Search Results - (Author, Cooperation:A. J. Robertson)
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1Latest Papers from Table of Contents or Articles in PressN. Waddell ; M. Pajic ; A. M. Patch ; D. K. Chang ; K. S. Kassahn ; P. Bailey ; A. L. Johns ; D. Miller ; K. Nones ; K. Quek ; M. C. Quinn ; A. J. Robertson ; M. Z. Fadlullah ; T. J. Bruxner ; A. N. Christ ; I. Harliwong ; S. Idrisoglu ; S. Manning ; C. Nourse ; E. Nourbakhsh ; S. Wani ; P. J. Wilson ; E. Markham ; N. Cloonan ; M. J. Anderson ; J. L. Fink ; O. Holmes ; S. H. Kazakoff ; C. Leonard ; F. Newell ; B. Poudel ; S. Song ; D. Taylor ; S. Wood ; Q. Xu ; J. Wu ; M. Pinese ; M. J. Cowley ; H. C. Lee ; M. D. Jones ; A. M. Nagrial ; J. Humphris ; L. A. Chantrill ; V. Chin ; A. M. Steinmann ; A. Mawson ; E. S. Humphrey ; E. K. Colvin ; A. Chou ; C. J. Scarlett ; A. V. Pinho ; M. Giry-Laterriere ; I. Rooman ; J. S. Samra ; J. G. Kench ; J. A. Pettitt ; N. D. Merrett ; C. Toon ; K. Epari ; N. Q. Nguyen ; A. Barbour ; N. Zeps ; N. B. Jamieson ; J. S. Graham ; S. P. Niclou ; R. Bjerkvig ; R. Grutzmann ; D. Aust ; R. H. Hruban ; A. Maitra ; C. A. Iacobuzio-Donahue ; C. L. Wolfgang ; R. A. Morgan ; R. T. Lawlor ; V. Corbo ; C. Bassi ; M. Falconi ; G. Zamboni ; G. Tortora ; M. A. Tempero ; A. J. Gill ; J. R. Eshleman ; C. Pilarsky ; A. Scarpa ; E. A. Musgrove ; J. V. Pearson ; A. V. Biankin ; S. M. Grimmond
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-02-27Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adenocarcinoma/drug therapy/genetics ; Animals ; Carcinoma, Pancreatic Ductal/drug therapy/genetics ; *DNA Mutational Analysis ; DNA Repair/genetics ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Markers/genetics ; Genome, Human/*genetics ; Genomic Instability/genetics ; *Genomics ; Genotype ; Humans ; Mice ; Mutation/*genetics ; Pancreatic Neoplasms/classification/drug therapy/*genetics ; Platinum/pharmacology ; Point Mutation/genetics ; Poly(ADP-ribose) Polymerase Inhibitors ; Xenograft Model Antitumor AssaysPublished by: -
2Latest Papers from Table of Contents or Articles in PressChitty, J. L., Butler, M. S., Suboh, A., Edwards, D. J., Cooper, M. A., Fraser, J. A., Robertson, A. A. B.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-01-26Publisher: The American Society for Microbiology (ASM)Print ISSN: 0066-4804Electronic ISSN: 1098-6596Topics: BiologyMedicinePublished by: -
3Latest Papers from Table of Contents or Articles in PressLoynes, C. A., Lee, J. A., Robertson, A. L., Steel, M. J., Ellett, F., Feng, Y., Levy, B. D., Whyte, M. K. B., Renshaw, S. A.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-09-06Publisher: American Association for the Advancement of Science (AAAS)Electronic ISSN: 2375-2548Topics: Natural Sciences in GeneralPublished by: -
4Articles: DFG German National LicensesHew, W. S. R. ; Robertson, A. J. ; Ross, P. ; Hopwood, D.
Oxford, UK : Blackwell Science Ltd
Published 1999Staff ViewISSN: 1365-2303Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Physiological processes in cervical squamous epithelium have not been extensively studied. Perhaps understandably, most of the research has concentrated on the pathology of the cervix, in particular dysplasia and malignancy. Fluid-phase endocytosis is a physiological process which has been demonstrated to be important in understanding disease development at other squamous epithelial sites, e.g. oesophagus. In this study, we have demonstrated by a new methodology developed in our laboratory using fluorescent microspheres and flow cytometry that fluid-phase endocytosis occurs in cervical squamous cells. The process has been shown to be dose- and time-dependent. This novel approach provides a means to improve our understanding of the physiological functions of the cervix and may provide insight into the pathogenesis of cervical neoplastic and non-neoplastic disease.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesPOTTS, R. C. ; SHERIF, M. M. ; ROBERTSON, A. J. ; GIBBS, J. H. ; BROWN, R. A. ; BECK, J. SWANSON
Oxford, UK : Blackwell Publishing Ltd
Published 1981Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The sera of ten Egyptian men with long-standing lepromatous leprosy (LL) (mean duration 17.4 years) that had failed to respond in dapsone treatment were shown to inhibit mitogen stimulation responses of normal human lymphocytes. When first tested, the sera partly inhibited the response to phytohaemagglutinin (PHA) and pokeweed mitogen and virtually abolished that to concanavalin A (Con A): after repeated freezing and thawing, the Con A inhibition had disappeared, whereas the PHA response was still partly Inhibited. The inhibitory serum factor(s) had similar actions on lymphocytes from each of six normal donors. Although the sera varied in potency, they showed similar dose response curves when tested against lymphocytes from a single donor. The principal action of the sera was to reduce the number of cells responding to mitogen, without modifying the kinetics of recruitment or rate of volume growth during G1-phase in those cells that were unaffected by the inhibitory substances(s). Study of PHA dose-response curves and of the effect of delayed addition of LL serum suggested that the serum factor(s) act by diminishing the responsiveness of the cells, rather than by reducing the concentrations of free mitogen or by blocking cell membrane mitogen receptors The serum from one apparently healthy attendant, who had nursed leprosy patients for 30 years but who did not have leprosy or other chronic infective disease, inhibited completely stimulation by all three mitogens in a manner different from that of LL sera. Serum from the other 13 control patients did not modify the response of normal lymphocytes to stimulation by any of the three mitogens studied. It was concluded that the inhibitory factor(s) in the scrum of patients, with LL were a consequence of the disease and not of the environment in which the patients lived. Microscopy confirmed that the techniques used for recovery of the cultured cells did not introduce bias into the volume spectroscopy measurements.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A case of angiolymphoid hyperplasia with eosinophilia arising from the radial artery is presented. Histologically, there was proliferation of atypical endothelial cells forming vascular spaces and solid cords, with a background infiltrate of inflammatory cells and prominent tissue eosinophilia. Immunohistochemical studies demonstrated vimentin and factor VIII related antigen in the endothelial cells. The lymphoid infiltrate was polyclonal. These lesions, which typically occur in the dermis and subcutaneous tissue of the head and neck, are known by a variety of different names reflecting disagreement regarding their pathogenesis. The probable nature of the process is discussed.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesROBERTSON, A. J. ; McINTOSH, W. ; LAMONT, P. ; GUTHRIE, W.
Oxford, UK : Blackwell Publishing Ltd
Published 1981Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A case of malignant granular cell tumour (myoblastoma) which metastasized from the vulva to the regional lymph nodes is presented. Electron microscopy of the metastases demonstrated the presence of numerous intra-cytoplasmic lysosomes, a feature characteristic of these neoplasms, and the neoplasm was shown to stain strongly for carcinoembryonic antigen (CEA) using the immunoperoxidase technique. Previous reports in the literature of malignant granular cell tumours are reviewed and discussed.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesMcLaren, K M ; Burnett, R A ; Goodlad, J R ; Howatson, S R ; Lang, S ; Lee, F D ; Lessells, A M ; Ogston, S A ; Robertson, A J ; Simpson, J G ; Smith, G D ; Tavadia, H B ; Walker, F
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aims: The Goseki grouping of gastric adenocarcinoma has been suggested as a possible prognostic factor. In those centres where it is used, it may be valuable to assess the Goseki grouping of a tumour on the initial diagnostic biopsy as well as on the resection specimen since it may in theory influence management. We examined the robustness of Goseki grouping of gastric adenocarcinoma in representative sections from resection and biopsy specimens in order to assess the consistency of agreement among a group of pathologists.Methods: A single representative block from 100 gastric resection specimens was studied using a haematoxylin and eosin and mucin (alcian blue/periodic acid–Schiff) stain. These were circulated in batches to members of a group of 12 pathologists who each completed a simple proforma confirming the presence of carcinoma and assigning a Goseki group. In a second circulation the diagnostic biopsy specimen taken prior to resection was examined in the same way. This allowed comparison of the Goseki group of the biopsy and resection specimens.Results: In both studies κ statistics showed good agreement on tubular differentiation of the carcinoma, but only moderate agreement for the intracellular mucin production, resulting in moderate agreement for the final Goseki group. Correlation between the Goseki group assigned on the biopsy and resected specimens was seen in 62% of the cases. However, the reproducibility was low (κ 0.375).Conclusions: The Goseki grouping of resected gastric adenocarcinoma is reproducible and can be used in prognostication. Goseki grouping of biopsy specimens is of limited value in predicting the Goseki group assigned to the resected carcinoma.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesMcLaren, K M ; Burnett, R A ; Goodlad, J R ; Howatson, S R ; Lang, S ; Lee, F D ; Lessells, A M ; Ogston, S ; Robertson, A J ; Simpson, J G ; Smith, G D ; Tavadia, H B ; Walker the Scottish Pathology Consistency Group, F
Oxford, UK : Blackwell Science Ltd
Published 2000Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: AimsClinical management of premalignant and malignant lesions of the larynx is dependent on histopathological evaluation. The Scottish Pathology Consistency Group assessed interobserver variation in the evaluation of laryngeal dysplasia.Methods and resultsOne hundred laryngeal biopsies ranging from normal to invasive carcinoma were assessed. The overall Kappa result of 0.32 was disappointing. However, agreement on those categories which dictate significantly different management was more favourable. The Kappa figure for mild dysplasia versus severe dysplasia/CIS was 0.7, the Kappa figure for mild dysplasia versus severe dysplasia/CIS and invasive carcinoma was 0.77. The Kappa figure for mild and moderate dysplasia versus severe dysplasia/CIS and invasive carcinoma was 0.57. An attempt to use a two grade system gave a Kappa figure of 0.52.ConclusionsOur group had a satisfactory agreement on the distinction of mild from severe dysplasia and on microinvasive carcinoma without any discussion as to histopathological criteria to be used. Clinical management — review endoscopy, repeat cord stripping, radiotherapy and laryngectomy — is in general dependent on histological assessment. Thus the agreement on categories which underpin clinical management is reassuring. However, assessment of moderate dysplasia remains problematic. An attempt to utilize a two grade system — low grade from high grade dysplasia/CIS — may have merit. The implications of the terminology used must be agreed among pathologists and clinicians working closely within clinicopathological cancer groups.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] TRUE detonation in high explosives normally gives as the major products gases such as carbon dioxide and monoxide, water, nitrogen and hydrogen1,2, the relative quantities obtained being in general accordance with calculations based on equilibrium considerations. The thermal ...Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesRANK, G. H. ; GERLACH, J. H. ; ROBERTSON, A. J. ; VAN HOEVEN, R. P.
[s.l.] : Nature Publishing Group
Published 1978Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] We used the procedure described by Fuhrmann et al.2 for the isolation of plasma membrane vesicles capable of galactose transport. A 5,000g pellet from mechanically disrupted cells was resuspended at 1 mg protein ml"1 in ice cold osmotic stabiliser (400mMKCl, lmMMgCl2, 20 mM tri-ethanolamine). The ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesRobertson, A. J. ; Rela, M. ; Karani, J. ; Steger, A. C. ; Benjamin, I. S. ; Heaton, N. D.
Springer
Published 1998Staff ViewISSN: 1432-2277Keywords: Key words Laparoscopic cholecystectomy ; bile duct injury ; liver transplantation ; Bile duct injury ; laparoscopic cholecystectomy ; Liver transplantationSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The introduction of laparoscopic cholecystectomy has been associated with a rise in the number of reported bile duct injuries (0.3 %–0.8 %). Significant vascular injuries are rare (0.16 %), but may lead to life-threatening complications. We present a case report of a patient undergoing transplantion for a laparoscopic cholecystectomy injury.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-2277Keywords: Key words Liver transplantation ; splenic artery aneurysm ; Splenic artery aneurysm ; liver transplantation ; Portal hypertension ; Alpha-1-antitrypsin deficiencySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Splenic artery aneurysms are a rare but potentially fatal complication after liver transplantation. We report three cases presenting in a 12-month period in adult patients who underwent transplantation for chronic liver disease. Doppler ultrasound of the splenic artery should be performed in all patients with cirrhosis and portal hypertension who are being assessed for liver transplantation. The aneurysm can be ligated at the time of transplantation.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1617-4623Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary Some physiological properties of a multiple-drug-resistant mutant with a permeability barrier to chloramphenicol and its isogenic parental strain were compared. The ATPase specific activity of plasma and mitochondrial membranes isolated from the mutant strain was approximately 20% lower (P(0.001, Tables 1 and 2) than that of membranes isolated from the isogenic parental strain. Additional evidence of altered mitochondrial function was: (i) the enhanced growth of the parental strain was eliminated by the [rho-] state (Table 3); (ii) the mutant strain had a greater resistance to petite induction by ethidium bromide (Table 4); (iii) the mutant strain was unable to use a nonfermentable energy source for respiratory adaptation (Table 5). It is proposed that a single gene mutation has resulted in an alteration of some physiological properties of the plasma and mitochondrial membranes.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1617-4623Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary A mutant strain (2–20) isolated by growth on medium containing oligomycin and cycloheximide was also found to be cross resistant to antimycin, cerulenin, chloramphenicol, tetracycline, triethyltin and triphenylmethylphosphonium bromide, but collaterally sensitive to dequalinium chloride, gentamycin, neomycin, paromomycin and thiolutin. Growth of 2–20, compared to the parental strain and 2 complete revertants, under a variety of environmental conditions revealed that strain 2–20 had an enhanced sensitivity to increased osmolality, elevated pH, and high temperature; in addition, strain 2–20 was unable to polymerize aminoimidazole ribotide at 37° C as shown by the failure to develop a red colony in the presence of ade 2. Four complex solid media (glucose-KCl, galactose, ethanol, ethanol-KCl, Table 1) unable to sustain the growth of strain 2–20 were arbitrarily chosen to monitor cellular growth under different physiological conditions. Tetrad analysis indicated that the complex phenotype (cross resistance, collateral sensitivity, inability to polymerize aminoimidazole ribotide, absence of growth under adverse physiological conditions) was inherited by an allele of a locus previously shown to result in a permeability barrier of the plasma membrane to chloramphenicol. 582 of 640 subclones used to isolate revertants of 2–20, under four different physiological conditions, were observed to produce a complete revertant of the complex phenotype. It is proposed that the pleiotropic phenotype could result from an alteration of the plasma membrane and mitochondrial inner membrane by a single nuclear gene mutation.Type of Medium: Electronic ResourceURL: