic recombination in the human genome. In contrast, AT-rich minisatellites appear to evolve by intra-allelic processes such as replication slippage. Curiously, minisatellites in other organisms appear to be more stable than their human counterparts, suggesting species-specific differences in turnover processes. Some yeast models display human-like minisatellite turnover processes at meiosis. However, all attempts to transfer human germline instability to transgenic mice have failed. Finally, tandem repeat instability in various species appears to be extremely sensitive to environmental agents such as radiation via a mechanism which remains enigmatic.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s000180050402

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    0165-1161
    Keywords:
    (Human) ; Flow cytometry ; HLA-A locus mutation ; Lymphocytes ; Somatic mutation
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0165-1161(92)90005-7

    Articles: DFG German National Licenses
  6. 6
    Jeffreys, A. J. ; Wilson, V. ; Thein, S. L.

    [s.l.] : Nature Publishing Group
    Published 1985
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Three human minisatellites, termed 33.5, 33.6 and 33.15, each comprised of tandem repeats of various versions of the core sequence, have been cloned previously and characterized5 (Fig. 1). Probe 33.15 has been shown to hybridize to multiple hyper-variable fragments in Hinfl digests of human DNA5. ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/316076a0

    Articles: DFG German National Licenses
  7. 7
    Blanchetot, A. ; Wilson, V. ; Wood, D. ; Jeffreys, A. J.

    [s.l.] : Nature Publishing Group
    Published 1983
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Diving mammals such as whales and seals have higher levels of skeletal muscle myoglobin than terrestrial mammals10'11 and are potentially rich sources of myoglobin mRNA. Previously, we have cloned a partial cDNA copy of myoglobin mRNA from the grey seal (Halichoerus grypus)12. This clone, termed ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/301732a0

    Articles: DFG German National Licenses
  8. 8
    Solomon, E. ; Voss, R. ; Hall, V. ; Bodmer, W. F. ; Jass, J. R. ; Jeffreys, A. J. ; Lucibello, F. C. ; Patel, I. ; Rider, S. H.

    [s.l.] : Nature Publishing Group
    Published 1987
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Tumour material and adjacent normal mucosa samples were collected from about 45 cases of colorectal carcinomas, mostly from St Mark's Hospital, London. DNA preparations from these matched normal-tumour pairs were analysed for restriction fragment length polymorphism (RFLP) differences with a ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/328616a0

    Articles: DFG German National Licenses
  9. 9
    Mathew, C. G. P. ; Smith, B. A. ; Thorpe, K. ; Wong, Z. ; Royle, N. J. ; Jeffreys, A. J. ; Ponder, B. A. J.

    [s.l.] : Nature Publishing Group
    Published 1987
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] We chose to search for loss of heterozygosity by using a panel of locus-specific minisatellite probes10'11 isolated from a human genomic library using the minisatellite probes 33.15 and 33.6 (ref. 12). These locus-specific probes each detect multiple alleles with a high degree of heterozygosity, ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/328524a0

    Articles: DFG German National Licenses
  10. 10
    JEFFREYS, A. J. ; BROOKFIELD, J. F. Y. ; SEMEONOFF, R.

    [s.l.] : Nature Publishing Group
    Published 1986
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] JEFFREYS ETAL. REPLY-We thank Professor Hill for his rigorous statistical analysis of the DNA fingerprint data of this immigration test-case. We are pleased that the new analysis gives ranges of values for the likelihood ratios which are broadly similar to ours. We reiterate that even the new ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/322291a0

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1432-1203
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary We have compared band sharing between the DNA fingerprints of members of an inbred human population with band sharing between members of an outbred population. It had not previously been determined whether the high rate of mutation at minisatellite loci is sufficient to prevent an increase in band sharing in moderately inbred populations. We have found that there is an increase in band sharing in the 2-kb to 9-kb size range, but not in the 〉9-kb size range, in the inbred population. The difference was consistently observed using four different multi-locus probes, viz. 33.6, 33.15, (CAC)5 and M13. Thus, we have demonstrated that moderate but prolonged inbreeding can lead to increased similarity in human DNA fingerprints. This should be considered when analysing DNA fingerprints in forensic or paternity cases involving members of an inbred community.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00200917

    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1432-1777
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00360569

    Articles: DFG German National Licenses