Search Results - (Author, Cooperation:A. Hasegawa)
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1Latest Papers from Table of Contents or Articles in PressIwano, S., Sugiyama, M., Hama, H., Watakabe, A., Hasegawa, N., Kuchimaru, T., Tanaka, K. Z., Takahashi, M., Ishida, Y., Hata, J., Shimozono, S., Namiki, K., Fukano, T., Kiyama, M., Okano, H., Kizaka-Kondoh, S., McHugh, T. J., Yamamori, T., Hioki, H., Maki, S., Miyawaki, A.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-02-23Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Cell BiologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressE. Arner ; C. O. Daub ; K. Vitting-Seerup ; R. Andersson ; B. Lilje ; F. Drablos ; A. Lennartsson ; M. Ronnerblad ; O. Hrydziuszko ; M. Vitezic ; T. C. Freeman ; A. M. Alhendi ; P. Arner ; R. Axton ; J. K. Baillie ; A. Beckhouse ; B. Bodega ; J. Briggs ; F. Brombacher ; M. Davis ; M. Detmar ; A. Ehrlund ; M. Endoh ; A. Eslami ; M. Fagiolini ; L. Fairbairn ; G. J. Faulkner ; C. Ferrai ; M. E. Fisher ; L. Forrester ; D. Goldowitz ; R. Guler ; T. Ha ; M. Hara ; M. Herlyn ; T. Ikawa ; C. Kai ; H. Kawamoto ; L. M. Khachigian ; S. P. Klinken ; S. Kojima ; H. Koseki ; S. Klein ; N. Mejhert ; K. Miyaguchi ; Y. Mizuno ; M. Morimoto ; K. J. Morris ; C. Mummery ; Y. Nakachi ; S. Ogishima ; M. Okada-Hatakeyama ; Y. Okazaki ; V. Orlando ; D. Ovchinnikov ; R. Passier ; M. Patrikakis ; A. Pombo ; X. Y. Qin ; S. Roy ; H. Sato ; S. Savvi ; A. Saxena ; A. Schwegmann ; D. Sugiyama ; R. Swoboda ; H. Tanaka ; A. Tomoiu ; L. N. Winteringham ; E. Wolvetang ; C. Yanagi-Mizuochi ; M. Yoneda ; S. Zabierowski ; P. Zhang ; I. Abugessaisa ; N. Bertin ; A. D. Diehl ; S. Fukuda ; M. Furuno ; J. Harshbarger ; A. Hasegawa ; F. Hori ; S. Ishikawa-Kato ; Y. Ishizu ; M. Itoh ; T. Kawashima ; M. Kojima ; N. Kondo ; M. Lizio ; T. F. Meehan ; C. J. Mungall ; M. Murata ; H. Nishiyori-Sueki ; S. Sahin ; S. Nagao-Sato ; J. Severin ; M. J. de Hoon ; J. Kawai ; T. Kasukawa ; T. Lassmann ; H. Suzuki ; H. Kawaji ; K. M. Summers ; C. Wells ; D. A. Hume ; A. R. Forrest ; A. Sandelin ; P. Carninci ; Y. Hayashizaki
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-02-14Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Binding Sites ; Cattle ; Cell Differentiation/*genetics ; Dogs ; *Enhancer Elements, Genetic ; *Gene Expression Regulation, Developmental ; Mice ; RNA, Messenger/genetics/metabolism ; Rats ; Stem Cells/*cytology/metabolism ; Transcription Factors/*metabolism ; *Transcription, GeneticPublished by: -
3Latest Papers from Table of Contents or Articles in PressA. R. Forrest ; H. Kawaji ; M. Rehli ; J. K. Baillie ; M. J. de Hoon ; V. Haberle ; T. Lassmann ; I. V. Kulakovskiy ; M. Lizio ; M. Itoh ; R. Andersson ; C. J. Mungall ; T. F. Meehan ; S. Schmeier ; N. Bertin ; M. Jorgensen ; E. Dimont ; E. Arner ; C. Schmidl ; U. Schaefer ; Y. A. Medvedeva ; C. Plessy ; M. Vitezic ; J. Severin ; C. Semple ; Y. Ishizu ; R. S. Young ; M. Francescatto ; I. Alam ; D. Albanese ; G. M. Altschuler ; T. Arakawa ; J. A. Archer ; P. Arner ; M. Babina ; S. Rennie ; P. J. Balwierz ; A. G. Beckhouse ; S. Pradhan-Bhatt ; J. A. Blake ; A. Blumenthal ; B. Bodega ; A. Bonetti ; J. Briggs ; F. Brombacher ; A. M. Burroughs ; A. Califano ; C. V. Cannistraci ; D. Carbajo ; Y. Chen ; M. Chierici ; Y. Ciani ; H. C. Clevers ; E. Dalla ; C. A. Davis ; M. Detmar ; A. D. Diehl ; T. Dohi ; F. Drablos ; A. S. Edge ; M. Edinger ; K. Ekwall ; M. Endoh ; H. Enomoto ; M. Fagiolini ; L. Fairbairn ; H. Fang ; M. C. Farach-Carson ; G. J. Faulkner ; A. V. Favorov ; M. E. Fisher ; M. C. Frith ; R. Fujita ; S. Fukuda ; C. Furlanello ; M. Furino ; J. Furusawa ; T. B. Geijtenbeek ; A. P. Gibson ; T. Gingeras ; D. Goldowitz ; J. Gough ; S. Guhl ; R. Guler ; S. Gustincich ; T. J. Ha ; M. Hamaguchi ; M. Hara ; M. Harbers ; J. Harshbarger ; A. Hasegawa ; Y. Hasegawa ; T. Hashimoto ; M. Herlyn ; K. J. Hitchens ; S. J. Ho Sui ; O. M. Hofmann ; I. Hoof ; F. Hori ; L. Huminiecki ; K. Iida ; T. Ikawa ; B. R. Jankovic ; H. Jia ; A. Joshi ; G. Jurman ; B. Kaczkowski ; C. Kai ; K. Kaida ; A. Kaiho ; K. Kajiyama ; M. Kanamori-Katayama ; A. S. Kasianov ; T. Kasukawa ; S. Katayama ; S. Kato ; S. Kawaguchi ; H. Kawamoto ; Y. I. Kawamura ; T. Kawashima ; J. S. Kempfle ; T. J. Kenna ; J. Kere ; L. M. Khachigian ; T. Kitamura ; S. P. Klinken ; A. J. Knox ; M. Kojima ; S. Kojima ; N. Kondo ; H. Koseki ; S. Koyasu ; S. Krampitz ; A. Kubosaki ; A. T. Kwon ; J. F. Laros ; W. Lee ; A. Lennartsson ; K. Li ; B. Lilje ; L. Lipovich ; A. Mackay-Sim ; R. Manabe ; J. C. Mar ; B. Marchand ; A. Mathelier ; N. Mejhert ; A. Meynert ; Y. Mizuno ; D. A. de Lima Morais ; H. Morikawa ; M. Morimoto ; K. Moro ; E. Motakis ; H. Motohashi ; C. L. Mummery ; M. Murata ; S. Nagao-Sato ; Y. Nakachi ; F. Nakahara ; T. Nakamura ; Y. Nakamura ; K. Nakazato ; E. van Nimwegen ; N. Ninomiya ; H. Nishiyori ; S. Noma ; T. Noazaki ; S. Ogishima ; N. Ohkura ; H. Ohimiya ; H. Ohno ; M. Ohshima ; M. Okada-Hatakeyama ; Y. Okazaki ; V. Orlando ; D. A. Ovchinnikov ; A. Pain ; R. Passier ; M. Patrikakis ; H. Persson ; S. Piazza ; J. G. Prendergast ; O. J. Rackham ; J. A. Ramilowski ; M. Rashid ; T. Ravasi ; P. Rizzu ; M. Roncador ; S. Roy ; M. B. Rye ; E. Saijyo ; A. Sajantila ; A. Saka ; S. Sakaguchi ; M. Sakai ; H. Sato ; S. Savvi ; A. Saxena ; C. Schneider ; E. A. Schultes ; G. G. Schulze-Tanzil ; A. Schwegmann ; T. Sengstag ; G. Sheng ; H. Shimoji ; Y. Shimoni ; J. W. Shin ; C. Simon ; D. Sugiyama ; T. Sugiyama ; M. Suzuki ; N. Suzuki ; R. K. Swoboda ; P. A. t Hoen ; M. Tagami ; N. Takahashi ; J. Takai ; H. Tanaka ; H. Tatsukawa ; Z. Tatum ; M. Thompson ; H. Toyodo ; T. Toyoda ; E. Valen ; M. van de Wetering ; L. M. van den Berg ; R. Verado ; D. Vijayan ; I. E. Vorontsov ; W. W. Wasserman ; S. Watanabe ; C. A. Wells ; L. N. Winteringham ; E. Wolvetang ; E. J. Wood ; Y. Yamaguchi ; M. Yamamoto ; M. Yoneda ; Y. Yonekura ; S. Yoshida ; S. E. Zabierowski ; P. G. Zhang ; X. Zhao ; S. Zucchelli ; K. M. Summers ; H. Suzuki ; C. O. Daub ; J. Kawai ; P. Heutink ; W. Hide ; T. C. Freeman ; B. Lenhard ; V. B. Bajic ; M. S. Taylor ; V. J. Makeev ; A. Sandelin ; D. A. Hume ; P. Carninci ; Y. Hayashizaki
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-03-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Atlases as Topic ; Cell Line ; Cells, Cultured ; Cluster Analysis ; Conserved Sequence/genetics ; Gene Expression Regulation/genetics ; Gene Regulatory Networks/genetics ; Genes, Essential/genetics ; Genome/genetics ; Humans ; Mice ; *Molecular Sequence Annotation ; Open Reading Frames/genetics ; Organ Specificity ; Promoter Regions, Genetic/*genetics ; RNA, Messenger/analysis/genetics ; Transcription Factors/metabolism ; Transcription Initiation Site ; Transcription, Genetic/genetics ; Transcriptome/*geneticsPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-11-07Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
5Articles: DFG German National LicensesYoshida, Z. ; Hasegawa, A. ; Wakatani, M.
New York, NY : American Institute of Physics (AIP)
Published 1993Staff ViewISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: Production of superthermal electrons through kinetic interactions with electromagnetic fluctuations is studied to account for observations of fast electrons and ion cyclotron waves in reversed field pinch plasmas. Low-frequency Alfvénic (torsional) modes can interact with electrons through the Landau resonance when the wavelength perpendicular to the magnetic field is as small as the ion gyroradius. Such kinetic Alfvén waves induce simultaneous diffusion (double diffusion) in the coordinate and velocity spaces, and produce a field aligned superthermal electron beam in the edge region. Microinstabilities are driven by the electron-beam and ion cyclotron waves are excited. Through these precesses the fluctuation energy in the low-frequency regime may be transported to the ion cyclotron frequency regime.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesWakatani, M. ; Watanabe, K. ; Sugama, H. ; Hasegawa, A.
New York, NY : American Institute of Physics (AIP)
Published 1992Staff ViewISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: By solving numerically the two-field nonlinear model equations for the potential and density fluctuations in the presence of a density gradient, magnetic curvature with shear, and poloidal velocity shear, turbulent spectra and diffusion rates are studied. When the adiabatic parameter (Ωe/νe)(ρs2/R2)/(κρs) is small, a trend of a dual cascade, normal cascade of the density fluctuations, and an inverse cascade of the potential fluctuations, is seen in the wave number spectra, producing a large particle flux proportional to νe1/3. Here R is the major radius, ρs is the ion Larmor radius at the electron temperature, Ωe is the electron cyclotron frequency, νe is the electron ion collision frequency, and κ is an inverse scale length of the background density gradient. Parallel wave numbers are represented by 1/R. For large (Ωe/νe)(ρs2/R2)/(κρs), the electrons become adiabatic, with a significantly reduced particle flux proportional to νe. In the presence of an externally imposed radial electric field with a negative (positive) polarity, Er〈0 (Er(approximately-greater-than)0), the poloidal velocity shear in the E×B drift motion suppresses (enhances) the fluctuation level in the growth phase; however, these effects practically disappear in the saturated state. The radial electric field produced by the inverse cascade due to the convective nonlinearity is also studied; however, its effect on the particle transport is mild.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesTanaka, Motohiko ; Sato, Tetsuya ; Hasegawa, A.
New York, NY : American Institute of Physics (AIP)
Published 1989Staff ViewISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: Simulation of the kinetic Alfvén wave is performed using a two-and-one-half-dimensional (2 (1)/(2) -D) macroscale particle [magnetohydrodynamic (MHD) scale kinetic] simulation code. An oscillating antenna current is applied in one of the boundary regions to launch MHD perturbations into an inhomogeneous plasma in which a sheared magnetic field is present. It is shown that the applied perturbation is mode converted into the kinetic Alfvén wave at the Alfvén resonance layers, resulting in resonant heating of both the ions and electrons. When the plasma beta is relatively low, only the electrons are heated along the ambient magnetic field. The electron heating rate is found to be scaled as dTe(parallel)/dt∝β1/2e 〈δB2y〉, where βe is the electron beta and 〈δB2y〉 is the wave magnetic field intensity. In contrast, ion heating occurs when the ion beta is close to unity and the temperature ratio satisfies Te/Ti〉1. Besides plasma heating, it is found that the plasma particles are accelerated along the ambient magnetic field in the direction of the wave propagation through Landau resonance with the kinetic Alfvén wave.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesNaulin, V. ; Spatschek, K. H. ; Hasegawa, A.
New York, NY : American Institute of Physics (AIP)
Published 1992Staff ViewISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: It is shown that one-field models can cover the selective decay in density and potential when the density is calculated appropriately.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: Heat and particle transports which are associated with the helicity transport are obtained in a current-carrying plasma. The helicity flux represents the transport of parallel current density and is produced by an electric field with a circularly polarized component. Fluctuations with circularly polarized components induce finite average in cross-field nonlinear parallel current, which leads to generation of frictional electron heat flux as well as ion nonlinear polarization current that produces particle flux. The circular polarization of the perturbed electric field thus relates the helicity flux, electron heat flux, and the particle flux in such a manner that the heat and the particle transports in the direction opposite to the helicity flux. This result applies whether the helicity is injected externally by oscillating fields or it is generated internally in the plasma.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: In the magnetohydrodynamic relaxation accompanying fast reconnections, magnetic fluctuations originating from kink-type instabilities yield a finite magnetic compression, and the corresponding transverse electric field is dissipated through transit-time damping. This dissipation mechanism does not change the helicity, while it dissipates the fluctuation energy to result in direct heating of ions. This is in contrast to a slow relaxation process based on the tearing mode turbulence, where the parallel electric field is predominantly dissipated, which accompanies preferential heating of electrons and dissipation of the helicity.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesWakatani, M. ; Sugama, H. ; Hasegawa, A.
[S.l.] : American Institute of Physics (AIP)
Published 1986Staff ViewISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: Finite Larmor radius (FLR) magnetohydrodynamic equations for stellarators are solved numerically to study the linear mode structure of the drift interchange mode. FLR stabilization correlates with the reduction of the phase difference between the pressure perturbation (or the magnetic perturbation) and the potential perturbation. In a cylindrical plasma model with a fixed boundary, the FLR effect, however, is found to destabilize the interchange mode in the large diamagnetic drift velocity regime.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesKiso, M. ; Tanaka, S. ; Fujita, M. ; Fujishima, Y. ; Ogawa, Y. ; Ishida, H. ; Hasegawa, A.
Amsterdam : ElsevierStaff ViewISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0008-6215Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1365-2842Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: summary Methyl-methacrylate autopolymerizing resin is used for multiple applications. Therefore, the mechanical properties of autopolymerizing resin should be assessed comprehensively including strength, stiffness and hardness. Any methods that effectively improve these mechanical properties are desirable. The objective of this study is to examine the effects of the curing environment: air or water with/without pressure, and air or water temperature during polymerization, on the strength, stiffness and hardness of autopolymerizing resin. In addition, we examined the polymerizing behaviour associated with the mechanical properties. Autopolymerizing methyl-methacrylate resin (Unifast II) was polymerized under the following conditions: in air and water with/without pressure at 10, 23, 30, 40, 60 and 80 °C. The resin specimens were subjected to a transverse test (three-point flexural test) and micro-Brinell surface hardness test. Fractured surfaces of the specimens after the transverse test were examined using a scanning electron microscope (SEM). The transverse strength and transverse modulus increased with increasing curing temperature in both wet and dry conditions. Pressured wet conditions increased transverse strength and transverse modulus over non-pressured wet and dry conditions. The resin polymerized in dry conditions showed higher surface hardness than the one polymerized in wet conditions at matching temperature. The SEM images of fractured surfaces cured at lower temperature exhibited porosity within the polymer base and cracks between the base and poly-methyl-methacrylate (PMMA) particulates. Surfaces of the resin polymerized in wet conditions were characterized with PMMA particulates having rougher surfaces suggestive of water incorporation. Raising temperature and pressuring during polymerization increase strength and stiffness of autopolymerizing resin. However, wet condition reduces surface hardness of resin compared with dry condition. These altered mechanical properties are associated with polymerization behaviour of the resin.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesSasaki, T. ; Kano, R. ; Sato, H. ; Nakamura, Y. ; Watanabe, S. ; Hasegawa, A.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Staphylococcus skin infection is characterized by the infiltration of numerous neutrophils within the epidermis; however, the precise mechanism of epidermal infiltration of neutrophils during skin infection with staphylococci is not well understood and the factors regulating the neutrophil recruitment are yet to be determined.Objectives We investigated the effects of staphylococci on cytokine production from keratinocytes, specifically to elucidate the mechanisms of neutrophil infiltration within the epidermis in cutaneous microbial infection.Methods Cytokine production from human keratinocytes was examined after stimulation with heat-killed Staphylococcus aureus, S. epidermidis and S. intermedius.Results Interleukin (IL)-6 and IL-8 were detected in the culture supernatants by enzyme-linked immunosorbent assay but IL-1β, monocyte chemotactic protein-1 and tumour necrosis factor-α were not. IL-6 and IL-8 mRNAs were also confirmed by reverse transcription–polymerase chain reaction in the keratinocytes stimulated with killed staphylococci for 1, 3, 6, 10 and 24 h.Conclusions These results could explain the epidermal infiltration of neutrophils in cutaneous infection with staphylococci, suggesting that the analysis of cytokines might add valuable information for the pathogenesis of cutaneous infection with Staphylococcus species.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesKashima, M. ; Kano, R. ; Mikami, Y. ; Takahama, H. ; Ito, M. ; Hasegawa, A. ; Mizoguchi, M.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We report a successfully treated case of mycetoma from which an unusual Nocardia species was isolated. The isolate was identified as N. veterana by biochemical characterization and 16S ribosomal RNA gene sequencing, and it has not been previously reported as a causative agent of human mycetomas. Treatment with various antibiotics over 6 years and surgical resection failed to cure the disease. However, the combination of intravenous imipenem/cilastatin and amikacin along with oral clarithromycin and minocycline proved very effective in this case. This is the first case report of mycetoma due to N. veterana in a clinical setting.Type of Medium: Electronic ResourceURL: