Search Results - (Author, Cooperation:A. Handler)

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  1. 1
    C. L. Tan ; J. L. Plotkin ; M. T. Veno ; M. von Schimmelmann ; P. Feinberg ; S. Mann ; A. Handler ; J. Kjems ; D. J. Surmeier ; D. O'Carroll ; P. Greengard ; A. Schaefer
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-12-07
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Corpus Striatum/cytology ; Dendrites/physiology ; Epilepsy/metabolism ; Hyperkinesis/metabolism ; MAP Kinase Signaling System ; Mice ; MicroRNAs/genetics/*metabolism ; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors/metabolism ; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors/metabolism ; *Motor Activity ; Neurons/*physiology ; Parkinsonian Disorders/metabolism/physiopathology ; Prosencephalon/cytology/*physiology ; RNA, Messenger/genetics/metabolism ; RNA-Induced Silencing Complex/metabolism ; Up-Regulation
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Rodríguez-Martín, E. ; Canals, S. ; Casarejos, M. J. ; De Bernardo, S. ; Handler, A. ; Mena, M. A.

    Oxford, UK : Blackwell Science Ltd
    Published 2001
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    The aim of this study was to investigate the effect of l-DOPA and glia-conditioned medium (GCM) on cell viability, tyrosine hydroxylase (TH) expression, dopamine (DA) metabolism and glutathione (GSH) levels of NB69 cells. l-DOPA (200 µm) induced differentiation of NB69 cells of more than 4 weeks in vitro, as shown by phase-contrast microscopy and TH immunocytochemistry, and decreased replication, as shown by 5-bromodeoxyuridine immunostaining. l-DOPA did not increase the number of necrotic or apoptotic cells, as shown by morphological features, Trypan Blue, lactate dehydrogenase activity, bis-benzimide staining and TUNEL assay. Furthermore, l-DOPA (200 µm) increased Bcl-xL protein expression. Incubation of cells with l-DOPA (50, 100, 200 µm) for 24 h resulted in an increase in TH protein levels (174, 196 and 212% versus control). Neither carbidopa, an inhibitor of l-aromatic amino acid decarboxylase enzyme, nor l-buthionine sulfoximine, which inhibits GSH synthesis, or ascorbic acid, an antioxidant, blocked the l-DOPA-induced effect on TH protein expression. l-DOPA (0, 50, 100 and 200 µm) plus GCM further increased the amount of TH protein (346, 446, 472 and 424%). l-DOPA (200 µm) increased TH protein levels to 132, 191 and 245% of controls after incubation for 24, 48 and 72 h. DA metabolism in NB69 cells was increased in cultures treated with either l-DOPA (200–300 µm) or GCM and these two agents had a synergistic effect on DA metabolism. In addition, l-DOPA (200 µm) or/and GCM-treated cells increased their GSH extracellular levels (223, 257, 300% of controls) after 48 h of treatment. The l-DOPA-induced increase of TH protein expression in NB69 cells was independent of DA production, free radicals and GSH up-regulation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1471-4159.2001.00440.x

    Articles: DFG German National Licenses
  3. 3
    Foley, G. E. ; Handler, A. H.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1958
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1958.tb54869.x

    Articles: DFG German National Licenses
  4. 4
    Handler, A. ; Peringer, P. ; Muller, E.P.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0022-328X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0022-328X(90)85418-X

    Articles: DFG German National Licenses
  5. 5
    Handler, A. ; Peringer, P. ; Muller, E.P.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0022-328X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0022-328X(91)86090-D

    Articles: DFG German National Licenses
  6. 6
    Handler, A. ; Peringer, P. ; Muller, E.P.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0277-5387
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/S0277-5387(00)86210-5

    Articles: DFG German National Licenses