Search Results - (Author, Cooperation:A. J. Windsor)

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  1. 1
    Staff View
    Publication Date:
    2012-09-01
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; Amino Acid Sequence ; Amino Acid Substitution ; Arabidopsis/genetics/metabolism/parasitology ; *Brassicaceae/genetics/metabolism/parasitology ; Cytochrome P-450 Enzyme System/*genetics ; Gene Dosage ; Gene-Environment Interaction ; Glucosinolates/biosynthesis/*genetics ; Herbivory/physiology ; Methionine/genetics/metabolism ; Molecular Sequence Data ; Plant Leaves/genetics/metabolism/parasitology ; Plants, Genetically Modified/genetics/metabolism/parasitology ; Polymorphism, Genetic ; *Quantitative Trait Loci ; *Quantitative Trait, Heritable ; *Selection, Genetic
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    GUILLOU, P. J. ; WINDSOR, A. J. ; NEJIM, A.

    Oxford BSL : Blackwell Science
    Published 1996
    Staff View
    ISSN:
    1365-2036
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    This article reviews some of the health-care economic data that have been acquired in recent assessments of minimal access surgery of the digestive tract, with particular reference to laparoscopic cholecystectomy and laparoscopic surgery for gastro-oesophageal reflux disease.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2036.1996.65236000.x

    Articles: DFG German National Licenses
  3. 3
    Staff View
    ISSN:
    1432-1238
    Keywords:
    Key words IL-10 ; HLA-DR ; Inflammation ; Sepsis ; Intensive care
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Objective: To assess the relationship between IL-10 release and anti-inflammatory response following blunt trauma. Design: Prospective longitudinal clinical study. Setting: Departments of trauma and anaesthetics in a university teaching hospital Patients: Forty-eight adult patients with a mean injury severity score of 14.5 (range 9–57) were prospectively studied following blunt trauma. Measurements and results: Venous blood samples were collected on arrival and at 16 and 24 h, and at 3, 5, and 7 days. Peripheral blood mononuclear cell (HLA-DR) expression on CD14 + monocytes was quantified by flow cytometry and serum IL-10 was assayed by ELISA. Anti-inflammatory response was defined as monocyte HLA-DR expression of less than 30 % of that seen in healthy controls. Serum IL-10 levels in trauma patients on arrival was significantly elevated, 70.0 [48.0–92.1, 95 % confidence interval, (CI)] compared to the control group, 3 (0–5) (P 〈 0.0001), and monocyte HLA-DR expression was significantly lower, 14.2 (12.1–16.3, 95 % CI), in patients versus 25.2 (22.4–28.1) in controls (P 〈 0.001). Patients with low HLA-DR expression (n = 14) had significantly higher serum IL-10 levels than those whose HLA-DR expression remained above 30 % of the control value (n = 34), (P 〈 0.038). In patients who developed sepsis (n = 11), serum IL-10 levels were greater on admission, [143.7 (80.2–207.2) pg/ml–1], and remained elevated during the study period compared with non-complicated patients, [50.16 (33.5–66.8) pg/ml–1]. Immediate IL-10 (2 h following trauma) was negatively correlated with simultaneous HLA-DR expression, (r = –0.49, P = 0.0005). Conclusion: These findings support the view that IL-10 release regulates monocyte HLA-DR expression and may be related to an anti-inflammatory response and development of sepsis following trauma.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001340051320

    Articles: DFG German National Licenses