Search Results - (Author, Cooperation:A. Goren)

2014-12-24

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Binding Sites ; Cell Differentiation/*genetics ; Cell Lineage/genetics ; Embryonic Stem Cells/*cytology/metabolism ; Epigenesis, Genetic/*genetics ; Epigenomics/*methods ; Humans ; Neural Stem Cells/*cytology/*metabolism ; RNA, Small Interfering/analysis/genetics ; Reproducibility of Results ; Transcription Factors/metabolism ; Transcription, Genetic/genetics

2013-07-06

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Cell Differentiation ; Cell Line ; Chromatin/chemistry/metabolism ; Female ; *Genome ; Male ; Mice ; Models, Genetic ; RNA, Long Noncoding/chemistry/*metabolism ; Transcription, Genetic ; X Chromosome/*metabolism/ultrastructure ; *X Chromosome Inactivation

2013-05-21

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Bone Marrow Cells/cytology/immunology ; Dendritic Cells/cytology/immunology/*metabolism ; *Gene Expression Profiling ; Gene Expression Regulation/*immunology ; In Situ Hybridization, Fluorescence ; Interferon Regulatory Factor-7 ; Interferons/immunology ; Lipopolysaccharides/immunology ; Mice ; Mice, Knockout ; Protein Isoforms/genetics ; RNA Splicing/*immunology ; RNA, Messenger/analysis/genetics ; Reproducibility of Results ; STAT2 Transcription Factor ; Sequence Analysis, RNA ; *Single-Cell Analysis ; Transcriptome/*genetics ; Viruses/immunology

1089-7690

AIP Digital Archive

Physics

Chemistry and Pharmacology

The 2+1 resonantly enhanced multiphoton ionization (REMPI) spectrum of sulfur atoms produced by two-photon photodissociation of sulfur dioxide is reported for the wavelength range 252–263 nm. Photoelectron spectroscopy of many resonant ionizations reveals a propensity toward preservation of ion core configuration in formation of ionic species. Several pathways for production of pure populations of excited state 2DJo sulfur ions are documented. Photoelectron angular distributions show contributions from outgoing electrons with a maximum angular momentum lmax=2. Intermediate state alignment from two-photon absorption of ground state 3P0 sulfur atoms is demonstrated.

Electronic Resource

1089-7690

AIP Digital Archive

Physics

Chemistry and Pharmacology

The (2+1) resonance-enhanced multiphoton ionization spectrum of phosphorus atoms is reported for the wavelength range 300–317 nm. Atomic phosphorus is formed by multiphoton photodissociation of phosphorus tribromide vapor. Photoelectron spectroscopy conducted at phosphorus ionization resonances produces pure populations of P+(3PJ) and P+(1D2) ions. Production of a mixture of phosphorus ionic states indicates a clear propensity to preserve the ion core electron configuration upon ionization of phosphorus. Four spin-changing transitions are assigned supported by photoelectron spectral data.

Electronic Resource

1749-6632

Blackwell Publishing Journal Backfiles 1879-2005

Natural Sciences in General

Electronic Resource

0911-6044

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Linguistics and Literary Studies

Biology

Medicine

Electronic Resource

0016-6480

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Medicine

Electronic Resource

0016-6480

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Medicine

Electronic Resource

0020-7381

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Physics

Electronic Resource

1432-1939

Springer Online Journal Archives 1860-2000

Biology

Summary Nicotiana tabacum L. Bel-W3, which is highly sensitive to ozone, was grown in two glass chambers and exposed to the ambient air at the periphery of Tel-Aviv, during winter, spring, summer and autumn 1978. During the exposure time, atmospheric ozone was continuously measured by a chemiluminescent monitor. Throughout the experiments, plants' height was measured and the number of leaves was determined three times weekly. The extent of injury to the tobacco plants was measured by the percentage of injured plants, the percentage of injured leaves and the percentage of leaves' area injured. Necrotic lesions, typical for ozone injury, appeared on the mature leaves of the exposed tobacco plants in three out of four exposures. Appearance of incipient injury and the extent of injury differed among the experiments and depended not only on exposure duration and on ozone concentrations, but also on the exposure conditions. The percentage of injured leaves and the percentage of leaves' area injured, increased with the duration of exposure and with rising cumulative ozone concentrations.

Electronic Resource

1432-1254

Springer Online Journal Archives 1860-2000

Geography

Physics

Abstract Bel-W3 Tobacco, which is highly sensitive to ozone, was grown in two glass chambers and exposed to the ambient air at the periphery of Tel-Aviv, during winter, spring, summer and autumn 1978. During the exposure time, atmospheric ozone was continuously measured by a chemiluminescent monitor. Throughout the experiments, plants' height was measured and the number of leaves was determined three times weekly. The extent of injury to the tobacco plants was measured by the percentage of injured plants, the percentage of injured leaves and the percentage of leaves' area injured. Necrotic lesions, typical for ozone injury, appeared on the mature leaves of the exposed tobacco plants in three out of four exposures. Appearance of incipient injury differed among the experiments and depended not only on exposure duration and on ozone concentrations, but also on the exposure conditions (like light intensity, temperature and humidity), which considerably influenced the appearance of the injury. The percentage of injured leaves and the percentage of leaves' area injured, increased with the duration of exposure and with rising cumulative ozone concentrations.

Electronic Resource

1432-1076

Key words Pulmonary function test ; Adjustment ; Children ; Prediction equations ; Population specific

Springer Online Journal Archives 1860-2000

Medicine

Abstract Fitting adequate prediction equations for pulmonary function test (PFT) parameters is crucial in the analysis of lung function tests and their interpretation. Our work aimed at studying the necessity of building population specific prediction equations, rather than using prediction equations built-in in commercial equipment. We used as an example results of studies carried out among Israeli schoolchildren. Second to sixth grade children (7–13 years old), 1064 boys and 1211 girls, were studied in Tel-Aviv. PFT (forced vital capacity, forced expiratory volume in 1st second, peak expiratory flow, forced expiratory flow in 50% volume, forced expiratory flow in 75% volume) performed by these children were adjusted for height, weight and age, for each sex separately, by a multiple regression procedure. Predicted PFT parameters of 300 boys and 301 girls aged 7–13 years, living along the southern shore of Israel, were calculated using the equations built for the same aged Tel-Aviv children as well as the prediction equations built-in in the spirometer used. The ratios between the observed PFT parameters in the southern children and their expected values, using the Israeli population specific equations, were around 1.00. Using the built-in equations resulted in ratios around 0.90. Conclusion The development of population specific prediction equations for PFT parameters is necessary. Such equations should be used both in clinical assessment to minimize misclassification (healthy/sick child) and in epidemiological studies.

Electronic Resource

1432-1076

Hypokalaemia ; Gall bladder ; Bartter syndrome

Springer Online Journal Archives 1860-2000

Medicine

Abstract A 5.5-month-old male infant with hypokalaemia and gall bladder dilatations is reported. The child was shown to have Bartter syndrome. After oral treatment with potassium and indomethacin, serum potassium levels became low normal and the gall bladder enlargement resolved. This entity should be included in the clinical spectrum of neuromuscular disturbances resulting from hypokalaemia and should be considered in a hypokalaemic infant with a right-sided abdominal mass.

Electronic Resource

1573-5168

fish ; Sparus aurata ; gonadotropin-releasing hormone ; analogs ; bioactivity ; pituitary ; gonadotropin ; degradation

Springer Online Journal Archives 1860-2000

Biology

Abstract Thein vivo andin vitro potency of native and modified forms of gonadotropin releasing hormone (GnRH) to release gonadotropin (GtH) was studied inSparus aurata and correlated with their relative susceptibility to degradation by cytosolic-bound enzymes of the pituitary, kidney, and liver. Salmon (s) GnRH and luteinizing hormone-releasing hormone (LHRH) are equipotent whereas analogs of these peptides ((D-Arg6-Pro9NET)-sGnRH, (D-Ala6-Pro9NET)-LHRH, (D-Trp6)-LHRH) are superactive in inducingin vivo GtH release (at 10 µg/kg body weight). In anin vitro superfusion system of pituitary fragments all analogs are equipotent to the native peptides (at 10−10 to 2.5 × 10−7M). sGnRH and LHRH are rapidly degraded by cytosolic peptidases of the pituitary, liver, and kidney. The preferred site of cleavage is the Tyr5-Gly6 bond. Substitution of the position 6 glycine by D-amino acids renders the 5–6 bond resistant to degradation and shifts the main site of cleavage to the Pro9-Gly10NH2 bond. Substitution at position 6 (as above) and at position 10 with Pro9NET results in analogs that are resistant to degradation. We propose that enzymatic cleavage terminates GnRH bioactivityin vivo and thus increased resistance to degradation is a major determinant of GnRH analog superactivity.

Electronic Resource

1573-7284

Respiratory symptoms ; Respiratory diseases ; Pulmonary function Passive smoking ; Socio-economic background ; Pulmonary disases in family

Springer Online Journal Archives 1860-2000

Medicine

Abstract Second and fifth grade schoolchildren living within 19 km from a 1400 megawatt coal fired power plant are followed up. Their parents filled out an ATS-NHLI health questionnaire and they performed pulmonary function tests (PFT), which included: FVC, FEV,, FEVt/FVC, and PEF. The effects of socioeconomic background, smoking habits and pulmonary diseases in the families on the distribution of respiratory symptoms, respiratory diseases and PFT of the children were analysed. Higher FEV1/FVC, lower prevalence of respiratory diseases and excess respiratory symptoms were present among children from crowded homes. Mothers' smoking was found to be connected with significantly higher prevalence of bronchitis, non significant higher prevalence of asthma, significant lower FEV1/FVC and a trend of lower FEV1 and PEF among their children. House heating did not effect the prevalence of respiratory symptoms and diseases of the children. Significantly higher prevalence of respiratory symptoms and diseases was found among children, whose families reported about a history of pulmonary diseases, but no reduction of PFT parameters could be found among them. Mothers' contribution to respiratory symptoms and diseases of their children seems to be more significant than that of the children's fathers. Most respiratory symptoms were more common among children with a history of pneumonia in childhood, especially those who had pneumonia recently.

Electronic Resource

1573-7284

Respiratory symptoms ; Respiratory diseases ; Pulmonary function ; Occupational exposure ; Smoking

Springer Online Journal Archives 1860-2000

Medicine

Abstract A panel of 377 healthy adults and 920 COPD patients aged 30–65 years, is annually interviewed (ATS-NHLI health questionnaire) and performs pulmonary function test (PFT), which includes: FVC, FEVI, FEVl/FVC, PEF, FEF50 and FEF75. Baseline data analysis showed a more significant excess in respiratory symptmos (8.8% to 21.4%) and lower PFT (2.4% to 8.0%) among patients occupationally exposed to dust, than among healthy exposed panelists (-0.7% to 7.7% excess symptomatology and -0.3 to 5.8% lower PFT). Among patients a significant correlation between PFT and degree of occupational dust exposure was found. Significantly lower FEVl/FVC and excess in respiratory symptoms (with relative risks of 2.47–16.38) was present in healty smokers vs. non smokers as compared with COPD patients.

Electronic Resource

0002-9106

Life and Medical Sciences ; Cell & Developmental Biology

Wiley InterScience Backfile Collection 1832-2000

Medicine

During the last one-third of their gestational period, lathyritic rats incorporate significantly lower amounts of Sr85 as revealed by whole body counting techniques. This difference was maximum at term. The study provides evidence for a lathyritic disturbance in the initial phases of mineralization of hard tissue matrices.

2 Ill.

Electronic Resource